SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
·
IF 4.6
Xiang-Cheng Lin,Jian Liu,Miaomiao Hu,Lingjun Song,Minzhe Li,Qinjie Kou,Rong Huang,Lixian Sun,Changchun Wen
The abnormal fluctuations of glutathione (GSH) in vivo often reflect disease progression and are closely linked to human metabolism and physiological functions. Highly sensitive and selective detection of GSH is crucial for guiding early diagnosis and treatment; however, achieving this remains a significant challenge. In this study, we developed an enzyme activity sensor platform for the efficient detection of GSH. This platform utilizes Au@CuS core–shell materials loaded with CuO 2 nanoparticles to create a composite nanosensor system. Under slightly acidic conditions, CuO 2 on the nanomaterial’s surface decomposes into H 2 O 2 and Cu 2+ ions. The generated H 2 O 2 then reacts with tetramethylbenzidine (TMB) in the presence of peroxidase-like CuS to yield oxidized tetramethylbiphenyl ( OX TMB), which generates a distinctive Raman signal. Upon addition of GSH to the system, the unique OX TMB signal diminishes due to GSH’s strong antioxidant capacity and the consequent consumption of OX TMB. This sensing method enables sensitive detection of GSH, with a detection limit as low as 1.2 × 10 -13 mol∙L -1 . This approach holds promise for providing researchers with rapid and precise in vitro analysis of GSH, serving as an indicator for early disease diagnosis and real-time evaluation of treatment efficacy.
研究领域:
生物化学
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纳米医学
·
诊断学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Chao Lei,Mingli Ye,Jun Tang,Cun Yu,Sha Yu
In this study, the performance of an efficient magnetic core-shell heterostructure, CuFe 2 O 4 /CuS (referred to as CFOCS), was assessed for the disintegration of amoxicillin (AMOX) under simulated sunlight irradiation in the presence of peroxymonosulfate (PMS). The Characterization analyses demonstrated the successful construction of the CFOCS magnetic core-shell. Comparative studies demonstrated the superior performance of the CFOCS/PMS/xenon ternary system compared to binary and individual processes, with a synergy index (SI) of 1.21. The purification experiments illustrated that complete removal of the AMOX antibiotic was achieved under optimized conditions, including a pH of 7.0, PMS dosage of 2 mM, CFOCS quantity of 0.5 g L −1 , and AMOX concentrations of 10 and 20 mg L −1 . To elucidate the charge carrier migration pathway, a type II heterojunction model was proposed, supported by radical scavenging experiments, UV–Vis DRS, electrochemical impedance spectroscopy (EIS), and Mott-Schottky (M-S) analyses. The mechanistic investigation revealed the dual activity of PMS, which can be activated both in the aqueous solution under xenon light and on the catalyst surface through Cu (I) and Cu (II) centers. A key aspect of this study was a comprehensive aquatic hazard assessment of amoxicillin (AMX) in both treated and untreated aqueous solutions, utilizing the hazard quotient (HQ) method. Eventually, the investigated ternary system demonstrated remarkable efficiency in AMX degradation across various water systems, including lake water, tap water, and deionized water (DIW). Notably, the system maintained exceptional stability in all tested water bodies, underscoring the practical applicability of CFOCS catalyst in real-world scenarios.
研究领域:
环境科学
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化学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Xiao-Fei Liu,Jun Zhang,Jiang-Jun Liu,Qi-Hui Zhou,Zhongqiang Liu,Peng-Yue Hu,Zhe Yuan,Seeram Ramakrishna,Da-Peng Yang,Yun-Ze Long
Outdoor sports or combat missions, such as jungle adventures or counter-piracy operations, often involve bleeding and infected wounds. Due to the poor and limited medical conditions in these outdoor situations, patients prefer an easy way to simultaneously treat blood loss and wound infection by using the same outdoor device and the same material. In this study, a portable electrospinning device (150 g in weight) for outdoor use was developed, and CuS composite nanofibers could be green-synthesized by this portable electrospinning device. These CuS composite nanofibers can be deposited in situ onto the wound to simultaneously achieve rapid hemostasis outdoors and ablate superbacteria without requiring the use of other materials or devices. These in situ electrospun nanofibers possess better compactness on the rough wound surface than conventional nanofiber mats pressed onto the wound site. Thus, the nanofiber not only accelerates the hemostasis (<6 s) but also shortens the healing time of the wound with superbacterial infection (18 days). These bifunctional nanofibers combined with a portable electrospinning device for outdoor rapid hemostasis and simultaneous superbug ablation could notably benefit the outdoor first aid.
研究领域:
材料科学
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生物医学工程
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纳米技术
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伤口护理
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2025
·
IF 4.8
Sun Yanyan,Natsuki Jun,Zhou Wanyu,Zou Lihua,Wang Zhen,Li Bingbing,Gao Yamin,Chu Changliu,Natsuki Toshiaki
Wearable electronics have gained considerable attention in recent years owing to their softness, flexibility, and compatibility with the human body. However, most conventional multifunctional smart textiles are developed by integrating various fibers or fabrics with single functionalities, facing challenges such as high integration complexity and poor stability, and struggling to meet the demands of wearable electronics. In this study, we present a simple and scalable method involving dip-coating and spray-coating to produce multifunctional, wearable, high-performance MXene/CuS/cotton fabrics. Leveraging the conductive networks formed by synergistic MXene/CuS and the porous structure of the fabrics, these MXene/CuS/cotton fabrics demonstrate impressive electromagnetic interference (EMI) shielding effectiveness (51.1 dB at a thickness of 335 μm) and notable Joule heating performance (approximately 60 °C at a voltage of 6 V). Moreover, when pressure is applied, MXene/CuS/cotton fabrics exhibit negative piezoresistivity, high sensitivity (− 18.2 kPa −1 for 1–4 kPa pressures), rapid response and recovery times (0.4 s), along with exceptional long-term durability and stability (over 2000 cycles). These remarkable properties suggest that MXene/CuS/cotton fabrics are highly promising for future applications in human motion detection, EMI shielding, thermal management, and other applications.
研究领域:
材料科学
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纳米技术
·
柔性电子学
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纺织工程
·
电磁兼容性
✓ 已验证
产品关联
DOI
高影响因子
Biosurface and Biotribology
·
2025
·Vol. 11
·期 1
·e12090
·
IF 1.8
Yi Duan,Qi Wu,Jiangtao Lin,Yourong Duan,Qi Wang,Yuanyuan Li
In this study, the authors designed a paper-based electrochemical immunodevice modified with copper embedded in copper sulphide hollow nanocages wrapped with Au nanoparticles (Cu@CuS@Au NPs) for the specific detection of prostate-specific antigen (PSA), aiming to advance point-of-care testing. The large specific surface area of Cu@CuS nanocages enables efficient capture of biotin antibodies, leading to the direct amplification of the signal through the inhibition of electron transport in the redox process of Cu, eliminating the need for universal redox electron mediators. Additionally, Au NPs on the surface of Cu@CuS can accelerate charge transfer and conjugate with anti-PSA. The hierarchical morphology and structure of Cu@CuS nanocages were characterised using scanning electron microscopy and transmission electron microscopy. The fabrication process of the immunodevice was monitored using cyclic voltammetry and electrochemical impedance spectroscopy analyses. PSA was sensitively detected using differential pulse voltammetry on this proposed immunodevice within a linear range from 0 to 100 ng/ml ( R 2 = 0.996), achieving a low detection limit of 0.077 ng/ml. In addition, the practicality of the developed immunosensor has been proven by successfully detecting PSA in human serum samples obtained from clinical settings. The integration of electrochemical sensors and microfluidic devices holds promise for developing cost-effective approaches in clinical immunoassays.
研究领域:
医学诊断
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生物传感器
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Pengyu Gao,Guotai Li,Zhiguo Wang,Hui Zhang,Yansheng Shan,Xin Yuan,Qiang Shi,Xue Dou,Qihui Zhou,Quanchen Xu
Periodontitis is a chronic inflammatory disease induced by a plaque biofilm, which can lead to the destruction of the periodontal support tissue and even teeth loss. The common strategies of periodontitis treatment are to eliminate bacterial/biofilm-related inflammation and subsequently inhibit alveolar bone resorption, for which antibiotic therapy is the most traditional one. However, impenetrable polymeric substances on bacterial biofilms make it difficult for traditional antimicrobial agents to take effect. In this study, a novel nanoparticle protease-loaded CuS NPs was developed, combining the advances of photodynamic and photothermal therapy from CuS and enzymatic degradation of the biofilm by a protease. The photothermal activity and the reactive oxygen generation capacity of the designed nanoparticles were verified by the experimental results, constituting the basis of antibacterial function. Next, the high antimicrobial activity of CuS@A NPs onFusobacterium nucleatumand its biofilm was demonstrated. The proper hemo/cytocompatibility of CuS-based NPs was demonstrated by in vitro assays. Last, effective treatment against periodontitis was achieved in a rat periodontitis model through the significant efficacy of inhibiting bone resorption and alleviating inflammation. Thus, the developed CuS@A NPs prove a promising material for the management of periodontitis.
研究领域:
纳米技术
·
牙科
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2018
·
IF 5.08
Meng Li,Ying Wang,Huiming Lin,Fengyu Qu
Here, hollow CuS nanocubes about 250–300 nm in size were synthesized based on the Kirkendall effect by using CuO nanocubeas precursor and template. The reactant concentration and reaction time could be adopted to adjust the final composition and hollow structure. The as-synthetic CuS nanocube was assembled by a great deal of nanoparticles (15–20 nm), making abundant porous structure in the shell layer. The localized surface plasmon resonance and the novel porous hollow structure (improve light reflex) further make sure the enhanced Near-infrared (NIR) light absorption as well as photothermal conversion efficiency (30.3%). Moreover, the mechanism of reactive oxygen species (ROS) generation was investigated in detail, revealing that the released Cu + ion and the oxygen are the determined factors. To further improve the monodispersity and biocompatibility, PEG-NH 2 modified nanostructure (CuS@PEG) was prepared and it possessed high loading efficiency to doxorubicin hydrochloride (DOX). Moreover, DOX-CuS@PEG reveals the acid and NIR sensitive-release performance. The synergistic effect of chemotherapy associated with photothermal therapy (PTT) and photodynamic therapy (PDT) display the enhanced specific cytotoxicity to cancer cells.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2016
·
IF 5.267
Xi Chen,Li Li,Wenzhi Zhang,Yixuan Li,Qiang Song,Li Dong
The photocatalyst CuS/CdIn2S4/ZnIn2S4 with attractive visible light absorption was prepared by a microwave-assisted one-step method and then characterized by XRD, XPS, UV–vis/DRS, N2 adsorption–desorption, SEM, TEM, and HRTEM tests. The results show that there are two kinds of crystal structures, hexagonal and cubic phase, in the product. Moreover, the composite has an absorption edge as high as 670 nm with a high visible light response. In addition, the composite possesses an excellent surface area of 239.3 m2/g, displays a favorable globular flower-like surface morphology, and consists mostly of three disparate shapes of crystals in the microstructure. Compared to heterogeneous ZnIn2S4 and P25, as-prepared composite demonstrates the greatest photocatalytic activity under simulated sunlight and visible light by methyl orange degradation. Together with Pt loading as a cocatalyst, hydrogen was achieved over CuS/CdIn2S4/ZnIn2S4 in Na2S–Na2SO3 aqueous solution, leading to a hydrogen production rate of 358.4 μmol·h–1·g–1 under simulated sunlight and a high hydrogen production rate of 233.9 μmol·h–1·g–1 under visible light (λ > 420 nm). Additionally, the related formulas were utilized to calculate the semiconductor energy band configuration and speculate on the possible photoreaction mechanism of CuS/CdIn2S4/ZnIn2S4. Finally, the effect of multipathway photoinduced charge migration during photocatalysis process was explained.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 17
·1-12
·
IF 2.8
Liu Yang,Yang Jingdong,Wen Jiaxin,Ye Junliu,Liu Huan,Lu Liwei
Recently, rechargeable magnesium-ion batteries (MIBs) and rechargeable magnesium/lithium hybrid-ion batteries (MLHBs) have gained recognition as promising energy storage devices. However, the conventional CuS cathodes exhibit sluggish kinetics and poor cycle stability, thereby impeding the advancement and application of CuS. In this work, we have developed an economical and simple in-situ approach for synthesizing CuS@Cu foam (CSC) and evaluated its potential as a cathode material for both MIBs and MLHIBs. In both MIBs and MLHIBs, the CSC cathode demonstrates competitive performance. In MIBs, at a current density of 100 mA g −1 , the initial discharge specific capacity of the CSC is 150.94 mAh g −1 , which is higher than that of commercial CuS (3.99 mAh g −1 ). In MLHIBs, the CSC exhibits a discharge specific capacity of 502.95 mAh g −1 after 70 cycles at a current density of 100 mA g −1 , which significantly surpasses the discharge specific capacity of commercial CuS (229.52 mAh g −1 ). This performance improvement is attributed to the presence of Li + ions, which expedite the reaction kinetics, obviate the need for an activation process, and effectively facilitate the conversion reaction. In conclusion, by in-situ synthesis of CSC, the active material CuS firmly adheres to the Cu foam current collector. This approach is not only economical and simple but also significantly enhances the reactivity of the electrode material, thereby improving the electrochemical performance. This work provides valuable insights for the design, synthesis, and performance optimization of cathode materials of magnesium metal-based batteries.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Yanci Zhang,Yujin Fan,Jiyuan Zhang,Yanxi Hu,Lili Duan,Zhanhui Wang,Yihong Wang,Jiansheng Cui,Liang Tian
The imbalanced expression of microRNA is related to many diseases and tumors, which can be used as a noninvasive biomarker to assist in the diagnosis, prognosis, and monitoring of cancer. A target conversion strategy-based electrochemical biosensor was developed by DNAzyme-cleavage dual cyclic signal amplification and the strand displacement reaction (SDR) to produce high electrochemical signals for microRNA-155 (miRNA-155) analysis. Thereinto, VSe2/multi-walled carbon nanotubes (MWCNTs) with high conductivity were applied as the electrode surface material to provide more active sites and accelerate electron transportation. Then, the excellent immobilization efficiency and large specific surface area of the ZnO@CuS nanoprobes were applied as a recognition molecule carrier. Furthermore, hexaammineruthenium(III) chloride (RuHex), with superior electrochemical redox activity, acted as the electroactive indicator by intercalating into double-helix DNA through electrostatic interaction, which produced high current responses in the presence of the target. Therefore, this miRNA-155 biosensing platform exhibited a relatively low limit of detection of 0.11 fM, ranging from 0.5 fM to 5 nM, and demonstrated excellent repeatability and stability. Hence, this platform appeared to possess favorable human serum detection capacity and be suitable for early cancer diagnostics.
研究领域:
生物医学工程
·
分子诊断学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Xiaohu Zhou,Tiantian Chen,Tengda Ma,Lizhao Yan,Haojie Wei,Shuang Liu,Zhiyin Dai,Zhizhong Xie,Jun Deng,Shengxiang Tao,Lihong Fan,Yingying Chu
Bacterial infection is a critical factor in wound healing. Due to the abuse of antibiotics, some pathogenic bacteria have developed resistance. Thus, there is an urgent need to develop a non-antibiotic-dependent multifunctional wound dressing for the treatment of bacteria-infected wounds. In this work, a multifunctional AOCuT hydrogel embedded with CuS@TA-Fe nanoparticles (NPs) through Schiff base reaction between gelatin quaternary ammonium salt – gallic acid (O-Gel-Ga) and sodium dialdehyde alginate (ADA) along with electrostatic interactions with CuS@TA-Fe NPs is prepared. These composite hydrogels possess favorable injectability, rapid shape adaptation, electrical conductivity, photothermal antimicrobial activity, and biocompatibility. Additionally, the doped NPs not only impart fast self-healing properties and excellent adhesion performance to the hydrogels, but also provide excellent peroxide-like properties, enabling them to scavenge free radicals and exhibit anti-inflammatory and antioxidant capabilities via photothermal (PTT) and photodynamic (PDT) effects. In an S. aureus infected wound model, the composite hydrogel effectively reduces the expression level of wound inflammatory factors and accelerates collagen deposition, epithelial tissue, and vascular regeneration, thereby promoting wound healing. This safe and synergistic therapeutic system holds great promise for clinical applications in the treatment of infectious wounds.
研究领域:
生物医学工程
·
材料科学
·
伤口护理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF INORGANIC BIOCHEMISTRY
·
2020
·
IF 3.212
Chunling Zhu,Xiuhui Yin,Xiaowen Li,Yuexue Wang
In order to effectively avoid the side effects induced by multiple components and tedious synthesis process, a simple therapy system based on one material to simultaneously realize both photothermal therapy (PTT) and photodynamic therapy (PDT) under single laser irradiation will promote the overall phototherapeutic efficiency and make the PTT/PDT system easier to operate. Here, by using transferrin (Tf) as protein template, ultrasmall [email protected] nanodots ( [email protected] NDs) were successfully synthesized through a facile one-pot protein-based biomineralization method. The obtained [email protected] NDs exhibited not only excellent photothermal conversion ability (34.4%) but also high photoactivated formation of reactive oxygen species (ROS) upon 980 nm near-infrared (NIR) irradiation. By loading the drug doxorubicin (DOX) to [email protected] NDs, a synergistic therapy system with multiple therapeutic effects combined PTT, PDT, chemotherapy (CT) and tumor targeting properties could be perfectly implemented together by [email protected] NDs without any complicated post-modification process. Results from the in vitro cell experiments confirmed that these [email protected] NDs could produce excellent effect on cancer cells with 88.5% cell inhibition rate. In comparison with the complicated systems based on “multiple-components-in-one” strategy, this therapy system based on one single material but possess multifunctional purpose is easy to operate and more suitable for clinical applications.
研究领域:
纳米技术
·
生物医学工程
·
癌症治疗
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）