Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 18
·10980-10987
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IF 10.733
Xiaoqing Cao,Jun Zhou,Hongna Wang,Song Li,Wei Wang,Gaowu Qin
Supported Au nanoparticles have been attracting increasing attention due to their unique catalytic performance. However, their thermal and catalytic stability against sintering and aggregation during preparation and reactions remains a serious issue in practical applications, and what is even more difficult is to solve this mutually exclusive problem by a feasible technique. Here, we propose a simple one-step ultra-low temperature interfacial plasma electrolytic oxidation (ULTPEO) process to successfully prepare sub-10 nm and highly stable Au NPs, supported on a porous MgO layer, with high activity and a long lifespan. The obtained Au NPs, with partially exposed free surfaces, are encapsulated into a porous MgO support film. This unique embedded structure restrains their sintering on the support surface during high temperature treatment even up to 600 °C and shows good thermal stability and excellent recyclability in a model reaction of the hydrogenation of 4-nitrophenol. Moreover, the developed technique allows the facile control of the average size of Au NPs down to ∼3 nm with high monodispersity by liquid nitrogen cooling, and hence a further significant improvement in catalytic activity and the lowest catalytic activation energy of ∼14 kJ mol−1 among the reported literature are obtained. This simple technique is also extended to other metal NP catalysts (e.g. Ru and Pd) that support MgO and exhibit excellent catalytic activity for the hydrolysis of sodium borohydride and oxidation of silanes, respectively.
研究领域:
材料科学
·
催化化学
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EUROPEAN JOURNAL OF MEDICAL RESEARCH
·
2023
·Vol. 28
·期 1
·1-10
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IF 4.2
Gu Shanshan,Lin Chen,Li Yanguo,Wei Zhengyu,cao Bing,Shen Zhisen,Deng Hongxia
Head and neck squamous carcinoma (HNSCC) is the seventh most common cancer worldwide. Targeted therapeutic drugs for HNSCC are still being explored. Among them, (S)-10-hydroxycamptothecin (10-HCPT), a specific inhibitor of TOP1, functions by DNA double-strand breaks that can inhibit DNA replication and trigger apoptotic cell death subsequently. Previous studies have reported that MLN4924 exerts potent anti-tumor effects by inhibiting cullin–RING ligases and causing substrate accumulation in a variety of cancers. Here, we show that MLN4924 effectively causes dose-dependent accumulation of topoisomerase I (TOP1) and blocks TOP1 ubiquitination. Importantly, neddylation inhibition with MLN4924 acts synergistically with 10-HCPT to suppress cell growth, migration and apoptosis in HNSCC cells. Mechanistically, transcriptome sequencing shows that the cytotoxic effects of the combination of MLN4924 and 10-HCPT may involve activation of the NFKB1 pathway. Taken together, our results suggest that combined treatment with MLN4924 and 10-HCPT may be an effective strategy in HNSCC.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-18
·
IF 16.6
Wu Yandi,Huang Tongsheng,Li Xinghui,Shen Conghui,Ren Honglin,Wang Haiping,Wu Teng,Fu Xinlu,Deng Shijie,Feng Ziqi,Xiong Shijie,Li Hui,Gao Saifei,Yang Zhenyu,Gao Fei,Dong Lele,Cheng Jianding,Cai Weibin
Diabetic cardiomyopathy is a primary myocardial injury induced by diabetes with complex pathogenesis. In this study, we identify disordered cardiac retinol metabolism in type 2 diabetic male mice and patients characterized by retinol overload, all-trans retinoic acid deficiency. By supplementing type 2 diabetic male mice with retinol or all-trans retinoic acid, we demonstrate that both cardiac retinol overload and all-trans retinoic acid deficiency promote diabetic cardiomyopathy. Mechanistically, by constructing cardiomyocyte-specific conditional retinol dehydrogenase 10-knockout male mice and overexpressing retinol dehydrogenase 10 in male type 2 diabetic mice via adeno-associated virus, we verify that the reduction in cardiac retinol dehydrogenase 10 is the initiating factor for cardiac retinol metabolism disorder and results in diabetic cardiomyopathy through lipotoxicity and ferroptosis. Therefore, we suggest that the reduction of cardiac retinol dehydrogenase 10 and its mediated disorder of cardiac retinol metabolism is a new mechanism underlying diabetic cardiomyopathy.
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MOLECULES
·
2023
·Vol. 28
·期 5
·2272
·
IF 4.6
Zhangxi Gao,Mei Xiang,Mingyang He,Weiyou Zhou,Jiayao Chen,Jiamin Lu,Zeying Wu,Yaqiong Su
Catalytic conversion of CO2with the surplus glycerol (GL) produced from biodiesel manufacturing has attracted much academic and industrial attention, which proves the urgent requirement for developing high-performance catalysts to afford significant environmental benefits. Herein, titanosilicate ETS-10 zeolite-based catalysts with active metal species introduced by impregnation were employed for coupling CO2with GL to efficiently synthesize glycerol carbonate (GC). The catalytic GL conversion at 170 °C miraculously reached 35.0% and a 12.7% yield of GC was obtained on Co/ETS-10 with CH3CN as a dehydrating agent. For comparison, Zn/ETS- Cu/ETS-10, Ni/ETS-10, Zr/ETS-10, Ce/ETS-10, and Fe/ETS-10 were also prepared, which showed inferior coordination between GL conversion and GC selectivity. Comprehensive analysis revealed that the presence of moderate basic sites for CO2adsorption-activation played a crucial role in regulating catalytic activity. Moreover, the appropriate interaction between cobalt species and ETS-10 zeolite was also of great significance for improving the glycerol activation capacity. A plausible mechanism was proposed for the synthesis of GC from GL and CO2in the presence of CH3CN solvent over Co/ETS-10 catalyst. Moreover, the recyclability of Co/ETS-10 was also measured and it proved to be recycled at least eight times with less than 3% decline in GL conversion and GC yield after a simple regeneration process through calcination at 450 °C for 5 h in air.Keywords:CO2;glycerol;glycerol carbonate;ETS-10 zeolite;cobalt-based catalyst
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
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2023
·
IF 6
Wenpeng Hong,Yu Zhang,Jiaxing Song,Haipeng Liu,Ling Zhang,Hang Wang,Yan Zhang,Haifeng Jiang
The extraction of phenolic compounds from biomass is an important way to replace chemical synthesis techniques, and catalytic pyrolysis of biomass is an effective method to obtain phenolic compounds with high selectivity. In this work, cobalt-modified montmorillonite K-10(CMT) catalyst was prepared by using cobalt salt and montmorillonite K-10(MMT), and used to catalyze the pyrolysis of corn stalk(CS) to produce phenol-rich bio-oil. The catalytic pyrolysis characteristics reflected by the liquid and gaseous components were compared using gas chromatography-mass spectrometry(GC-MS) and online mass spectrometry(online MS), and the catalytic pyrolysis behavior of corn stalk was analyzed by using the thermogravimetric analyzer(TGA). The addition of catalyst resulted in the increase of apparent activation energy of pyrolysis process but increased selectivity for phenolic compounds. Compared with the blank sample, the relative content of phenolic compounds in bio-oil increased by 11.99 %, and the selectivity of alkyl-phenols was stronger. In addition, the results also showed that the synthesized catalyst promoted the production of H 2 and CH 4 during the catalytic pyrolysis. The optimum ratio of the prepared catalyst was 6%Co/15%MMT. These works provide an alternative approach to upgrading bio-oil product.
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Oxidative Medicine and Cellular Longevity
·
2023
·
IF 7.31
Hongwei Shi,Liang Duan,Ying Lan,Quan He,Peng Pu,Heng Tang
Pirarubicin (THP) is one of the classic chemotherapy drugs for cancer treatment. It is often clinically limited because of its cardiotoxicity. The occurrence and development of THP-mediated chemotherapy-related cardiotoxicity (CRC) may be reversed by RING finger protein 10 (RNF10). This study was performed with the aim of evaluating the inhibitory effect of RNF10 on THP-mediated CRC and its molecular mechanism. In vivo, we found that the expression of RNF10 decreased in THP-induced CRC rats, accompanied by Meox2 inhibition and AP-1 activation, resulting in increased cardiomyocyte apoptosis. After small interfering RNA (siRNA) and lentivirus transfection (Lv) of RNF10 in vitro, the expression of RNF10, Meox2, and AP-1 proteins and the degree of cardiomyocyte apoptosis were detected. We found that overexpression of RNF10 in H9C2 cardiomyocytes significantly promoted Meox2 and inhibited AP-1, alleviated apoptosis, and showed further inhibitory activity on THP-induced cardiomyocyte toxicity. Silencing RNF10 showed the opposite result. Our study showed that RNF10 inhibited THP-induced CRC through the activity of Meox2 and AP-1 proteins. RNF10 may be the next drug target for the treatment of CRC and other related cardiovascular diseases.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
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2022
·
IF 7.305
Xiatong Qin,Bin Xu,Jianjun Lin,Jiaqi Chen,Hanyu Tong,Ye Chen,Pingxiong Yang,Junhao Chu,Lin Sun
Electrodeposition is a promising method to fabricate Cu 2 ZnSn(S,Se) 4 (i.e., CZTSSe) absorber layer thanks to its many advantages such as low-cost and large-scale. However, the secondary phases and intrinsic defects in electrodeposited CZTSSe solar cells inevitably limit the photoelectric performance. Herein, two different kind of precursor films (binary-ternary selenide vs. quaternary selenide) are deliberately fabricated and the effect of these precursors on the secondary phases and intrinsic defects of CZTSSe absorber layer are investigated comprehensively. The absorber layer obtained from binary-ternary selenide precursor has a small amount of ZnSe secondary phases and Cu Sn deep defects , whereas that obtained from the quaternary selenide precursor exhibits the favorable V Cu shallow defects, which is beneficial to the efficiency improvement in CZTSSe. Based on the quaternary selenide precursor film, the CZTSSe solar cell with 10.03% total area efficiency (the active area efficiency is 10.9%) was obtained. This is the highest efficiency of CZTSSe solar cells prepared by the electrodeposition method.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2021
·
IF 5.875
Wei He,Yawei Du,Tao Wang,Ji Wang,Lei Cheng,Xinsong Li
7-Ethyl-10-hydroxycamptothecin (SN38), a potent camptothecin derivative specifically targeting DNA topoisomerase I cleavage complexes, has shown great potential in the treatment of solid tumors . Because of its poor solubility and chemical and metabolic stability, the clinical application of SN38 is highly limited. To address these problems, a novel redox-responsive SN38 conjugate based liposomal formulation is developed in this report. First, SN38 was conjugated with lysophospholipid by using a cleavable disulfide bond linker. After that, the conjugate (SN38-SS-PC) was assembled into liposomes by thin film method. Dynamic light scattering (DLS) characterization indicated that SN38-SS-PC liposomes possessed a narrow size distribution (172.8 ± 10.5 nm) and negative charged zeta potential (-8.9 ± 0.3 mV). The results of storage and physiological stabilities showed that SN38-SS-PC liposomes was stable under different conditions. More importantly, a reduction responsive release of parent drug SN38 was observed in the medium containing glutathione (GSH). In addition, SN38-SS-PC liposomes had a much more rapid cellular uptake behavior against cancer cells. The enhanced anti-cancer efficacy of SN38-SS-PC liposomes was further demonstrated by in vitro cytotoxicity assay against MCF-7 and A549 cells. Under in vivo evaluation in 4 T1 xenograft tumor model, SN38-SS-PC liposomes were observed to have lower systemic toxicity and higher tumor inhibition rate of 53.3% compared with the commercialized SN38 prodrug Irinotecan (Ir). In summary, SN38-SS-PC liposomes could be a promising redox responsive delivery system of SN38 for cancer therapy.
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NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 11
·4311-4318
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IF 3.288
Weitao Xu,Xinyu Deng,Xin Xiao,Bing Bian,Qing Chen,Scott J. Dalgarno,Zhu Tao,Carl Redshaw
A benzyl substituted 4-pyrrolidinopyridinium salt (G) with multiple active sites including benzyl, pyridinium and pyrrole groups has been synthesized. The interaction between G and a series of cucurbit[n]urils (TMeQ[6], Q[7], Q[8], Q[10]), has been studied both in aqueous solution and in the solid state. The binding interaction site between G and the Q[n] can be controlled by the size of the cavity of the Q[n]s. In the case of TMeQ[6], the benzyl is accommodated within the cavity, whilst for Q[7] and Q[8], the pyrrole ring and the benzyl are accommodated within the cavity of the Q[7/8], and the latter can shuttle on the guest G in a state of dynamic equilibrium. For the larger cavity of Q[10], the entire G molecule is located within the cavity of the Q[10].
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JOURNAL OF MEMBRANE SCIENCE
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2021
·
IF 8.742
Yunhao Li,Shuhao Wang,Hengyu Li,Guodong Kang,Yang Sun,Haijun Yu,Yan Jin,Yiming Cao
The enhancement in selectivity of nanofiltration (NF) membranes is of great significance for extending the application areas and improving the process economy, especially for the separation of monovalent/divalent ions. The characteristics of moderately increased pore size, fewer nonselective defects and a more uniform structure are conducive to NF membrane exhibiting higher rejection of divalent ions but lower rejection of monovalent ions. Nonylphenol polyoxyethylene ether (NP-10) was introduced in interfacial polymerization process in this study to optimize the microstructure and surface properties of polyamide (PA) layer to manufacture highly selective NF membranes. The hydrophobic benzene ring and aliphatic chain in NP-10 could form a local space that restricted the interfacial polymerization reaction on the side of the oil phase, thereby appropriately increasing the pore size of the PA layer. It was advantageous to the permeation of water molecules and monovalent ions with a smaller radius. The long hydrophilic oxyethylene group as a guide could facilitate the uniform diffusion of the monomer to the water/hexane interface. NP-10 as an amphiphilic substance would form a self-assembled network at the water/hexane interface, which was expected to optimize the distribution of aqueous amine monomers at the phase interface . Meanwhile, introducing NP-10 can form a stable interface and reduce the interface disturbance, thus inhibiting the formation of non-selective macropores (or “defects”) in PA layer, which could improve the separation selectivity of monovalent/divalent ions. In addition, the hydrophilicity and electronegativity were also enhanced. The results showed that the MWCO of NF membrane increased from 210.1 Da (TFC-0) to 269.6 Da (TFC-0.25), and the average pore radius increased from 0.248 nm to 0.276 nm. The water flux of optimized membrane was doubled compared to the control membrane. Most important, the optimized exhibited higher rejection of divalent Na 2 SO 4 (from 98.07% to 99.43%), and meanwhile lower rejection of monovalent NaCl (from 54.07% to 27.52%). NaCl/Na 2 SO 4 separation factor reached up to 130.53, which was about four times of TFC-0 membrane.
研究领域:
材料科学
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环境工程
·
化学工程
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JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Yuanjiang Wang,Jianluo Zhang,Kun Li,Shengjin Xia,Shaohua Gou
In this work, a series of multitargeting histone deacetylase (HDAC) inhibitors capable of regulating the signal transduction between RAS protein and downstream effectors were obtained by introducing a zinc-ion-binding group into the framework of rigosertib via different linkers. Among them, two representative compounds, XSJ-7 and XSJ-10, not only showed stronger antiproliferative activity against many types of cancer cells including solid tumor cells but also presented more potent inhibition on different subtypes of HDAC than suberoylanilide hydroxamic acid (SAHA). Significantly, XSJ-10 presented moderate pharmacokinetic behaviors and showed stronger antitumor activity than oxaliplatin, SAHA, and rigosertib in the HT-29 xenograft mouse models without significant systemic toxicity. Research on the anticancer mechanism of XSJ-10 revealed that it can effectively induce the apoptosis of cancer cells and suppress the tumor by strongly inhibiting the RAS-RAF-MEK-ERK signaling pathway and the acetylation level of HDAC3.
研究领域:
药理学
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肿瘤学
·
分子生物学
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ANALYST
·
2012
·Vol. 138
·期 3
·887-893
·
IF 4.23
Lu Zhang,Kao Zhu,Tao Ding,Xianyun Hu,Qingjiang Sun,Chunxiang Xu
We have developed a new fluorescent probe based on direct conjugation between 1,10-phenanthroline (Phen) and water-soluble thioglycolic acid (TGA) capped CdTe quantum dots (QDs) for the detection of double-stranded DNA (dsDNA). Phen could directly adsorb onto the QDs surface by metal-affinity driven coordination, quenching the photoluminescence (PL) of QDs via the photoinduced hole transfer process; addition of dsDNA would bring the restoration of QDs PL, as Phen could intercalate into dsDNA followed by its dissociation from the QDs surface. The dependence of QDs PL on the dsDNA amount as well as temperature was utilized to investigate the Phen–dsDNA interaction. The obtained binding constant of the QD–Phen dyad was 2–3 orders of magnitude higher than that of Phen-based metal complexes. Both the binding constant and the binding site of dsDNA with Phen increased with the elevated temperature, owing to an endothermic process. At 37 °C, sensitive detection of dsDNA with a detection limit of ∼3 nmol L−1 was achieved. Therefore, the QD-molecule direct conjugation based fluorescent probe could provide an effective alternative to those based on QD-bioconjugation and QD-ionic conjugation.
研究领域:
生物化学
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分子生物学
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纳米生物学
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高影响因子
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