Kidney International Reports
·
2026
·
IF 6.2
Shangbin Kao,Yuemiao Zhang,Shaoqing Dang,Shichao Hu,Mengwei Li,Tianyu Zheng,Yuan Qin,Biao Huang,Qiang He,Jicheng Lv
Introduction IgA nephropathy (IgAN) diagnosis remains dependent on invasive renal biopsy because currently available serologic biomarkers, including galactose-deficient IgA1 (Gd-IgA1), have limited diagnostic performance. This study aimed to develop and evaluate a high-sensitivity time-resolved fluorescence immunoassay (TRFIA) based on a novel anti-Gd-IgA1 monoclonal antibody (MH33) for Gd-IgA1 detection in IgAN. Methods MH33 glycoepitope specificity was characterized by surface plasmon resonance (SPR). A MH33-based TRFIA was developed and evaluated for analytical and diagnostic performance in healthy controls, non-IgAN renal disease controls, and IgAN patients, with comparison to a KM55-based assay. Results SPR analysis showed that MH33 recognized a GalNAc-modified IgA1 hinge-region glycopeptide distinct from the KM55 epitope. The MH33-based TRFIA achieved a detection limit of 0.20 Ru/mL, a quantification range of 0.20–600 Ru/mL, and acceptable analytical performance (intra-/inter-assay CVs: 2.32%–5.49% and 3.97%–5.23%; recoveries: 89.80%–103.76%). Correlation with KM55 was moderate (IgAN, r = 0.23, p =0.09). For distinguishing IgAN from combined controls (healthy controls and non-IgAN renal diseases), the MH33-based TRFIA yielded an AUC of 0.90 (95% CI: 0.86–0.93), compared with 0.78 (95% CI: 0.71–0.86) for KM55 . At the optimal cutoff value (22.0 Ru/mL), the assay achieved a specificity of 93.82% and sensitivity of 64.44%. Conclusion MH33-based TRFIA provides a sensitive approach for Gd-IgA1 detection and demonstrates favorable diagnostic performance for IgAN.
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高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Anish Bhattacharya,Xiangfeng Chu,Qi Gao,Xue Li,Yongping Dong,Shiming Liang,Amit K. Chakraborty
Ethanol sensing is an important area of research given its relevance to human health, traffic control and various industries. Metal oxide semiconductor nanostructures are most commonly used as gas sensors. In this study, enhanced ethanol sensing properties were obtained by incorporation of Gd 3+ ions into Barium Stannate (GBSO), a bimetallic oxide microrods prepared through a simple co-precipitation method. The GBSO films, when exposed to ethanol, showed that incorporation of Gd improved the sensing response till 3 wt% of Gd (3GBSO) loading while further increase in Gd content resulted in reduced response. 3GBSO sample showed response as high as 76 to 500 ppm of ethanol vapor at an operating temperature of 220 °C along with a very low detection limit of 0.1 ppm (response of 1.5). Good repeatability and moderate stability were also observed suggesting its potential as low-cost ethanol sensor. Significant increase in both specific surface area as well as oxygen content (as measured by x-ray photoelectron spectroscopy) was observed in 3GBSO sample compared to that of BSO. Thus, we showed that incorporation of Gd improved the surface area of BSO microrods and in turn the surface adsorption of oxygen which led to their enhanced response to ethanol.
研究领域:
材料科学
·
传感器技术
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DOI
高影响因子
INORGANIC CHEMISTRY
·
2012
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IF 4.601
Wenlong Yin,Kai Feng,Wendong Wang,Youguo Shi,Wenyu Hao,Jiyong Yao,Yicheng Wu
The twelve quaternary rare-earth selenides Ba2MLnSe5 (M = Ga, In; Ln = Y, Nd, Sm, Gd, Dy, Er) have been synthesized for the first time. The compounds Ba2GaLnSe5 (Ln = Y, Nd, Sm, Gd, Dy, Er) are isostructural and crystallize in a new structure type in the centrosymmetric space group P1̅ of the triclinic system while the isostructural compounds Ba2InLnSe5 (Ln = Y, Nd, Sm, Gd, Dy, Er) belong to the Ba2BiInS5 structure type and crystallize in the noncentrosymmetric space group Cmc21 of the orthorhombic system. The structures contain infinite one-dimensional anionic chains 1∞[GaLnSe5]4– and 1∞[InLnSe5]4–, and both chains are built from LnSe6 octahedra and MSe4 (M = Ga, In) tetrahedra in the corresponding selenides. As deduced from the diffuse reflectance spectra, the band gaps of most Ba2MLnSe5 (M = Ga, In; Ln = Y, Nd, Sm, Gd, Dy, Er) compounds are around 2.2 eV. The magnetic susceptibility measurements on Ba2GaGdSe5 and Ba2InLnSe5 (Ln = Nd, Gd, Dy, Er) indicate that they are paramagnetic and obey the Curie–Weiss law, while the magnetic susceptibility of Ba2InSmSe5 deviates from the Curie–Weiss law as a result of the crystal field splitting. Furthermore, Ba2InYSe5 exhibits a strong second harmonic generation response close to that of AgGaSe2, when probed with the 2090 nm laser as fundamental wavelength.
研究领域:
材料科学
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固体化学
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物理学
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PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 16
·2783
·
IF 5.719
Shasha Li,Xinan Zhang,Penglin Zhang,Guoxiang Song,Li Yuan
The use of the semiconductor heterojunction channel layer has been explored as a method for improving the performance of metal oxide thin-film transistors (TFTs). The excellent electrical performance and stability of heterojunction TFTs is easy for vacuum-based techniques, but difficult for the solution process. Here, we fabricated In2O3/In2O3:Gd (In2O3/InGdO) heterojunction TFTs using a solution process and compared the electrical properties with single-layer In2O3TFTs and In2O3:Gd (InGdO) TFTs. The In2O3/InGdO TFT consisted of a highly conductive In2O3film as the primary transmission layer and a subconductive InGdO film as the buffer layer, and exhibited excellent electrical performance. Furthermore, by altering the Gd dopant concentration, we obtained an optimal In2O3/InGdO TFT with a higher saturation mobility (µ) of 4.34 cm2V−1s−1, a near-zero threshold voltage (Vth), a small off-state current (Ioff) of1.24×10−9A, a large on/off current ratio (Ion/Ioff) of3.18×105, a small subthreshold swing (SS), and an appropriate positive bias stability (PBS). Finally, an aging test was performed after three months, indicating that In2O3/InGdO TFTs enable long-term air stability while retaining a high-mobility optimal switching property. This study suggests that the role of a high-performance In2O3/InGdO heterojunction channel layer fabricated by the solution process in the TFT is underlined, which further explores a broad pathway for the development of high-performance, low-cost, and large-area oxide electronics.Keywords:solution process;TFTs;doping;heterojunction channel layer;mobility;stability
研究领域:
材料科学
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电子工程
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PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
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2022
·Vol. 57
·期 4
·2870-2882
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IF 4.682
Han Ni,Xu Shishi,Zhang Qinfang
The Bi 2 MO 4 Cl (M = Gd and Nd) nanosheets were prepared by a molten salt flux method for the first time. The resulted Bi 2 GdO 4 Cl (F-BG) nanosheets showed the highest photocatalytic activity for oxygen (O 2 ) evolution and trypan blue (TB) degradation than Bi 2 NdO 4 Cl (F-BN), Bi 2 GdO 4 Cl (S-BG) and Bi 2 NdO 4 Cl (S-BN) synthesized by a solid-state method. The F-BG nanosheets showed the larger specific surface areas and abundant pores, which could provide more reactive sites. The photoelectrochemical and photoluminescence (PL) results revealed that F-BG sample had the excellent separation and transfer rates of photogenerated charge carriers, leading to the highly photocatalytic performance for both O 2 evolution and TB degradation. The UV–Vis diffuse reflectance spectra (DRS) showed all samples had the visible-light-responsive characteristic. The radical trapping experiment revealed hole (h + ) played a major role, while superoxide radical ( \(\cdot {\text{O}}_{{2}}^{ - }\) ) contributed a little to photocatalytic degradation process. Thus, a possible photocatalytic mechanism was proposed based on the radical trapping experiment. This work shows us a useful insight into the preparation of highly active bismuth-based oxyhalide nanosheets photocatalysts by a molten salt synthesis through surface modification and morphology control and provides the possibility of water splitting under visible light.
研究领域:
材料科学
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光催化技术
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环境科学
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DOI
高影响因子
Journal of Cancer
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2024
·Vol. 15
·期 17
·5594-5604
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IF 3.3
Cheng Yuanyuan,Gong Shushu,Li Qianqian,Shen Juan,Huang Hongjuan
Objective: To demonstrate the efficacy of photodynamic therapy (PDT) using hematoporphyrin derivative (HPD) nanomedicine in combination with conventional chemotherapy based on gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) magnetic resonance imaging (MRI) for hepatocellular carcinoma (HCC) therapy.Methods: HPD nanomedicine was prepared, and the cytotoxicity of HPD nanomedicine at different concentrations on HCC cells and the half-maximal inhibitory concentration (IC50) were analyzed. Sixty HCC patients who visited our hospital from 2021 to 2023 were retrospectively analyzed. Patient data were analyzed, with 30 cases in control group (CG) receiving conventional chemotherapy for HCC, and 30 cases in observation group (OG) receiving conventional chemotherapy combined with HPD nanomedicine PDT. Gd-DTPA MRI was utilized to monitor the morphological and biological characteristics of the lesions in patients. After treatment completion, the long-term efficacy of patients and the levels of bcl-2 and bax proteins in primary HCC cells were evaluated.Results: The IC50 values of HPD on HepG2 cell proliferation and the cell inhibition rates gradually increased with increasing doses of HPD (50 μM, 25 μM, 12.5 μM, 6.25 μM, 3.13 μM, 1.56 μM, 0.78 μM). HPD exhibited great anti-proliferative effects on HepG2 cells at relatively low concentrations. The differences in expression rates of bcl-2 protein and bax protein between groups were considerable (P<0.05). There were neglectable changes in AST and ALT levels between the two groups before treatment, but they were markedly reduced after treatment versus before treatment (P<0.05), with OG showing considerably lower levels than CG after treatment (P<0.05). Additionally, patients in OG exhibited better survival rates after the course of treatment versus those in CG.Conclusion: This study demonstrates that the combination of conventional chemotherapy based on Gd-DTPA MRI with HPD nanomedicine PDT greatly improves the efficacy of treatment for HCC patients. This combined treatment strategy not only enhances therapeutic outcomes but also alleviates adverse reactions associated with conventional treatment, providing a novel approach for future research in the treatment of HCC.
研究领域:
肿瘤学
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药理学
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医学影像学
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纳米技术
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细胞生物学
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DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
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2025
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IF 4.7
Ritao Huang,Jin Zhou,Yi Yang,Qingyuan Zeng,Jingxin Li,Langsheng Ling,Wei Tong,Zhaoming Tian
Two-dimensional rare earth (RE)-based honeycomb lattice magnets provide a fertile platform for exploring exotic magnetic ground states in view of reduced spatial dimensionality and anisotropic exchange interactions, while the reported 2D honeycomb lattice materials are quite limited. Herein, we report a family of quasi-two-dimensional layered RE-based honeycomb lattice magnets RE2Te4O11 (RE = Gd–Er and Yb), where the magnetic honeycomb layers are well separated by nonmagnetic TeO4 polyhedra with large interlayer distances of 8.353–8.452 Å. Magnetic susceptibility characterizations reveal that all synthesized RE2Te4O11 (RE = Gd–Er and Yb) compounds exhibit dominant antiferromagnetic (AFM) interactions; three RE2Te4O11 (RE = Gd, Tb, and Dy) family members show magnetic transitions with Néel temperatures (TN) of 1.97, 3.61, and 2.52 K, respectively. For Tb2Te4O11, a field-induced spin-flop transition is observed below TN = 3.61 K in the isothermal magnetization M(B) curves. Based on the analysis of the magnetocaloric effect (MCE), a crossover behavior is observed from the inverse MCE at low fields (ΔB < 1.8 T) to conventional MCE at high fields (ΔB > 1.8 T) below the TN in Tb2Te4O11; this is in contrast to the conventional MCE in all measured field regions in other RE2Te4O11 compounds.
研究领域:
凝聚态物理
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磁性材料
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低维量子系统
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固态化学
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产品关联
DOI
PubMed
高影响因子
Small Methods
·
2024
·
IF 10.7
Ruizhe Hu,Xue He,Yuqi Luo,Chongbo Liu,Shiyu Liu,Xintong Lv,Jinxi Yan,Yuhui Peng,Mingyue Yuan,Renchao Che
Structural design and interface regulation are useful strategies for achieving strong electromagnetic wave absorption (EMWA) and broad effective absorption bandwidth ( EAB ). Herein, a monomer-mediated strategy is employed to control the growth of covalent organic framework (COF) wrapping flower-shaped Gd-doped FeNi 3 (GFN), and a novel raspberry-like absorbent based on biomimetic design is fabricated by thermal catalysis. Further, a unique dielectric-magnetic synergistic system is constructed by utilizing the COF-derived nitrogen-doped porous carbon (NPC) as the shell and anisotropic GFN as the core. The electromagnetic parameters of the GFN@NPC composites can be tuned by adjusting the proportions of GFN and NPC. Off-axis electron holography results further clarify the interface polarization and microscale magnetic interactions affecting the EMW loss mechanism. As a result, the GFN@NPC samples exhibit broad EMWA performance. The EAB values of all GFN@NPC composites reach up to 6.0 GHz, with the GFN@NPC-2 sample showing a minimum reflection loss ( RL min ) of −69.6 dB at 1.68 mm. In addition, GFN@NPC-2 achieves a maximum radar cross–section (RCS) reduction of 29.75 dB·m 2 . A multi-layer gradient structure is also constructed using metamaterial simulation to achieve an ultra-wide EAB of 12.24 GHz. Overall, this work provides a novel bio-inspired design strategy to develop high-performance EMWA materials.
研究领域:
材料科学
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电磁学
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DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
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2024
·
IF 4.3
Junjiang Li,Huanke Zhao,Xinyuan Zhang,Pifu Gong,Zheshuai Lin,Yicheng Wu
The band gap is one of the significant parameters for nonlinear optical (NLO) materials, which is the key factor in their application band in laser technology. This study reports the synthesis of two rare-earth selenite NLO crystals, namely, RE(HSeO3)(SeO3)(H2O)·(H2O) (RE = Y, Gd), utilizing the hydrothermal technique. The two compounds are isostructural, and both belong to the orthorhombic chiral space group of P212121 and possess three-dimensional structures consisting of two-dimensional rare-earth selenite layers connected by hydrogen bonds (O–H··O). These two compounds exhibit a moderate second harmonic generation intensity of 0.5/0.8 × KDP and wide energy band gaps reaching 4.8 eV. Comprehensive density functional theory analyses based on first-principles were carried out to unravel the relationship between the structural and corresponding properties. This work provides an approach for band gap enlargement in rare-earth selenite systems and is beneficial to the design of future NLO materials.
研究领域:
材料科学
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晶体学
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PubMed
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2018
·
IF 3.849
Keyu Cui,Baihui Gao,Meng Tai,Bin Su
Rapid development of rare earth industry has led to an increasing demand for highly purified rare earth elements (REEs). The combination of ion-imprinted technique (IIT) and membrane separation technique (MST) is recently regarded as a promising strategy for selectively separating specific ions from multiple REEs. In this work, a facile bionic strategy for preparation of Gd (III)-imprinted membranes (GIMs) were developed via interlaced stacking of one-dimensional Gd (III)-imprinted carbon nanotubes (GICNTs) and two-dimensional polydopamine-modified graphene oxide (pDA@GO). Polydopamine was synthesized on graphene oxide to large enhance the interfacial adhesion, and ion-imprinting polymerization is implemented on carbon nanotubes (CNTs) by direct cross-link of linear polymers. The obtained materials are characterized in detail by FTIR, SEM, TEM and AFM to explorer the evolution of chemical composition and morphology. Selectivity towards Gd (III) is obtained by isothermal adsorption, kinetic adsorption and time-depended permeation. Isothermal and kinetic models are fitted with adsorption data to obtain the mechanism of selective separation on GIMs. The as-synthesized GIMs with high permeation selectivity (2.91 and 2.49) towards Gd (III) and stable permeation regeneration would potentially be applied to separation and purification of specific ions form multiple REEs.
研究领域:
材料科学
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化学工程
·
环境科学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
·
IF 9.038
Yuzhe Zhang,Tingting Bian,Rong Jiang,Yi Zhang,Xudong Zheng,Zhongyu Li
High selective recovery of Gd(Ⅲ) from end-of-life rare earth productions is essential for cleaner production. Chitosan(CS), a biomaterial, has shown excellent results in water treatment . The amino and hydroxyl groups on the surface of CS play a vital role in adsorbing metal ions . Polydopamine has good stability, strong water dispersibility, and excellent biocompatibility. As a bio-crosslinking agent, the amino and phenolic hydroxyl groups on its surface can be combined with metal ions to help the material absorb metal ions. This paper combines the active groups of biomimetic materials and the mechanical properties of new nanomaterials multi-walled carbon nanotubes and graphene oxide, and prepared a high-performance chitosan-based aerogel MWCNT-PDA-CS-GO through heat and mass transfer at low temperature and low pressure. The adsorption mechanism of MWCNT-PDA-CS-GO for Gd(Ⅲ) was analyzed through a series of characterization and adsorption experiments. At pH 7.0, the maximum adsorption capacity of aerogel for Gd(Ⅲ) reached 150.86 mg g −1 . The relative selectivity of imprinted ions is 48.02 times higher than other ions. All the results indict MWCNT-PDA-CS-GO aerogel exhibits excellent selectivity and stability for effective recovery of Gd(Ⅲ).
研究领域:
环境科学
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材料科学
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生物工程
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PubMed
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 30
·6390-6401
·
IF 5.344
Tingting Zhou,Guofeng Wan,Bao Li,Lixin Wu
This article describes the fabrication of nanosized paramagnetic drug carriers via the assembly of a pH-responsive hydrophilic block copolymer poly(polyethylene glycol methyl ether methacrylate)-b-poly(methacrylic acid-co-trimethyl ammonium bromide propyl methacrylate) (PPMT) and polyoxometalate K13[Gd(β2-SiW11O39)2] (GdSiW11) through electrostatic interaction. Owing to the hydrophilicity, large molecular weight, and high content of the GdSiW11 cluster bearing in the nanocomposites, the organic–inorganic nanocomposite exhibited an impressive longitudinal relaxivity as a contrast agent for magnetic resonance imaging (MRI). The surplus negative charges from the polyoxometalate cluster in the polymer nanocomposites facilitated the capture of the anti-tumor drug doxorubicin (DOX). The DOX-loaded nanocomposites were stable under the physiological environment, whereas a responsive release of DOX was achieved at pH values similar to the tumor microenvironment due to the regulation of the polyoxometalate and carboxyl groups. The DOX-loaded PPMT2–GdSiW11 nanocomposites were observed to enrich effectively at tumor sites through MRI after intravenous injection. Furthermore, the DOX-loaded composites manifested enhanced in vivo anti-tumor therapeutic efficacy and sustainable circulation time of more than 5 h, which were favourable for imaging measurement. With the advantages of the designed composite system, the present experiments propose a strategy for developing a new multiple imaging-drug delivery-local therapy platform for synergistic diagnosis and therapy.
研究领域:
材料科学
·
医学影像
·
肿瘤学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）