JOURNAL OF MATERIALS SCIENCE
·
2015
·Vol. 50
·期 24
·8120-8127
·
IF 2.371
Liu Yongkun,Jiang Guohua,Li Lei,Chen Hua,Huang Qin,Jiang Tengteng,Du Xiangxiang,Chen Wenxing
Due to their high surface energy, naked gold nanoparticles (AuNPs) tend to form agglomerates, which could lead to the decrease of active sites and catalytic activity of AuNPs. Herein, the gold nanoparticles/polyacrylonitrile (AuNPs/PAN) nanofibrous membranes have been prepared via an environmentally friendly and efficient route combining electrospinning, amination, and electroless plating technique. The abundant amine and imine groups can be introduced onto the surface of PAN nanofibrous membranes via amination treatment which could be used as “anchoring sites” to immobilize AuNPs. The resultant composite membranes were applied as the new catalytic materials for reduction of 4-nitrophenol to 4-aminophenol under room temperature. The new catalytic membranes exhibited the significant advantages, such as low dosage, high catalytic activity, easy recycling, and excellent stability.
研究领域:
材料科学
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环境科学
·
化学工程
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产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2021
·
IF 5.097
Jiaqi Chen,Ting Zhong,Xi Lu,Feng Zhao,Pan Wang,Xue Yu,Yuxin Yang,Fengyun Sun,Xiaochun Wu,Wei Feng
Nitrite (NO2–) in water and food is a potential threat to human health. The determination of nitrite content is very significant for people’s life safety. Here, 4-aminothiophenol (4-ATP)-modulated silver growth on gold nanospheres (GNSs) was designed to detect nitrite. It was verified that the exposed amino groups of 4-ATP molecules on GNSs can accelerate Ag overgrowth. On the contrary, the deamination reaction of 4-ATP with nitrite can reduce the Ag overgrowth rates. 4-ATP modified on GNSs can not only increase the spectrophotometry response of nitrite with a low limit of detection (LOD = 36 nM) but also obtain a wide and flexible detection range (0–60 μM). In addition, this method showed good selectivity to nitrite. The excellent optical response, the sharp contrast between the acceleration and deceleration of Ag growth, and the customizable basic setting of the sensing ligands can provide a universal design scheme for high-performance detection methods.
研究领域:
分析化学
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纳米技术
·
环境科学
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产品关联
DOI
高影响因子
LIQUID CRYSTALS
·
2024
·
IF 2.4
Rui-Zhe Zhou,Yan Zhang,Ji-Feng Gao,Shuai-Yin Ma,Hong-Shuang Zhang,Xiao-Zhi He
By introducing two cholesteric liquid crystal monomers with different chain lengths (M1 and M2) and brominated naphthalimide fluorescent monomer (M3) into polymethyl hydrosiloxane, a series of fluorescent cholesteric liquid crystal polymers (FL-LCP) was prepared, which not only have excellent performance of liquid crystal and fluorescence but also own performance of selective reflection. Their chemical structures were confirmed to be in accord with molecular design by FT-IR and 1 H NMR spectroscopy, and found them with excellent thermal stability, mesomorphic behaviour and thermal performance by TGA, POM, DSC and XRD, and confirmed all the polymers belonged to the cholesteric phase. The FL-CLCPs emitted different intensity fluorescence under UV light, and conclusions about the relationship between fluorescence and temperature had been drawn. A comparative study was conducted on the fluorescence properties of powders and films of monomers and polymers.
研究领域:
材料科学
·
化学
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产品关联
DOI
高影响因子
GeroScience
·
2024
·
IF 5.3
Zhou Yiming,Chen Lijuan,Wang Meijing,Yang Yang,Hu Bin,Li Guolin,Wei Fang
Paroxetine, a selective serotonin reuptake inhibitor, is widely used in the clinical treatment of depression. While several antidepressants show promise as geroprotectors, the role of paroxetine in aging remains unclear. In this study, we evaluated the lifespan extension effect of paroxetine in Caenorhabditis elegans ( C. elegans ) and elucidated the underlying mechanisms. The results showed that paroxetine can prolong lifespan concomitant extension of healthspan as indicated by increasing mobility and reducing lipofuscin accumulation, as well as confer protection to nematodes against different abiotic stresses. Paroxetine upregulated ser-7 expression and downregulated dop-4 expression. dop-4 RNA interference (RNAi) mimicked the beneficial effect of paroxetine on lifespan. Conversely, ser-7 RNAi abolished paroxetine-induced lifespan extension and the expression changes of dop-4 and genes related to insulin/insulin-like growth factor 1 signaling (IIS). Moreover, paroxetine exhibited a comparable lifespan extension effect to that observed in daf-2 or age-1 mutants; however, this effect was abolished in daf-16 mutant. Taken together, these results suggest that paroxetine promotes health and longevity in C. elegans through the ser-7 - dop-4 -IIS pathway, underscoring its potential as a geroprotector.
研究领域:
生物学
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老年医学
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神经科学
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产品关联
DOI
PubMed
高影响因子
Nano Energy
·
2019
·
IF 15.548
Shu-qi Yang,Peng-bo Wang,Han-xin Wei,Lin-bo Tang,Xia-hui Zhang,Zhen-jiang He,Yun-jiao Li,Hui Tong,Jun-chao Zheng
Li-rich Mn-based cathode materials are regarded as promising cathode materials for Li-ion batteries (LIBs) owing to their high electrochemical capacity and low cost. However, residual Li compounds on the surface and dissolution of metal ions cause severe degradation of the electrochemical performance, thereby hindering their practical applications. Li 4 V 2 Mn(PO 4 ) 4 is a composite cathode material with three-dimensional Li-ion diffusion channels and a stable structure at high operating voltages (>4.5 V). Herein, we modify the surface of Li[Li 0.2 Mn 0.54 Ni 0.13 Co 0.13 ]O 2 with Li 4 V 2 Mn(PO 4 ) 4 . The Li 4 V 2 Mn(PO 4 ) 4 coating layer can not only reduce the content of residual Li compounds on the surface but also restrain the dissolution of transition metals. Theoretical calculations illustrate that Li 4 V 2 Mn(PO 4 ) 4 reduces the Li-ion diffusion energy barrier and provides efficient diffusion pathways. Li[Li 0.2 Mn 0.54 Ni 0.13 Co 0.13 ]O 2 @Li 4 V 2 Mn(PO 4 ) 4 compounds deliver a discharge capacity of 300 mAh g −1 with a high initial coulombic efficiency (84.2%) and an excellent cycling stability (capacity retention of 78.1% after 200 cycles at 1C). Hence, the proposed modification strategy of phosphate-based materials could shed light on the structural design of surface-sensitive electrode materials for LIBs.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
Minerals
·
2024
·Vol. 14
·期 12
·1255
·
IF 2.2
Chenglong Du,Jiang Yu,Guangyi Liu
Iron ore is the main raw material of the iron and steel metallurgy industry, but quartz in iron ore reduces metallurgical efficiency and increases metallurgical costs. Therefore, iron ore desiliconization by flotation plays an important role in the iron and steel metallurgy industry. In this study, 4-tert-butyl-catechol (TBC) was designed as a collector to directly float out hematite from quartz. The micro-flotation tests demonstrated that under pH ~9.0, 1 × 10−5mol·L−1TBC recovered 98% hematite from its mixture with quartz, while the recovery of quartz was only about 17%. Zeta potential and contact angle results inferred that the adsorption affinity of TBC toward hematite was greater than that to quartz. The results of FTIR and XPS inferred that TBC adsorbed on the Fe3+sites of hematite interfaced via the O atom of its two adjacent hydroxyl groups to form a stable five-membered chelating ring at pH 9.0. This study offered new research insight on the development of novel collectors for hematite flotation through bionics technology.
研究领域:
矿物加工工程
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材料科学与工程
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产品关联
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2023
·Vol. 25
·期 12
·8556-8563
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IF 3.3
Zijian Wang,Jiaxin Zhang,Lele Yan,Bo Zhao,Lin Zheng,Haoran Guo,Yuxue Yue,Deman Han,Xianlang Chen,Rongrong Li
4-Chloroaniline (4-CAN) plays an important role in chemical and industrial production. However, it remains a challenge to avoid the hydrogenation of the C–Cl bond in the synthesis process to improve selectivity under high activity conditions. In this study, we in situ fabricated ruthenium nanoparticles (Ru NPs) containing vacancies inserted into porous carbon (Ru@C-2) as a highly efficient catalyst for the catalytic hydrogenation of 4-chloronitrobenzene (4-CNB) with remarkable conversion (99.9%), selectivity (99.9%), and stability. Experiments and theoretical calculations indicate that the appropriate Ru vacancies affect the charge distribution of the Ru@C-2 catalyst, promote the electron transfer between the Ru metal and support, and increase the active sites of the Ru metal, thus facilitating the adsorption of 4-CNB and the desorption of 4-CAN to improve the activity and stability of the catalyst. This study can provide some enlightenment for the development of new 4-CNB hydrogenation catalysts.
研究领域:
催化
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材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yuan Zhang,Kangping Cui,Xueyan Liu,Minshu Cui,Xing Chen,Yuchao Tang,Haiyang Li,Kun Wang
In order to improve the photocatalytic activity of pristine carbon nitride while maintaining its metal-free property to achieve the activation of peroxymonosulfate (PMS), a series of carbon-doped g-C 3 N 4 (BCN) with different carbon contents were synthesized in this paper by adding benzotriazole to urea. The catalyst obtained by this approach significantly promoted PMS activation and enhanced the degradation efficiency of 4-chlorophenol (4-CP). Experiments and theoretical calculations showed that the introduction of carbon not only narrowed the band gap, but also accelerated the separation of photoinduced electron-hole pairs, which greatly improved the photocatalytic activity of g-C 3 N 4 . In the degradation of pollutants, free radicals and non-free radicals acted simultaneously, with non-free radicals playing a dominant role. This study explained the origin of 1 O 2 by Density functional theory (DFT) calculations, visible light excited photocatalysts to form holes, while carbon introduction decreased the valence-electron density around the area, inducing electron transfer from PMS toward g-C 3 N 4 directed to generate 1 O 2 . The 1 O 2 -dominated degradation process improved the application of the catalysts in complex aqueous matrices. In addition, we proposed 4-CP degradation pathways, and the toxicity of intermediates derived from 4-CP degradation process reduced.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
Letters in Drug Design & Discovery
·
2020
·Vol. 17
·期 4
·502-511
·
IF 1.169
Song Mingxia,Liu Bing,Yu Shengwang,He Shihui,Liang Yuqiu,Li Sifan,Chen Qiuyan,Deng Xianqing
Background: Several series of hydrazone derivatives of pyrazole-4-carboxaldehydes (4- 11) were designed and synthesized to screen their inflammatory activity. Methods: The products were characterized by 1H NMR, 13C NMR and HRMS. In vitro LPS-induced TNF-α model and in vivo
xylene-induced ear-edema model were used to evaluate their antiinflammatory activity. Results and Conclusion: Bioassays indicated that most of the compounds markedly inhibited the expression of TNF-α at the concentration of 10 μg/mL. Compounds 7b and 11c, two of the most potent
compounds, exhibited TNF-α inhibitory ability in a dose-dependent manner with IC50 values of 5.56 and 3.69 μM, respectively. In vivo, intraperitoneal administration with 7b and 11c markedly inhibited the ear edema at the doses of 20 and 50 mg/kg. Compound 11c, inhibited edema by 49.59
% at the dose of 20 mg/kg, was comparable to the reference drug dexamethasone at the same dose (with an inhibition of 50.49 %). To understand the binding pattern, molecular docking of representative 7b and 11c was performed, which demonstrated that both compounds have a forceful binding with
the TNF-α, and that the phenyl and hydrazide moieties of them play a significant role in binding with the target site.
研究领域:
药物化学
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炎症研究
·
分子生物学
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DOI
高影响因子
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
·
2025
·
IF 3.4
Xinxin Zhou,Yicheng Mei,Baowei Yang,Jing Wang,Huiling Tang,Xiaolong Zhang,Changchun Liu
Eight 4-(morpholinyl arylamino)quinazoline-6-carbamoyl carboxylic acid methyl esters and four 4-(morpholinyl arylamino)quinazoline-6-carbamoyl hydroxamic acid derivatives were designed and synthesized by integrating morpholine moieties into the 4-aminoquinazoline scaffold, with additional modifications at the 6-position of quinazoline ring. The antitumor potential of these twelve derivatives was evaluated against human lung cancer A549 cells and breast cancer MDA-MB-231 cells using the Cell Counting Kit-8 (CCK-8) proliferation assays. The bioassay results indicated that most of the derivatives exhibited moderate to potent in vitro antiproliferative activity against both cancer cells. Particularly, compound 7bb demonstrated superior potency against MDA-MB-231 cells and A549 cells, with half maximal inhibitory concentration (IC 50 ) values of 4.286 and 4.720 μM, respectively, compared to the reference drug afatinib (IC 50 = 7.640 and 5.173 μM, respectively). This study provides valuable insights for the development of novel antitumor agents based on the 4-aminoquinazoline scaffold.
研究领域:
药物化学
·
肿瘤学
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DOI
高影响因子
BIOTECHNOLOGY LETTERS
·
2018
·Vol. 40
·期 7
·1049-1055
·
IF 1.846
Zhao Weirui,Ding Huanru,Hu Sheng,Huang Jun,Lv Changjiang,Mei Jiaqi,Jin Zhihua,Yao Shanjing,Mei Lehe
Objective To develop a new and efficient biocatalytic synthesis method of imidazole-4-acetic acid (IAA) from l -histidine ( l -His). Results l -His was converted to imidazole-4-pyruvic acid (IPA) by an Escherichia coli whole-cell biocatalyst expressing membrane-bound l -amino acid deaminase (m l -AAD) from Proteus vulgaris firstly. The obtained IPA was subsequently decarboxylated to IAA under the action of H 2 O 2 . Under optimum conditions, 34.97 mM IAA can be produced from 50 mM l -His, with a yield of 69.9%. Conclusions Compared to the traditional chemical synthesis, this biocatalytic method for IAA production is not only environmentally friendly, but also more cost effective, thus being promising for industrial IAA production.
研究领域:
生物化学
·
工业微生物学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Zhenjun Zhao,Jingyi Chi,Zhang FangFang,Yinglin Song,Wenda Xv,Yan Li,Hui Shi
4-Octylphenol, a major environmental degradation product of alkylphenols (Aps) used in industry, is an endocrine-disrupting chemical with significant estrogenic activity. It is one of the most toxic Aps, poorly biodegradable in the environment, and can accumulate in organisms through the food chain, thereby affecting the male reproductive system. In this study, the effect of 4-octylphenol on male reproductive health was analyzed. Male pubertal mice were exposed to 4-octylphenol at doses of 0, 1, 10, and 100 mg/kg once daily for 28 days. Our findings indicated that pubertal exposure to 4-octylphenol has significant negative effects on the male reproductive system. Pubertal mice exposed to 4-octylphenol exhibited dose-dependent reproductive toxicity. In the medium- and high-dose groups, a significant reduction in testicular mass, structural damage to the seminiferous tubules, increased oxidative stress and apoptosis within the testicular tissue, and a decline in sperm quality were observed. Additionally, autophagy processes in the testicular tissue, germ cell proliferation, and meiotic processes are inhibited. Serum testosterone and estradiol levels decreased, whereas oxidative stress levels in the testes and spermatozoa increased. In contrast, the low-dose group showed only a reduction in body weight, a decrease in motile sperm count, and mild oxidative stress in the testes without significant pathological changes in Western blot experiments. These results indicate that 4-octylphenol exposure during puberty caused reproductive toxicity in male mice.
研究领域:
毒理学
·
内分泌学
·
生殖健康
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）