POLYMER BULLETIN
·
2016
·Vol. 74
·期 4
·911-930
·
IF 1.371
Yang Jin,Lu Shaorong,Pan Lulu,Luo Qiyun,Song Laifu,Wu Lingyan,Yu Jinhong
A new green compatibilizer named epoxidized soybean oil grafted poly(12-hydroxy stearate) (ESO- g -PHS) was successfully synthesized using 12-hydroxy stearic acid and epoxidized soybean oil (ESO). The chemical structure of ESO- g -PHS was investigated through Fourier transformed infrared spectroscopy, thermogravimetric analysis, and gel permeation chromatography. ESO- g -PHS was used as a compatibilizer to enhance the interfacial compatibility between polypropylene (PP) and microcrystalline cellulose fibers (MCF). The results showed that the impact strength and tensile strength were 33.55 and 27.57 MPa when the content loading of MCF reached 10 wt% and ESO- g -PHS was 4 wt%, which enhanced by 75.4 and 30.04 %, respectively, compared to that of composites without ESO- g -PHS. In addition, the SEM images of the fracture surfaces display that PP was highly bonded to MCF with ESO- g -PHS treated. In addition, the wide angle X-ray diffraction measurement revealed that the addition of ESO- g -PHS did not change the crystal structure of PP. Moreover, there was a slight improvement in thermal properties for PP composites with the addition of ESO- g -PHS.
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APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Jian Lu,Yingying Qin,Qi Zhang,Yilin Wu,Jiuyun Cui,Chunxiang Li,Liang Wang,Yongsheng Yan
High-selective multilayered Li + -imprinted membranes (Li-IIMs) with enhanced hydrophilicity and stability were developed based on polyether sulfone substrate membranes. The multilayered structure was prepared with polydopamine (pDA) as the interfacial adhesion layer, SiO 2 nanoparticles as the hydrophilic layer and Li + -imprinted polymers as the imprinted layer. The selective “Li + -recognition sites” were formed using 12-crown-4 (12C4) as the adsorbing units. The optimal relative selectivity coefficients (α) of Li + /Na + and Li + /K + reached up to 1.85 and 2.07 with the imprinting factor ( β ) of 2.51, and the high permselectivity factors ( γ ) of Na + /Li + (7.39) and K + /Li + (9.86) were achieved on Li-IIMs. The Langmuir isotherm model and the pseudo-second-order kinetics model best fitted the rebinding data of Li-IIMs, as well as the rebinding capacities reached up to 90.3% of initial binding after 5 cycles of adsorption/desorption and just declined to 88.1% after another 5 cycles a month later. Therefore, the as-prepared Li-IIMs would have potential applications for the separation of lithium ions from salt lake brines.
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JOURNAL OF HETEROCYCLIC CHEMISTRY
·
2014
·Vol. 52
·期 4
·1219-1225
·
IF 0.873
Guang-Fan Han,Li-Jun Zhao,Li-Zhuang Chen,Jia-Wei Du,Zhong-Xia Wang
The 2-arylidene-3-oxobutanenitrile derivatives 2 were prepared by the Knoevenagel condensation between aldehydes and 3-oxobutanenitrile 1 , which was obtained by acid hydrolysis of β-aminocrotononitrile. 3-Acetyl-2-amino-4 H -chromen-5(6 H )-one derivatives 3 were synthesized by reaction of 2-arylidene-3-oxobutanenitrile 2 and 5-substituted-1,3-cyclohexanedione in ethylene glycol. The 11-methyl-3,8-disubstituted-12-aryl-3,4,7,8,9,12-hexahydro-1 H -chromeno[2,3- b ]quinoline-1,10(2 H )-dione derivatives 4 were obtained by Friedländer reaction of compounds 3 with 5-substituted-1,3-cyclohexanedione, using p -toluenesulfonic acid monohydrate as catalyst. The structures of all novel compounds were characterized by elemental analysis, IR, MS, and 1 H NMR spectra. The crystal and molecular structure of compound 4f has been determined by single crystal XRD analysis.
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Analytical Methods
·
2015
·Vol. 7
·期 14
·5838-5846
·
IF 1.821
Xiao-Hong Chen,Yong-Gang Zhao,Yun Zhang,Hao-Yu Shen,Sheng-Dong Pan,Mi-Cong Jin
A novel fluoroquinolone molecularly imprinted polymer (MIP) on the surface of ethylenediamine-functionalized magnetic carbon nanotubes (EDA@Mag-CNTs–MIP) was synthesised. The properties of the EDA@Mag-CNTs–MIP were characterized by using a transmission electron microscope (TEM) and vibrating sample magnetometer (VSM). With using EDA@Mag-CNTs–MIP as the adsorbent, a simple and sensitive method based on the use of a magnetic molecularly imprinted polymer matrix solid phase dispersion extraction (Mag-MIP-MSPD) procedure combined with ultra-fast liquid chromatography-tandem quadrupole mass spectrometry (UFLC-MS/MS) was developed to determine 12 fluoroquinolones in river water. Fluoroquinolones adsorbed with EDA@Mag-CNTs–MIP could be simply and rapidly isolated through a magnetic field, and the main factors, i.e., the pH value and sample volume, affecting the extraction were investigated in detail. Under optimal experimental conditions, the enhancement factor of the Mag-MIP-MSPD procedure was 100 times. The obtained results demonstrated the higher extraction capacity of EDA@Mag-CNTs–MIP with recoveries between 80.2 and 116%. The limits of quantification (LOQs) for the fluoroquinolones were between 0.26 and 1.78 ng L−1. The developed Mag-MIP-MSPD UFLC-MS/MS method had been successfully applied to sixty real samples, and it was confirmed that the EDA@Mag-CNTs–MIP was a kind of highly effective Mag-MIP-MSPD material for fluoroquinolone analyses.
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ACS Nano
·
2024
·
IF 15.8
Bin Wang,Maoping Tang,Qijing Chen,William Ho,Yilong Teng,Xiaojian Xiong,Zhitong Jia,Xiuling Li,Xiaoyang Xu,Xue-Qing Zhang
T cell exhaustion has emerged as a major hurdle that impedes the clinical translation of stimulator of interferon genes (STING) agonists. It is crucial to explore innovative strategies to rejuvenate exhausted T cells and potentiate the antitumor efficacy. Here, we propose an approach utilizing MSA-2 as a STING agonist, along with nanoparticle-mediated delivery of mRNA encoding interleukin-12 (IL-12) to restore the function of T cells. We developed a lipid nanoparticle (DMT7-IL12 LNP) that encapsulated IL12 mRNA. Our findings convincingly demonstrated that the combination of MSA-2 and DMT7-IL12 LNP can effectively reverse the exhausted T cell phenotype, as evidenced by the enhanced secretion of cytokines, such as tumor necrosis factor alpha, interferon gamma, and Granzyme B, coupled with reduced levels of inhibitory molecules such as T cell immunoglobulin and mucin domain-3 and programmed cell death protein-1 on CD8+ T cells. Furthermore, this approach led to improved survival and tumor regression without causing any systemic toxicity in melanoma and lung metastasis models. These findings suggest that mRNA encoding IL-12 in conjunction with STING agonists has the potential to confer superior clinical outcomes, representing a promising advancement in cancer immunotherapy.
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DYES AND PIGMENTS
·
2014
·
IF 3.468
Kun Zhou,Chao Qin,Li-Kai Yan,Wen-E Li,Xin-Long Wang,Hai-Ning Wang,Kui-Zhan Shao,Zhong-Min Su
Three silver(Ι) alkynyl compounds, [Ag 5 (C C t Bu)(CF 3 COO) 7 ( n Bu 4 N) 3 ·H 2 O] ( 1 ), [Ag 8 (C C t Bu) 2 (CF 3 COO) 10 (Et 3 N) 4 ] ( 2 ), and [Ag 12 (C C t Bu) 6 (CF 3 COO) 8 ( n Bu 4 N) 2 (Et 3 N) 2 (CF 3 COO) 2 ] ( 3 ), have been obtained. Concomitantly, isolated [Ag 5 (C C t Bu)(CF 3 COO) 7 ] 3– , [Ag 8 (C C t Bu) 2 (CF 3 COO) 10 ] 4– and [Ag 12 (C C t Bu) 6 (CF 3 COO) 8 ] 2– clusters ( Ag 5 , Ag 8 and Ag 12 for short) appear in 1 – 3 , respectively. The synthesis of 1 – 3 demonstrates silver(I) alkynyls are better systems for the study of the template effect. ESI-MS analysis indicates compounds 1 – 3 can stably exist in methanol, and they have been proved to be potential wide gap semiconductor materials by the reflectance spectra. Notably, the second hyperpolarizabilities ( γ values) of Ag 5 , Ag 8 and Ag 12 have been studied by using time-dependent density functional theory (TDDFT) calculations and the finite filed (FF) approach combining CAM-B3LYP. The calculated results show that they can be applied as potential third-order nonlinear optical (NLO) materials owing to their second hyperpolarizabilities rising from 39.1 × 10 −36 , 60.3 × 10 −36 to 97.7 × 10 −36 esu with the growth of the number of Ag atoms and C C groups.
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Science of Advanced Materials
·
2015
·Vol. 7
·期 5
·985-992
·
IF 2.598
Sun Yue,Liu Jiangang,Wang Haiyang,Yu Xinhong,Xing Rubo,Han Yanchun
Bicontinuous phase structure in Poly(3,3 -didodecylquaterthiophene) (PQT-12)/[6,6]-phenyl-C71-butyric acid methyl ester (PC71BM) blend films was formed by using thiophene as solvent to suppress the compatibility between PC71BM and side chains of PQT-12. The interaction
between PQT-12 chains was enhanced and the interaction between PC71BM and PQT-12 was weakened in thiophene because of the good compatibility of thiophene with PQT-12 and its planar molecular structure. Thus, the energy barrier for PC71BM nucleation was overcome. As a
result, spherical PC71BM domains surrounded by the continuous phase of PQT-12 were formed after spin-coating. This structure was not stable and secondary phase separation was induced by thermal annealing. During thermal annealing, adjacent spherical PC71BM domains grew
and connected together, which cut off PQT-12 continuous phase. Subsequently, the PQT-12 phase grew further and connected again. At last, bicontinuous structure was formed. The power conversion efficiency of the device prepared from solution in thiophene was almost 1.9 times of the one from
chloroform.
研究领域:
材料科学
·
有机电子学
·
聚合物物理
·
光伏技术
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TALANTA
·
2026
·
IF 6.7
Feng Chen,Ziwei Deng,Yueping Jiang,Yayun Tan,Xiaoxia Yang,Huanhuan Li,Wendan Zhang,Xiangjin Shu,Aimin Wang,Chengfeng Qiu
Therapeutic drug monitoring (TDM) is essential for optimizing antimicrobial therapy and curbing resistance, yet conventional venipuncture limits its widespread application due to invasiveness and operational complexity. This study aimed to establish a rapid LC-MS/MS method for simultaneous quantification of 12 antimicrobial agents and to evaluate the feasibility of using fingertip capillary serum as an alternative to venous serum for TDM. A liquid chromatography tandem mass spectrometry method was developed and validated for the simultaneous quantification of vancomycin, linezolid, voriconazole, sulfamethoxazole, trimethoprim, piperacillin, cefoperazone, ceftazidime, ceftobiprole, meropenem, imipenem, and cilastatin in human serum. The method was applied to analyze 379 paired clinical samples (fingertip serum versus venous serum), and agreement between the two sampling approaches was assessed using Deming regression and Bland Altman analysis. The method required only 10 μL of serum and a total run time of 4 min. Deming regression slopes ranged from 0.910 to 1.017. Bland Altman analysis showed that 100.0% of the data points fell within ±20.0% limits of agreement for all antibiotics except vancomycin (96.7%) and cilastatin (97.5%). This study provides large scale clinical evidence demonstrating high concordance between fingertip serum and venous serum concentrations for 12 antimicrobial agents. By directly obtaining serum, this approach fundamentally avoids the hematocrit effect and matrix conversion issues inherent in whole blood microsampling, offering a minimally invasive TDM strategy fully aligned with the gold standard matrix. This strategy is particularly suitable for special populations such as children, the elderly, and critically ill patients.
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ANALYST
·
2023
·Vol. 148
·期 12
·2725-2731
·
IF 4.2
Yuhan Ji,Yupu Wei,Jinghui Shen,Jinlong Zhuo,Mingqi Xu,Yunliang Wang,Jingquan Sha
To improve the peroxidase-like activities of metal–organic frameworks (MOFs) as nanozymes, a ternary MIL-100(Fe)@PMo12@3DGO nanocomposite was designed and fabricated by encapsulating Keggin-type H3PMo12O40 (PMo12) with fast and reversible multi-electron redox processes and an electron-rich structure into MIL-100(Fe), then being covered by three-dimensional graphene (3DGO) with higher conductivity, larger surface area, higher porosity, and better chemical stability. As a consequence, the as-prepared MIL-100(Fe)@PMo12@3DGO nanocomposite exhibits excellent peroxidase-like activities, namely, the lowest limit of detection (0.14 μM) in the range of 1–100 μM for glucose to date, to the best of our knowledge, attributed to the individual and synergistic effects of H3PMo12O40, 3DGO and MIL-100(Fe).
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Solar RRL
·
2022
·Vol. 6
·期 8
·2200150
·
IF 9.173
Chengfeng Ma,Chunxu Xiang,Xinge Liu,Bingyan Li,Xinyu Li,Shuaiqi Han,Qi Dai,Weibo Yan,Hao Xin
Solution-processed chalcopyrite copper indium gallium sulfoselenide (Cu(In,Ga)(S,Se) 2 , CIGSSe) thin-film solar cells have achieved efficiency beyond 18% and have great potential as an alternative to vacuum-based ones. However, most of the efficient solution-based CIGSSe solar cells are fabricated by spin-coating in an inert atmosphere, which limits the transfer from lab protocol to industrial large-scale production. Herein, a scalable doctor-blading technique is applied to fabricate CuIn(S,Se) 2 (CISSe) absorbers from N,N-dimethylformamide molecular precursor solution in ambient air. With the optimization of the precursor concentration to reduce the residue solvent and change the thermal annealing process from one-step to two-step to separate solvent evaporation and complex decomposition to suppress fluidity, high-quality absorber films with densely packed large grains have been fabricated and a champion CISSe solar cell with a power conversion efficiency of 12.54% has been achieved. Importantly, unlike the spin-coating technique which may cause composition change due to the different solubilities of the precursors, the doctor-bladed film has a composition very close to the precursor solution, which is very important for precise control of the absorber composition for industrial production.
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NEUROTOXICOLOGY
·
2015
·
IF 3.379
Lihua Hu,Chuanyang Su,Xiufang Song,Qiong Shi,Juanli Fu,Xiaomin Xia,Demei Xu,Erqun Song,Yang Song
Although there are few studies suggested PCP exposure induced developmental and behavioral disorders, however, the occurrence of neurotoxicity and PCP has not been firmly established. Tetrachlorobenzoquinone (TCBQ) is a reactive metabolite of environmental pollutant pentachlorophenol (PCP). To the best of our knowledge, there has no information regarding to the neurological toxic effect of TCBQ available. Here, we demonstrated that TCBQ induces cytotoxicity in pheochromocytoma PC12 cell line, and the mode-of-action analysis indicated the involvement of apoptotic signalings, such as the activation of caspase family proteins, the increased expressions of Fas and Fas-associated death domain (FADD), the loss of mitochondrial membrane potential (MMP), the release of cytochrome c (Cyt c ) and the cleavage of the caspase substrates poly(ADP-ribose) polymerase (PARP). BI-6C9, a specific BH3-interacting domain death agonist (Bid) inhibitor, repressed TCBQ-induced Bid truncation, along with the activation of caspase 3 and the release of Cyt c , suggested the cross-talk of extrinsic and intrinsic apoptotic signalings. Furthermore, the inhibition of caspase 8 impaired TCBQ-induced the activation of caspase 3, as well as the release of Cyt c and the cleavage of Bid, suggesting caspase 8 acting as the upstream molecule of Bid, and TCBQ-induced apoptosis is initiated via caspase 8, leads to the activation of caspase 9/3 through Bid-mediated amplification loop. Finally, the pretreatment of antioxidant NAC ameliorated Fas, FADD and caspase 8/3 expressions, which illustrated that TCBQ-induced apoptotic signaling is ROS dependent. Taken together, these results indicated that the cleavage of Bid may play an important role in TCBQ-induced neurotoxicity which promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in PC12 cells.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2013
·
IF 1.977
Fengling Tian,Jidong Yang,Wei Huang,Shang Zhou,Gengyang Yao
The interaction of mebendazole (MBZ) with12-tungstophosphoric acid (TP) has been investigated by using resonance Rayleigh scattering (RRS) and frequency doubling scattering (FDS) combining with absorption spectrum. In pH 1.0 HCl medium, MBZ reacted with TP to form 3:1 ion–association complex. As a result, not only the spectrum of absorption was changed, but also the intensities of RRS and FDS were enhanced greatly. The maximum RRS, FDS and absorption wavelengths are located at 372, 392 and 260 nm, respectively. The increments of scattering intensity (Δ I ) and absorption (Δ A ) are directly proportional to the concentrations of MBZ in certain ranges. The detection limits (3 σ ) of RRS, FDS and absorption are 0.56, 0.86 and 130.16 ng/mL, respectively. The sensitivity of RRS method is higher than FDS and absorption methods. The optimum conditions of RRS method and the influence factors were discussed in the paper, in addition, the structure of ion–association complex and the reaction mechanism were investigated. Based on the ion–association reaction and its spectral response, the rapid, simple and sensitive RRS method for the determination of MBZ has been developed.
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