JOURNAL OF HAZARDOUS MATERIALS
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2023
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IF 13.6
Shuai Zhang,Jiating Zhao,Lizhong Zhu
Thermal desorption (TD) is known as an effective technique to remediate PAHs-contaminated sites. However, effectively removing PAHs using TD while saving time, and energy, and minimizing soil damage remains a challenge. In this study, we examined the combined effects of various factors on the removal efficiency of pyrene (PYR) by TD and developed an optimal numerical model based on conducting a series of soil experiments. The results showed that temperature (T) and time (t) promoted the desorption of PYR, while water ( S w ) and organic matter ( f om ) were just the opposite. Besides, water and organic matter had a synergistic effect proportionally. It was found that adjusting the soil-water ratio (which can be controlled by organic matter) maximized the desorption rate of PYR. An ideal S w / f om 1.56 and a minimized recommended temperature (173 °C) were proposed based on the model. Finally, the efficacy of the optimized scheme was validated in real-world site soil. These findings not only mechanistically revealed the desorption behavior of PYR under the influence of various factors, but also provided an optimized scheme for efficiently removing PAHs using TD, thereby accelerating the remediation process and reducing energy consumption. The modeling ideas and conclusions obtained may be applicable to other PAHs, guiding the effective remediation of PAHs-polluted sites.
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CHEMICAL ENGINEERING SCIENCE
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2023
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IF 4.7
Wen-shuo Zhang,Li-peng Tan,Jun Shen,Yu-gao Wang,Gang Liu,Qing-bai Xu
Coal-tar pitch (CTP) output in China has consistently exceeded 7 million tons annually since 2011. CTP contains 16 toxic polycyclic aromatic hydrocarbons (PAHs) that are preferentially monitored by the American Environmental Protection Agency (EPA). As a result, the widespread and extensive use of CTP is restricted. Consequently, finding ways to reduce the toxicity of CTP has become an urgent concern. In the paper, the reaction conditions were optimized using model compounds (naphthalene, fluorene, anthracene, phenanthrene, fluoranthene, pyrene, benzo [a]pyrene) of CTP. Subsequently, the CTP was modified through alkylation reaction using 1-dodecene, and the detoxification effect was evaluated based on chemical index, fumes, and water-soluble substances. The total content of 16 toxic PAHs in the modified CTP (MCTP) decreased by 75.56% compared to the original CTP. The toxicity equivalent quotient (TEQ) of the MCTP was reduced by more than 65% according to different environmental standards. The content of the 16 PAHs detected in MCTP fumes released at 140 °C decreased by 80.89%, while in water-soluble substances it decreased by 64.04% and 76.67% at 30 °C and 60 °C, respectively. These results strongly indicate the effectiveness of the alkylation method in reducing the toxicity of CTP. However, in order to develop more environmentally-friendly materials, it is necessary to explore more efficient catalysts and cheaper modifiers, which will be the focus of our future research. Novelty Statement This study investigated the toxicity inhibition of CTP to reduce the content of PAHs by alkylation method. The modification process was analyzed using model compounds to understand the potential reaction pathways. The objective of toxicity inhibition was achieved by creating low-toxicity and long-chain alkyl substitutes. Additionally, the toxicity of CTP and MCTP was assessed by introducing fumes and water-soluble substances.
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SENSORS AND ACTUATORS B-CHEMICAL
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2023
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IF 8.4
Haohao Li,Yanrong Li,Fengshan Liu,Yang Xu,Huanrong Li
Microplastics (MPs) pollution has become a vital issue of worldwide concern owing to its associated hazards and the ubiquitous accumulation of MPs particles, which is correlated to their small sizes. Rapid identification and quantification of MPs represents an ongoing challenge in the field of environmental research. In this work, we prepared a fluorescence nanoprobe for identifying polyethylene (PE) MPs and developed a readily available method for the fast quantification of PE MPs in fluorescence mode. A kind of sulfur-doped carbon nanoparticles (S-CNPs) was prepared using nitrated pyrene and dithiosalicylic acid as precursors via a solvothermal process. S-CNPs showed no fluorescence emission in the solid state, whereas visible fluorescence was observed by labeling PE MPs. The surface environment-dependent emission of S-CNPs is an important factor in explaining the different emissions of different types of MPs, such as PE, polyvinyl chloride (PVC), and polystyrene (PS) for MPs identification. Notably, the distinction between PE and polypropylene (PP) was achieved using these S-CNPs according to their different staining efficiencies. Owing to its fast staining ability, a paper-based method for PE MPs quantification in water samples was developed using a simple vacuum-assisted suction filtration method and filter paper soaked with S-CNPs. Utilized as a readily available identification and quantification platform, these S-CNPs have great potential and could pave the way for MPs monitoring.
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Processes
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2023
·Vol. 11
·期 7
·2199
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IF 3.5
Liang Shen,Yifang Liu,Jiabao Gong,Erle Qiao
Soil is the main aggregation site of polycyclic aromatic hydrocarbons and an important pathway of migration to other media. In this paper, the adsorption behavior of pyrene and seven different types of surfactants on kaolinite surfaces was studied by molecular dynamics simulation and desorption testing. The molecular dynamics simulation results showed that pyrene was more easily adsorbed on the 001 (-) side of kaolinite. SDBS, SDS, TW80, and TX-100 had strong interactions with pyrene, encapsulating pyrene molecules in aggregates. However, when the concentration of surfactant was too high, the desorption of pyrene molecules on a kaolinite surface will be inhibited. The desorption of pyrene molecules will be inhibited in the presence of BS-12, TW80, and TX-100, while the desorption process can be promoted by using CTAC, DDBAC, SDBS, and SDS as soil remediation agents. The removal rate of pyrene gradually increased with the increase of SDS dosage, while for SDBS, the removal rate showed a trend of first increasing and then decreasing. When the concentration of SDS was 0.014 mol/L, the elution rate of pyrene reached 72.86%. The molecular dynamics simulation results were similar to the desorption test results, verifying the reliability of molecular dynamics simulation. The research results provide theoretical support for the selection of surfactants in the remediation process of pyrene-contaminated soil.Keywords:soil remediation;polycyclic aromatic hydrocarbons;surfactants;molecular simulation
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Advanced Healthcare Materials
·
2023
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IF 10
Xinmiao Lan,Jie Zhong,Regina Huang,Yuhan Liu,Xiaowei Ma,Xuan Li,Dan Zhao,Guangchao Qing,Yuxuan Zhang,Lu Liu,Jinjin Wang,Xu Ma,Ting Luo,Weisheng Guo,Yuji Wang,Li-Li Li,Yu-Xiong Su,Xing-Jie Liang
Antimicrobial peptides (AMPs) are a developing class of natural and synthetic oligopeptides with host defense mechanisms against a broad spectrum of microorganisms, including viruses, bacteria, and fungi. With in-depth research on the structural conformations of AMPs, synthesis or modification of peptides has shown great potential in effectively obtaining new therapeutic agents with improved physicochemical and biological properties. Notably, AMPs with self-assembled properties have gradually become a hot research topic for various materials and biomedical applications. Compared to monomeric peptides, these peptides can exist in diverse forms (e.g., nanoparticles, nanorods, and nanofibers) and possess several advantages, such as high stability, good biocompatibility, and potent biological functions, after forming aggregates under specific conditions. In particular, the stability and antibacterial property of these AMPs can be modulated by rationally regulating the peptide sequences to promote self-assembly, leading to the reconstruction of molecular structure and spatial orientation while introducing some peptide fragments into the scaffolds. In this work, we have developed four self-assembled AMPs, and the relationship between their chemical structures and antibacterial activity were explored extensively through different experiments. Importantly, the evaluation of antibacterial performance in both in vitro and in vivo studies has provided a general guide for using self-assembled AMPs in subsequent treatments for combating bacterial infections. This article is protected by copyright. All rights reserved
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International Journal of Nanomedicine
·
2023
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IF 8
Yan Liang,Ping-Yu Wang,Ze-Yun Liu,Hong-Fang Sun,Qin Wang,Guang-Bin Sun,Xia Zhang,You-Jie Li,Shu-Yang Xie
Introduction As the special modality of cell death, immunogenic cell death (ICD) could activate immune response. Phototherapy in combination with chemotherapy (CT) is a particularly efficient tumor ICD inducing method that could overcome the defects of monotherapies.Methods In this study, new dual stimuli-responsive micelles were designed and prepared for imaging-guided mitochondrion-targeted photothermal/photodynamic/CT combination therapy through inducing ICD. A dual-sensitive methoxy-polyethylene glycol-SS-poly(L-γ-glutamylglutamine)-SS-IR780 (mPEG-SS-PGG-SS-IR780) polymer was synthesized by grafting IR780 with biodegradable di-carboxyl PGG as the backbone, and mPEG-SS-PGG-SS-IR780/paclitaxel micelles (mPEG-SS-PGG-SS-IR780/PTXL MCs) were synthesized by encapsulating PTXL in the hydrophobic core.Results In-vivo and -vitro results demonstrated that the three-mode combination micelles inhibited tumor growth and enhanced the therapeutic efficacy of immunotherapy. The dual stimuli-responsive mPEG-SS-PGG-SS-IR780/PTXL MCs were able to facilitate tumor cell endocytosis of nanoparticles. They were also capable of promoting micelles disintegration and accelerating PTXL release. The mPEG-SS-PGG-SS-IR780/PTXL MCs induced mitochondrial dysfunction by directly targeting the mitochondria, considering the thermo- and reactive oxygen species (ROS) sensitivity of the mitochondria. Furthermore, the mPEG-SS-PGG-SS-IR780/PTXL MCs could play the diagnostic and therapeutic roles via imaging capabilities.Conclusion In summary, this study formulated a high-efficiency nanoscale platform with great potential in combined therapy for tumors through ICD.
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FOOD CHEMISTRY
·
2023
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IF 8.8
Furong Jin,Xinyue Yin,Yang Wan,Jiukai Zhang,Jindi Wang,Xiangbo Fu,Tianxin Fu,Buwei Liu,Yongshi Chen,Bo Tian,Zhibiao Feng
It is important to detect the presence of biogenic amines (BAs) as indicators of food freshness. The purpose of this study was to develop a novel ultrasonic–microwave synergistic supramolecular solvent liquid–liquid microextraction based on solidification of floating organic droplet (UMS-SUPRAS-SFO-LLME) combined with high-performance liquid chromatography for the determination of BAs. The physical properties and microstructure of SUPRAS based on 1-dodecanol and tetrahydrofuran were studied, and the extraction conditions such as the SUPRAS volume, the UMS process, and the centrifugal conditions were optimized. The results for the extraction kinetics and thermodynamics showed that UMS-SUPRAS-SFO-LLME is a spontaneous, endothermic diffusion process. The linear ranges of this method are 0.1–2.0 × 10 5 ng·mL −1 ( R 2 > 0.994), the limits of detection are 4.0 × 10 -3 -6.0 × 10 -2 ng·mL −1 , and the recoveries were 96.28–103.15%. Compared with existing analysis methods, UMS-SUPRAS-SFO-LLME is a sensitive, green and economical sample pretreatment method for analyzing the enrichment of BAs in beer and fish.
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MOLECULAR PHARMACEUTICS
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2023
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IF 4.9
Qingfa Tang,Yao Chen,Yusheng Zhang,Kewei Wang,Li Liu,Dongmei Pan,Qiang Liu,Cuiping Jiang
Tanshinone IIA (TS-IIA) and salvianic acid A (SAA) are the main pharmacological active constituents of Danshen, which exhibit potent effects on atherosclerosis. A combination of TS-IIA and SAA might exert a synergistic antiatherosclerotic effect. However, the opposite solubility profiles of TS-IIA and SAA might lead to difficulty in achieving a synergistic combined effect of the two active components. Therefore, in this work, we fabricated a ROS-responsive prodrug micelle for the codelivery of TS-IIA and SAA (TS-IIA-PM) by self-assembling amphiphilic block copolymer PEG5000-SAA/PLA10000-APBA. The amphiphilic polymer was characterized by 1H NMR, FTIR, and alizarin red S competition tests. The ROS responsiveness of TS-IIA-PM was evidenced by time-course monitoring of particle size and morphology changes and drug release behavior in the presence of 1 mM H2O2. We found TS-IIA-PM was stable according to its critical micelle concentration and the unchanged particle sizes in 10% FBS for 7 days. The results of in vitro and in vivo tests revealed that TS-IIA-PM was safe and biocompatible. Furthermore, it was observed that TS-IIA and prodrug micelle could produce synergistic antiatherosclerotic effect based on the results of the antioxidant study, which was further confirmed by a series of pharmocodynamics studies, such as in vitro DiI-oxLDL uptake study, oil red O staining, cholesterol efflux study, inflammatory cytokine analysis, in vivo CD68 immunostaining, and lipid disposition staining studies. Collectively, TS-IIA-PM holds great potential for the safe and efficient codelivery of TS-IIA and SAA for synergistic antiatherosclerosis.
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FOOD CHEMISTRY
·
2023
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IF 8.8
Xiumin Yang,Junmin Wang,Guifen Chang,Cuihong Sun,Qiuhua Wu,Zhi Wang
Analysis of organochlorine pesticides (OCPs) residues in milk faces a significant challenge. Herein, a sea urchin structured covalent organic framework bearing boric acid groups named COF-B(OH) 2 was synthesized and applied as a coating material for solid-phase microextraction (SPME) of the OCPs in cattle’s milk. Its performance was superior to that of three commonly used commercial SPME fibers, which could be due to the coexistence of hydrogen bonding , halogen bonding, π-stacking and electrostatic interactions. Besides, the fiber coating displayed good stability and reusability. After optimization, a COF-B(OH) 2 based SPME coupled with gas chromatography-electron capture detection was established for the sensitive detection of the OCPs from milk samples. The limits of detection (S/N = 3) were between 0.04 and 1.00 μg kg −1 . Satisfactory accuracy was achieved with the method recoveries in the range of 87.5 % to 112.5 %. These results manifest the feasibility of the COF-B(OH) 2 coated fiber for the enrichment of the trace OCPs from milk samples.
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ANALYTICAL CHEMISTRY
·
2023
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IF 7.4
Yuanji Gao,Hongru Feng,Bing Xia,Lei He,Congling Yang,Lijuan Zhao,Yuanjiang Pan
Ultratrace organic pollutants in the environment pose severe threats to human health; hence, their accurate detection is essential. In this study, we develop a secondary solvent-free enrichment strategy based on bubbling extraction (BE). Especially, we used BE solid-phase microextraction and BE carbon nanotube paper absorption to capture aerosols from a liquid water surface, desorb analytes, and analyze the analytes using mass spectrometry. The application of a solvent-free enrichment strategy helps overcome technical challenges in implementing BE technology, including reproducibility, quantification, and sensitivity. This approach objectively demonstrates the enrichment efficiency of BE, resulting in improved mass spectrometry response and quantification. It effectively tackles the difficulties in detecting and quantifying ultratrace environmental pollutants in mass spectrometric analysis. The present study successfully conducted a quantitative analysis of 16 polycyclic aromatic hydrocarbons and 7 antibiotics in 48 environmental water samples. This strategy proved effective in detecting the presence and distribution of polar and nonpolar environmental pollutants in rivers and lakes. Moreover, this strategy has several advantages, such as ultrahigh sensitivity at the femtograms per liter level, good greenness, multiplexed quantitation, low sample consumption, and ease of operation. Overall, the utilization of the ultrasensitive and environmentally friendly BE approach presents a reliable and adaptable method for the identification of ultratrace environmental pollutants in water specimens, thereby enabling early monitoring of pollutant levels.
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WATER AIR AND SOIL POLLUTION
·
2023
·Vol. 234
·期 7
·1-13
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IF 2.9
Zhou Danli,Zhang Dong,Zhang Ming,Lü Ting,Huang Jingang,Zhao Hongting,Lin Jun
To clarify the sorption mechanism and removal efficiency of PAHs by waste biomass-based magnetic sorbents, the sorption performance of magnetic Myriophyllum aquaticum biomass (MMaB) for PAHs was studied. The structural characteristics and magnetic properties of MMaB were measured by FTIR, SEM–EDS, XRD and VSM. Batch experiments were carried out to evaluate the effects of contact time, initial concentration and properties of PAHs, pH, ionic strength and temperature on PAH sorption. The results showed that the sorption of seven PAHs achieved equilibrium at approximately 4–6 h, which fit well to the pseudo-second-order kinetic model. The isotherms followed the Freundlich model and linear model well, indicating that the sorption process was controlled by chemisorption. The distribution parameter ( K d ) values were 91.3, 563.7, 1010.5, 2917.8, 2706.6, 9046.8 and 15969.0 L·kg −1 for naphthalene, acenaphthene, fluorene, phenanthrene, anthracene, pyrene, and fluoranthene on MMaB, respectively, following the order of their hydrophobicity (e.g., K ow ). A positive correlation was obtained: log K d = 0.8091log K ow + 1.7034. Water chemical properties such as pH and ionic strength had no obvious effect on PAH removal. The spontaneity, feasibility and exothermic properties of PAH removal by MMaB were explained from thermodynamic point of view. The as-prepared MMaB sorbent underwent four consecutive sorption cycles and had good cycling performance. These studies indicate that MMaB has great potential as an easily-prepared, easy-to-operate and efficient biosorbent to remove PAHs from wastewater.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Zhaowen Liu,Hongcai Wang,Yanan Bu,Ting Wu,Xiuqiong Chen,Huiqiong Yan,Qiang Lin
The application of hydrophobic β-carotene in the food industry are limited due to its susceptibility to light, high temperature, pH value, and other factors, leading to poor stability and low bioavailability. To address this problem, we adopt a more green and environmentally friendly reducing agent, 2-methylpyridine borane complex (pic-BH 3 ), instead of traditional sodium borohydride, to achieve the simple green and efficient synthesis of amphiphilic oxidized sodium alginate grafted oleoamine derivatives (OSAOLA) through the reduction amination reaction of Schiff base. The resultant OSAOLA with the degree of substitution (DS) of 7.2 %, 23.6 %, and 38.8 % were synthesized, and their CMC values ranged from 0.0095 to 0.062 mg/mL, indicating excellent self-assembly capability in aqueous solution. Meanwhile, OSAOLA showed no obvious cytotoxicity to RAW 264.7 cells, thus revealing good biocompatibility. Furthermore, β-carotene, as the hydrophobic active ingredients in foods was successfully encapsulated in the OSAOLA micelles by ultrasonic-dialysis method. The prepared drug-loaded OSAOLA micelles could maintain good stability when stored at room temperature for 7 d. Additionally, they were able to continuously release β-carotene and exert long-term effects in pH 7.4 PBS at 37 °C, effectively improving the bioavailability of β-carotene, which exhibited tremendous application potential in functional food and biomedical fields.
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