CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Zheng Jia,Yadong Gao,Husile Han,Chaonan Wang,Jiaqing Wang,Junjie Guo,Shuhe Zhang,Yifan Li,Junwei Ge,Fang Wang,Mingchun Gao
Subunit vaccines represent a leading platform in modern vaccinology due to their defined antigenicity and favorable safety profiles. However, their efficacy requires advanced adjuvants to overcome limited immunogenicity. While plant-derived polysaccharides are widely recognized for their immunostimulatory properties, their capacity to induce trained immunity remains largely unexplored. This study demonstrates, for the first time, that a Konjac glucomannan (KGM)-based hydrogel can induce trained immunity. Specifically, we developed an injectable hydrogel composed of KGM and carboxymethyl cellulose (CMC) that confers protection against Staphylococcus aureus infection via trained immunity. Mechanistically, peritoneal macrophages from KGM/CMC-trained mice exhibited a metabolic shift toward oxidative phosphorylation, accompanied by the significant accumulation of key metabolites such as succinate and palmitate. This KGM/CMC-induced trained immunity provided rapid protection within 3 days and broad-spectrum defense against Gram-positive bacteria. Furthermore, the hydrogel synergized with specific antigens and aluminum adjuvants to significantly potentiate single-dose subunit vaccines, increasing the survival rate of challenged mice to 50%. These findings identify the KGM/CMC as a promising delivery vehicle for vaccines leveraging trained immunity and establish a proof-of-concept for adapting plant-derived bioactive polysaccharides into next-generation immunomodulatory tools.
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高影响因子
DESALINATION
·
2025
·
IF 9.8
Xiaotong Zhang,Dongxue Wang,Chunyu Yang,Zhuoran Yang,Wei Guo
Water pollution and freshwater scarcity are pressing global challenges. Solar-driven interfacial water evaporation (SDIWE) emerges as a promising and eco-friendly strategy to tackle both challenges simultaneously. Utilizing a high-temperature carbonized soft-template approach, the Konjac Glucomannan/Curdlan/C 3 N 4 (KCN) evaporator features a highly porous network and a superhydrophilic surface, which enhance water transport efficiency. The evaporator efficiently absorbs over 90 % of solar radiation from 200 to 2500 nm and contains an optimized proportion of pyrrolic nitrogen, thereby lowering water evaporation enthalpy and enhancing vapor generation. Consequently, the KCN-based evaporator reaches an impressive evaporation rate of 4.70 kg·m −2 ·h −1 and demonstrates a photothermal conversion efficiency of 97.92 %. The system also ensures effective ion rejection, successfully eliminating Na + , Mg 2+ , K + , and Ca 2+ to levels compliant with World Health Organization guidelines, while exhibiting antimicrobial activity. Additionally, it degrades persistent organic pollutants, such as phenol, via advanced oxidation processes (AOPs). The incorporation of nitrogen functionalities boosts peroxymonosulphate adsorption and activation, facilitating abundant active sites for reactive oxygen species generation. This study integrates SDIWE with AOPs, offering an efficient and sustainable solution for desalination and wastewater purification.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·123815
·
IF 7.5
Lan Ma,Pengyu Hu,Jiazhi Han,Longwen Lei,Xindi He,Yanzhu Guo
The inherent hydrophilicity and limited functionality of konjac glucomannan (KGM) have restricted its widespread utilization as a competitive candidate as food packaging materials. In this study, lotus leaf-inspired KGM-based composite films were prepared by replicating hierarchical micro/nano-papillae from lotus leaf surfaces via a template method, followed by single-sided impregnation with beeswax to reduce surface energy and enhance hydrophobicity. The resulting biomimetic film exhibited a water contact angle up to 134.63°. Quercetin (QR), a natural flavonoid compound, was incorporated into the KGM matrix and endowed the films with strong antioxidant, antibacterial, and UV-shielding properties. Furthermore, the QR-loaded films showed excellent pH-responsive colorimetric behavior for real-time freshness indication and stable fluorescence suitable for preliminary anti-counterfeiting demonstration. In the pork preservation test, the biomimetic film delayed lipid oxidation and quality deterioration, resulting in a modest shelf-life extension of 2 days compared with commercial polyethylene packaging under laboratory storage conditions. In addition, the film demonstrated excellent biodegradability and biocompatibility, as evidenced by 83.07% of mass loss after 35 days of soil burial, 90% of cell viability, and no adverse effects on pak choi seed germination. Therefore, this study provides a lotus-leaf-inspired structural integration strategy for developing biodegradable KGM/BC-based packaging films and offers a feasible pathway for the functional application of biomass materials in food packaging.
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高影响因子
POLYMER BULLETIN
·
2023
·Vol. 81
·期 2
·1373-1388
·
IF 3.2
Jin Yu,Lu Zhenbang
Market demand for food packing bags is large. However, low mechanical properties and strong electrostatic damage limit their use. In this work, carrageenan/konjac glucomannan/graphene oxide (GO) nanocomposite films were prepared by solution casting. First, Hummers method was used to obtain GO nanosheets. Then, GO-filled composites (various GO dosages) were fabricated. Surface morphology of films was investigated. After that, stress–strain curves of films were determined, and mechanical properties of films after 80 °C thermal aging were studied. In the end, electrical and thermal conductivities of films were measured. GO can play an important role in improving mechanical, antistatic and heat-conducting performances of films. The optimal composite (3.6 wt% GO) can exhibit promising features including a high breaking strength of ~ 130 MPa (~ 65 MPa after 80 °C thermal aging for 30 min), high electrical conductivity of ~ 0.01 S m −1 at 20 Hz under 1 V and high thermal conductivity of ~ 0.74 W m −1 K −1 at room temperature. This research will favor a large-scale fabrication of functional and environmental composites for food packaging.
研究领域:
材料科学
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纳米技术
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高分子科学
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食品包装
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机械工程
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高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Peng Lu,Jinying Guo,Jiawei Fan,Ping Wang,Xiang Yan
The effects of dual sequential modification using konjac glucomannan and ultrasound treatments at power densities of 15–37.5 W/L on the hydration, rheology and structural characteristics of frozen dough were investigated in this study. The results revealed that the konjac glucomannan and ultrasound treatments improved the textural properties of frozen dough, but had a negative impact on its viscoelasticity. Furthermore, konjac glucomannan and ultrasound treatments increased the content of free sulfhydryl group and disulfide bond, as well as improved the freeze tolerance of dough. The results exhibited that the enthalpy of frozen dough decreased by 20.42 % compared with the frozen blank control dough under ultrasonic power density of 22.5 W/L. The network structure of frozen dough treated by konjac glucomannan and ultrasound was more ordered and integral than that of frozen blank control dough. These results provide valuable knowledge on the application of konjac glucomannan and ultrasound to frozen wheat-based foods.
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PubMed
高影响因子
Polymers
·
2026
·Vol. 18
·期 18
·2246
·
IF 5.8
Xinyun Mai,Surapon Saensouk,Piyaporn Saensouk,Xingyu Wang,Qinjiabao Hu,Lingling He,Bin Huang,Caihua Liu
Cuminaldehyde (CA), a major bioactive constituent of cumin essential oil, was incorporated into gelatin/konjac glucomannan (Gel/KGM) composite films at different levels, expressed relative to the polymer content (mL/g polymer), to investigate its effects on film structure, physicochemical properties, and antioxidant activity. Structural characteristics of the films were examined using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). Mechanical properties, surface wettability, optical properties, water sensitivity, and antioxidant activity were also determined. Spectroscopic analyses indicated changes in the molecular interactions of the Gel/KGM matrix following CA incorporation, while XRD and SEM analyses showed reduced structural order and a more heterogeneous microstructure at higher CA levels. Representative contact-angle observations showed an initial angle of 40.2° for the Control and 58.0° for CA-10, suggesting a tendency toward reduced surface wettability after CA incorporation. The addition of CA also improved UV-shielding properties and enhanced antioxidant responses, although the magnitude and trend of the antioxidant effect depended on the assay. In contrast, higher CA levels significantly reduced tensile strength and increased water solubility, whereas the tensile strength of films containing 1 mL CA did not differ significantly from that of the control (p> 0.05). These results demonstrate that the structural, physicochemical, and functional responses of Gel/KGM composite films varied with the nominal CA loading. Among the tested formulations, CA-3 represented a possible compromise between structural integrity and functional performance. Further studies using real food matrices are required to validate its practical applicability under actual food-packaging conditions.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Gaiying Li,Yongchao Jiang,Mengya Li,Wenjie Zhang,Qian Li,Keyong Tang
Herein, oxidized konjac glucomannan (OKG) with different molecular weight (M w ) were prepared as polysaccharide crosslinker to reinforce gelatin-based hydrogels. Then, properties of composite hydrogels with various OKGs were investigated via a series of methods, including Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), rheology, mechanical and biocompatibility tests. The results confirmed an increased degree of crosslinking and entanglement between gelatin and OKG with higher M w . Besides, composite hydrogels not only showed increased mechanical strength, but self-healing ability at the same time, which were closely affected by the M w of OKG. Furthermore, both composite hydrogels could support well proliferation of cells, which showed excellent capacity in tissue engineering and biomedical applications. In brief, this work provides a facile method to promote the overall properties of gelatin-based hydrogels, meanwhile revealed the relationship and mechanism underlying the effects of OKG with different M w on composite hydrogels.
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高影响因子
Polymers
·
2020
·Vol. 12
·期 2
·385
·
IF 3.426
Dongling Qiao,Zhong Wang,Chi Cai,Song Yin,Hong Qian,Binjia Zhang,Fatang Jiang,Xiang Fei
Here, we tailored the multi-level structural and practical (mechanical/hydrophilic) features of gelatin films by varying the konjac glucomannan (KGM) content and the film-forming temperatures (25 and 40 °C). The addition of KGM apparently improved the mechanical properties and properly increased the hydrophilicity. With the lower temperature (25 °C), the increase in KGM reduced the gelatin crystallites of films, with detectable KGM–gelatin interactions, nanostructures, and micron-scale cracks. These structural features, with increased KGM and negligibly-occurred derivatizations, caused initially an insignificant decrease and then an increase in the strength, with a generally-increased elongation. The higher temperature (40 °C) could reduce the strength and slightly increase the elongation, related to the reduced crystallites of especially gelatin. With this higher temperature, the increase in KGM concurrently increased the strength and the elongation, mainly associated with the increased KGM and crystallites. Additionally, the increase in KGM made the film more hydrophilic; the multi-scale structural changes of films did not dominantly affect the changing trend of hydrophilicity.Keywords:konjac glucomannan/gelatin film;multi-level structure;practical features
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xiaowei Xu,Jie Yong,Lin Wang,Su Chen,Jie Pang
The aim of this study was to utilize pH-responsive hydrogel skin scaffolds to achieve the sustained release of bioactive compounds (BCs) to promote wound healing. ZIF-8@flavanone nanoparticles were successfully synthesized through microfluidic channels and integrated into a hydrogel scaffold consisting of carrageenan (KC) and konjac glucomannan (KGM) to create a pH-responsive composite hydrogel scaffold. The unique pore structure of ZIF-8 efficiently loaded the active material, and the coordination bonds were disrupted in a slightly acidic environment, allowing the release of flavonoids. The natural macromolecular polysaccharides KC and KGM have good biocompatibility, and as a moist but not wet hydrogel scaffold substrate, they more closely resemble the growth environment of cells and are more favorable for wound healing. The hydrogel scaffolds developed in this study had a tensile strength of 1.15 MPa, an elongation at break of 320 %, good biocompatibility, a relative cell viability of 99.6 %, relative antimicrobial rate of 96.3 % ( E. coli ) and 95.8 % ( S. aureus ), respectively, and a release rate of 43.3 % at a pH of 5.0, and a wound closure rate at 15 d of 90.5 %, contributing to the improvement of wound healing performance and providing new possibilities for customized antimicrobial wound dressings.
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高影响因子
Food Packaging and Shelf Life
·
2024
·
IF 8.5
Yile Zhao,Zheng Wu,Chen Chen,Olaniyi Amos Fawole,Aili Jiang,Xiangzheng Yang,Da Wang,Xian Li,Di Wu,Kunsong Chen
Preservation of fresh-cut fruits is crucial due to their susceptibility to oxidative browning, and environmentally friendly food packaging has emerged as a promising solution. In the present study, deacetylated konjac glucomannan/carboxylated cellulose nanofibers (DKGM/CCNF) composite films were prepared through a stepwise reinforcement strategy. L-Cysteine and glutathione, screened as the two best anti-browning substances, were respectively loaded into the DKGM/CCNF composite films. The anti-browning effect and mechanism of the DKGM/CCNF functional films were explored on fresh-cut apples. The results demonstrated that deacetylation improved the mechanical properties, surface hydrophobicity, and thermal stability of the films. The incorporation of CCNF further improved the mechanical properties, surface hydrophobicity, and water vapor barrier properties of the films. The fresh-cut apples packaged in the DKGM/CCNF functional films exhibited satisfactory appearance during the 9 d storage. The browning of fresh-cut apples was inhibited by enhancing the activity of related antioxidant enzymes, maintaining higher total phenolic content, and reducing hydrogen peroxide levels. Overall, the DKGM/CCNF functional films prepared in the present study have the potential application prospects of extending the shelf life of fresh-cut fruits.
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高影响因子
BMC Oral Health
·
2024
·Vol. 24
·期 1
·1-15
·
IF 2.6
Zou Yin,Mei Xue,Wang Xinhe,Zhang Xuan,Wang Xun,Xiang Wen,Lu Naiyan
Background Effective treatments for the alveolar bone defect remain a major concern in dental therapy. The objectives of this study were to develop a fibrin and konjac glucomannan (KGM) composite hydrogel as scaffolds for the osteogenesis of nasal mucosa-derived ectodermal mesenchymal stem cells (EMSCs) for the regeneration of alveolar bone defect, and to investigate the osteogenesis-accelerating effects of black phosphorus nanoparticles (BPNs) embedded in the hydrogels.Methods Primary EMSCs were isolated from rat nasal mucosa and used for the alveolar bone recovery. Fibrin and KGM were prepared in different ratios for osteomimetic hydrogel scaffolds, and the optimal ratio was determined by mechanical properties and biocompatibility analysis. Then, the optimal hydrogels were integrated with BPNs to obtain BPNs/fibrin-KGM hydrogels, and the effects on osteogenic EMSCs in vitro were evaluated. To explore the osteogenesis-enhancing effects of hydrogels in vivo, the BPNs/fibrin-KGM scaffolds combined with EMSCs were implanted to a rat model of alveolar bone defect. Micro-computed tomography (CT), histological examination, real-time quantitative polymerase chain reaction (RT-qPCR) and western blot were conducted to evaluate the bone morphology and expression of osteogenesis-related genes of the bone regeneration.Results
The addition of KGM improved the mechanical properties and biodegradation characteristics of the fibrin hydrogels. In vitro, the BPNs-containing compound hydrogel was proved to be biocompatible and capable of enhancing the osteogenesis of EMSCs by upregulating the mineralization and the activity of alkaline phosphatase. In vivo, the micro-CT analysis and histological evaluation demonstrated that rats implanted EMSCs-BPNs/fibrin-KGM hydrogels exhibited the best bone reconstruction. And compared to the model group, the expression of osteogenesis genes including osteopontin (Opn, p < 0.0001), osteocalcin (Ocn, p < 0.0001), type collagen (Col , p < 0.0001), bone morphogenetic protein-2 (Bmp2, p < 0.0001), Smad1 (p = 0.0006), and runt-related transcription factor 2 (Runx2, p < 0.0001) were all significantly upregulated.Conclusion s
EMSCs/BPNs-containing fibrin-KGM hydrogels accelerated the recovery of the alveolar bone defect in rats by effectively up-regulating the expression of osteogenesis-related genes, promoting the formation and mineralisation of bone matrix.
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高影响因子
Foods
·
2024
·Vol. 13
·期 13
·2007
·
IF 4.7
Huimin Xiao,Lin Wang,Nitong Bu,Jie Duan,Jie Pang
Due to the growing concerns surrounding microbial contamination and food safety, there has been a surge of interest in fabricating novel food packaging with highly efficient antibacterial activity. Herein, we describe novel photodynamic antibacterial konjac glucomannan (KGM)/polyvinylpyrrolidone (PVP) nanofibers incorporated with lignin-zinc oxide composite nanoparticles (L-ZnONPs) and curcumin (Cur) via electrospinning technology. The resulting KGM/PVP/Cur/L-ZnONPs nanofibers exhibited favorable hydrophobic properties (water contact angle: 118.1°), thermal stability, and flexibility (elongation at break: 241.9%). Notably, the inclusion of L-ZnONPs and Cur endowed the nanofibers with remarkable antioxidant (ABTS radical scavenging activity: 98.1%) and photodynamic antimicrobial properties, demonstrating enhanced inhibitory effect against bothStaphylococcus aureus(inhibition: 12.4 mm) andEscherichia coli(12.1 mm). As a proof-of-concept study, we evaluated the feasibility of applying nanofibers to fresh strawberries, and the findings demonstrated that our nanofibers could delay strawberry spoilage and inhibit microbial growth. This photodynamic antimicrobial approach holds promise for design of highly efficient antibacterial food packaging, thereby contributing to enhanced food safety and quality assurance.
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高影响因子
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