OPTICAL MATERIALS
·
2023
·
IF 3.9
Jie Chen,Chao Wang,Yu Yin,Rong Liu,Fanxu Meng,Shanshan Wang,Zhigang Liu,Shihua Yu
Intelligent regulation of energy transfer process among different rare earth ions doped in the matrix is an effective strategy to realize high-performance upconversion (UC) luminescence. Based on this, wheat ears like Yb 3+ /Er 3+ /(Tm 3+ , Ho 3+ ) triple doped YF 3 microrods were fabricated via hydrothermal method , and the morphology, crystal structure, UC luminescence performance dependent on Tm 3+ /Ho 3+ doping concentrations were studied. By comparing with the Yb 3+ , Er 3+ co-doped YF 3 microrods, the UC luminescence intensity is enhanced in Yb 3+ /Er 3+ /(Tm 3+ , Ho 3+ ) triple doped YF 3 samples due to the cross relaxation processes between Er 3+ and Tm 3+ /Ho 3+ . Moreover, red emission is enhanced more significantly than green emission in YF 3 : Yb 3+ , Er 3+ , Tm 3+ , which is contrary to that in YF 3 : Yb 3+ , Er 3+ , Ho 3+ . The possible energy transfer upconversion mechanism involved is discussed in detail. Meanwhile, an adjustable emission color is easy to achieve via altering the doped Er 3+ /Tm 3+ /Ho 3+ ion concentration . These studies on the UC luminescence enhancement mechanism of Yb 3+ /Er 3+ /(Tm 3+ , Ho 3+ ) triple doped YF 3 microrods are expected to provide a reference for the development of high-efficiency luminescent materials .
研究领域:
材料科学
·
光学材料
·
光子学
·
稀土掺杂
·
纳米光子学
✓ 已验证
DOI
高影响因子
DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 34
·13106-13118
·
IF 4.569
Hang Liu,Haiyan Wang,Xingke Zheng,Pengcheng Wang,Yuhong Zhang
In this work, Yb3+/RE3+ (RE = Er/Ho) co-doped Zn3Mo2O9 phosphors were synthesized by high-temperature solid-state reactions. Under 980 nm excitation, the upconversion (UC) luminescence thermal enhancement was obtained for Zn3Mo2O9:Yb3+/RE3+ phosphors. The green emission intensity of the Zn3Mo2O9:Yb3+/Er3+ sample was increased 5 times from 373 to 573 K. The red emission intensity of the Zn3Mo2O9:Yb3+/Ho3+ sample was enhanced 7.92 times. The anomalous thermal enhancement of UC emission was induced by the negative thermal expansion (NTE) of the Zn3Mo2O9 host. The energy transfer rate from the sensitizer (Yb3+) to the activator (RE3+) was enhanced because of the lattice contraction and distortion for NTE materials. Compared with the UC emission of Er3+single doped Zn3Mo2O9 sample, the luminescence thermal enhancement was absent, which contributed to proving the physical mechanism. The temperature sensing properties of the Zn3Mo2O9:Yb3+/Er3+ and Zn3Mo2O9:Yb3+/Ho3+ samples were also investigated based on the fluorescence intensity ratio (FIR) technology. The absolute sensitivity (SA) and relative sensitivity (SR) of Zn3Mo2O9:Yb3+/Er3+ phosphor reached 0.0060 K−1 and 0.72% K−1, which is based on the thermal coupling levels (2H11/2, 4S3/2) FIR of Er3+ ions. In addition, the SA and SR of Zn3Mo2O9:Yb3+/Ho3+ phosphor reached 0.0119 K−1 and 0.86% K−1, that is based on the non-thermal coupling levels (5S2/5F4, 5F5) FIR of Ho3+ ions. The research results indicate that the Zn3Mo2O9 host shows NET. The Yb3+/RE3+ co-doped Zn3Mo2O9 phosphors are good materials for highly sensitive optical temperature measurement, which can be used to develop thermally enhanced ratiometric optical thermometers.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 58
·36689-36697
·
IF 3.361
Hang Liu,Xiukai Jian,Mingtai Liu,Kailin Wang,Guangyao Bai,Yuhong Zhang
SrWO4 phosphors doped with Ho3+(Er3+)/Yb3+ are successfully prepared by a high temperature solid-state reaction method. The upconversion (UC) luminescence properties of all the samples have been investigated under 980 nm excitation. Strong green emissions are obtained in the SrWO4:Yb3+/Ho3+ and SrWO4:Yb3+/Er3+ samples with the naked eyes. In a temperature range going from 303 K to 573 K, the UC emission spectra of the phosphors have been measured. Then the temperature sensing properties also have been discussed via fluorescence intensity ratio (FIR) technology. For the SrWO4:Yb3+/Ho3+ phosphor, the FIR technologies based on thermal coupling levels (TCLs)(5F4,5F5) and non-thermal coupling levels (non-TCLs)(5S2, 5F4/5F5) are used for investigating the sensitivity. The results show that the maximum absolute sensitivity reaches 0.0158 K−1 with non-TCLs. As for Yb3+/Er3+ codoped SrWO4 phosphor, the maximum absolute sensitivity reaches 0.013 K−1 with TCLs (2H11/2,4S5/2) at a temperature of 513 K. These significant results demonstrate that the SrWO4:Ho3+(Er3+)/Yb3+ phosphors are robust for optical temperature sensors.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2023
·
IF 4.7
Haitong Wu,Haoye Li,Haihua Huo,Xinrun Li,Heyun Zhu,Lijiao Zhao,Jianzhao Liao,Zhaoxin Tang,Jianying Guo
Terbuthylazine (TBA) is one of the most commonly used and effective herbicides. However, due to its affinity for soil organic matter and water solubility, TBA can lead to biological health concerns. This study exposed broilers to TBA (0 mg/kg bw, 0.4 mg/kg bw, 4 mg/kg bw) for 28 days. The results showed significant pathological damage in broiler myocardial tissue, such as widening of the interstitial space, rupture of muscle fibers, and deposition of myocardial collagen fibers. In addition, Under the 0.4 mg/kg bw TBA exposure, myocardial oxidative stress was observed in broilers, which was accompanied by the activation of Nrf2/HO-1 pathway and the increased protein and mRNA levels of NQO1, NOX2 and SOD2 antioxidant enzymes . However, Nrf2/HO-1 protein and mRNA levels were reversed at 4 mg/kg bw TBA exposure. Meanwhile, the Nrf2/HO-1 mediated antioxidant defense was impaired. In contrast with the low dose, the protein and gene expression levels of NQO1, NOX2, and SOD2 were reduced in 4 mg/kg bw TBA group. The expression of GPX4 and SLC7A11 was significantly downregulated at both protein and mRNA levels. Beyond that, ACSL4 expression was significantly up-regulated, and the protein result was consistent with the mRNA expression, demonstrating the occurrence of ferroptosis . In general, TBA exposure activated the Nrf2/HO-1 pathway, resulting in ferroptosis . This study links ferroptosis to the Nrf2/HO-1 pathway, providing new insights into the potential role of TBA in myocardial toxicity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2025
·
IF 7.5
Yang Yu,Yurong Wang,Ziqi Yang,Zhanqiang Li,Dianxiang Lu,Xingmei Nan
Pulmonary hypertension is divided into five groups, and chronic exposure to hypoxia causes pulmonary hypertension in the third group -- high altitude pulmonary hypertension, which is commonly seen in patients with chronic obstructive pulmonary disease, sleep-disordered breathing, and interstitial lung disease. Its clinicopathological features include right heart overload and right ventricular hypertrophy, with severe patients potentially experiencing right heart failure or even death. The pathogenesis of high altitude pulmonary hypertension is complex; it includes oxidative stress, mitochondrial dysfunction, apoptosis, and pyroptosis. Pharmacological therapy may alleviate the condition if immediate descent to lower altitudes or supplemental oxygen is not possible. Herein, we preliminarily investigated the effect of methyleugenol on high altitude pulmonary hypertension through in vitro and in vivo experiments. Methyleugenol alleviated pulmonary arteriole constriction by acting on potassium ion channels, and inhibited the proliferation of pulmonary artery smooth muscle cells(PASMCs) by decreasing and reactive oxygen species levels, as well as inhibiting the expression of HIF-1α. The cardiac systolic function improved and mitochondrial structure of pulmonary artery smooth muscle cells in rats with high altitude pulmonary hypertension was significantly improved after methyleugenol gavage intervention, and malondialdehyde levels in serum of rats were decreased while those of superoxide dismutase and glutathione increased, suggesting that the reduction of oxidative stress may be one of the mechanisms to improve mitochondrial function. Western blot experiments showed that methyleugenol regulated the oxidative stress level in rats by activating Nrf2/HO-1 signaling pathway, activate p27Kip1, inhibit CDK4/CCND1/ p-ERK1/2 and inhibited HIF-1α/RASSF1/Ras axis to inhibit cell proliferation, thereby improving the occurrence and development of high altitude pulmonary hypertension in rats. The results of this study reveal that methyl eugenol has the potential to alleviate pulmonary vasoconstriction and remodeling in rat models of high-altitude pulmonary hypertension, providing a scientific basis for the application of this compound in improving pulmonary vascular remodeling.
研究领域:
药理学
·
心血管病学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Redox Biology
·
2024
·
IF 10.7
Xin Zhong,Kangwei Wang,Yonghua Wang,Luya Wang,Sudan Wang,Weijian Huang,Zhuyin Jia,Shan-Shan Dai,Zhouqing Huang
Continuous remodeling of the heart can result in adverse events such as reduced myocardial function and heart failure. Available evidence indicates that ferroptosis is a key process in the emergence of cardiac disease. P2 family purinergic receptor P2X7 receptor (P2X7R) activation plays a crucial role in numerous aspects of cardiovascular disease. The aim of this study was to elucidate any potential interactions between P2X7R and ferroptosis in cardiac remodeling stimulated by angiotensin II (Ang II), and P2X7R knockout mice were utilized to explore the role of P2X7R and elucidate its underlying mechanism through molecular biological methods. Ferroptosis is involved in cardiac remodeling, and P2X7R deficiency significantly alleviates cardiac dysfunction, remodeling, and ferroptosis induced by Ang II. Mechanistically, Ang II interacts with P2X7R directly, and LYS-66 and MET-212 in the C-type domain form a binding complex with Ang II. P2X7R blockade influences HuR-targeted GPX4 and HO-1 mRNA stability by affecting the shuttling of HuR from the nucleus to the cytoplasm and its expression. These results suggest that focusing on P2X7R could be a possible therapeutic approach for the management of hypertensive heart failure.
研究领域:
心血管疾病
·
分子生物学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Hongliang Li,Yingmeng Hou,Shiyu Jia,Mingqian Tan,Haitao Wang
Fucoxanthin (Fx) has garnered significant interest due to its exceptional biological properties. However, its efficacy in enhancing food quality and human health is contingent upon the solubility of the compound in water and its physicochemical stability. Therefore, nanocarriers must be developed to enhance the stability and biocompatibility of Fx. In this study, oxidized paramylon and Fx self-assembled nanoparticles (Fx-OEP) were prepared via the anti-solvent method, with a loading rate of 82.47 % for Fx. The Fx-OEP exhibited robust storage and photostability. In vitro simulated digestion assays demonstrated that Fx-OEP effectively protected Fx from premature gastric release, while achieving a release efficiency of 72.17 % in the intestinal phase. Fx-OEP has the capacity to scavenge a range of reactive oxygen species (ROS) induced by cellular oxidative stress. Treatment with Fx-OEP resulted in a significant reduction in ROS accumulation in insulin-resistant HepG2 cells, which was attributed to the activation of the nuclear factor E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) pathway. This, in turn, activated insulin receptor substrate 1/glucose transporter type 4 (IRS1/GLUT4), promoting cellular glucose absorption and utilization. These findings indicate the potential of self-assembled nanoparticles based on oxidized paramylon as a new type of nanocarrier for delivering hydrophobic substances.
研究领域:
营养学
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2022
·
IF 3.322
Zixin Li,Luchen Shan,Pei Yu
Nitroglycerin (NTG) is recommended as the first-line drug in angina pectoris though its prolonged use impacts nitroglycerin tolerance. In this study, we investigated the preventive effect of Tetramethylpyrazine (TMP), a famous Chinese medicine used for cardiovascular diseases, on NTG-induced tolerance and further explained the underlying mechanism of its action. The results revealed that pretreatment of TMP improved NTG-induced tolerance in vitro thoracic aorta rings and in rats. Proteomic analysis showed oxidative stress and ribosome proteins dyshomeostasis in NTG-tolerance vessels. TMP attenuated the oxidative stress by enhancing the protein expression of ALDH2 , Nrf2 and HO-1. In addition, TMP recovered the down-regulated expression of RpL10a induced by nitroglycerin. Therefore, TMP could prevent nitroglycerin tolerance in rats, which may be mediated by up-regulation of ALDH2 and Nrf2/HO-1 signaling pathway and involved in the restoration of ribosome homeostasis . These findings indicate the potential of TMP as a promising medicine for preventing the development of nitroglycerin-induced tolerance.
研究领域:
心血管药理学
·
分子生物学
·
药物动力学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food & Function
·
2025
·
IF 5.4
Jiaxuan Li,Yu Li,Xunyu Song,Yuxiao Wang,Yinxu Zhang,Xinghua Gao,Mingqian Tan,Wentao Su
High-fat diets (HFDs) impair the intestinal barrier by increasing permeability and oxidative stress, which contributes to obesity-related disorders. Ulva lactuca, a marine green alga, produces extracellular vesicles (UEVs) that remain underexplored as functional food components. In this study, UEVs were isolated and characterized, showing a cup-like shape morphology with average diameter of 188.8 nm. Functional assays demonstrated that UEV treatment attenuated oxidative stress, reduced apoptosis, and restored tight junction proteins. In a gut-on-a-chip model, UEVs improved transepithelial electrical resistance (TEER) and enhanced mucin secretion under HFD-mimicking stress. Mechanistic studies revealed that UEVs activated the Nrf2/Keap1/HO-1 signaling pathway, promoting nuclear translocation of Nrf2 and upregulation of antioxidant genes. Collectively, these findings highlight UEVs as novel food-derived nanostructures with dual functions in oxidative stress reduction and intestinal barrier protection, supporting their potential in functional food applications targeting metabolic gut disorders.
研究领域:
海洋生物学
·
营养科学
·
分子生物学
·
纳米技术
·
胃肠病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 89
·56229-56238
·
IF 3.108
Wei Wang,Yunxi Li,Shanshan Hu,Xuemei Zhang,Jianfeng Tang,Jun Yang
Ba3Sc2F12:Yb3+, Ln3+ (Ln = Er, Ho, Tm) crystals with various morphologies have been synthesized via a one step hydrothermal route. X-ray diffraction (XRD), scanning electron microscopy (SEM), and up conversion photoluminescence (UCPL) spectra were used to characterize the samples. The influences of surfactants, pH values, and molar ratio of F−/Sc3+ on the crystal phase, size and shape of final products have been studied in detail. The aspect ratio of products increased gradually with the increase of F−/Sc3+ molar ratio. Additionally, the luminescence properties of Ba3Sc2F12:Yb3+, Ln3+ (Ln = Er, Ho, Tm) crystals were systematically studied. The blue emission is attributed to the 1G4 → 3H6 transition of Tm3+; the green emission can be obtained due to the 2H11/2/4S3/2 → 4I15/2 transitions of Er3+ and the 5S2/5F4 → 5I8 transition of Ho3+; the red emission comes from the 4F9/2 → 4I15/2 transition of Er3+ and the 1G4 → 3F4 transition of Tm3+. Based on the generation of red, green, and blue emissions in the different Ln ion-doped Ba3Sc2F12, the white light emission can be obtained by appropriately doping Yb3+, Er3+, and Tm3+ in the present Ba3Sc2F12 crystals due to the color superposition principle. Here, the sample Ba3Sc1.5856F12:0.4Yb3+, 0.01Er3+, 0.0044Tm3+ crystals showed suitable intensity ratio of blue, green and red (RGB) emissions resulting in bright white light with CIE-x = 0.274 and CIE-y = 0.287, which was illustrated by a photograph under excitation of 980 nm. The prepared Ba3Sc2F12:Ln3+ phosphor has potential applications in the fields of three dimensional displays, back lighting and white light sources.
研究领域:
材料科学
·
光学材料
·
发光学
·
光子学
·
无机化学
✓ 已验证
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2026
·
IF 5.2
Tianqi Wang,Shaoze Jing,Ke Ma,Fan Zhang,Bing Wang,Yu Lei,Jun Zhang
Osteoarthritis (OA) is a progressive degenerative joint disorder characterized by articular cartilage degradation, persistent oxidative stress, and chronic inflammation. Targeting oxidative damage within the joint microenvironment represents a promising avenue for disease modification, offering potential to preserve cartilage integrity, alleviate inflammatory cascades, and ultimately delay structural progression. Lipid nanoparticles were prepared by thin-film hydration and extrusion, then embedded into GelMA microspheres via a microfluidic droplet platform with UV crosslinking to form a sustained-release system. Biocompatibility, ROS-scavenging, anti-inflammatory, and chondroprotective effects were evaluated in vitro and in vivo, while transcriptome sequencing was applied to elucidate system-induced molecular alterations. In vitro , Api-LNP@GMS markedly attenuated ROS accumulation and inflammatory responses in IL-1β-stimulated chondrocytes, as demonstrated by ROS fluorescence imaging, immunofluorescence, Western blotting, and qRT-PCR analyses. In vivo , intra-articular administration in anterior cruciate ligament transection (ACLT) rats effectively alleviated joint inflammation while preserving cartilage integrity and functional capacity. Moreover, transcriptome-wide RNA sequencing, integrated with pathway enrichment analysis and validated by molecular assays, revealed robust activation of the Nrf2–HO-1 antioxidant signaling axis. Api-LNP@GMS is a multifunctional antioxidant biomaterial platform that integrates a natural therapeutic with a sustained-release delivery system, offering a safe and effective strategy to reprogram the osteoarthritic microenvironment and mitigate disease progression. Download: Download high-res image (281KB) Download: Download full-size image
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DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 14
·118532
·
IF 6.3
Jingdan Lei,Xiaoyun Yang,Mengxiang Wu,Xiwei Zhang,Di Yuan,Huijuan Geng,Chong Han,Zhaoyang Han,Zhenjie Tang,Chao Wang
Mg 3 (Sb, Bi) 2 is a promising mid- to low- temperature thermoelectric material owing to its earth-abundant composition. However, its performance is limited by low intrinsic carrier concentration and the inherent trade-off among thermoelectric parameters. Herein, large-grain sized Mg 3.01 Sb 1.3 Bi 0.69 Te 0.01 Ho 0.07 are fabricated via melting method at 1423 K using a tantalum-sealing technique. A high peak zT of 1.6 at 700 K is realized, along with a peak power factor of 24 μW cm −1 K −2 and a low κ L of 0.41 W m −1 K −1 . The superior performance originates from synergistic manipulation of electron and phonon transport. Ho doping optimizes carrier concentration up to 7.2 × 10 19 cm −3 due to its small electronegativity difference with Mg, while the large grain ensures high carrier mobility. Simultaneously, atomic-scale alloy disorder suppresses phonon propagation, resulting in a substantial reduction in lattice thermal conductivity. This work highlights the great potential of synergistic transport engineering for high-performance Mg 3 (Sb, Bi) 2 -based thermoelectric materials.
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DOI
高影响因子
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