FOOD CHEMISTRY
·
2024
·
IF 8.5
Ying-Lin Zhu,Wei-Xuan Li,Yu-Hui Zhang,Han Yan,Long-Yu Guo,Yue Zhang,Hai-Peng Lv,Ling-Hong Zhou,Zhi Lin,Wen-Liang Wu,Yin Zhu
Jianghua Kucha (JHKC) is an ancient tea germplasm, which presents a high value for resource utilization but was less developed in aroma research. In this study, volatile metabolites in fresh leaves and corresponding black teas of JHKC, along with odorants of JHKC black teas were systematically investigated using stir-bar sorptive extraction in combination with gas chromatography–mass spectrometry (GC–MS) and GC–olfactometry/MS (GC–O/MS) technologies. A total of 128 and 135 volatile compounds were identified in fresh leaves and black teas, respectively, along with 13 key differential volatile components derived from fatty acids, pigments, glycoside precursors, and the terpene pathway. An odorant wheel for JHKC black teas was developed based on 29 important odorants determined through a combination of GC–O/MS perception, aroma extract dilution analysis, odor activity value measurement. Trans - β -Damascenone, cis -jasmone, and cis -jasmin lactone have been identified as significant contributors to the “sweet” flavor of JHKC black teas.
研究领域:
农业科学
·
食品科学
·
化学
·
植物科学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Sulfur Chemistry
·
2022
·
IF 2.325
Ling Jiang,Qingqing Lu,Qianqian Huang,Yue Cheng,Xiaohe Chu
In this paper, a simple and environment-friendly protocol was developed for the synthesis of arylsulfonyl 4H-pyrans via L-proline-catalyzed one-pot two-step reaction of aromatic aldehyde with phenylsulphonyl acetonitrile and dimedone under ball-milling conditions. Environmental acceptability, wide substrate scope, low cost and operational simplicity are the key features of this method.
研究领域:
有机化学
·
绿色化学
✓ 已验证
DOI
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2022
·
IF 3.571
Zhenyao Lu,Sijia Li,Nan Aa,Yuanmao Zhang,Ran Zhang,Chen Xu,Shize Zhang,Xiangqing Kong,Guangji Wang,Jiye Aa,Yue Zhang
Purine and pyrimidine metabolism are vital metabolic pathways in the development, proliferation or repairment of cells or tissues associated with various diseases. Here, a simple, all-in-one injection hydrophilic interaction liquid chromatography-tandem mass spectrometry method was developed for simultaneous determination of 20 metabolites: adenine , adenosine, deoxyadenosine , adenosine 5′-monophosphate, cyclic adenosine monophosphate, hypoxanthine , xanthine , inosine , deoxyinosine , xanthosine , xanthosine 5′-monophosphate and uric acid , which are products of purine metabolism; uridine , deoxyuridine , uridine 5′-monophosphate and uracil , are products of pyrimidine metabolism; and corticosterone , methionine , acetylcholine and serotonin. To minimize interference of endogenous molecules in sample matrixes, a combination of activated carbon adsorption and a serum substitute matrix (5% bovine serum albumin in phosphate buffered saline) was utilized and jointly applied. The sensitivity, linearity, stability, precision, accuracy and extraction recovery were evaluated, and the method was demonstrated to be accurate, sensitive and reliable. An analytical strategy was successfully applied to quantitatively determine 20 metabolite levels in the serum and hippocampus of mice with chronic social defeat stress-induced depression. The results showed greatly perturbed purine metabolism in the depressed mice, which was primarily characterized by dramatic increases in hypoxanthine, xanthine and inosine in serum and reduced levels of adenine, adenosine and adenosine 5′-monophosphate in the hippocampus. These findings suggest that this novel strategy can facilitate the quantitative analysis of adenine and other purine and pyrimidine metabolites in tissue and serum and exhibits great potential in the exploration of metabolism-related mechanisms of relevant diseases.
研究领域:
生物化学
·
医学
·
神经科学
✓ 已验证
DOI
高影响因子
Biology Open
·
2017
·Vol. 6
·期 4
·489-495
·
IF 2.095
Wang Baocai,Ge Zhenwei,Cheng Zhaoyun,Zhao Ziniu
The profound inhibitory effect of Tanshinone IIA (Tan IIA) on atherosclerosis has been demonstrated, whereas the latent mechanism is not completely cleared. This study aimed to investigate the cellular and molecular mechanisms underlying Tan IIA protecting against atherosclerosis. Oil Red O staining and ELISA assay showed that Tan IIA suppressed the progress of atherosclerosis and reduced the levels of inflammatory cytokines in serum of apolipoprotein E deficient (ApoE –/– ) mice. Flow cytometry assay revealed that Tan IIA inhibited oxidized LDL (ox-LDL)-induced apoptosis of VSMCs. MTT and transwell assay indicated that Tan IIA suppressed the ox-LDL-stimulated proliferation and migration of RAW264.7 cells. Moreover, Tan IIA ameliorated inflammatory cytokine upregulation elicited by ox-LDL in RAW264.7 cells. Additionally, Tan IIA inhibited the apoptosis of VSMCs and decreased the levels of MMP-2, MMP-9 in ApoE –/– mice. In conclusion, our study demonstrated Tan IIA suppressed the progression of atherosclerosis by inhibiting vascular inflammation, apoptosis of VSMCs and proliferation and migration of macrophages induced by ox-LDL.
研究领域:
药理学
·
心血管疾病
·
分子生物学
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2022
·
IF 6.978
Zhaoyue Li,Yilin Qian,Yihuan Lai,Fu-Sheng Du,Zi-Chen Li
Poly(α-methylene ester)s are an attractive type of functional aliphatic polyesters that represent a platform for the fabrication of various biodegradable and biomedical polymers. Herein, we report the controlled ring-opening polymerization (ROP) of a seven-membered α-methylene lactone (3-methylene-1,5-dioxepan-2-one, MDXO) that was synthesized based on the Baylis–Hillman reaction. The chemoselective ROP of MDXO was catalyzed by diphenyl phosphate (DPP) at 60 °C or stannous octoate (Sn(Oct)2) at 130 °C, generating α-methylene-containing polyester (PMDXO) with a linear structure and easily tunable molar mass. The ring-opening copolymerization of MDXO with ε-caprolactone or 1,5-dioxepan-2-one was also performed under the catalysis of DPP or Sn(Oct)2 to afford copolymers with different compositions and sequence structures that are influenced by the kinds of monomers and catalysts. PMDXO is a slowly crystallizable polymer with a glass transition temperature of ca. −33 °C, and its melting temperature and enthalpy are significantly influenced by the thermal history. The thermal properties of the copolymers are dependent on their composition and sequence structure. Finally, the post-modification of PMDXO based on the thiol-Michael addition reaction was briefly explored using triethylamine as a catalyst. Given the optimized condition, PMDXO could be dually modified to afford biodegradable polyesters with different functionalities.
研究领域:
材料科学
·
高分子化学
·
生物医学工程
✓ 已验证
DOI
高影响因子
ACS Applied Energy Materials
·
2020
·
IF 4.473
Chongyang Zhang,Xigui Yue,Jiashuang Luan,Nan Lu,Yongfeng Mu,Shuling Zhang,Guibin Wang
The composite membranes that combine pore-filling with a matrix having precisely assembled sulfonated groups are designed here for use in the applications of direct methanol fuel cells. A porous crystalline poly(ether ether ketone)/sulfonated poly(ether ether ketone) blended matrix with continuous pore structures is first fabricated using a phase inversion process. Solvent treatment of the porous matrix is then employed to induce the enrichment of sulfonated groups at the pore surfaces, based on the interaction between the solvent and functional groups in polymer chains. This strategy effectively shortens the proton transport path, accelerating the proton transfer rate. The pores of the matrix are then filled with Nafion ionomers, resulting in a reinforced composite membrane consisting of interconnected hydrophilic domains in a fuel-insulating rigid matrix. A single cell made using the novel composite membrane exhibits a relatively high power density of 91.7 mW/cm2 and an open circuit voltage of 0.67 V at 70 °C using 10 M methanol, significantly higher than a test device made using Nafion 117. This work supplies a simple and highly efficient strategy to address the low proton conductivity that is normally seen in composite membranes made using pore-filling technology.
研究领域:
材料科学
·
能源工程
✓ 已验证
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Wenchang Liu,Zhe Wang,Xinming Du,Jingmei Xu,Chang Liu,Haiqiang Li,Zhaoyu Chen,Chunmei Wang,Hao Chen,Li Chen
The practice of site control for functional groups to achieve better interactions has become popular in recent years. Capitalizing on such developments, sulfonated 5-carboxybenzotriazole (SCBTA), serving as a new monomer that combines multiple functional groups, is grafted onto pendant chains of poly(arylene ether ketone) (PAEK) via an amidation reaction to fabricate a series of novel proton-exchange membranes (NmAn-SCBTA). The structure of the resulting membranes is confirmed by 1H NMR and Fourier transform infrared (FT-IR). Transmission electron microscopy (TEM) and small-angle X-ray spectroscopy (SAXS) analyses reveal well-defined microphase-separated structures. Among these samples, a membrane having an amino bisphenol monomer content of 70% (N7A3-SCBTA) exhibits high conductivity (0.089 S·cm–1, at 90 °C), oxidative stability (95.7%), and tensile strength (65.74 MPa), while its selectivity is as high as 91.9 × 104 S·s·cm–3 at 25 °C; this value is even more than 27 times that of recast Nafion (3.3 × 104 S·s·cm–3). These results indicate that there is great potential for these membranes to be used in direct methanol fuel cells (DMFCs).
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Cheng-Hui Zeng,Xiao-Ting Meng,Song-Song Xu,Li-Jun Han,Shengliang Zhong,Mei-Ye Jia
A rarely reported polymorphic lanthanide complex is prepared by acetylacetone (acac) tuning method. Luminescence properties of 1 are studied. Interestingly, 1 is proved to be a multifunctional material. It is a highly selective and sensitive Co 2+ sensor, among 24 species, only Co 2+ quenching the Tb 3+ centered luminescence. The possible sensing mechanism is the decomposition of 1 which induced by Co 2+ . The limit of detection (LOD) for sensing Co 2+ is as low as 330 nM, which is lower than the standard of Chinese environmental protection department. Mechanism study confirmed the luminescence quenching can be ascribed to the decomposition of 1 which induced by Co 2+ . Further investigations find 1 -Co 2+ can be applied as tunable luminescent timer, by tuning the ratio of 1 /Co 2+ . CIE coordinates of 1 -Co 2+ change regularly (has excellent linearity) from green to violet with the time increasing.
研究领域:
分析化学
·
无机化学
·
材料科学
·
环境监测
·
生物传感
·
分子探针
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Liyong Du,Jing Pan,Qing Dong,Yi Liu,Heming Sun
Multi-shelled hollow structures have been drawing wide attention in various fields because of their large surface area , short diffusion path and less agglomerated configuration. Herein, ZnSnO 3 hollow microspheres with controllable shell numbers have been prepared by a facile solvothermal reaction and following annealing treatment. The test results show that multi-shelled ZnSnO 3 hollow microspheres exhibit excellent acetone sensing performance, which is superior than that of double-shelled samples. In particular, multi-shelled ZnSnO 3 hollow microspheres not only show high responses of 105.1 and rapid response/recovery speed (1/18 s) to 100 ppm acetone, but also exhibit good repeatability, long-term stability and anti-humidity properties. Furthermore, they can easily distinguish healthy breath from simulated diabetic breath. And they still show rapid response/recovery speed in actual breath detection, which is beneficial to the achievement of real-time detection. The enhanced sensing performance has been studied systematically. Thus, multi-shelled ZnSnO 3 hollow microspheres have a great potential for the diagnosis of diabetes.
研究领域:
材料科学
·
生物医学工程
·
传感器技术
·
纳米医学
·
转化医学
✓ 已验证
DOI
高影响因子
RUSSIAN CHEMICAL BULLETIN
·
2024
·Vol. 73
·期 9
·2725-2729
·
IF 1.7
Yang Zhihui,Wang Xiaochen,Wang Yuanrong,Yang Jinyun,Lu Haifeng
A new route for the synthesis of siloxanes containing substituents with the phosphonate and amino groups based on the catalyst-free Kabachnik—Fields reaction was developed. The synthesis was accomplished under mild conditions using 3-aminopropylsilanes, cyclic ketones, and diethyl phosphite as the starting materials to give the corresponding 1-(3-silylpropylamino)cycloalkylphosphonates in high yields.
研究领域:
有机化学
·
药物化学
·
材料化学
·
分子合成
·
功能材料
✓ 已验证
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2017
·
IF 3.181
Qin Li,Yanbei Tu,Chao Zhu,Wei Luo,Wencai Huang,Wenbing Liu,Yanfang Li
Traditional Chinese medicinal (TCM) plants have a long history of usage in the treatment of different diseases. Neurodegenerative disorder prevention and treatment using TCM have attracted increasing interest in recent year. In current study, the ethanolic extracts of 26 Chinese medicinal plants were prepared, two cholinesterases (ChEs), β -amyloid aggregation inhibitory, and antioxidant capacities were further investigated for evaluation their anti-Alzheimer’s disease (AD) potential as well as total phenolics and flavonoids contents (TPC, TFC). Of these, Polygonum multiflorum and Spatholobus suberectus were the most active ones against acetylcholinesterase (AChE, IC 50 = 9.11, 9.27 μg/mL), butyrylcholinesterase (BChE, IC 50 = 4.83, 5.37 μg/mL), and 2, 2-diphenyl-1-picrilhydrazyl (DPPH, IC 50 = 5.69, 3.60 μg/mL) with highest TPC (267, 377 mg GAE/g dw) and relative higher TFC (80, 594 mg RE/g dw), respectively. The highest activity was observed with the extracts of Rheum officinale in 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt assay (ABTS, IC 50 = 1.60 μg/mL) and ferric reducing antioxidant power method (FRAP, 5495.43 μmol Fe 2+ /g). Meanwhile, both R. officinale and S. suberectus exhibited the strongest inhibition (>90%) in β -amyloid peptide (A β 1-42 ) aggregation assay. The present findings may reveal the interesting potential of S. suberectus , P. multiflorum, and R. officinale as a valuable plant source of natural bioactive molecules against AD.
研究领域:
中药学
·
神经科学
·
植物化学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2018
·Vol. 98
·期 13
·4885-4894
·
IF 2.379
Lei Deng,Ai-Min Shi,Qiang Wang
INTRODUCTION Peanut stems and leaves (PSL) have traditionally been used as both a special food and a herbal medicine in Asia. The sedative–hypnotic and anxiolytic effects of PSL have been recorded in classical traditional Chinese literature, and more recently by many other researchers. In a previous study, four sleep-related ingredients (linalool, 5-hydroxy-4′,7-dimethoxyflavanone, 2′- O -methylisoliquiritigenin and ferulic acid), among which 5-hydroxy-4′,7-dimethoxyflavanone and 2′- O -methylisoliquiritigenin were newly found in Arachis species, were screened by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC/QTOF-MS). In the current study, quantitative examination of the above four ingredients was conducted. Serious fundamental functional studies were done in mice, including locomotor activity, direct sleep tests, pentobarbital-induced sleeping time tests, subthreshold dose of pentobarbital tests and barbital sodium sleep incubation period tests, to determine the material base for the sedative–hypnotic and anxiolytic effects of aqueous extracts of PSL. Furthermore, neurotransmitter levels in three brain regions (cerebrum, cerebellum and brain stem) were determined using UHPLC coupled with triple-quadrupole mass spectrometry (UHPLC/QQQ-MS) in order to elucidate the exact mechanism of action. RESULTS Aqueous extract of PSL at a dose of 500 mg kg −1 (based on previous experience), along with different concentrations of the above four functional ingredients (189.86 µg kg −1 linalool, 114.75 mg kg −1 5-hydroxy-4′,7-dimethoxyflavanone, 32.4mg kg −1 2′- O -methylisoliquiritigenin and 44.44 mg kg −1 ferulic acid), had a sedative−hypnotic effect by affecting neurotransmitter levels in mice. CONCLUSION The data demonstrate that these four ingredients are the key functional factors for the sedative–hypnotic and anxiolytic effects of PSL aqueous extracts and that these effects occur via changes in neurotransmitter levels and pathways. © 2018 Society of Chemical Industry
研究领域:
药理学
·
植物化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）