ACS Sensors
·
2023
·
IF 8.9
Yan-Xiong Wang,Shan-Fei Fu,Meng-Xin Xu,Pan Tang,Jun-Ge Liang,Yan-Feng Jiang,Tian Qiang
In this work, a new type, highly sensitive, and reusable nanoplastics (NPs) microwave detection method is proposed, which can be used to rapidly analyze NPs with different surface charges and sizes. The effective dielectric constant of NPs varies according to the different concentrations, particle sizes, and surface charges of NPs in aqueous solution. The feasibility of the microwave method for differential-charged NPs detection is verified using a complementary split ring resonator sensor manufactured on a cost-effective printed circuit board, which shows a high sensitivity only for positively charged NPs (PS-NH2) detection. To achieve microwave detection of both positively and negatively charged NPs (PS-SO3H), a microscale spiral-coupled resonator sensing chip is manufactured through integrated passive technology, which demonstrates extremely low detection limits and high sensitivity for both PS-NH2 and PS-SO3H, with different concentrations, particle sizes, and charges. In addition, for NPs solution doped with methyl orange, the device can still perform stable measurements, overcoming the inability of traditional NPs molecular element determination and optical detection methods to detect NPs aqueous solution with organic matter doping and color presence. The proposed microwave detection method could also be extended to sensing detection for detecting other hazardous environmental substances.
研究领域:
环境科学
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材料科学
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电气工程
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分析化学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Chemistry
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2019
·
IF 1.727
Hao Zhou,Yilin Song,Zheng Yang
A coupled chip aiming at economical and highly selective ammonium detection was fabricated. It consisted of a reaction chip, a gas-diffusion chip, and a detection chip. Zinc tetraphenylporphyrin dyed on the cation-exchange resin microbeads was used as the indicating material to avoid excess consumption for its reversibility. PDMS was selected as the material of the gas-diffusion membrane. A portable spectrometer was applied for spectrum analysis. By analysis of spectrum change, the high selectivity was confirmed because no component had interference on detection effect. Good performance was shown for all the tested concentrations (0.2–50 mg·L−1). The stability and reversibility were also judged by the spectrum data obtained from the indicating process and the recovering process. Finally, real samples containing ammonium were tested and the results were compared to those came from a standard method to confirm the accuracy of our method.
研究领域:
分析化学
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环境科学
✓ 已验证
DOI
高影响因子
Materials Chemistry Frontiers
·
2016
·Vol. 1
·期 5
·859-866
·
IF 0
Guangdi Nie,Xiaofeng Lu,Wei Wang,Maoqiang Chi,Yanzhou Jiang,Ce Wang
A simple and green strategy was proposed for the first time to fabricate uniform polyaniline (PANi) thorn/BiOCl chip (BPB) heterostructures at a low temperature without the assistance of any surfactant. During the synthetic process, Bi2S3 nanowires acted as both the sacrificial template and the Bi source for BiOCl, affording the synchronous formation of HCl-doped PANi conductive arrays and BiOCl chips supported on residual Bi2S3 nanowires. As expected, when utilized as electrode materials for supercapacitors, the obtained BPB nanocomposite exhibited a better electrochemical performance in neutral media with enhanced specific capacitance, a more acceptable rate capability and a smaller charge-transfer resistance in comparison with the individual PANi nanofibers due to the unique hierarchical nanostructure of BPB and the synergistic effect between the ionizable BiOCl and the PANi chain.
研究领域:
材料科学
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电化学
✓ 已验证
DOI
ANALYST
·
2022
·Vol. 147
·期 16
·3723-3731
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IF 5.227
Jianhua Liu,Hui Chang,Xiangyu Zhang,Shimeng Chen,Yongxin Song,Dongqing Li
Building an optical filtration function into a microfluidic chip is a promising way of simplifying the optical detection system of a microfluidic device. In this paper, a PDMS microfluidic chip filter that is capable of transmitting chlorophyll fluorescence and blocking interfering light in the visible wavelength range was developed for living algae detection with a smartphone. The chip was fabricated by sealing a layer of crystal violet solution in a PDMS layer on the top of the Sudan II-doped PDMS slab, which has a straight microchannel. Optimum dye concentrations and thicknesses for the crystal violet solution layer and Sudan II-doped PDMS slab were investigated and determined by spectrum measurements. It was found that the cut-on range of this integrated microfluidic chip is extended to about 625 nm and the transmittance in the chlorophyll fluorescence range (650 nm to 710 nm) is as high as 95%, when 25 mg L−1 Sudan II-doped PDMS slab (with a 3 mm thickness) and 2 mg L−1 crystal violet solution (with a 0.3 mm thickness) were used. Living algae detection using this chlorophyll-fluorescence-filtering PDMS microfluidic chip and a smartphone-based imaging platform was achieved, and the results compared favorably with those using a commercial filter.
研究领域:
生物技术
·
光学检测
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Hui Jiang,Donglei Jiang,Xinmei Liu,Jun Yang
A portable imprinted electrochemical sensor with a self-driven polyethylene terephthalate (PET) chip was developed for the fast detection of Salmonella. A chip with a siphon inlet connecting the reaction chamber and a capillary connecting the reaction chamber to the press chamber was innovatively designed to achieve self-drive. Based on siphonage and hydrophilicity , the liquid entered the reaction chamber automatically, and quantitative sampling was completed when the liquid reached the capillary. Waste liquid was discharged from the reaction chamber by pressing the press chamber. The self-driven PET electrode chip was prepared by screen-printing and laser-cutting, and Salmonella -imprinted film was then prepared on the chip working electrode via electropolymerization . Characterization studies of the modification of the working electrode were then carried out via SEM, AFM , water contact angle and electrochemistry . The detection of Salmonella was performed by differential pulse voltammetry within the range of 3.0 × 10 2 to 3.0 × 10 7 CFU mL −1 , and the limit of detection was 100 CFU mL −1 (S/N = 3). The selectivity of the proposed sensor was then examined via the use of interfering bacteria, including E. coli , L. monocytogenes, and P. aeruginosa . The practical application value of the sensor was demonstrated by a recovery rate of 92–109% and a relative standard deviation of less than 2.96% in the detection of Salmonella in milk and orange juice samples. In summary, a self-driven PET chip-based imprinted electrochemical sensor for the detection of Salmonella within 20 min was developed, and has the potential to monitor and quickly control Salmonella contamination in food processing and food circulation.
研究领域:
食品科学
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生物传感技术
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微生物学
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DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2021
·
IF 6.986
Jingjing Xue,Qiang Zhang,Jun Cao,Youli Tian,Genhan Zha,Xiaoping Liu,Weiwen Liu,Yuxing Wang,Dingkun Gui,Chengxi Cao
Gel electrophoresis (GE) is one of the most general tools in biomedicine. However, it suffers from low resolution, and its mechanism has not been fully revealed yet. Herein, we presented the dispersion model of w2 (t) ∝ Tt, showing the band dispersion (w) via temperature (T) and running time (t) control. Second, we designed an efficient GE chip via the time control and rapid Joule heat self-dissipation by thermal conductive plastic (TCP) and electrode buffer. Third, we conducted the simulations on TCP and polymethylmethacrylate (PMMA) chips, unveiling that (i) the temperature of TCP was lower than the PMMA one, (ii) the temperature uniformity of TCP was better than the PMMA one, and (iii) the resolution of TCP was superior to the PMMA one. Fourth, we designed both TCP and PMMA chips for experimentally validating the dispersion model, TCP chip, and simulations. Finally, we applied the TCP chip to thalassemia and model urine protein assays. The TCP chip has merits of high resolution, rapid run of 6–10 min, and low cost. This work paves the way for greatly improving electrophoretic techniques in gel, chip, and capillary via temperature and time control for biologic study, biopharma quality control, clinical diagnosis, and so on.
研究领域:
生物医学工程
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分析化学
·
生物技术
✓ 已验证
DOI
PubMed
高影响因子
LAB ON A CHIP
·
2024
·
IF 6.1
Yushen Wang,Junlei Han,Wenteng Tang,Xiaolong Zhang,Jiemeng Ding,Zhipeng Xu,Wei Song,Xinyu Li,Li Wang
Microplastics (MPs) are pervasive pollutants present in various environments. They have the capability to infiltrate the human gastrointestinal tract through avenues like water and food, and ultimately accumulating within the liver. However, due to the absence of reliable platforms, the transportation, uptake, and damage of microplastics in the gut-liver axis remain unclear. Here, we present the development of a gut-liver-on-a-chip (GLOC) featuring biomimetic intestinal peristalsis and a dynamic hepatic flow environment, exploring the translocation in the intestines and accumulation in the liver of MPs following oral ingestion. In comparison to conventional co-culture platforms, this chip has the capability to mimic essential physical microenvironments found within the intestines and liver (e.g., intestinal peristalsis and liver blood flow). It effectively reproduces the physiological characteristics of the intestine and liver (e.g., intestinal barrier and liver metabolism). Moreover, we infused polyethylene MPs with a diameter of 100 nm into the intestinal and hepatic chambers (concentrations ranging from 0 to 1 mg mL−1). We observed that as intestinal peristalsis increased (0%, 1%, 3%, 5%), the transport rate of MPs decreased, while the levels of oxidative stress and damage in hepatic cells decreased correspondingly. Our GLOC elucidates the process of MP transport in the intestine and uptake in the liver following oral ingestion. It underscores the critical role of intestinal peristalsis in protecting the liver from damage, and provides a novel research platform for assessing the organ-specific effects of MPs.
CAS / MDL:
研究领域:
环境科学
·
生物医学工程
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2024
·
IF 3.7
Lanfeng Guo,Renlong Liu,Zhaobo He,Shaoping Li,Tong Tan,Changyuan Tao
The copper connectivity technique is essential for achieving electrical interconnection in wafer level packaging (WLP), system in packaging (SiP), and 3D packaging. The essential processing material for copper connectivity is a copper sulfate electroplating solution in which organic additives play a crucial role in the regularity of copper electrodeposition. In this study, electrochemical tests, X-ray diffraction, 3D profiling, and scanning electron microscopy were used to investigate the leveling effect and mechanism of polyquaternary ammonium urea-containing polymer (PUB2) in the process of copper electrodeposition on-chip copper connections. PUB2 has excellent polarization ability on the target surface, remains unaffected by the sulfur additive SPS and poly(ethylene glycol), and displays a strong ability to regulate the copper deposition rate of through-holes and surface wiring. The waviness of the wafer surface wiring was reduced from 130 to approximately 70 nm after optimizing the PUB2 concentration, and the surface roughness was reduced from 10 to approximately 7 nm. The coating was dispersed evenly, and the rate of through-hole filling was improved by 57%. This study not only examined PUB2 leveling performance and mechanisms but also devised a research method and system for electroplating additives to facilitate the development and application of new electroplating additives.
研究领域:
材料科学
·
电子工程
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2024
·Vol. 16
·期 39
·6736-6745
·
IF 2.7
Shuai Yuan
Water environments contaminated by heavy metal ions present significant challenges because these pollutants do not degrade naturally, leading to their gradual bioaccumulation in animals and plants, which ultimately poses an insurmountable threat to human health. Therefore, rapid and accurate detection of heavy metal ions in water is of great significance for environmental protection and disease prevention. In this work, we developed a novel method based on microfluidic electrophoresis coupled with indirect chemiluminescence for the immediate detection of Cd(II), Pb(II) and Hg(II) heavy metal ions. The displacement of the Co(II) ions within the chemiluminescence mixture by the above migrating sample cations caused a measurable reduction in the background signal. The results showed that the detection limits of Cd(II), Pb(II) and Hg(II) ions under the best detection conditions were 5.83 × 10−8 M, 5.38 × 10−8 M and 2.09 × 10−8 M, respectively, which were 1–2 orders of magnitude lower than those of the indirect UV method and 1 order of magnitude lower than that of the indirect laser induced detection method. This method can provide a possibility for the rapid detection of multiple heavy metal ions in actual water environments.
研究领域:
环境科学
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yang Yuan,Hui Jia,Jibao Liu,Fei Gao,Xu Zhu,Zihan An,Jie Wang
The development of new low-cost, highly selective and efficient methods for the separation and detection of heavy metal ions in aqueous environments is of great importance for water safety and biological health. In this study, a novel ion separation membrane was prepared for the separation of copper ions in cadmium ion detection solution. Compared with the commercial membrane, the ion mobility was increased by 64.02 %, and further separated by selective complexation of thiacalix[4]arene-p-tetrasulfonate (TCAS), and the separation factor for Cu/Cd reached 34.66. This allowed Cd to be detected preferentially, and reduced the interference of other ions in the detection. The joint electric field environment was regulated to separate the organics and reduce the interference to the detection. The sensing performance was enhanced by modifying the screen-printed electrodes. The proposed sensing platform allows for simultaneous pre-processing and detection and has a detection limit of 0.19 μg-L −1 (S/N = 3) for Cd 2+ .
研究领域:
环境科学
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2026
·
IF 11.8
Wenhong Zhang,Yushen Wang,Jinlin Yu,Ke Wang,Ligang Xing,Chonghai Xu,Li Wang,Jing Wang
Mechanical stimulation can remodel the physiological mechanical microenvironment of cardiomyocytes and influence their maturation and injury progression. However, the dynamic process by which cardiomyocytes transition from adaptive maturation to injury remains unclear, because conventional endpoint assays cannot continuously track cellular states. Here, we developed a heart-on-a-chip platform that reconstructs physiological strain and fluidic microenvironments. The chip integrates traction force microscopy (TFM) and a cardiac troponin I (cTnI) biosensor, enabling synchronous monitoring of cardiomyocyte contractility and injury-associated phenotypes. Under physiological cyclic stretch (20% strain), the platform induced a mature cardiomyocyte phenotype, with the gap junction protein CX43 and cytoskeletal protein F-actin increasing by 1.22- and 2.03-fold, respectively. Through 14 days of dynamic mechano-chemical monitoring, we identified 25% strain as a critical turning point in cardiomyocyte mechanical responses. Below this threshold (5%-20%), mechanical stimulation promoted cellular maturation and enhanced contractile stress, whereas above this threshold (30%), it induced an injury-associated phenotype. This heart-on-a-chip provides a controllable and quantitative in vitro platform for optimizing mechanical stimulation windows, evaluating cardiomyocyte injury, and screening cardioprotective therapeutics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Donghui Wang,Yuanyuan Liu,Ningning Li,Wei Liu,Yang Li,Yiming Zhang
Molecularly imprinted polymers (MIPs) have gained significant traction in food contaminant analysis owing to their tailorable binding sites and functionalities. Nevertheless, the analysis performance of MIPs fabricated via conventional imprinting methods has been hindered by heterogeneous binding cavities. Herein, we first present a template-derivatization-based oriented surface imprinting strategy to construct paper-based metal organic framework (MOF)-imprinted chips with highly ordered MIPs (FP@B-MOF@MIP) for enhanced sulfadiazine (SDZ) analysis. Cis-dihydroxy-derived SDZ (SDZ-CD) as the dummy template endowed imprinting cavities with high orientation via boronate-affinity oriented recognition. FP@B-MOF@MIP achieved good absorption capacity (76.30 mg g −1 ) and selectivity with the imprinting factor of 5.6 for SDZ. A colorimetric sensor based on FP@B-MOF@MIP was further successfully constructed for the visual determination of trace SDZ in food samples with a low detection limit of 0.0048 mg L −1 . This work provides a flexible strategy to improve the performance of MIPs for monitoring trace contaminants in foodstuffs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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