Petroleum Science
·
2024
·
IF 6
Jing Tan,Wei Zhang,Xiu-Ling Yan,Hao Zhou,Sher Bahadar Khan,Seitkhan Azat,Shi-You Yan,Hao-Jie Ma,Xin-Tai Su
Humic acids (HAs) are widely used as filtrate and viscosity reducers in drilling fluids. However, their practical utility is limited due to poor stability in salt resistance and high-temperature resistance. High-temperature coal pitch (CP) is a by-product from coal pyrolysis above 650 °C. The substance's molecular structure is characterized by a dense arrangement of aromatic hydrocarbon and alkyl substituents. This unique structure gives it unique chemical properties and excellent drilling performance, surpassing traditional humic acids in drilling operations. Potassium humate is prepared from CP (CP-HA-K) by thermal catalysis. A new type of high-quality humic acid temperature-resistant viscosity-reducer (Graft CP-HA-K polymer) is synthesized with CP-HA-K, hydrolyzed polyacrylonitrile sodium salt (Na-HPAN), urea, formaldehyde, phenol and acrylamide (AAM) as raw materials. The experimental results demonstrate that the most favorable conditions for the catalytic preparation of CP-HA-K are 1 wt% catalyst dosage, 30 wt% KOH dosage, a reaction temperature of 250 °C, and a reaction time of 2 h, resulting in a maximum yield of CP-HA-K of 39.58%. The temperature resistance of the Graft CP-HA-K polymer is measured to be 177.39 °C, which is 55.39 °C higher than that of commercial HA-K. This is due to the abundant presence of amide, hydroxyl, and amine functional groups in the Graft CP-HA-K polymer, which increase the length of the carbon chains, enhance the electrostatic repulsion on the surface of solid particles. After being aged to 120 °C for a specified duration, the Graft CP-HA-K polymer demonstrates significantly higher viscosity reduction (42.12%) compared to commercial HA-K (C-HA-K). Furthermore, the Graft CP-HA-K polymer can tolerate a high salt concentration of 8000 mg·L − 1 , measured after the addition of optimum amount of 3 wt% Graft CP-HA-K polymer. The action mechanism of Graft CP-HA-K polymer on high-temperature drilling fluid is that the Graft CP-HA-K polymer can increase the repulsive force between solid particles and disrupt bentonite's reticulation structure. Overall, this research provides novelty insights into the synthesis of artificial humic acid materials and the development of temperature-resistant viscosity reducers, offering a new avenue for the utilization of CP resources.
研究领域:
化学工程
·
材料科学
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DOI
高影响因子
Virtual and Physical Prototyping
·
2024
·
IF 10.2
Wang Guo,Ping Li,Yanting Wei,Lei Zhao,Yuanheng Pang,Yanjian Huang,Xiaotong Ye,Shan Wang,Bin Liu,Hui You,Yu Long
Hydroxyapatite (HA) is widely used in bone scaffold development, but still faces problems of forming difficulty, slow degradation, and limited biological performance. In this study, triply periodic minimal surface (TPMS) porous HA scaffolds were prepared using desktop-level DLP and then doped with bredigite (BR) to enhance their performance through ion substitution to adjust microstructure. The DLP-prepared scaffolds displayed intricate curved surface porous structure, and their micro-porosity decreased while grain size increased with sintering holding time. During sintering, Mg2+ from BR substituted Ca2+ in HA, forming new secondary phases, which slightly decreased grain size while significantly increased micro-porosity. These factors slightly reduced mechanical properties while significantly enhanced degradation. The rapid release of inorganic active ions from BR and new phases enhanced the biomineralization and cell response. This study demonstrated the potential of using desktop-level DLP to construct complex porous ceramic scaffolds and using ion substitution to modulate their microstructure and performance.
研究领域:
生物材料学
·
骨组织工程
·
3D打印技术
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产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2018
·
IF 1.911
Ruirui Feng,Rongzhan Fu,Zhiguang Duan,Chenhui Zhu,Xiaoxuan Ma,Daidi Fan,Xian Li
Polyvinyl alcohol (PVA) hydrogels have been widely studied for biomedical applications due to their water solubility, non-toxicity, non-carcinogenicity, and biocompatibility. However, PVA hydrogels prepared by the physical crosslinking method usually do not exhibit a macroporous structure, which limits their application when PVA hydrogels are used alone as a wound dressing. Here, we reported a sponge-like macroporous PVA hydrogel (SPH) prepared by employing polyethylene glycol and nano-hydroxyapatite (n-HA) to enhance phase separation. After being fabricated through cyclic freezing/thawing, the resulting PVA hydrogels possessed macroporous structures. The swelling ratio could reach nearly 1500%, resulting from the excellent water absorption capacity, and the sample could rapidly restore to the original state after being pressed, suggesting a sponge-like characteristic. Furthermore, cell experiments showed that macroporous PVA hydrogels exhibited good biocompatibility and the results of wound closure and H&E analysis consistently indicated that SPHs could significantly promote the wound healing process.
研究领域:
材料科学
·
生物医学工程
·
伤口愈合
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DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2018
·
IF 4.525
Tierong Bian,Kang Zhao,Qingnan Meng,Yufei Tang,Hua Jiao,Jing Luo
Synthetic materials allow easy processing and modification for bone defect repairing with a good immunological compatibility and minimal risks of infections and donor site morbidity. But compared with an autologous bone graft, these artificial scaffolds still have limitations in terms of the osteogenic capacity and mechanical properties including excellent strength and toughness of super-light natural bone. In this study, we aimed to construct a bone scaffold with both a biomimetic multi-level hierarchical structure and similar constituents of a natural bone using HA/collagen composite nanofibers. The electrospinning technique and rolling method were used for bottom-up synthesis of this artificial system from nano-level to micro-level and then to macro-level. MicroCT scanning and scanning electron microscopy confirmed successful preparation of the bone scaffold composed of fully assembled microscopic fibers. The mechanical properties of the mineralized scaffolds were double reinforced by a large number of newborn HA nano particles and the chemical bonds. The bonds were formed between HA and collagen within and between the layers of the scaffold's matrix membrane. The scaffold showed an excellent biocompatibility profile. These suggest the scaffold potential for use in bone tissue engineering.
研究领域:
生物材料学
·
组织工程学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Min Han,Ming-Yi Huang-Fu,Wang-Wei Guo,Ning-Ning Guo,JieJian Chen,Hui-Na Liu,Zhi-Qi Xie,Meng-Ting Lin,Qi-Chun Wei,Jian-Qing Gao
Currently, the limited penetration of nanoparticles remains a major challenge for antitumor nanomedicine to penetrate into the tumor tissues. Herein, we propose a size-shrinkable drug delivery system based on a polysaccharide-modified dendrimer with tumor microenvironment responsiveness for the first time to our knowledge, which was formed by conjugating the terminal glucose of hyaluronic acid (HA) to the superficial amidogen of poly(amidoamine) (PAMAM), using a matrix metalloproteinase-2 (MMP-2)-cleavable peptide (PLGLAG) via click reaction. These nanoparticles had an initial size of ∼200 nm, but once deposited in the presence of MMP-2, they experienced a dramatic and fast size change and dissociated into their dendrimer building blocks (∼10 nm in diameter) because of cleavage of PLGLAG. This rapid size-shrinking characteristic not only promoted nanoparticle extravasation and accumulation in tumors benefited from the enhanced permeability and retention effect but also achieved faster nanoparticle diffusion and penetration. We have further conducted comparative studies of MMP-2-sensitive macromolecules (HA-pep-PAMAM) and MMP-2-insensitive macromolecules (HA–PAMAM) synthesized with a similar particle size, surface charge, and chemical composition and evaluated in both monolayer cells and multicellular spheroids. The results confirmed that the enzyme-responsive size shrink is an implementable strategy to enhance drug penetration and to improve therapeutic efficacy. Meanwhile, macromolecule-based nanoparticles with size-variable characteristics not only promote drug penetration, but they can also be used as gene delivery systems, suggesting great potential as nano-delivery systems.
研究领域:
纳米医学
·
癌症治疗
·
药物递送系统
·
生物材料
·
肿瘤微环境工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 2
·1274
·
IF 5.6
Yuanhang Zhao,Hong Zhang,Lihua Hong,Xinying Zou,Jiazhuo Song,Rong Han,Jiawen Chen,Yiyan Yu,Xin Liu,Hong Zhao,Zhimin Zhang
Dental caries, particularly secondary caries, which is the main contributor to dental repair failure, has been the subject of extensive research due to its biofilm-mediated, sugar-driven, multifactorial, and dynamic characteristics. The clinical utility of restorations is improved by cleaning bacteria nearby and remineralizing marginal crevices. In this study, a novel multifunctional dental resin composite (DRC) composed of Sr-N-co-doped titanium dioxide (Sr-N-TiO2) nanoparticles and nano-hydroxyapatite (n-HA) reinforcing fillers with improved antibacterial and mineralization properties is proposed. The experimental results showed that the anatase-phase Sr-N-TiO2nanoparticles were synthesized successfully. After this, the curing depth (CD) of the DRC was measured from 4.36 ± 0.18 mm to 5.10 ± 0.19 mm, which met the clinical treatment needs. The maximum antibacterial rate againstStreptococcus mutans(S. mutans) was 98.96%, showing significant inhibition effects (p< 0.0001), which was experimentally verified to be derived from reactive oxygen species (ROS). Meanwhile, the resin exhibited excellent self-remineralization behavior in an SBF solution, and the molar ratio of Ca/P was close to that of HA. Moreover, the relative growth rate (RGR) of mouse fibroblast L929 indicated a high biocompatibility, with the cytotoxicity level being 0 or I. Therefore, our research provides a suitable approach for improving the antibacterial and mineralization properties of DRCs.Keywords:dental resin composite;dental caries;secondary caries;titanium dioxide;antibacterial property;remineralization
研究领域:
牙科材料
·
龋齿
·
纳米技术
·
生物相容性
·
抗菌剂
·
矿化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Tingting Yang,Yunsheng Dong,Jinpeng Wan,Xiangsheng Liu,Yufei Liu,Jiaxing Huang,Jie Zhou,Hui Xiao,Lizong Tang,Yanying Wang,Shufang Wang,Hong Cai
Extracellular vesicles (EVs) play an important role in intercellular communication, and the function of EVs mainly depends on the state of source cells. To determine the effect of diabetic microenvironment on EVs secreted by bone marrow mesenchymal stem cells (BMSCs), this work explores the effect of normal glucose (5.5 m m ) cultured BMSCs derived EVs (NG-EVs) and high glucose (30 m m ) cultured BMSCs derived EVs (HG-EVs) in regulating the migration, proliferation and osteoblastic differentiation of BMSCs in vitro. In order to improve the bioavailability of EVs, this work constructs a sustained release system of polydopamine (PDA) functionalized 3D printing gelatin/hyaluronic acid/nano-hydroxyapatite (Gel/HA/nHAP) scaffolds (S/PDA) and verifies its function in the calvarial defect model of diabetic rats. This work confirms that both NG-EVs and HG-EVs can promote proliferation and migration, inhibit apoptosis and promote osteogenic differentiation, but the function of HG-EVs is weaker than that of NG-EVs. Therefore, EVs secreted by autologous cells of diabetic patients are not suitable for self-repair. This work hopes that the 3D printing scaffold designed for sustained-release EVs will provide a new strategy for acellular tissue engineering bone repair in diabetic patients.
研究领域:
组织工程
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生物医学工程
·
再生医学
·
细胞生物学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 7
·6844
·
IF 5.6
Guoying Zhou,Jiayan Zhu,Liang Jin,Jing Chen,Ruojiao Xu,Yali Zhao,Tingzi Yan,Haitong Wan
Inflammatory dysfunction and angiogenesis inhibition are two main factors leading to the delayed healing of diabetic wounds. Hydrogels with anti-inflammatory and angiogenesis-promoting effects have been considered as promising wound care materials. Herein, a salvianolic acid B (SAB)-loaded hyaluronic acid (HA) self-healing hydrogel (HA/SAB) with anti-inflammatory and pro-angiogenesis capacities for diabetic wound healing is reported. The HA hydrogel was prepared via the covalent cross-linking of aldehyde groups in oxidized HA (OHA) and hydrazide groups in adipic dihydrazide (ADH)-modified HA (HA-ADH) with the formation of reversible acylhydrazone bonds. The obtained HA hydrogel exhibited multiple favorable properties such as porous structures, excellent self-healing properties, a sustainable release capacity of SAB, as well as excellent cytocompatibility. In addition, the effects of the SAB-loaded HA self-healing hydrogel were investigated via a full-thickness skin defect model using diabetic rats. The HA/SAB hydrogel showed enhanced skin regeneration effects with accelerated wound closure, shorter remaining dermal space length, thicker granulation tissue formation, and more collagen deposition. Furthermore, reduced inflammatory response and enhanced vascularization were found with HA/SAB2.5 hydrogel-treated wounds, indicating that the hydrogel promotes diabetic wound healing through the promotion of anti-inflammation and angiogenesis. Our results suggest that the fabricated SAB-loaded HA self-healing hydrogel is promising as a wound dressing for the treatment of diabetic wounds.Keywords:diabetic wound healing;self-healing hydrogel;salvianolic acid B;anti-inflammation;angiogenesis
研究领域:
药学
·
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Dandan Fang,Xiangqin Zheng,Huan Yi,Hong Dai,Zhensheng Hong,Yiru Peng,Yanyu Lin
A highly sensitive electrochemiluminescence (ECL) immunosensor was fabricated for the quantitative analysis of deoxynivalenol (DON) based on an effective all-in-one bioprobe that composed of TiO 2 -B with Fluoro-coumarin silicon phthalocyanine (F-couSiPc) and luminol. Herein, TiO 2 -B with large specific area was served as a favorable carrier, greatly increased the loading of enhancer F-couSiPc and luminophore luminol, resulting in the tremendous enhancement of ECL signal. Specifically, F-couSiPc as coreaction accelerator could facilitate the decomposition of dissolved O 2 to generate substantial reactive oxygen species (ROS) to participate in the ECL reaction of luminol. Additionally, the prepared PEDOT/HA@mp MnO 2 was employed as the sensing platform of biosensor, which can not only capture substantial antibody to improve the sensitivity, but also could expedite the electronic transmission rate to make the ECL intensity further amplified. Ultimately, the proposed immunosensor presented favorable performance for the determination of DON, such as high sensitivity, good stability, wide liner range (from 1.0*10 −6 ng/mL to 10 ng/mL) and a low detection limit of 3.3*10 -7 ng/mL.
研究领域:
分析化学
·
食品安全检测
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Jing Hong,Zhanchi Zhu,Leisha Cui,Zhaojun Wang,Ying Hao,Xiaopeng Tian,Guosheng Cheng
Hematopoietic stem cell (HSC) expansion offers a key strategy to address the source limitation and donor shortages of HSCs for the treatment of various blood disorders. Specific remodeling of the complex bone marrow microenvironment that contributes to efficient in vitro expansion of HSCs remains challenging. Here, inspired by the regions with different stiffness levels in the bone marrow niche, a three dimensional (3D) bone marrow-mimicking composite scaffold created based on gelatin–hyaluronic acid (Gel–HA) hydrogels and graphene foams (GFs) was engineered to support the in vitro expansion of HSCs. The composite scaffold was prepared by forming a photo-cross-linked Gel–HA hydrogel surrounding the GF. The “soft” Gel–HA hydrogel and “stiff” GF replicate the structure and stiffness of the vascular niche and endosteal niche in the bone marrow, respectively. Furthermore, HSCs cultured in the Gel–HA/GF scaffold proliferated well and retained the CD34+CD38− immunophenotype and pluripotency, suggesting that the Gel–HA/GF composite scaffold supported the in vitro expansion of HSCs, maintaining the primitive phenotype and the ability to differentiate into functional blood cells. Thus, the hydrogel/graphene composite scaffold offers a means of facilitating HSC expansion through structurally and mechanically mimicking bone marrow niches, demonstrating great promise for HSC transplantation.
研究领域:
生物材料
·
组织工程
·
干细胞生物学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2016
·Vol. 16
·期 11
·1632-1642
·
IF 3.68
Yuankun Dai,Zhenzhen Gao,Lie Ma,Dongan Wang,Changyou Gao
A bioactive scaffold with desired microstructure is of great importance to induce infiltration of somatic and stem cells, and thereby to achieve the in situ inductive tissue regeneration. In this study, a scaffold with oriented pores in the radial direction is prepared by using methacrylated hyaluronic acid (HA-MA) via controlled directional cooling of a HA-MA solution, and followed with photo-crosslinking to stabilize the structure. Poly(lactide- co -glycolide) (PLGA) is further infiltrated to enhance the mechanical strength, resulting in a compressive modulus of 120 kPa. In vitro culture of bone marrow stem cells (BMSCs) reveals spontaneous cell aggregation inside this type of scaffold with a spherical morphology. In vivo transplantation of the cell-free scaffold in rabbit knees for 12 w regenerates simultaneously both cartilage and subchondral bone with a Wakitani score of 2.8. Moreover, the expression of inflammatory factor interleukin-1β (IL-1β) is down regulated, although tumor necrosis factor-α (TNF-α) is remarkably up regulated. With the anti-inflammatory, bioactive properties and good restoration of full thickness cartilage defect in vivo, the oriented macroporous HA-MA/PLGA hybrid scaffold has a great potential for the practical application in the in situ cartilage regeneration.
研究领域:
组织工程学
·
再生医学
·
生物材料科学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124262
·
IF 7.5
Siyu Song,Yirou Hu,Fanglin Guo,Dan Li,Tao Wang,Wei Peng,Feigao Xu
Antibiotic pollution in aquatic environments poses critical ecological and health risks worldwide. In this study, a novel Fe 3 S 4 /PDA/HA (FPA) composite was designed as a heterogeneous photo-Fenton catalyst for peroxymonosulfate (PMS) activation to degrade tetracycline hydrochloride (TCH). The FPA catalyst was synthesized through a solvothermal route combined with polydopamine (PDA) coating and humic acid (HA) functionalization. Characterizations revealed that PDA and HA modification effectively suppressed nanoparticle agglomeration, reduced iron leaching, broadened the visible-light response, and accelerated Fe 2 + /Fe 3+ redox cycling. Under visible-light irradiation, the FPA/PMS system attained 86.8% TCH removal and 45.6% total organic carbon mineralization within 60 min, with a pseudo-first-order rate constant (0.06658 min −1 ) 2.72-fold higher than that of pure Fe 3 S 4 . The catalyst maintained excellent catalytic activity over a wide pH range (2–10) and showed strong resistance to common coexisting anions. After five cycles, TCH degradation efficiency remained above 87%, confirming excellent reusability. Quenching tests and electron paramagnetic resonance demonstrated that •OH, •O 2 ⁻, SO 4 •⁻, and 1 O 2 were generated, with 1 O 2 acting as the predominant reactive oxygen species. Liquid chromatography–mass spectrometry revealed three TCH degradation pathways, and ECOSAR toxicity analysis verified that most intermediates exhibited lower toxicity than the parent compound. This work provides a promising and stable photo-Fenton catalyst for efficient degradation of antibiotic pollutants and offers new insights into advanced oxidation processes for wastewater remediation.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）