MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Xiaomeng Li,Beibei Hu,Lijie Ma,Yuechan Shi,Yongshuai Jing,Zhongqiu Li,Zhiwei Li,Shiguo Sun
Growth hormone-releasing hexapeptide (GHRP-6) is a kind of stimulant, which can be illegally used in athletic performance enhancement during sports. The accurate and sensitive detection of GHRP-6 is crucial for ensuring fair competition. Electrochemical sensors achieve quantitative analysis by monitoring the changes in electrochemical signals induced by target analytes. In this study, we developed an electrochemical sensor based on voltammetry to detect GHRP-6, providing a novel and advanced analytical methodology for its detection. The GHRP-6 was used as templates, phenol as polymer monomers, and MWCNTs as signal amplification materials, to build a detection method based on molecularly imprinted electrochemistry (MIEC). The fabricated sensor displayed rapid binding kinetics due to the location of all imprinting cavities on the polymer’s surface. This method displayed a linear relationship in the concentration range of 0.1 ∼ 100 ng/mL, featuring a detection limit of 1.21 pg/mL (S/N = 3). The percent recovery of GHRP-6 was 96.0 ∼ 103.2 % with the RSD in the range of 1.49 ∼ 5.56 %. The reproducibility test of the method resulted in an RSD of 3.19 %. Compared to the normal detection method, this technique shows more reproducibility and stability in real human serum samples. This study introduces an advanced, simple, and practical detection method for GHRP-6 in clinical samples.
研究领域:
分析化学
·
生物医学工程
·
运动科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Wei Tao,Juan Li
In this paper, nitrogenous bases adenine (A), guanine (G), cytosine (C), and uracil (U), were used to tailor the hydrogen-bonded network of melamine cyanurate (MCA) and were noted as A-MCA, G-MCA, C-MCA, U-MCA, respectively. The results showed that the size, morphology and thermal behavior of MCA are regulated by base due to the formation of hydrogen bonds between them. These modified MCAs were used to improve the flame retardancy of polyamide 6 (PA6) which was evaluated by using the limiting oxygen index (LOI) and the vertical burning (UL-94) test, etc. The results showed that the PA6 sample containing 9 wt% C-MCA achieves the UL-94 V-0 rating and has a LOI value of 30.7%, while the other samples with equal amounts of MCA only pass the UL-94 V-2 rating. The flame retardant mechanism was studied, and the results reveal that C-MCA with smaller size has greater contact area with PA6 which helps to catalyze the decomposition of PA6; Thus the PA6/C-MCA releases more NH 3 , CO 2 etc., and produces more droplets than others, which dilutes combustible gas and takes away heat to make the samples extinguish.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Evidence-based Complementary and Alternative Medicine
·
2015
·Vol. 2015
·期 1
·239749
·
IF 1.88
Zhiping Wang,Junbiao Wu,Qun Zhou,Yifei Wang,Tongsheng Chen
Berberine (Ber), an isoquinoline derivative alkaloid and active ingredient of Coptis, has been demonstrated to possess antidiabetic activities. However its low oral bioavailability restricts its clinical application. In this report, Ber nanosuspension (Ber-NS) composed of Ber and D- α -tocopheryl polyethylene glycol 1000 succinate (TPGS) was prepared by high pressure homogenization technique. Antidiabetic effects of Ber-NS relative to efficacy of bulk Ber were evaluated in streptozotocin (STZ) induced diabetic C57BL/6 mice. The particle size and zeta potential of Ber-NS were 73.1 ± 3.7 nm and 6.99 ± 0.17 mV, respectively. Ber-NS (50 mg/kg) treatment via oral gavage for 8 weeks resulted in a superior hypoglycemic and total cholesterol (TC) and body weight reduction effects compared to an equivalent dose of bulk Ber and metformin (Met, 300 mg/kg). These data indicate that a low dosage Ber-NS decreases blood glucose and improves lipid metabolism in type 2 diabetic C57BL/6 mice. These results suggest that the delivery of Ber as a nanosuspension is a promising approach for treating type 2 diabetes.
研究领域:
药剂学
·
药理学
·
分子药理学
·
药物递送系统
·
糖尿病研究
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药物代谢
·
纳米医学
✓ 已验证
DOI
高影响因子
AUSTRALIAN JOURNAL OF CHEMISTRY
·
2020
·Vol. 73
·期 7
·601-607
·
IF 1.073
Si-Yuan Cheng,Yun-Xia Qu,Zhu Tao,Kai-Zhi Zhou,Lian-Tong Wei,Cong Wang,Wei-Wei Zhao,Dao-Fa Jiang,Pei-Hua Ma
The interactions between cyclopentanocucurbit[6]uril (abbreviated as CyP6Q[6]) and a series of dialkyl-4,4′-bipyridinium and diaryl-4,4′-bipyridinium dicationic guest molecules, where the alkyl group is CH3(CH2)n with n = 0–6 (expressed as G1 to G7) and the aryl group is phenylene (G8) and xylene (G9), have been investigated in aqueous solution using 1H NMR spectroscopy, isothermal titration calorimetry (ITC), and electronic absorption spectroscopy. Our results show that G1 and G2 form 1 : 1 host–guest inclusion complexes with CyP6Q[6], in which the bipyridinium core is partially embedded in the cavity of CyP6Q[6]. G3–G9 form 2 : 1 dumbbell-type host–guest inclusion complexes, in which the substituents are encapsulated by CyP6Q[6]. At the same time, CyP6Q[6] was compared with several other cucurbit[n]urils (Q[n]s) and their derivatives, such as Q[6], Q[7], and TMeQ[6], which have been reported to interact with this type of guest molecule. In its binding mode, CyP6Q[6] shows many interesting and different properties, and this difference was mainly reflected with G1 and G2.
研究领域:
超分子化学
·
物理化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Xuan Huang,Xuezhong Du
The synthesis and host–guest chemistry of pillararene (PA) derivatives are a hot research topic, and the applications of PAs in relevant research fields are essential to explore. Carboxylate-substituted pillar[6]arene (CPA[6])-valved mesoporous silica nanoparticles (MSNs) functionalized with dimethylbenzimidazolium (DMBI) and bipyridinium (BP) stalks were constructed, respectively, for multiresponsive controlled release. CPA[6] encircled the DMBI or BP stalks to develop supramolecular nanovalves for encapsulation of cargo within the MSN pores. The release of cargo was triggered by acidic pH or competitive binding for the dethreading of CPA[6] and the opening of the nanovalves; moreover, coordination chemistry is the first strategy to activate CPA nanovalves by metal chelating with the carboxylate groups of CPA for cargo release. The controlled release of the CPA[6]-valved MSN delivery systems can meet diverse requirements and has promising biological applications in targeted drug therapy.
研究领域:
材料科学
·
药物化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2024
·
IF 12.7
Yanlu Sun,Xilin Pei,Zhengqi Wang,Dequn Wu,Xueli Wang,Jianyong Yu,Ruchao Yuan,Faxue Li
In the pursuit of enhancing the fire safety of polyamide 6 (PA6), the addition of flame retardants generally leads to hydrogen bond dissociation, which results in detrimental effects on the mechanical properties of PA6 composites and impedes processing and application in the textile field. In this study, a macromolecular flame retardant, PPB, designed with hydrogen bond donor-acceptor spacing aligned with PA6, was synthesized to increase the number of hydrogen bonds. The addition of 10 wt% PPB to the PA6 matrix (PA6/PPB10) endowed the composite with the limiting oxygen index (LOI) increased to 31.6 % and V-0 rating in the vertical burning (UL-94) test. PA6/PPB10 also exhibited significant enhancement in tensile strength by 12.6 % compared to pure PA6 and demonstrated a superior ultraviolet protection factor (UPF) value of 573, greatly exceeding the value of 3 for PA6. The quenching effect, diluting effect in the gas phase, and hydrogen bond interactions between PPB and PA6 backbones imparted PA6/PPB composites with satisfactory flame retardancy and mechanical properties. As a representative example, PA6/PPB10 was melt-spun into filaments with a pleasing tenacity of 3.6 cN/dtex and self-extinguishing capability within 5 s after ignition, confirming the sustained comprehensive properties after spinning and drawing into filaments.
研究领域:
材料科学
·
纺织工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2024
·
IF 5.8
Xinlv Peng,Caixia Pei,Eika W. Qian,Yuguang Du,Jian-Jun Li
6′-Sialyllactose (6′-SL), the most abundant sialylated human milk oligosaccharide, has attracted attention for its potential application in supplementary infant formulas. Herein, we report a facile strategy to construct a cascade bioreactor for the enzymatic synthesis of 6′-SL by co-immobilizing an enzymatic module consisting of CMP–sialic acid synthase and α-2,6-sialyltransferase into hierarchically porous MIL-53 (HP-MIL-53). The as-prepared HP-MIL-53 showed high enzyme immobilization capacity, reaching 226 mg g−1. Furthermore, the co-immobilized enzymes exhibited higher initial catalytic efficiency, and thermal, pH and storage stability than the free ones. Finally, the 6′-SL yield remained >80% after 13 cycles of use. We expect that HP-MIL-53 would have potential industrial applications in the enzymatic modular synthesis of 6′-SL and other glycans.
研究领域:
生物化学
·
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Yongcai Wu,Yan Chai,Liqian Yu,Wensheng Gao,Yongxiao Bai
Eco-friendly flame-retardant fabrics have recently been widely concerned and developed due to highly flammable characteristics of fabrics and environmental protection issues. Phytic acid (PA) was optimized as a common flame-retardant relying on its environmentally friendly and flame retardant characteristics. However, the strong acidity of PA always results in the loss in mechanical properties of the fabric. Herein, a synergetic strategy by compositing PA and ethanolamine (ETA) was proposed to enhance the flame resistance of the PA6 fabric. As a result, after the flame-retardant coatings prepared by the synergy of PA and ETA are impregnated on the surface of PA6 fabric, the limiting oxygen index (LOI) of PA6 fabrics increased from 21.2 % to 30.4 % with on a well mechanical strength retention rate (MSR) (more than 75 %), which is much better than the PA6 fabric treated by pure PA (LOI: 25.3 %, MSR: less than 40 %). The analysis results indicate that ETA not only reduces the damage of PA to PA6 fabrics but also plays an important role as a carbon and nitrogen source in the intumescent flame-retardant mechanism. This synergistic strategy provides a new reference for the development of environmentally friendly flame-retardant coatings.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
SYNTHESIS-STUTTGART
·
2019
·Vol. 51
·期 21
·4048-4065
·
IF 2.867
Rui-Xiang Wang,Zhuang Fang,Guanyinsheng Qiu,Wenlin Xie,Jin-Biao Liu
The copper-catalyzed synthesis of 3-vinylisocoumarin-1-imine is reported. The transformation proceeds smoothly with good yields in THF and the regioselectivity was determined by a O-nucleophilic 6-endo cyclization. Studies on the mechanism indicate that copper trifluoroacetate serves as a Lewis acid, and the use of vinyl-connected 2-alkynylbenzamide is important for this O-nucleophilic 6-endo cyclization.
研究领域:
有机化学
·
合成化学
✓ 已验证
DOI
高影响因子
PLoS One
·
2021
·Vol. 16
·期 9
·e0255504
·
IF 3.24
Jing Zhang,Zhou-Tao Pei,Ya-Ni Zhao,Meng Zhang,Li-Ling Zhang,Wen-Qiang Wang,Jing-Ya Wu,Ran Yu,Li-Wei Sun
Benzophenone (BPs) and 4-Methylbenzylidene Camphor are used as ultraviolet (UV) filters to protect the skin and hair in personal care products. The discharging of the three chemicals may endanger the receiving water ecosystem. In the present study, the mutagenicity of BP-6, BP-8, and 4-Methylbenzylidene Camphor was tested using the Salmonella typhimurium reverse mutation test (Ames test) in the system with and without rat liver microsomal preparations (S9). Four S . typhimurium strains, TA97, TA98, TA100, and TA102 were employed in the Ames tests. The mutagenicity was detected from all three chemicals. The addition of S9 increased the mutation ratios of three chemicals to four strains, except BP-6 to TA100 strain and 4-MBC to TA97 and TA98 strain. In the mixed experiment, all positive effects were detected in the absence of S9. However, the results all became negative in the presence of S9. For the mixture of BP-6 and 4-MBC, positive results were detected on four tester strains except for the TA100 strain. For the mixture of BP-6, BP-8, and 4-MBC, positive results were detected on four strains. The mixture test results showed antagonism in mutagenicity for the mixture of BP-6 and 4-MBC to TA98 and TA100 strains and the mixture of BP-6, BP-8, and 4-MBC to TA100 and TA102 strains.
研究领域:
环境科学
·
毒理学
·
生物学
✓ 已验证
DOI
高影响因子
POLYMER
·
2025
·
IF 4.5
Xuelian Liu,Qian Li,Yuying Zheng,Weijie Zheng
Antistatic nylon-6 (PA6) composites have attracted considerable attention due to their tailored properties for electronics, textiles, and automotive applications. In this paper, the antistatic PA6 composites comprising with polypropylene (PP), aminated multi-walled carbon nanotubes (MWCNTs-NH 2 ) and aminated carbon black (CB–NH 2 ) were prepared by melt blending and compression molding. In the composite system, PP was used as the co-matrix to assist the phase separation of PA6. MWCNTs-NH 2 and CB-NH 2 were introduced as conductive fillers. All composites showed good thermal stability with the T 5 % higher than 376 °C and the composites containing fillers showed higher residues after thermal degradation due to the good thermal stability of MWCNTs-NH 2 and CB-NH 2 . The DSC and XRD results indicated that the crystallization properties of the composite materials were determined by PA6 and PP rather the conductive fillers. In general, the introduction of conductive fillers decreased the mechanical properties but effectively improved the conductivity of the composites and then the antistatic properties. Besides, the antistatic analysis and mechanical test denoted that MWCNTs-NH 2 and CB-NH 2 showed synergistic effect on improving the antistatic and mechanical properties of the composites, which was more evident at high MWCNTs-NH 2 quantity. The micromorphologies obtained by SEM first confirmed the ductile fracture of these composites, and then disclosed a two-phase structure of PA6 and PP polymer matrix, where the conductive fillers were found in the PA6 phase. Considering both mechanical and antistatic properties, the composite (PCNB-3) containing both 3 phr MWCNTs-NH 2 and CB-NH 2 was proposed for the antistatic PA6 composite.
研究领域:
材料科学
·
复合材料工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2025
·
IF 3.6
Haoyang Liu,Hailiang Xing,Peilan Yu,Yanjie Wang,Jia-Lei Yan,Junyang Liu,Min Wang
A facile copper-catalyzed, base-controlled cyclization reaction has been developed for the synthesis of 9-membered cycloalkyne and 6-membered heterocycle sultams under mild conditions. This protocol utilizes a copper-catalyzed intramolecular A3 (alkyne–aldehyde–amine) coupling reaction to efficiently synthesize 9-membered cycloalkyne sultams in yields up to 90%. Alternatively, by substituting NaHCO3 with DBU, the protocol achieves selective deprotection of the N-propargyl group, thereby facilitating the formation of 6-membered heterocyclic sultams, also in high yields.
研究领域:
有机化学
·
合成化学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）