MOLECULES
·
2023
·Vol. 28
·期 6
·2531
·
IF 4.6
Da Song,Jia-Jun Liang,Shi-Biao Pu,Pan-Pan Zhang,Yun-Lin Peng,Xia Liu,Ting-Ting Feng,Xiang Pu,Ying Zhou,Xiong-Wei Liu,Xin Wei
Two new monoterpenoid indole alkaloids, gelselegandines F (1) and G (2), were isolated from the aerial parts ofGelsemium elegans. Their structures were elucidated by means of spectroscopic techniques and quantum chemical calculations. The ECD calculations were conducted at the B3LYP/6-311G(d,p) level and NMR calculations were carried out using the Gauge-Including Atomic Orbitals (GIAO) method. Structurally, the two new compounds possessed rare, cage-like, monoterpenoid indole skeletons. All isolated compounds and the total alkaloids extract were tested for cytotoxicity against four different tumor cell lines. The total alkaloids extract ofG. elegansexhibited significant antitumor activity with IC50values ranging from 32.63 to 82.24 ug/mL. In order to discover anticancer leads from the active extraction, both new indole compounds (1–2) were then screened for cytotoxicity. Interestingly, compound2showed moderate cytotoxicity against K562 leukemia cells with an IC50value of 57.02 uM.Keywords:gelselegandines F and G;cytotoxicity;leukemic cells;Gelsemium elegans
研究领域:
药理学
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有机化学
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癌症研究
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Hongyan Xi,Xinyu Yang,Wenhao Guo,Huaipeng Pang,Xuning Leng,Xiaolei Huang,Fanlu Meng
Amidst the escalating global energy crisis, the quest for efficient electrocatalysts for water splitting has become increasingly imperative. Herein, we develop a bifunctional electrocatalyst comprising RuNi alloy nanoparticles anchored on fluorine-doped NiMoO 4 nanorods (RuNi-F-NiMoO 4 ), engineered for efficient hydrogen production from seawater and urea oxidation reactions. The strategic F doping effectively reduces the difference in work functions and modulates the electronic interactions between the RuNi alloy and the NiMoO 4 substrate, enhancing electron transfer kinetics and significantly improving electrocatalytic activity and stability. Notably, the RuNi-F-NiMoO 4 exhibits outstanding hydrogen evolution reaction performance in both alkaline freshwater (248 mV at 1 A cm −2 ) and alkaline seawater (277 mV at 1 A cm −2 ), enabling industrial-scale high-current–density hydrogen production and maintaining durability over 1,000 h at 100 mA cm −2 in alkaline seawater. Furthermore, RuNi-F-NiMoO 4 achieves a current density of 1 A cm −2 at a low potential of 1.59 V during the urea oxidation reaction, and facilitates a complete urea total cracking system operating at 1.88 V at 1 A cm −2 in alkaline seawater, thereby reducing energy consumption for hydrogen production. This work offers a promising avenue for the development of efficient electrocatalysts in seawater electrolysis and urea oxidation, potentially advancing sustainable energy technologies.
研究领域:
材料科学
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电化学
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可再生能源
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DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Lei Mao,Yaxin Chen,Ruifang Zhang,Chun Yang,Yanhong Zhou,Guangya Zhang
The utilization of carbonic anhydrases (CAs) for CO2 capture aligns with the principles of environmental sustainability. However, there is an urgent need to minimize the cost of CA purification while improving their performance in harsh environments. A novel strategy was proposed to solve the above problems by employing the ferritin-tagged CA variant (DvCA8.0-F). The purification is achieved by low-speed centrifugation, yielding 92% activity recovery and 95% purity. After 14 weeks of incubation in a 50% MDEA solution at 50 °C, DvCA8.0-F maintained activity nearly equivalent to the initial activity, which showed remarkable stability compared to the free ones. Encouragingly, DvCA8.0-F had a yield of up to 800 mg/L, allowing for cost-effective CA-assisted CO2 absorption and desorption in MDEA solutions. The results show that DvCA8.0-F reduced the absorption time from 70 to 50 min at 40 °C and desorption time from 40 to 25 min at 96 °C in 25%MDEA+1%[N1111][Gly] solution with a final CO2 load and a stripped amount of CO2 at the same time. DvCA8.0-F exhibits the maximum reaction rate at 96 °C; the CO2 regeneration efficiency improved from 60% at 87 °C to 72%. When the concentration of DvCA8.0-F was 1.5 g/L, the absorption rate of CO2 reached about 90% of that of the 25% MEA solution. These results demonstrate the simplicity of preparation and the outstanding properties of DvCA8.0-F, which paves a feasible way for CA-assisted CO2 capture. This exciting strategy may also have excellent potential in enzymes for innovative chemical synthesis to achieve the sustainable development of green chemistry.
研究领域:
生物化学
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环境科学
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绿色化学
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DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 13
·5170
·
IF 4.6
Jinyuan Zhu,Yingying Zhu,Yifan Zhou,Chen Wu,Zhen Chen,Geng Chen
The direct or indirect discharge of organic pollutants causes serious environmental problems and endangers human health. The high electron–hole recombination rate greatly limits the catalytic efficiency of traditional TiO2-based catalysts. Therefore, starting from low-cost activated carbon (AC), a photocatalyst (F-Si-TiO2/AC) comprising fluorine (F)- and silicon (Si)-doped TiO2loaded on AC has been developed. F-Si-TiO2/AC has a porous structure. TiO2nanoparticles were uniformly fixed on the surface or pores of AC, producing many catalytic sites. The band gap of F-Si-TiO2/AC is only 2.7 eV. In addition, F-Si-TiO2/AC exhibits an excellent adsorption capacity toward methyl orange (MO) (57%) in the dark after 60 min. Under the optimal preparation conditions, F-Si-TiO2/AC showed a significant photodegradation performance toward MO, reaching 97.7% after irradiation with visible light for 70 min. Even under the action of different anions and cations, its degradation efficiency is the lowest, at 64.0%, which has good prospects for practical application. At the same time, F-Si-TiO2/AC has long-term, stable, practical application potential and can be easily recovered from the solution. Therefore, this work provides new insights for the fabrication of low-cost, porous, activated, carbon-based photocatalysts, which can be used as high-performance photocatalysts for the degradation of organic pollutants.Keywords:F-Si-TiO2;methyl orange;visible light;doped;electronic cage
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2026
·
IF 10.6
Miaoyang Hu,Ayiguzaili Manglike,Xiaozhu Li,Jin Wei,Xinyu Lou,Jing Liu,Zhiru Tang,Weiping He,Guixiang Ji,Wenjuan Wang,Tengfei Ma,Rong Gao,Jun Wang
Bisphenol F (BPF), a major bisphenol A substitute widely used in packaging and pharmaceuticals, poses emerging neuropsychiatric risks with unknown mechanisms. Here, we first linked elevated urinary BPF in newly diagnosed depressed patients to human depressive phenotypes. In mice, we found that BPF exposure resulted in depletion of Lactobacillus acidophilus (L. acidophilus) , whose transplantation obviously reversed the depression-like behaviors. With the Multi-omics (16S rRNA sequencing, untargeted/targeted metabolomics) assays, we revealed the two key reduced target metabolites produced by L. acidophilus , indole-3-lactic acid (ILA) and indole-3-acetic acid (IAA). Exogenous supplementation of ILA/IAA strikingly rescued the BPF-induced depressive behaviors. Mechanistically, the molecular docking and microscale thermophoresis results showed that BPF serves as a novel exogenous aryl hydrocarbon receptor (AHR) ligand, competing with ILA/IAA at MET109/LEU110 to activate cytochrome P450 1B1 (CYP1B1) signaling; Critically, knockout of AHR in mice (AHR -/- ) substantially impeded the BPF induced depression like behaviors, CYP1B1 activation and microglia mediated abnormal synaptic pruning. Collectively, the present study uncovers a novel "microbiota-indole metabolite-AHR-CYP1B1" axis mediating BPF-induced depressive changes, supporting targeted interventions (e.g., L.acidophilus ) transplantation, ILA/IAA supplementation, AHR modulation) as potential therapies for neuropsychiatric disorders induced by BPF.
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DOI
PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 56
·32325-32332
·
IF 2.936
Yuhan Zhu,Yu Pan,Wenjun Wang,Haibing Xu,Liqun Zhou,Xiaoguang Liu,Ling Li
The local crystal sites occupied by Eu3+ in Ca5(BO3)3F:1% Eu3+ phosphor were investigated experimentally and theoretically. Ca5(BO3)3F:1% Eu3+ was synthesized by high-temperature solid-state method in air. The crystal structure and optical properties of the phosphor were studied by X-ray powder diffraction and photoluminescence, respectively. Two different O2− → Eu3+ CT broad bands with the peaks at 266 and 283 nm in Ca5(BO3)3F:1% Eu3+ were detected, indicating the Eu3+ sites occupied Ca2 and Ca1, respectively. The different sharp f–f emission spectra under the excitation of 283 and 266 nm proved that there are two different local lattice environments around Eu3+ existing in Ca5(BO3)3F:1% Eu3+. Environmental factor he, the standard deviation of environmental factor (EFSD) and the bond energy were used to illustrate and explain the site occupancy mechanism of Eu3+ into the host lattice. By comparing the intensity ratios of 5D0 → 7F2 transition to the 5D0 → 7F1 transition, I(5D0/7F2)/I(5D0/7F1) of Eu3+ at Ca2 (7.381) was found to be 2.5 times stronger than that of Eu3+ at Ca1 site (2.933). was calculated to analyze the I(5D0/7F2)/I(5D0/7F1) value. On the basis of the bond valence model, a bond-energy method was used to study the occupancy of the Eu ion, which indicated that the preferential sites of Eu ion occupancy in the Ca5(BO3)3F are the Ca2 and Ca1 sites. All three theoretical calculation results are consistent with each other.
研究领域:
材料科学
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固体化学
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光学
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晶体学
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DOI
高影响因子
Materials Research Express
·
2019
·Vol. 6
·期 4
·045601
·
IF 1.449
Hao Li,Genliang Hou,Qi Tian,Song Bi,Zhaohui Liu,Yangyang Lin,Jin Tang,Xunjia Su
Fluorinated graphene oxide (FGO) with high fluorine content is a suitable alternative for superhydrophobic materials due to the existence of the C–F bond. In this paper, we demonstrate a facile, large-scale method for the preparation of FGO with higher oxygen content and fluorine content by adopting proper oxidants and solvent to oxidize commercial graphite fluoride (GIF) on the basis of modified Hummers' method. Chemical composition, morphology and hydrophobicity are characterized by FT-IR, XPS, TGA, TEM and contact angle (CA) test respectively. The results indicate that the increase in oxygen content is accompanied by a decrease in fluorine content and FGO fabricated by using KMnO4 and the mixture of CH3COOH: H2SO4 with a volume ratio of 3:1 owns higher O/C and F/C ratio and superhydrophobicity. The oxidation mechanism is speculated that fluorine atom detaches from GiF in a strong oxidation environment, resulting in the restoration of sp2 C=C bond partly, and then sp2 C=C bond could be oxidized by KMnO4 or K2FeO4 efficiently. More oxygen groups broaden the applications of FGO as hydrophobic materials.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2024
·
IF 5.3
Bao Guo,Hongjun Kang,Xinzhi Wang,Yitong Duan,Xiaotong Li,Baiqi Gao,Zhiqiang Wang,Yang Li,Songtao Lu,Xiaohong Wu
Addressing the issue of dust deposition on photovoltaic (PV) panels is of profound scientific significance and practical value for enhancing PV power generation. Transparent superhydrophobic coating is expected to be applied in the self-cleaning of PV panels. However, developing the transparent superhydrophobic dust removal coatings remains a challenge. Herein, we developed a highly transparent F-SiO 2 coating with dual self-cleaning and dust removal functions, composed of polydimethylsiloxane (PDMS) and SiO 2 . The coating demonstrates a high transmittance of 97 %. After self-cleaning and dust removal tests, conversion efficiency of F-SiO 2 coated PV decreased by only 0.03 % and 0.01 %, respectively, demonstrating excellent self-cleaning and dust removal performance. Additionally, the F-SiO 2 exhibits high stability. Mechanism analysis of dust removal performance reveals that the decreased effective dielectric constant from the porous structure and the reduced actual contact area between the particles and the superhydrophobic surface, thereby effectively reduces the van der Waals force between dust and coating. This work provides a novel strategy to prepare self-cleaning and dust removal coatings on PV cover plate.
研究领域:
材料科学
·
能源技术
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Zhaocan Zhong,Xiaoyong Xia,Xiaoying Yang,Najun Li,Jinghui He,Dongyun Chen,Peiyang Gu,Qingfeng Xu,Jianmei Lu
Porphyrin based photocatalysts have demonstrated exciting features, such as outstanding photoelectric properties, good photothermal stability, and structural diversity. Meanwhile, hydrophilic porphyrin is easily dispersed in water, increasing photocatalyst contact with pollution while also reducing the distance of carrier transport. In this study, porphyrin-based porous organic polymers (POPs), TEPP-F-TBT, was successfully fabricated for degradation of bisphenol A (BPA) using Sonogashira coupling. To enhance the dispersion of TEPP-F-TBT, modification of TEPP-F-TBT by 3-mercapto-1-propanesulfonic acid sodium was performed using the thiol-alkyne click reaction. Subsequently, under illumination, the modified polymer TEPP-F-TBT-S degrades more than 99.0% of 10 ppm BPA within 30 min, but TEPP-F-TBT can only degrade 25% of 10 ppm BPA under the same conditions. A possible mechanism of photocatalytic degradation of BPA was speculated using characterizations, such as electron spin resonance and trapping experiments. Our study presents a green approach for modifying POPs to design and synthesize organic photocatalysts with outstanding performance.
研究领域:
环境科学
·
材料科学
·
化学
·
光催化
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Qiongfang Zhuo,Jinbao Wang,Junfeng Niu,Bo Yang,Yang Yang
BDD/SnO 2 -F electrode was synthesized by spin-coating and heat treatment, and it was characterized by scanning electron microscope-energy dispersive spectrometer (SEM-EDS), X-ray diffraction (XRD), and linear sweep voltammetry (LSV). Electrochemical oxidation of chlorinated polyfluorinated ether sulfonate (F-53B, ClCF 2 CF 2 CF 2 CF 2 CF 2 CF 2 -O-CF 2 CF 2 -SO 3 K) as PFOS substitute was carried out with the BDD, BDD/SnO 2 , BDD/PbO 2 , and BDD/SnO 2 -F anodes. The effects of F and Sn ratio, current density, initial pH, initial F-53B concentration, the supporting electrolyte, NaCl concentration, and electrode distance on the degradation ratios were investigated. The defluorination and the desulfurization were evaluated by ion chromatography and UV–vis spectra. The intermediate products were analyzed on the liquid chromatography system coupled with a triple-stage quadrupole mass spectrometer (LC-MS/MS). The experimental results showed that BDD/SnO 2 -F had the most outstanding electrochemical oxidation performance. After introduction of F into SnO 2 crystal, the grain size of SnO 2 -F was reduced, the oxygen evolution potential was increased by 0.13 V, and the degradation ratio of F-53B was increased by 15.07%. Under the optimum operating parameters, F-53B removal ratio of 95.6% was obtained, and the defluorination ratio reached 61.39% with NaCl supporting electrolyte concentration of 1 mol/L at current density of 30 mA/cm 2 after electrolysis of 30 min. Finally, the electrochemical degradation pathways and the mechanisms of F-53B were proposed based on the intermediate products and the previous literature reported. This study indicates that the electrochemical performance of BDD anode can be much improved by modification with SnO 2 -F, and BDD/SnO 2 -F anode is kind of effective anode to decompose refractory compounds.
研究领域:
环境科学
·
分析化学
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DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Xinglong Liu,Zexing Wang,Xinyao She,Quanliang Jia,Jiamao Li
In this study, LiF was utilized to decrease sintering temperature , improve microstructure, enhance Q × f , and regulate τ f of Li 2 Ti 0.9 (Zn 1/3 Ta 2/3 ) 0.1 O 3 (abbreviated as LTZT) ceramics. A complete solid solution together with a phase transition from monoclinic to cubic rock salt structure occurred. The cell volume of LTZT ceramics decreased as the LiF content increased. Relatively dense and uniform microstructures were observed for the ceramics as the LiF content was not less than 2 wt%. The dielectric constant of LTZT ceramics initially increased and then decreased with the increasing LiF content. The FWHM of the Raman band at about 808 cm −1 was closely related to the Q × f value. Notably, the samples with 3 wt% LiF exhibited the highest relative density of 97.4 % and satisfactory microwave dielectric properties of ε r = 23.14 ± 0.16, Q × f = 110,090 ± 1100 GHz, and τ f = +3.25 ± 1.45 ppm/°C when sintered at 950 °C. Good chemical compatibility with silver indicated the ceramic is a promising candidate in LTCC applications.
研究领域:
材料科学
·
电子工程
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Shucheng Liu,Xiaoqing Chen,Pengcheng Zhang,Quanzhang Wen,Linzhao Ma,Hao Li
A novel low-loss La 5 Sn 4 O 15 ceramic is fabricated via traditional solid-state route. The investigation mainly focused on phase composition, dielectric characteristics and crystalline from 1300 to 1400 °C. The XRD analyses confirmed the La 5 Sn 4 O 15 ceramic is consisted of cubic and hexagonal structure. The effects of relative density on the Q × f and permittivity are also investigated. The satisfactory properties (ε r of 17.4, Q × f of 84,760 GHz and τ f of −19.08 ppm/°C) are obtained at optimum sintering condition (sintered at 1350 °C for 4 h), indicating La 5 Sn 4 O 15 ceramic is a promising ceramic for using in wireless applications region.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）