PROCESS BIOCHEMISTRY
·
2020
·
IF 2.952
Yuan Lu,Hongqian Dai,Hanbing Shi,Lan Tang,Xingyuan Sun,Zhimin Ou
Fe 3 O 4 -Arg was selected as the optimal carrier due to its high activity recovery of immobilized cells in the preparation of Fe 3 O 4 -Arg-Cells. The optimal immobilization conditions for the preparation of Fe 3 O 4 -Arg-Cells were 30 °C, 4 h, pH 7, and 3 g dry yeast. The activity recovery of immobilized cells reached 76.8 %. For a batch reduction in a shaker in an alternating magnetic field, Fe 3 O 4 -Arg-Cells were used as a catalyst to gain ethyl ( R )-4-chloro-3-hydroxybutyrate (( R )-CHBE). For further improvement in reduction productivity, a continuous reduction in the magnetic fluidized bed reactor system (MFBRS) was completed. Under their optimal transformation conditions, it took 24 h for Fe 3 O 4 -Arg-Cells to complete the conversion of ethyl 4-chloro-3-oxobutanoate (COBE) (0.8553 mol/L) in the shaker and only 8 h for the batch reduction in an alternating magnetic field. Continuous reduction in MFBRS provided new ideas for the efficient production of ( R )-CHBE; 1.5882 mol/L (10 mL) of COBE can be completely converted in 6 h. The conversion and enantiomeric excess (e.e.) of ( R )-CHBE were 100 % and above 99.9 % respectively, in the three reaction systems mentioned above.
研究领域:
生物化学
·
合成生物学
·
纳米技术
✓ 已验证
DOI
高影响因子
SYNLETT
·
2018
·Vol. 29
·期 09
·1244-1248
·
IF 2.369
Xiangwen Kong,Lihua Liu,Siqin Luo,Shilu Fan,Haisheng Qian,Hua Xiao
A triphenylphosphine-promoted [3+2] cycloaddition of α,γ-bis-substituted allenoates and N-tosylaldimines followed by alkene isomerization was disclosed, affording a series of functionalized 2-pyrroline derivatives in moderate chemical yields with random diastereoselectivities.
研究领域:
有机化学
·
药物化学
·
合成方法学
·
杂环化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2020
·
IF 2.369
Haigang Liu,Bing Jia,Weizhen Sun,Shihua Dong
Liquid–liquid equilibrium (LLE) data for water + 2-methyl-3-buten-2-ol + (isopropyl ether or 4-methylpentan-2-ol or p-xylene or ethyl acetate) ternary systems was measured at 308.2 K under 101.3 kPa. Distribution coefficients and separation factors were obtained and applied to evaluate the extraction capacity of selected solvents. Furthermore, the experimental LLE data were successfully correlated by the nonrandom two-liquid (NRTL) and universal quasi-chemical (UNIQUAC) models, which showed a root-mean-square deviation (RMSD) of less than 0.78% for all systems.
研究领域:
化学工程
·
热力学
✓ 已验证
DOI
高影响因子
Energy Storage Materials
·
2019
·
IF 0
Junfeng Yang,Dongdong Li,Xusheng Wang,Xinxiang Zhang,Jian Xu,Jitao Chen
NASICON-structure Na 3 V 2 (PO 4 ) 3 (NVP) is a potential cathode for sodium ion battery , which however needs nano-crystallization to improve its rate performance. On the other hand, most practical electrodes are fabricated through slurry printing process, which needs to control the particle size to avoid the falling of the composite. Herein, for practical high-loading electrode fabrication, the micro-nano architecture, i.e. the micro particle plus nano channels inside, is suggested in this paper. The micro-nano information about NVP is obtained through Ga + focused ion beam-scanning electron microscopy to reconstruct the 3D model of a single NVP particle, fully exhibiting the continuous nano channels inside the micro sphere . The as-obtained NVP/C sample in the micro size exhibits remarkable enhanced rate performance of 106, 104, 101, 96, 89, 70 and 44 mAh g −1 at rates of 2, 5, 10, 20, 50, 100 and 200 C respectively, compared to the control sample in the nano size with the capacity of 106, 103, 85, 77 and 60 mAh g −1 at 2, 5, 10, 20 and 50 C respectively, meanwhile maintaining good adhesion towards Al foil and electrochemical performance at the areal loading of 10 mg cm −2 .
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
SENSORS AND ACTUATORS B-CHEMICAL
·
2011
·
IF 3.37
Min Sun,Bin Ding,Jianyong Yu,You-Lo Hsieh,Gang Sun
A highly sensitive coating comprising 3-mercaptopropionic acid (MPA) monolayer modified electrospun polystyrene (PS) membranes was constructed on the electrode of quartz crystal microbalance (QCM) for Cu 2+ detection. The three-dimensional fibrous PS membranes with high specific surface area (SSA) were deposited on the electrode of QCM via electrospinning. The PS membranes were sputter coated with gold, then modified with self-assembled monolayer of MPA. The PS-MPA sensors showed fast response (2–3 s) to Cu 2+ and a detection limit down to 100 ppb. Additionally, sensor sensitivity increased concurrently with both increasing PS loading and SSA on QCM electrodes . The response of the PS-MPA sensors with a PS membrane loading of 978 Hz and SSA of 43.31 m 2 /g was 40 times larger than that without membranes when exposed to 1 ppm of Cu 2+ . The sensor responses were reproducible toward Cu 2+ in the 100–5 ppm concentration range, whereas a linear response was found in the 100–1 ppm concentration range. The sensor response to Cu 2+ showed a linear relationship with an increase in pH from 2 to 7. Moreover, the sensors also exhibited chelation selectivity for other transition metal ions in the descending order Cu 2+ > Ni 2+ > Zn 2+ > Fe 2+ at concentration between 1 and 5 ppm.
研究领域:
分析化学
·
环境监测
·
材料科学
·
生物传感器
·
纳米技术
·
重金属检测
·
表面功能化
✓ 已验证
DOI
高影响因子
Materials Chemistry Frontiers
·
2021
·Vol. 5
·期 14
·5336-5343
·
IF 6.482
Shuyuan Li,Zhongyuan Huang,Yinguo Xiao,Chunwen Sun
Solid-state electrolytes (SSEs) are expected to replace liquid electrolytes in lithium metal batteries (LMBs) with good safety and mechanical strength. However, the existing problems of the Li1.3Al0.3Ti1.7(PO4)3 (LATP) electrolyte, like its poor contact with electrodes, serious side reactions and low ionic conductivity, limit its practical application. In this work, a chlorine (Cl)-doped LATP electrolyte showing a high ionic conductivity of 0.423 mS cm−1 was successfully synthesized. Neutron powder diffraction (NPD) results reveal that the change of the Li+ coordination environment after Cl doping has an effect on the ion diffusion path in the bulk LATP. The fabricated Li symmetric battery with the Cl-doped LATP exhibits long-term compatibility and electrochemical stability against the lithium metal anode. The enhanced performance may be attributed to the in situ formed stable solid electrolyte interphase (SEI) layer. Meanwhile, compared to the LATP electrolyte, the Li|LiFePO4 (LFP) full battery with Cl-doped LATP as an electrolyte has an improved rate performance and cycling performance. This work demonstrates that Cl doping may be an effective approach for improving the performance of the LATP electrolyte.
研究领域:
材料科学
·
电化学
·
电池技术
✓ 已验证
DOI
高影响因子
ACTA PHARMACOLOGICA SINICA
·
2024
·
IF 6.9
Su Qi,Wang Jing-jing,Ren Jia-yan,Wu Qing,Chen Kun,Tu Kai-hui,Zhang Yu,Leong Sze Wei,Sarwar Ammar,Han Xu,Zhang Mi,Dai Wei-feng,Zhang Yan-min
Parkin ( PARK2 ) deficiency is frequently observed in various cancers and potentially promotes tumor progression. Here, we showed that Parkin expression is downregulated in liver cancer tissues, which correlates with poor patient survival. Parkin deficiency in liver cancer cells promotes migration and metastasis as well as changes in EMT and metastasis markers. A negative correlation exists between TMEFF1 and Parkin expression in liver cancer cells and tumor tissues. Parkin deficiency leads to upregulation of TMEFF1 which promotes migration and metastasis. TMEFF1 transcription is activated by Parkin-induced endogenous TGF-β production and subsequent phosphorylation of Smad2/3 and its binding to TMEFF1 promotor. TGF-β inhibitor and TMEFF1 knockdown can reverse shParkin-induced cell migration and changes of EMT markers. Parkin interacts with and promotes the ubiquitin-dependent degradation of HIF-1α/HIF-1β and p53, which accounts for the suppression of TGF-β production. Our data have revealed that Parkin deficiency in cancer leads to the activation of the TGF-β/Smad2/3 pathway, resulting in the expression of TMEFF1 which promotes cell migration, EMT, and metastasis in liver cancer cells.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2018
·
IF 1.703
Zi-Mei Ding,Wen-Li Cao,Xiao-Jing Hang,Xiao Ma,Hui Zheng,Kang-Zhen Xu,Jie Huang
The green nitrogen-rich coordination compound Cd(SCZ)2(AFT)2 (1) (AFT =4-amino-3-(5-tetrazolate)-furazan and SCZ = semicarbazide) was first synthesized and characterized by EA and Fourier Transform Infrared (FT-IR). The single crystal was cultivated and determined with X-ray diffraction. It revealed that 1 crystallizes in the monoclinic space group P21/c. A Cd2+ ion is coordinated by four N atoms and two O atoms to form a distorted octahedral structure. Among them, two nitrogen atoms are from the two AFT ions and the other four atoms are from two SCZ molecules. The thermal decomposition behavior of 1 was studied with DSC and TG-DTG methods. The apparent activation energy (E), thermal stability, and safety parameters (T
SADT, T
TIT, and T
b) were calculated for 1. Moreover, entropy of activation (ΔS
≠), enthalpy of activation (ΔH
≠), free energy of activation (ΔG
≠), specific heat capacity (C
p), and impact sensitivity were also discussed in detail.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2020
·
IF 4.825
Yun-Xiang Ma,Ya-Ping Gong,Chun-Li Hu,Fang Kong,Jiang-Gao Mao
The search of novel second-harmonic generation crystals in gallium selenite systems results in three new compounds of MGa2(SeO3)4 (M = Sr, Pb) and BiGa(SeO3)3. The isostructural MGa2(SeO3)4 (M = Sr, Pb) are centrosymmetric (P1̅, no. 2). The structures represent a complicated three-dimensional skeleton containing two different types of Ga4Se4 8-member polyhedral ring tunnels with the counter cations located at the broad ones. When the divalent counter cations were substituted by a trivalent lone pair cation of Bi(III), a novel noncentrosymmetric compound of BiGa(SeO3)3 was achieved. BiGa(SeO3)3 displays a 3D gallium selenite framework with 1D bismuth oxide chains filling in the 12-member polyhedral ring tunnels. Frequency doubling measurements showed that BiGa(SeO3)3 presented an apparent SHG signal comparable to the commercial KDP and can realize phase matching. The lone pair anionic groups of SeO32– made the major contribution according to the SHG density analyses. BiGa(SeO3)3 exhibits a wide transparent range and large optical bandgap (3.90 eV). The laser-induced damage threshold of BiGa(SeO3)3 was estimated to be 98.68 MW/cm2, about 44 × AGS.
研究领域:
材料科学
·
光学
·
晶体学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Z.B. Feng,B.J. Tao,W.F. Wang,H.Y. Liu,H.T. Wu,Z.L. Zhang
Novel low temperature sintered Li 4 Mg 3 [Ti 0.8 (Mg 1/3 Ta 2/3 ) 0.2 ] 2 O 9 (LMT 0.8 (MT) 0.2 ) ceramics with 1–5 wt% LiF additives were successfully prepared by the solid-state reaction method. The effects of LiF additives on the phase composition, sintering characteristic, microstructure and microwave dielectric properties of LMT 0.8 (MT) 0.2 ceramics were investigated in detail for the first time. The sintering temperature of LMT 0.8 (MT) 0.2 ceramics could be effectively lowered to 950 °C by the addition of LiF. A single rock salt crystalline phase structure belonging to a space group of Fm-3m (No.225) was obtained through X-ray diffraction patterns. Dense uniform morphology was observed at 950 °C for LMT 0.8 (MT) 0.2 ceramics with 3–5 wt% LiF in terms of scanning electron microscopy photographs. Particularly, the LMT 0.8 (MT) 0.2 -4 wt% LiF ceramics sintered at 950 °C for 4 h possessed optimum microwave dielectric properties of ε r = 16.10, Q·f = 114,313 GHz (at 8.18 GHz) and τ f = −7.72 ppm/°C. In addition, the excellent chemical compatibility with silver metal electrodes indicated that the LMT 0.8 (MT) 0.2 -4 wt% LiF ceramics might be a promising candidate for the low-loss low temperature co-fired ceramics (LTCC) applications in microwave devices.
研究领域:
材料科学
·
陶瓷
·
微波工程
·
低温共烧陶瓷(LTCC)
✓ 已验证
DOI
高影响因子
Foods
·
2022
·Vol. 11
·期 20
·3225
·
IF 5.561
Xinrui Tang,Yingfeng An,Muhammad Waheed Iqbal,Hongri Cong,Guoyan Zhang,Yufei Zhang,Yuvaraj Ravikumar,Hossain M. Zabed,Mei Zhao,Haixing Zhou,Xianghui Qi
D-allulose is a natural rare sugar with important physiological properties that is used in food, health care items, and even the pharmaceutical industry. In the current study, a novel D-allulose 3-epimerase gene (Bp-DAE) from the probiotic strainBlautia producawas discovered for the production and characterization of an enzyme known as Bp-DAE that can epimerize D-fructose into D-allulose. Bp-DAE was strictly dependent on metals (Mn2+and Co2+), and the addition of 1 mM of Mn2+could enhance the half-life of Bp-DAE at 55 °C from 60 to 180 min. It exhibited optimal activity in a pH of 8 and 55 °C, and theKmvalues of Bp-DAE for the different substrates D-fructose and D-allulose were 235.7 and 150.7 mM, respectively. Bp-DAE was used for the transformation from 500 g/L D-fructose to 150 g/L D-allulose and exhibited a 30% of conversion yield during biotransformation. Furthermore, it was possible to employ the food-grade microbial speciesBacillus subtilisfor the production of D-allulose using a technique of whole-cell catalysis to circumvent the laborious process of enzyme purification and to obtain a more stable biocatalyst. This method also yields a 30% conversion yield.Keywords:D-allulose 3-epimerase;D-allulose;Blautia produca;probiotics;biochemical characterization;biotransformation
研究领域:
生物化学
·
生物技术
·
食品科学
·
药学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 18
·7049-7057
·
IF 8.067
Yingyuan Chen,Feilong Liu,Ziwang Zhang,Junyu Hong,Maxim S. Molokeev,Ivan A. Bobrikov,Jianxin Shi,Jianbang Zhou,Mingmei Wu
Red-light-emitting materials, as pivotal components of warm white light-emitting diodes (WLEDs), have drawn increasing public focus. Among these, Mn4+-doped red light-emitting fluorides have drawn considerable attention when combined with an InGaN chip; however, they suffer from poor water stability under humid conditions. In this work, a novel fluoride red phosphor, Cs30(Nb2O2F9)9(OH)3·H2O:xMn4+ (CNOFM), with good water resistance was synthesized for the first time using a facile co-precipitation method at ambient temperature. Experiments were implemented for the precise analysis of its crystal structure, optical properties, micro-morphology, thermal behavior, and waterproof properties. 6.66% Mn4+-doped CNOFM maintained a stable crystal structure and possessed strong PL intensity located at 633 nm with high color purity of 96%. CNOFM showed better thermal and waterproof stability compared with the commercial K2SiF6:Mn4+ red phosphor. Without any surface modifications, the PL intensity remained at about 83% of the initial value after immersion in water for 60 min, and the mechanism was investigated. Finally, a warm WLED with a CRI of 92.3 and CCT of 3271 K was fabricated using the CNOFM red phosphor.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）