Pharmaceutics
·
2022
·Vol. 14
·期 7
·1337
·
IF 6.525
Lijun Song,Jiabo Chen,Yuxuan Feng,Yujing Zhou,Feng Li,Guiqin Dai,Yue Yuan,Haosen Yi,Yupei Qian,Siyan Yang,Yang Chen,Wenchang Zhao
Genistein (Gen), a kind of natural isoflavone drug monomer with poor water solubility and low oral absorption, was incorporated into oral nanoparticles with a new mesoporous carrier material, NH2-MCM-41, which was synthesized by copolycondensation. When the ratio of Gen to NH2-MCM-41 was 1:0.5, the maximum adsorption capacity of Gen was 13.15%, the maximum drug loading was 12.65%, and the particle size of the whole core–shell structure was in the range of 370 nm–390 nm. The particles were characterized by a Malvern particle size scanning machine, XRD, Fourier transform infrared spectroscopy, scanning electron microscopy, and nitrogen adsorption and desorption. Finally, Gen-NH2-MCM-41 was encapsulated by sodium alginate (SA), and the chimerism of this material, denoted as GEN-NH2[email protected], was investigated. In vitro release experiments showed that, after 5 h in artificial colon fluid (pH = 8.0), the cumulative release reached 99.56%. In addition, its anti-rotavirus (RV) effect showed that the maximum inhibition rate was 62.24% at a concentration of 30 μM in RV-infected Caco-2 cells, and it significantly reduced the diarrhea rate and diarrhea index in an RV-infected-neonatal mice model at a dose of 0.3 mg/g, which was better than the results of Gen. Ultimately, Gen-NH2[email protected]was successfully prepared, which solves the problems of low solubility and poor absorption and provides an experimental basis for the application of Gen in the clinical treatment of RV infection.Keywords:genistein;mesoporous silica;Caco-2 cells;sodium alginate;targeted release
研究领域:
药学
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纳米技术
·
病毒学
·
药物递送系统
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DOI
PubMed
高影响因子
Food Chemistry-X
·
2026
·
IF 9.2
Kangqing Yuan,Fangxuan Yi,Jiawei Wang,Xiangyou Wang
The postharvest quality of Agaricus bisporus declines rapidly during refrigerated storage. A controlled-release system (Eugenol@MCM-41) was prepared by loading eugenol into MCM-41, with a loading capacity of 51%. Physicochemical characterization and all-atom molecular dynamics (MD) simulations were combined to clarify the sustained-release mechanism. MD simulations provided supportive evidence for favorable eugenol–silica interfacial interactions and restricted surface-associated mobility in the mesoporous model. In vitro release exhibited clear medium dependence and followed the Weibull model, consistent with diffusion-dominated release under confinement. In storage trials at 4 ± 1 °C, Eugenol@MCM-41 extended acceptable mushroom quality to 15 days. The treatment reduced weight loss, maintained firmness, delayed browning, and lowered malondialdehyde accumulation versus the control and pristine MCM-41. These results connect nanoscale confinement with preservation performance and support Eugenol@MCM-41 as an effective eugenol delivery system for preserving highly perishable foods.
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DOI
PubMed
高影响因子
ChemCatChem
·
2026
·Vol. 18
·期 2
·e01717
·
IF 3.9
Yimeng Li,Shiji Guo,Ruchao Yin,Jinlong Huang,Ying Kan,Yufei Lan,Hong Zhang,Hailian Tang,Guoyi Bai
The hydrogenation of dioctyl phthalate (DOP) to dioctyl 1,2-cyclohexanedicarboxylate represents an effective pathway for the production of environmentally friendly plasticizers. However, due to the intrinsic stability of the aromatic ring, the development of efficient and stable non-noble metal catalysts remains a key challenge. In this work, an efficient and stable La-modified MCM-41-supported Ni catalyst (Ni/La-M) was developed. The effects of different La introduction methods on the structural and catalytic properties of the catalyst were systematically investigated. The Ni/La-M catalyst, prepared via a two-step hydrothermal method, achieved 99% DOP conversion under mild conditions (140 °C, 2 MPa H 2 , 1 h) and retained over 90% activity after nine cycles. Characterization results revealed that La incorporation significantly enhanced the interaction between Ni and the support, effectively suppressed Ni particle sintering, and increased the fraction of exposed active sites. Compared with other La-introduction methods, the “La-first, Ni-second” strategy exhibited superior activity retention and cycling stability. This approach provides a new design strategy concept for constructing high-performance non-noble metal catalysts in a controllable manner. Graphical La was introduced during MCM-41 synthesis to build a La-modified support, enhancing Ni–support interaction, dispersing Ni species, and increasing catalyst acidity. This strategy improves catalytic activity for dioctyl phthalate hydrogenation to dioctyl 1,2-cyclohexanedicarboxylate and suppresses Ni sintering and leaching, providing mechanistic insight for designing stable green hydrogenation catalysts.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaosong Zhou,Xukai Li,Weirui Chen,Laisheng Li
Perfluorinated compounds (PFCs), which were difficult to biodegrade and posed significant ecological and health risks, had made their removal an urgent global challenge. Herein, NH 2 -MCM-41 was designed by modifying MCM-41 with 3-aminopropyltriethoxysilane (APTS) to remove PFOA, PFOS and OBS. X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) results indicated that though the implanting of NH 2 – on MCM-41 decreased S BET and pore size, but it dramatically increased the PFOA, PFOS and OBS adsorption capacity. The maximum uptake capacity of NH 2 -MCM-41 increased from 14.41 to 350.61, 19.53 to 445.11, and 28.6 to 452.98 mg/g for PFOA, PFOS and OBS, respectively. Three PFCs adsorptions were more favorable under acidic condition. Both the pseudo-second-order and intra-particle diffusion models provided a good fit for the kinetic data, and the adsorption isotherms were well described by the Langmuir and Freundlich models. The primary adsorption mechanisms involved hydrophobic interactions, electrostatic forces, H bond interaction and micellar or sub-micellar effects. This study demonstrated valuable insights into the applicability of NH 2 -MCM-41 for environmental remediation.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
ChemistrySelect
·
2026
·Vol. 11
·期 1
·e05258
·
IF 2
Qiong-Ru Wu,Meng-Ge Mao,Cheng-Yang Jiao,Jian-Bo Yang,Xin-Yu Li,Hua Mei,Yan Xu
Methanol steam reforming for hydrogen production is a promising hydrogen production technology that can meet the process or operation of hydrogen preparation, storage, transportation, and downstream utilization, contributing to the achievement of carbon neutrality. In this study, copper-based catalysts Cu x /MCM-41/HCOOH (x = 0.10, 0.15, 0.25) and Cu 0.15 X 0.01 /MCM-41/HCOOH (X = Y, Ga, Zr) were prepared by the modified impregnation method using MCM-41 as the carrier. In addition, the catalysts were comprehensively characterized using a variety of test methods, and the effects of copper content and type of additives on catalyst performance were investigated. Among the six catalysts, the Cu 0.15 Y 0.01 /MCM-41/HCOOH catalyst exhibited the lowest reduction temperature for CuO, the most effective dispersion of active metal, and the formation of more Cu 0 /Cu + species, demonstrating outstanding catalytic performance. Specifically, the methanol conversion rate achieved 99.85% with a H 2 selectivity of up to 99.91% and CO selectivity and CO 2 selectivity of 1.55% and 98.45%, respectively, at optimal reaction conditions of 250°C, the S/C molar ratio of 3:2, and the weight hourly space velocity (WHSV) of 0.16 h −1 . Graphical The Cu 0.15 Y 0.01 /MCM-41/HCOOH catalyst was prepared via a modified impregnation method for methanol steam reforming. At a reaction pressure of 1 MPa, a reaction temperature of 250°C, a steam-to-carbon ratio of 1.5, and a weight hourly space velocity of 0.16 h −1 , the catalyst exhibited a methanol conversion of 99.85%, a H 2 selectivity of 99.91%, and a CO selectivity of 1.55%. The catalyst demonstrated good stability, with no significant deactivation observed during the 110-h stability test.
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高影响因子
JOURNAL OF POROUS MATERIALS
·
2022
·Vol. 30
·期 1
·71-81
·
IF 2.523
Xu Xiaofei,Song Ke,Guo Jie,Liu Shima,Zhou Xianwu,He Jian
In this study, an amino-functionalized MCM-41 mesoporous material was prepared via hydrothermal method for the adsorption of chlorogenic acid from Eucommia ulmoides leaf extracts. The as prepared NH 2 -MCM-41 was characterized by X-ray diffraction, FT-IR spectroscopy and N 2 adsorption–desorption isotherms. The results show that have good mesoporous structure. The batch experiments showed that adsorption process was more in line with the pseudo-second order kinetic model, which indicated the chemisorption played an important role in the adsorption process; Isothermal adsorption results showed that the adsorption of chlorogenic acid by NH 2 -MCM-41 was more consistent with Langmuir model, indicating that multilayer adsorption process occurred. Thermodynamic analyses demonstrated that the chlorogenic acid adsorption on NH 2 -MCM-41 abided by a spontaneous and exothermic procedure with entropy decreased. The purity of chlorogenic acid could be increased from 17.36 to 85.60% under the optimal conditions t = 9 h, temperature = 333 K, pH 6. These results indicated that NH 2 -MCM-41 is a promising adsorbent for the separation and purification of chlorogenic acid from Eucommia ulmoides leaf extracts.
研究领域:
材料科学
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植物化学
·
药物分离纯化
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高影响因子
AICHE JOURNAL
·
2013
·Vol. 59
·期 12
·4696-4704
·
IF 2.493
Jun Xiong,Wenshuai Zhu,Huaming Li,Yehai Xu,Wei Jiang,Suhang Xun,Hui Liu,Zhen Zhao
MCM-41-supported Fenton-like ionic liquid catalysts were synthesized by the grafting method and applied in the removal of sulfur compounds in model oil. The structure and property of the catalysts were characterized by Fourier transform infrared spectra, X-ray diffraction, diffuse reflectance spectra, transmission electron microscopy, thermogravimetric and differential scanning calorimetry, and N 2 adsorption-desorption. Results suggested that Fenton-like ionic liquid was supported on mesoporous material MCM-41. Different desulfurization systems were studied. The results indicated that at room-temperature (30°C) for 1 h, MCM-41-supported Fenton-like ionic liquid in extraction combined with catalytic oxidative desulfurization (ECODS) system showed a high catalytic activity with H 2 O 2 as the oxidant, and [Omim]BF 4 as the extractant. Different factors, such as temperature, the amount of H 2 O 2 , solvent, and different sulfur-containing compounds for sulfur removal were investigated. Through the gas chromatography-mass spectrometer (GC-MS) analysis, dibenzothoiphene sulfone was proved to be the only product of dibenzothiophene oxidizing reaction. Furthermore, the process of ECODS was confirmed by GC-MS results. © 2013 American Institute of Chemical Engineers AIChE J , 59: 4696–4704, 2013
研究领域:
化学工程
·
环境科学
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DOI
高影响因子
TALANTA
·
2016
·
IF 4.035
Li-Shun Zhang,Qing-Li Zhao,Xin-Xin Li,Xi-Xi Li,Yan-Ping Huang,Zhao-Sheng Liu
A hybrid monolith incorporated with mesoporous molecular sieve MCM-41 of uniform pore structure and high surface area was prepared with binary green porogens in the first time. With a mixture of room temperature ionic liquids and deep eutectic solvents as porogens, MCM-41 was modified with 3-(trimethoxysilyl) propyl methacrylate (γ-MPS) and the resulting MCM-41-MPS was incorporated into poly (BMA-co-EDMA) monoliths covalently. Because of good dispersibility of MCM-41-MPS in the green solvent-based polymerization system, high permeability and homogeneity for the resultant hybrid monolithic columns was achieved. The MCM-41-MPS grafted monolith was characterized by scanning electron microscopy, energy dispersive spectrometer area scanning, transmission electron microscopy, FT-IR spectra and nitrogen adsorption tests. Chromatographic performance of MCM-41-MPS grafted monolith was characterized by separating small molecules in capillary electrochromatography , including phenol series, naphthyl substitutes, aniline series and alkyl benzenes. The maximum column efficiency of MCM-41-MPS grafted monolith reached 209,000 plates/m, which was twice higher than the corresponding MCM-41-MPS free monolith. Moreover, successful separation of non-steroidal anti-inflammatory drugs and polycyclic aromatic hydrocarbons demonstrated the capacity in broad-spectrum application of the MCM-41-MPS incorporated monolith. The results indicated that green synthesis using room temperature ionic liquid and deep eutectic solvents is an effective method to prepare molecular sieve-incorporated monolithic column.
研究领域:
分析化学
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材料科学
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PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 14
·8677-8687
·
IF 3.108
Guoxia Yun,Qingxin Guan,Wei Li
Although HDS and HDN reactions over transition metal phosphides have been widely studied, few publications about aromatic hydrodearomatization (HDA) over transition metal phosphides are found. Using ordered mesoporous Al-MCM-41 (Al-M) as the support, a series of supported nickel phosphide catalysts with different Ni/P molar ratios and loadings have been prepared by a temperature-programmed reduction and characterized. The HDA activity of naphthalene was measured in a fixed bed reactor at 250–330 °C and 3 MPa. The results showed that the catalyst with initial Ni/P molar ratio of 1.25 and 15 wt% loading displayed the highest HDA activity as well as 99.0% of selectivity of decalin at 270 °C, which is even higher than that of 0.5 wt% Pt–Al-M catalyst. As a comparison, the HDA performance of various catalysts was also examined. The results revealed that the presence of framework aluminum favors HDA processes and a synergistic effect between nickel phosphide and the suitable acidity resulted in an improvement of the catalytic activity. Finally, the possible reaction pathway of naphthalene hydrogenation (HYD) on nickel phosphide catalysts was proposed. Taking into consideration the high catalytic activity, Al-M supported nickel phosphide can be considered as a very efficient HDA catalyst to decrease the contents of aromatics in the fuels.
研究领域:
化学工程
·
催化科学
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高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2023
·Vol. 37
·期 4
·e7037
·
IF 3.9
Linbo Li,Baogang Su,Linjun Shao,Shujing Zhou,Jinjing Li,Chenze Qi
A series of Schiff-base functional groups modified MCM-41 materials have been synthesized and used as the supports of palladium species. The chemical structures of MCM-41 functionalized by nine Schiff-base functional groups were characterized by Fourier transform infrared spectroscopy (FT-IR), whereas their grafting densities of functional groups were achieved from the results of thermogravimetric analysis (TGA) and elemental analysis (EA). Small angle powdered X-ray (SAX) patterns demonstrate that the ordered mesoporous structures of MCM-41 were well retained after modification of functional groups and immobilization of Pd 2+ cations. Moreover, the regular mesoporous structures of supports and homogeneous dispersions of Pd 2+ cations were characterized by transmission electron microscopy (TEM). The positron annihilation lifetime spectroscopic (PALS) results revealed that the electronic and steric factors of functional groups could affect the o -Ps annihilation properties of support Pd 2+ cations. Meanwhile, the catalytic activities of these supported Pd 2+ cations chelated by different functional groups were determined by the Heck reaction of iodobenzene with n -butyl acrylate. At last, the catalytic activities of these supported Pd 2+ cations were linearly correlated to their o -Ps annihilation properties. This result demonstrates that the catalytic activities of supported Pd 2+ cations chelated by different functional groups can be readily determined by the o -Ps annihilation, which can be potentially used in the design and preparation of highly active palladium catalysts.
研究领域:
化学
·
催化科学
·
材料科学
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高影响因子
Foods
·
2026
·Vol. 15
·期 10
·1738
·
IF 6
Yu Wang,Chengming Wang,Guowei Ling,Mingshuang Xia,Yuhan Yi,Shilin Liu,Wenlin Li
Traditional activated clay (AC) bleaching usually shows limited adsorption selectivity, leading to micronutrient loss during pigment removal, and also suffers from high residual oil retention and poor regenerability. Developing mild bleaching materials with both high adsorption efficiency and selectivity is therefore important for oil refining. Mesoporous Al-MCM-41 (AM) adsorbents with different Si/Al ratios were prepared and characterized in pore structure and acidity, and the bleaching performance against AC in terms of pigment removal and the retention of micronutrients in rapeseed oil and the bleaching mechanism were studied. The results showed that AM25 (Si/Al = 25) exhibited the best overall performance among the AM samples under the tested conditions (70 °C, 20 min). It achieved a bleaching efficiency of 92.3% and removed 94.56% of chlorophyll, 92.94% of lutein, and 84.09% of β-carotene. In addition, AM25 reduced the peroxide value from 2.52 to 0.58 mmol/kg. High retentions of tocopherols (93.89%), phytosterols (98.73%), and squalene (96.32%) were also observed. Meanwhile, the adsorption rates of α-tocopherol, brassicasterol, and α-linolenic acid showed the highest values in their relative homologues of tocopherols, phytosterols, and free fatty acids (FFAs), respectively, due to differences in the methyl amount of tocopherols, the side-chain unsaturation of phytosterols, and the fatty acid chain unsaturation of fatty acids. Furthermore, the kinetic and isotherm data for chlorophyll and carotenoids were better described by the pseudo-second-order and Freundlich models, respectively. Combined with thermodynamic analysis, they indicated that adsorption was a spontaneous, endothermic, entropy-driven, heterogeneous multilayer process dominated by physical adsorption. Further, pigment adsorption was mainly governed by uniform mesopores and Si–OH/Si–OH–Al sites in AM. Among them, carotenoid removal depended primarily on the dispersion effect of moderately strong acid sites within pore-confined regions, whereas chlorophyll removal was more sensitive to the number of acidic sites in AM. AM25 still maintained 83.31% bleaching efficiency after five regeneration cycles. These performances of AM25 are significantly superior to that of AC.
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PubMed
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Desalination and Water Treatment
·
2024
·
IF 1
Mingyue Piao,Xue Peng,Huishi Du,Hongxue Du,Wei Zhang,Yuwei Sun,Honghui Teng
Cadmium (Cd) emissions have a negative impact on both human health and the environment. Although nano zero-valent iron (nZVI) offers a lot of potential for water pollution treatment, it has been constrained by its instability and ease of aggregation. For the elimination of Cd(II) from aqueous solution, nZVI/MCM supported nZVI (nZVI/MCM-41/rGO) was designed to improve its dispersion and stability. It had a rough, porous structure with apparent Fe (0) crystallinity and slight rGO crystallinity. On the surface of nZVI/MCM-41/rGO, several oxygen-containing groups were detected. The specific surface area was 15.94 cm 2 /g, and the pore diameter was concentrated at 23.82 nm. The best performance was occurred at pH 6 with an adsorbent dosage of 2 g/L, and a maximum adsorption capacity of 31 mg/g was achieved after 600 min. Cd(II) removal process was well fitted with second-order kinetic, Langmuir and Freundlich isotherm. The thermodynamic parameter was also analyzed and proved that it was an endothermic (ΔH° > 0) and spontaneous (ΔG° < 0) progress. During adsorption, the crystal type and functional groups of nZVI/MCM-41/rGO did not change, but Fe (0) was oxidized.
研究领域:
环境科学
·
材料科学
·
水处理
·
纳米技术
·
吸附技术
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DOI
高影响因子
危险品化学品经营许可证（带存储）