EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
·
2013
·Vol. 2013
·期 32
·7411-7420
·
IF 3.344
Zhengkai Chen,Weijun Yang,Lijun Xu,Lili Zhang,Maozhong Miao,Hongjun Ren
Graphical Highly substituted 2-hydroxyflavanones can be obtained through a tandem O -arylation/hydroxylation process from triazenylaryl-substituted diketones in the presence of a Lewis acid. A transition-metal-free tandem O -arylation/hydroxylation approach has been developed for the efficient synthesis of highly substituted 2-hydroxyflavanones from triazenylaryl-substituted diketones. The intermediate benzopyrylium cation may be involved in these reactions.
研究领域:
有机化学
·
药物化学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Tiantian Wang,Jianhong Wei,Furong Shi,Hejie Wang,Jinye He,Xudong Lv,Yuan Zhou,Pengzhi Guo,Chenglong Wang,Yangjun Xia
In recent years, polymerized small molecule acceptors (PSMAs) have emerged as a promising strategy that combines the strong absorption of small molecules with the film-forming ability and stability of polymers, thereby greatly boosting the performance of all-polymer solar cells (all-PSCs). We designed a non-fused acceptor, DTBT-IC, and its polymeric counterpart, PDTBT-Br-T, by selecting DTBT as the core, bithiophene as the π-bridge, and IC as the terminal group. PDTBT-Br-T was synthesized via Stille coupling and used with PM6 as the donor to fabricate organic solar cells. The PDTBT-Br-T-based device delivered superior performance, with a VOC of 1.050 V, JSC of 9.32 mA cm−2, FF of 45.33%, and a PCE of 4.44%, outperforming the DTBT-IC-based counterpart. Morphological and structural analyses revealed that PDTBT-Br-T exhibits more ordered backbone stacking and defined phase separation, enhancing exciton dissociation and charge transport, and suppressing energy loss. The study highlights that polymerization of DTBT-IC enhances intermolecular packing and microstructure, offering critical design insights for efficient all-PSCs.
研究领域:
材料科学
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高分子化学
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有机电子学
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光伏技术
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DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2020
·Vol. 34
·期 4
·e5451
·
IF 3.14
Shuang Huang,Xi Hong,Yong Sun,He-Zhen Cui,Quan Zhou,Yue-Jian Lin,Xiu-Feng Hou
Six tridentate NNN ligand precursors derived from 2-(pyridin-2-yl)benzo[d]thiazole(PBT) with different linkers, PBT NN X N (X = NH, NMe, O, S) ( 1a – 1f ), have been successfully prepared. The electronic properties of PBT NN X N ligands are well tunable by differing linkers between PBT skeleton and the pyridine ring, and/or by introducing electron-donating/withdrawing groups on the pyridine ring (R = OMe or F). The ligand precursors and representative complexes Ru ( PBT NN NH N )Cl 2 (PPh 3 ) ( 2a ), Ru ( PBT NN NMe N )Cl 2 (PPh 3 ) ( 2b ), and Ru ( PBT NN S N )Cl 2 (PPh 3 ) ( 2f ) have been characterized by NMR spectroscopy, high-resolution mass spectroscopy, and Fourier transform infrared (FT-IR). The molecular structures of 1f , 2a , and 2f have been determined by X-ray diffraction study. The results indicate that PBT NN NH N ligand in the complex presented coplanar with two five-membered chelating rings. It should be noted that 2a featuring a NH group exhibits superior performance compared to those with other linkers (such as NMe, O, or S). A variety of heterocyclic and aromatic nitriles with aromatic and aliphatic alcohols have been explored in α -alkylation for good to excellent yields. Based on kinetic experiments and mechanistic studies, a proposed mechanism was put forward. Ru-H species and benzaldehyde, which was oxidized from benzyl alcohol, were detected in the catalytic cycle.
研究领域:
无机化学
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有机化学
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催化
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材料科学
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DOI
高影响因子
Journal of Pharmaceutical Innovation
·
2025
·Vol. 20
·期 6
·1-17
·
IF 2.7
Lin Jinsheng,Wu Qilin,Liu Xueyang,Cao Renjian,Yong Qiyun,Li Dan,Chen Wenbin,Li Min,Shen Weiyang
Purpose This study intended to investigate two unknown impurity peaks (DP-1 and DP-2, at 0.29% and 0.20%, respectively) observed during the stability testing of brexpiprazole drug substance, which exceeded the unspecified impurity threshold (≤ 0.10%) and triggered an out-of-specification (OOS) investigation in a GMP environment. The objectives are to identify their structures, determine whether they are true impurities or artificial degradants, and establish appropriate control procedures for the pharmaceutical analysis of brexpiprazole. Methods The impurities were initially characterized using LC-UV/PDA high-resolution MS n ( n = 1 to 3), which identified DP-1 as an isomer of brexpiprazole and DP-2 as a dimer. Further structural elucidation of DP-1 was performed using semi-preparative HPLC and 1D/2D NMR spectroscopy. Forced degradation studies were conducted under photolytic conditions to confirm the formation of DP-1 and DP-2, with freshly prepared solutions kept in the dark as controls. Results DP-1 and DP-2 are both photo-degradants of brexpiprazole in solution. DP-1 is confirmed as an intramolecular [2 + 2] cycloaddition product of brexpiprazole, which is a novel and unreported impurity found in the product of brexpiprazole. DP-2 is identified as an intermolecular [2 + 2] cycloaddition product and consistent with a prior literature [ 1 ]. Both impurities formed only under light exposure and were absent in the light-protected samples, confirming their photodegradation origin rather than inherent impurities. Conclusion Both DP-1 and DP-2 are photo-induced degradants of brexpiprazole, rather than real impurities. These findings enhance understanding of brexpiprazole’s degradation chemistry and emphasize the need for light-protected sample preparation to prevent artifactual peaks in pharmaceutical analysis of brexpiprazole drug substance and its formulations.
研究领域:
药物化学
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分析化学
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药物稳定性
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杂质谱分析
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质谱分析
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核磁共振（NMR）
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2021
·
IF 6.986
Liu Shi,Lin Wang,Xuemei Ma,Xiaona Fang,Liangliang Xiang,Yongxiang Yi,Jinlong Li,Zhaofeng Luo,Genxi Li
With the outbreak of COVID-19, which is fast transmitting and highly contagious, the development of rapid, highly specific, and sensitive detection kits has become a research hotspot. The existing assay methods for SARS-CoV-2 are mainly based on enzymatic reactions, which require expensive reagents, hindering popular use, especially in resource-constrained areas. Herein, we propose an aptamer-based method for the assay of SARS-CoV-2 via binding of the spike protein using functionalized biomimetic nanochannels. To get the analogous effect of human ACE2, a receptor for the spike protein, the aptamer to bind to the spike S1 protein has been first screened by a SELEX technique and then immobilized on the previously prepared nanochannels. In the presence of SARS-CoV-2, the changes in steric hindrance and charge density on the surface of the nanochannels will affect the ion transport, along with a rapid electrochemical response. Our method has been successfully applied to detect the viral particles in clinical pharyngeal swab specimens in one step without sample treatment. We expect this rapid, reagent-free, and sensitive assay method to be developed as a useful tool for diagnosing COVID-19.
研究领域:
生物医学工程
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病毒学
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诊断学
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DOI
PubMed
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2025
·
IF 2.7
Fei Yuan,Yiyuan Xin,Caifeng Yuan,Zhuo Chen,Tongling Qin,Wenxia Hu,Jiahuan Duan,E Tang
A simple, exogenous-base-free, and NBS-mediated C-selenocyanation/cyclization reaction of enaminones with KSeCN under mild conditions, providing a facile route to 2-aminoselenazole products, has been developed. This efficient protocol is postulated to first undergo the NBS-oxidated polarity reversal of the reactive SeCN- anion to form N-selenocyanosuccinimide as an electrophilic selenium source, which can induce the C-selenocyanation of enaminones and enamino esters, followed by a nucleophilic cyclization promoted by in-situ yielded HBr.
研究领域:
有机化学
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合成化学
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硒化学
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DOI
PubMed
高影响因子
Molbank
·
2024
·Vol. 2024
·期 2
·M1828
·
IF 0.6
Zhongwei Wang,Lin Song,Yukun Qin
This study aims to develop an efficient and green one-pot method for the synthesis of 6-en-1-yl furan-2-carboxylic acid heptyl ester. Initially, using furfural as the starting substrate, hept-6-en-1-yl furan-2-carboxylate was prepared using a one-pot method. This study developed a new experimental scheme for preparing ester compounds, using cuprous chloride as a catalyst and tert butyl hydrogen peroxide as an oxidant to prepare furoic acid. Without the need for intermediate treatment, the target product can be directly obtained from furfural by adding 7-bromo-1-heptene, TBAB, and potassium carbonate. This method effectively utilizes furfural as a platform chemical, demonstrating its potential for synthesizing high-value chemicals. The entire synthesis process is simple and efficient, following the principles of green chemistry.
研究领域:
有机化学
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绿色化学
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合成化学
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DOI
高影响因子
DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 32
·12352-12361
·
IF 4.569
Hongqiang Cui,Yongze Cao,Yuhang Zhang,Lei Li,Guojian Li,Sai Xu,Yichao Wang,Jinsu Zhang,Baojiu Chen
A series of Er3+/Yb3+ co-doped Cs3BiSr(P2O7)2 (CBSPO) phosphors with significant thermal enhancement were successfully prepared using the solid-state method and the thermal-enhancing effect was studied in detail. When the temperature increased from 303 to 723 K, the upconversion luminescence (UCL) emission intensities of 2H11/2 → 4I15/2 and 2H11/2 + 4S3/2 → 4I15/2 of Er3+ in CBSPO:0.1Er3+/0.2Yb3+ were enhanced 22.81 and 10.06 times under 980 nm laser excitation, respectively. Meanwhile, the UCL color of the sample obviously changed from orange to green with the increase in temperature. Furthermore, the UCL thermal enhancement mechanism was demonstrated, which originates from phonon-assisted transitions. In addition, the maximum absolute temperature sensitivity for CBSPO:0.1Er3+/0.2Yb3+ was calculated to be 0.01026 K−1 at 563 K via luminescence intensity ratio (LIR) technology. All the results show that the CBSPO:Er3+/Yb3+ phosphors can be used for safety warning and temperature measurement at high temperatures.
研究领域:
材料科学
·
光学
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DOI
高影响因子
ACS Synthetic Biology
·
2025
·
IF 3.9
Bicheng Yu,Wei Song,Shenjie Wang,Wanqing Wei,Guipeng Hu,Xiaomin Li,Cong Gao,Jia Liu,Jian Wen,Jing Wu
2-Pyrrolidone is an important chemical intermediate with broad applications in the materials and pharmaceutical industries. Traditional petrochemical synthesis methods pose significant environmental challenges. In the case of biosynthesis, the limited thermostability of coenzyme A ligase (CaiC) represents a major barrier to industrial-scale production. This study focused on enhancing the thermostability and catalytic efficiency of EcCaiC through protein engineering. Conserved sequences were identified, and flexible regions were targeted for virtual mutagenesis using FoldX and Rosetta. The resulting mutant, M3, exhibited a 7.86-fold increase in half-life(t1/2) at 55 °C and a Tm of 59.3 °C. Additionally, the catalytic efficiency (kcat/Km) of M3 improved by 52.8%, reaching 5.73 mM–1 s–1 compared to the wild type. Subsequently, EcCaiCM3 was introduced into Corynebacterium glutamicum S9114, with targeted knockout of byproduct synthesis genes. Finally, fed-batch fermentation in a 5 L bioreactor achieved a 2-pyrrolidone yield of 58.28 g/L, a glucose conversion rate of 0.32 g/g, and a productivity of 0.97 g/L/h. This work establishes an efficient biosynthetic platform for 2-pyrrolidone, providing a robust foundation for its industrial production.
研究领域:
生物化学
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工业微生物学
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蛋白质工程
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DOI
PubMed
高影响因子
Russian Journal of Physical Chemistry A
·
2019
·Vol. 93
·期 4
·696-702
·
IF 0.581
Huanxin Li,Zhang Haihan,Dou Yonghui,Xu Li,Liu Guoji
Abstract The solubility of (1R,2R)-(+)-1,2-diaminocyclohexane L-tartrate (DHT) in methanol + water, ethanol + water, and 2-propanol + water mixed solvents were measured using a synthetic method with alcohols mass fractions varying from 0.1 to 0.5 over 278.15 to 318.15 K under atmospheric pressure ( P = 0.1 MPa). It was proved that the solubility of DHT in the three binary solvents increased with increasing temperature, while decreased with the mass fraction of alcohols rising. The experimental solubility data were correlated by the modified Apelblat equation and Sun model. The modified Apelblat model showed better agreement with the experimental data than the other model. Furthermore, the thermodynamic parameters including \(\Delta G_{{{\text{sol}}}}^{^\circ }\) , \(\Delta H_{{{\text{sol}}}}^{^\circ }\) , and \(\Delta S_{{{\text{sol}}}}^{^\circ }\) for DHT in the dissolution process were obtained from Van’t Hoff plots.
研究领域:
物理化学
·
药物化学
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DOI
高影响因子
Journal of Translational Medicine
·
2025
·Vol. 23
·期 1
·1271
·
IF 7.5
Zhu Jiru,Xia Yutong,Li Xiang,Wen Yingying,Zhang Xuhong,Jin Le,Zhang Liyue,Wang Ziyu,Li Yanqing,Yu Xin,Chen Zhitong,Ge Jiayun,Shen Ye,Tong Jianping
Background Myopia has reached epidemic proportions globally with limited therapeutic targets. This study elucidated the pivotal role of retinal epitranscriptomic regulation in myopia pathogenesis, aiming to identify novel therapeutic targets for myopia control. Methods The study enrolled 38 myopic patients scheduled for refractive surgery to analyze peripheral blood N6-methyladenosine (m6A) levels. In parallel, we established a murine form-deprivation myopia (FDM) model to examine retinal m6A dynamics and Alkylation repair homolog protein 5 (ALKBH5) expression. Pharmacological interventions using the ALKBH5 inhibitor DDO-2728 and Extracellular signal-related kinases 1 and 2 (ERK1/2) activator Ro67-7476 were administered intravitreally. To genetically validate the role of ALKBH5, ALKBH5-knockout (ALKBH5-KO) mice were subjected to the FDM model. Comprehensive assessments included refractive measurements, retinal structure analysis, and molecular profiling of inflammatory and extracellular matrix (ECM) markers. Statistical analyses employed Pearson’s correlation for clinical data and ANOVA with Tukey’s post hoc tests for experimental comparisons. Results Clinical data revealed significant inverse correlations between blood m6A levels and myopia severity (refraction: r = 0.435, p < 0.01; axial length: r = -0.338, p < 0.05). FDM retinas exhibited progressive m6A reduction and specific upregulation of ALKBH5 in the ganglion cell layer (GCL), with no changes observed in other m6A regulators. Mechanistic studies demonstrated that intravitreal injection of the selective ALKBH5 inhibitor DDO-2728 (2.5 mM) effectively attenuated myopia progression, mitigated retinal thinning, suppressed inflammatory mediators, and modulated early ECM dysregulation through specific suppression of ERK1/2 hyperphosphorylation. Crucially, genetic ablation of ALKBH5 recapitulated the protective phenotype of the inhibitor, conferring significant resistance to myopia development and associated retinal pathology. Importantly, co-administration of the ERK1/2 activator Ro 67-7476 completely abolished DDO-2728’s protective effects. Conclusions Peripheral blood m6A reduction correlates with human myopia severity. Retinal ALKBH5 upregulation drives myopia progression through ERK1/2 hyperactivation. Both pharmacological inhibition and genetic deletion of ALKBH5 effectively protect against myopia, attenuate inflammatory responses, and mitigate ECM dysregulation, mechanistically linked to the suppression of ERK1/2 signaling. These findings collectively identify ALKBH5 as a novel therapeutic target and DDO-2728 as a promising strategy for myopia control. Graphical
研究领域:
眼科学
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分子生物学
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表观遗传学
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信号转导
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药理学
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产品关联
DOI
PubMed
高影响因子
MATERIALS AND STRUCTURES
·
2023
·Vol. 56
·期 1
·1-15
·
IF 3.8
Song Yufeng,Zhang Yi,Shen Siyi,Pan Chenyu,Yan Dongming,Wang Zhiguang,Wang Su,Ruan Shaoqin
This study aims to explore the effects of different Ca(OH) 2 contents on the mechanical performance and corrosion behaviors of steel in Calcium sulfoaluminate (CSA) cement, where compressive strength, corrosion potentials of reinforcements, corrosion current density, pH of pore solution as well as mortar resistivity of CSA/Ca(OH) 2 mortar were researched, and the corrosion behaviors were further interpreted by the clarification of hydration phases through microstructural analyses. The initial results highlighted the positive effects of using adequate Ca(OH) 2 (~ 6%) in CSA mortar in terms of strength, yet its excessive addition could delay the subsequent hydration reaction of CSA. Meanwhile, with an increased quantity of Ca(OH) 2 , the amount of some hydration phases, such as Al(OH) 3 reduced, resulting from their reaction with Ca(OH) 2 . Finally, the corrosion current density increased with the reduced mortar resistivity when the reinforcement in CSA/Ca(OH) 2 system was corroded, and their relationship was also provided in this study.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）