Materials Today Communications
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2022
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IF 3.662
Yuanyang Zhang,Xiaoping Liang,Tao Jiang,Zishang Chen,Xiujie Ji
Waste water with boron is a widespread environmental problem. This work presents a kind of novel organic-inorganic composite boron adsorbent of NGN, N-methyl- D -glucamine (NMDG) @γ-glycidoxypropyl-trimethoxysilane (GPTMS) on the nonwoven basalt fibers (NBF), which is environmentally friendly, water resistance, non-toxicity and low cost. The effect of various parameters on the adsorption performance of NGN, such as pH value, boron concentration, contact time and different ion concentrations, was investigated. The optimum adsorption capacity of 1.64 mmol/g occurred in the vicinity of pH 9.0, and NGN possessed the fast adsorption equilibrium of boron within 40 min. In the presence of competing ions, Na + and Li + had little effect on the adsorption of boron, while Mg 2+ promoted the adsorption of boron. The features of NGN adsorption process were assessed by Langmuir and Freundlich adsorption isotherms . The experimental data of NGN boron adsorbent was well described by using the pseudo-second-order kinetic model. In addition, after eight times adsorption-desorption cycles, NGN still featured excellent regeneration performance. All the experimental results illustrate that NGN could be efficiently utilized for separating and recycling boron from aqueous solutions.
研究领域:
环境科学
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材料科学
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化学工程
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水处理
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CHINESE JOURNAL OF CHEMISTRY
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2013
·Vol. 31
·期 8
·1095-1101
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IF 0.917
Hongyan Bai,Qian Sun,Haiyu Tian,Junhong Qian,Lingyi Zhang,Weibing Zhang
A single boronic acid-based fluorescent probe (compound CSP) for saccharides was designed and synthesized. The probe, with an α , β -unsaturated ketone conjugated into the coumarin fluorophore, was synthesized by 4 steps from the commercial material 4-diethylamino salicylaldehyde. The electron push-pull effect is enhanced with the N , N -diethyl amino as the electron donor and the carbonyl as the electron acceptor. Both the absorption (463 nm) and emission (616 nm) maxima of CSP are in the visible wavelength region with a Stokes shift of about 150 nm, which ensures CSP a potential probe for biological application. Under near physiological conditions, significant fluorescence enhancement of CSP was observed upon the addition of some saccharides, namely, D -sorbitol, D -fructose, D -glucose, D -mannose and D -galactose. The probe showed relatively high sensitivity towards D -fructose and D -sorbitol, and their detection limits were 0.05 mmol/L and 0.1 mmol/L, respectively.
研究领域:
分析化学
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生物化学
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Zhihui Liu,Jian Liang,Yan Qiao,Zongxi Zhang,Yu Liu,Yingxiong Wang
Porous organic cages (POCs) are discrete, three-dimensional molecular species constructed from organic building blocks via covalent bonds. In this work, we found that RCC3, a tetrahedral [4 + 6] porous organic cage possessing 6 vicinal diamine pairs, can selectively separate d -glucose and d -fructose. RCC3 exhibited high binding capacity for d -glucose (0.4 mg/mg of RCC3). This binding process can be reversibly controlled. After a capture-dissociation cycle, the recovery yields of d -glucose and RCC3 were 75% and 83%, respectively. In addition, three binding/dissociation experiments on the binary system of d -glucose and RCC3 demonstrated its reusability. The binding mechanism of RCC3 to d -glucose was investigated via nuclear magnetic resonance spectroscopy (NMR), matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), and control experiments with various POCs and monosaccharides, revealing the aminal formation between diamines on RCC3 and the carbonyl group of d -glucose. This work demonstrated a novel strategy for the molecular recognition and isolation of d -glucose utilizing porous organic cages.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
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IF 4.1
Li Xiang,Ling Ling,Chi Chaoxian,Ding Chuan-Fan
The development of a rapid analytical method for distinguishing chiral sulfur-containing compounds is essential due to the significant differences in biological activity exhibited by different enantiomers. This work presents a straightforward and rapid method for the chiral discrimination of D/L-homocysteine (D/L-Hcy), D/L-homocystine (D/L-Hcy 2 ), and S-allyl-D/L-cysteine (D/L-SAC) using cyclodextrin (CD) and metal adducts in conjunction with ion mobility-mass spectrometry (IM-MS). Through the formation of ternary complexes, separation was achieved with IM peak resolutions of 1.41 for [α-CD+D/L-Hcy+Co−H] + , 1.24 for [α-CD+D/L-Hcy 2 +Ca−H] + , and 1.65 for [β-CD+D/L-SAC+Fe−H] + . Theoretical calculations were performed to identify the optimal conformations of these ternary complexes. Conformational analysis elucidated distinct structural differences at the molecular level, providing insight into the chiral separation mechanism. Owing to its superior resolving power, this method enables the direct quantification of D/L enantiomers in mixtures. It was successfully applied to the determination of D/L-SAC in garlic samples, obviating the need for laborious sample pretreatment or derivatization steps. Overall, this work establishes a robust analytical platform for the chiral analysis of sulfur-containing amino acids and their derivatives. Graphical abstract
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xiaofei Zhou,Guijuan Wei,Chang Liu,Qian Zhao,Hui Gao,Wenbo Wang,Xixia Zhao,Xin Zhao,Honglei Chen
The production of hydrogen through seawater electrolysis has recently garnered increasing concern. However, hydrogen evolution reaction (HER) by alkaline seawater electrocatalysis is severely impeded by the slow H 2 O adsorption and H* binding kinetics at industrial current densities . Herein, a face-centered cubic/hexagonal close packed (fcc/hcp) NiRu alloy heterojunction was fabricated on Ni foam (N doped NiRu-inf/NF) by a low-temperature nitrogen plasma activation. Simultaneously, nitrogen atoms are introduced into the alloy to facilitate d-p hybridization. When N doped NiRu-inf/NF is integrated into a dual-electrode cell for urea-assisted seawater electrolysis, it achieves 100 mA cm −2 with an ultra-low voltage of 1.36 V and excellent stability. Density functional theory (DFT) verifies that the robust d-p hybridization among Ni, Ru and N exhibits more energy level matching for H 2 O molecule adsorption at the Ru sites, while simultaneously reducing the interaction between H* and Ni sites in N -doped NiRu-inf.
研究领域:
材料科学
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电化学
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能源材料
·
催化
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Zhihong Zhu,Liqun Shen,Cheng Yu,Yang Li,Bo Zhang,Lingfei Hua,Zhibo Leng,Zijie Li
D-Tagatose is a low-calorie rare sugar with glycemic control and obesity prevention benefits, making it a promising functional sweetener. One-step epimerization of D-fructose to D-tagatose by D-tagatose 4-epimerase (T4E) is an attractive approach, but current T4Es suffer from low activity and poor thermostability. To address this, a novel T4E from the Thermoproteales archaeon (TaDt4e) was identified and engineered. A truncation variant Δ104–123 increased activity by 76.9%, and directed evolution produced the double mutant S46A/I113M with a 153.8% increase over wild-type enzyme. Using 100 g/L D-fructose, whole-cell biotransformation with S46A/I113M achieved 12.1% conversion within 10 min, and the purified enzyme reached 23.8% within 90 min. These results show that coordinated engineering of noncatalytic and active-site regions can substantially improve the catalytic performance of TaDt4e. This study not only identifies TaDt4e as a promising candidate for D-tagatose production, but also provides insights into the semirational or rational engineering of T4Es and related enzymes.
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高影响因子
Journal of Innovative Optical Health Sciences
·
2025
·
IF 2.2
Haitao Liao,Qingxuan Meng,Yuhao Li,Senqiang Zhu,Rui Liu,Hongjun Zhu
Optical imaging in vivo holds significant implications for disease diagnosis, and nanoprobes with near-infrared (NIR) emission leverage the deep tissue penetration and high spatiotemporal resolution provided by NIR light, demonstrating considerable application potential. This study presents the design and synthesis of three nitrogen-doped boron–dipyrrin (Aza-BODIPY) molecules: Aza–BDP–OCH 3 , Aza–BDP–OH, and Aza–BDP-I. Leveraging the strong electron-accepting properties of the Aza-BODIPY core, we developed a donor–acceptor–donor (D-A-D) structure for Aza–BDP–OCH 3 through modifications with triphenylamine and methoxy groups, resulting in NIR fluorescence. Aza–BDP–OH was obtained via demethylation using boron tribromide, whereas Aza–BDP-I was synthesized by introducing iodine into Aza–BDP–OCH 3 . These three molecules self-assemble with the amphiphilic polymer PMHC 1 8 -mPEG to form nanoparticles (NPs), yielding optical nanoprobes. The resulting NPs exhibit NIR emission, good water solubility, and biocompatibility. At a concentration of 100 μ g ⋅ mL − 1 , these NPs demonstrate low biological toxicity, highlighting their potential for biological applications. Following tail vein injection, Aza–BDP-I NPs accumulate in tumors and effectively illuminate them via the enhanced permeability and retention (EPR) effect. Furthermore, these organic NPs were metabolized by the liver. Therefore, Aza-BODIPY-based NIR fluorescent NPs offer a promising platform for the development of in vivo optical nanoprobes.
研究领域:
生物医学成像
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纳米技术
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有机化学
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分子探针
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癌症诊断
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Molecular Catalysis
·
2024
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IF 3.9
Yuqiu Wu,Fanjin Meng,Jiaolong Fu,Yuyang Zhou,Huan Fan,Xin Ju,Liangzhi Li
D-xylose, a biomass derivative, is used as a substrate to generate D-xylulose and D-ribulose with high-added value through a cascade reaction. During this process, the thermal stability and catalytic efficiency of rate-limiting enzymes during cascade reactions are important issues that must be addressed in industrial applications. In this study, we prepared and validated PDA/SiO 2 microspheres as highly loaded immobilization carriers by oxidative self-polymerization of polydopamine (PDA) on silica (SiO 2 ) microspheres. D-xylose was successfully catalyzed by the co-immobilized D-5-phosphate ribose isomerase B (RpiB) and D-tagatose-3-epimerase (DTE), denoted PDA/SiO 2 -RpiB-DTE, to produce D-ribulose and D-xylulose. After immobilization, the K m of co-immobilized RpiB and DTE decreased, which suggested increased substrate affinity. The half-life of the co-immobilized enzymes was 3.5–8 fold higher than that of the free enzymes at 50–70 °C, and the inactivation rate constant was reduced, demonstrating that immobilization improved significantly the thermal stability. The conversion of D-xylose at 10 mM was 29.98% under optimal conditions, which contained 9.85% D-ribulose and 20.13% D-xylulose. PDA/SiO 2 -RpiB-DTE showed up to 89.10% initial enzyme activity after 3 recycle runs. The thermal stability and recovery aspects were improved by immobilization, which facilitates the use of biomass to produce high-value-added products and further exploitation.
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NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Tiantian Wang,Jianhong Wei,Furong Shi,Hejie Wang,Jinye He,Xudong Lv,Yuan Zhou,Pengzhi Guo,Chenglong Wang,Yangjun Xia
In recent years, polymerized small molecule acceptors (PSMAs) have emerged as a promising strategy that combines the strong absorption of small molecules with the film-forming ability and stability of polymers, thereby greatly boosting the performance of all-polymer solar cells (all-PSCs). We designed a non-fused acceptor, DTBT-IC, and its polymeric counterpart, PDTBT-Br-T, by selecting DTBT as the core, bithiophene as the π-bridge, and IC as the terminal group. PDTBT-Br-T was synthesized via Stille coupling and used with PM6 as the donor to fabricate organic solar cells. The PDTBT-Br-T-based device delivered superior performance, with a VOC of 1.050 V, JSC of 9.32 mA cm−2, FF of 45.33%, and a PCE of 4.44%, outperforming the DTBT-IC-based counterpart. Morphological and structural analyses revealed that PDTBT-Br-T exhibits more ordered backbone stacking and defined phase separation, enhancing exciton dissociation and charge transport, and suppressing energy loss. The study highlights that polymerization of DTBT-IC enhances intermolecular packing and microstructure, offering critical design insights for efficient all-PSCs.
研究领域:
材料科学
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高分子化学
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有机电子学
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光伏技术
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高影响因子
Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Wang Jing,Chen Qiaoyu,Wang Xin,Chen Kequan,Ouyang Pingkai
D-1,2,4-Butanetriol (BT) has attracted much attention for its various applications in energetic materials and the pharmaceutical industry. Here, a synthetic pathway for the biosynthesis of BT from d-arabinose was constructed and optimized in Escherichia coli. First, E. coli Trans1-T1 was selected for the synthesis of BT. Considering the different performance of the enzymes from different organisms when expressed in E. coli, the synthetic pathway was optimized. After screening two d-arabinose dehydrogenases (ARAs), two d-arabinonate dehydratases (ADs), four 2-keto acid decarboxylases (ADXs), and three aldehyde reductases (ALRs), ADG from Burkholderia sp., AraD from Sulfolobus solfataricus, KivD from Lactococcus lactis IFPL730, and AdhP from E. coli were selected for the bio-production of BT. After 48 h of catalysis, 0.88 g/L BT was produced by the recombinant strain BT5. Once the enzymes were selected for the pathway, metabolic engineering strategy was conducted for further improvement. The final strain BT5ΔyiaEΔycdWΔyagE produced 1.13 g/L BT after catalyzing for 48 h. Finally, the fermentation conditions and characteristics of BT5ΔyiaEΔycdWΔyagE were also evaluated, and then 2.24 g/L BT was obtained after 48 h of catalysis under the optimized conditions. Our work was the first report on the biosynthesis of BT from d-arabinose which provided a potential for the large-scale production of d-glucose-based BT.
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PubMed
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CHEMICAL ENGINEERING SCIENCE
·
2021
·
IF 4.311
Xiaoyan Chen,Fan Wang,Qiang Yu,Shijie Liu,Wen Wang,Yu Zhang,Zhongming Wang,Zhenhong Yuan
One pot cascade of enzymatic catalysis was applied for d -allulose synthesis from d -glucose by the combination of d -glucose isomerase (GI) from Escherichia coli MG1655 and d -allulose 3-epimerase (DAE) from Agrobacterium tumefaciens C58. The synthesis process was investigated by characterizing the initial substrate concentration, molar ratios of GI and DAE, the enzyme loading, and contents of cobalt and magnesium ions. The increase of enzyme loading and the molar ratios of GI vs DAE caused the raising of d -allulose yield from 4% to 9%, verifying that the generation rate of d -fructose was an essential factor for rare sugar conversion improvement. The optimal enzyme loadings required for reactions with substrate concentrations of 100 g L −1 and 200 g L −1 were 60 U and 200 U. Kinetics stimulation was conducted to reveal the underlying relationship within the three sugars converted by dual-enzyme, with the fitting curve validated the reliability of the model.
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高影响因子
Theranostics
·
2018
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IF 8.537
Xinglong Yang,Yan Dang,Jinli Lou,Huawu Shao,Xingyu Jiang
Rationale: Rapid and facile detection of pathogenic bacteria is challenging due to the requirement of large-scale instruments and equipment in conventional methods. We utilize D-amino acid as molecules to selectively target bacteria because bacteria can incorporate DADA in its cell wall while mammalian cells or fungi cannot. Methods: We show a broad-spectrum bacterial detection system based on D-amino acid-capped gold nanoparticles (AuNPs). AuNPs serve as the signal output that we can monitor without relying on any complex instruments. Results: In the presence of bacteria, the AuNPs aggregate and the color of AuNPs changes from red to blue. This convenient color change can distinguish between Staphylococcus aureus ( S. aureus ) and methicillin-resistant Staphylococcus aureus (MRSA). This system can be applied for detection of ascites samples from patients. Conclusion: These D-amino acid-modified AuNPs serve as a promising platform for rapid visual identification of pathogens in the clinic.
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高影响因子
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