Biomaterials Science
·
2021
·Vol. 9
·期 7
·2732-2742
·
IF 6.843
Sihan Ji,Yaodong Chen,Xianglong Zhao,Yunyu Cai,Xiaopeng Zhang,Feilong Sun,Qi Chen,Qingmei Deng,Changhao Wang,Kun Ma,Bo Hong,Changhao Liang
The construction of surface structures of manganese oxide nanoparticles (MONs) in order to promote their longitudinal relaxivity r1 to surpass those of commercially available Gd(III) complexes is still a significant challenge. Herein, we successfully obtained Mn3O4/PtOx nanocomposites (NCs) with an r1 of 20.48 mM−1 s−1, four times higher than that of commercially available Gd-DTPA (5.11 mM−1 s−1). The r2/r1 ratio of these NCs is 1.46 lower than that of Gd-DTPA (2.38). This is the first time that such excellent T1 contrast performance has been achieved using MONs via synergistically utilizing the surface morphology and surface payload. These NCs are composed of porous Mn3O4 “skeleton” nanostructures decorated with tiny PtOx nanoparticles (NPs) that are realized using laser ablation and irradiation in liquid and ion etching steps. Experimental results showed that the enlarged specific area of the porous Mn3O4/PtOx NCs and the payload of ultrafine PtOx NPs synergistically facilitated the T1 contrast capabilities. The former favors sufficient proton–electron interactions and the latter reduces the global molecular tumbling motion. These NCs also exhibit an evident computed tomography (CT) attenuation value of 24.13 HU L g−1, which is much better than that achieved using the commercial product iopromide (15.9 HU L g−1). The outstanding magnetic resonance (MR) imaging and CT imaging performances of the Mn3O4/PtOx NCs were proved through in vivo experiments. Histological examinations and blood circulation assays confirmed the good biosafety of the NCs. These novel findings showcase a brand-new strategy for fabricating excellent MON T1 contrast agents (CAs) on the basis of the surface structure and they pave the way for their practical clinical applications in dual-modal imaging.
研究领域:
材料科学
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医学影像
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生物医学工程
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DOI
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Mingzhu Liu,Xueyan He,Bo Peng,Jin Wu,Zunquan Zhao,Jialei Bai,Jingran Sun,Yanjun Fang
Highly mimetic enzymatic Mn₃O₄/gold nanoparticle (AuNP) composites were prepared, which catalyze the oxidation of tert-butylhydroquinone (TBHQ) to red 2-tert-butyl-1,4-benzoquinone (TBBQ) for TBHQ detection. Absorbance at 487 nm (A₄₈₇) correlates linearly with TBHQ concentrations in the range of 0.52–50 μg/mL, with a limit of detection (LOD) of 0.063 μg/mL, and a limit of quantification (LOQ) of 0.21 μg/mL. TBBQ quenches the fluorescence of copper/iodine-doped carbon dots (Cu,I-CDs) at 500 nm via the inner filter effect (IFE), forming an “on-off” fluorescence probe for TBHQ. TBHQ concentration correlates linearly with the fluorescence intensity difference (F₀ − F) in the range of 0.31–54 μg/mL, with an LOD of 0.054 μg/mL and an LOQ of 0.18 μg/mL. This study uses a dual-mode detection approach to determine TBHQ in various food samples, with recovery rates ranging from 82.5% to 103.0%. The method is sensitive, accurate, cost-effective, and suitable for the rapidly analyzing of TBHQ in food.
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PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2024
·
IF 20.2
Jianmin Chen,Tianjian Ji,Zuyi Lu,Yawei Xie,Zhaowei Jia,Liqin Zhou,Zhongfeng Shi,Zhenxia Zhao,Zhongxing Zhao
Herein, we report the rational design of Cu-MnCO 3 -Mn 3 O 4 /C by partially reduced CuMn/C-300 (300 represents the calcination temperature) for highly efficient mineralization of TC. Mechanism studies indicate that Cu-MnCO 3 -Mn 3 O 4 /C with abundant oxygen vacancies could be enhance the adsorption capacity of TC and O 3 as comparing with CuMn/C-300. Moreover, the degradation and mineralization rates of TC can be enhanced over Cu-MnCO 3 -Mn 3 O 4 /C due to the existence of synergetic catalysis between Cu, MnCO 3 , and Mn 3 O 4 . Combining catalytic ozonation with Fenton-like reaction (by-reaction) could enhance O 3 decomposition and •OH generation, facilitating the degradation and mineralization rates of TC. As expected, Cu-MnCO 3 -Mn 3 O 4 /C exhibits an excellent catalytic ozonation performance for degradation of TC with a k = 0.265 min −1 and almost 100 % of mineralization rate, outperforming to the most of non-noble-based catalysts ever reported. This work presents a combined reaction mechanism for catalytic ozonation to eliminate pollutant through a catalyst with heterogeneous interface in water purification.
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高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Xiaoyan Feng,Qiong Wu,Li Li,Ping Wang,Qiang Wang,Jun Liang
Simulating natural photosynthesis to convert CO 2 and H 2 O into fuels achieving overall reaction is a promising solution for addressing environmental problems and energy crises. Constructing an S-scheme catalyst of two or more catalytic sites with rapid electron transfer and strong redox capability may be an effective strategy for coupling photocatalytic CO 2 reduction and H 2 O oxidation. Here, an oxygen vacancies-rich S-scheme semiconductor photocatalyst composed of monoclinic lead chromate oxide (Pb 2 (CrO 4 )O) coupled with Mn 3 O 4 quantum dots (QDs) (Pb 2 (CrO 4 )O@Mn 3 O 4 QDs) are synthesized and tested for photoconversion of CO 2 with H 2 O under visible light. Through the integration of Pb 2 (CrO 4 )O with Mn 3 O 4 QDs, the photocatalytic C1-evolution rate on Pb 2 (CrO 4 )O@Mn 3 O 4 QDs is radically increased by 6.0 and 8.1 times, which is much faster than that of pristine Pb 2 (CrO 4 )O and Mn 3 O 4 . The origin of the greatly raised activity is revealed by advanced characterizations, and in situ X-ray photoelectron spectroscopy (XPS) confirms the electron transport pathway in Pb 2 (CrO 4 )O@Mn 3 O 4 QDs with light illumination, unveiling the efficient spatial separation/transfer of charge carriers in oxygen vacancies-rich Pb 2 (CrO 4 )O@Mn 3 O 4 QDs S-scheme heterojunction. Consequently, powerful photoelectrons and holes accumulate in the Mn 3 O 4 conduction band and Pb 2 (CrO 4 )O valence band, respectively, exhibiting prolonged long lifetimes and facilitating their involvement in CO 2 photoreduction and H 2 O photooxidation through altering the interfacial charge dynamics.
研究领域:
材料科学
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环境科学
·
化学
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DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2019
·
IF 6.864
Ling Kang,Chun Huang,Jian Zhang,Mengyao Zhang,Nan Zhang,Yaqin He,Chen Luo,Chaolun Wang,Xiaofeng Zhou,Xing Wu
The intrinsically low electrical conductivity and the poor cycling stability are two major obstacles of manganese oxides to hamper their further application in high-performance supercapacitors . One effective way to enhance their electrochemical properties is construction of appropriate nanocomposite with different structures. Herein, we demonstrated the fabrication of a hierarchical MnO 2 nanowires-Mn 3 O 4 nanoparticles nanocomposite by an effective and innovative two-step synthesis strategy. Further, the Mn 3 O 4 nanoparticles were exfoliated from the surface of α -MnO 2 nanowires . And the optimum composition was calculated to be ~ 35% Mn 3 O 4 and ~ 65% α -MnO 2 . The capacitance of the optimized MnO 2 –Mn 3 O 4 nanocomposite electrode reaches 278.2 F g −1 at a current density of 20 A g −1 , and the capacitance retained at 99.3% even after 5000 cycles. The asymmetric supercapacitor was also fabricated with optimized MnO 2 –Mn 3 O 4 as the positive electrode and activated carbon as the negative electrode . It could deliver an excellent energy density of ~ 41.3 Wh kg −1 at a power density of ~ 1153W kg −1 . And the superior cycling stability achieves as well. The excellent capacitance properties of the MnO 2 –Mn 3 O 4 nanocomposite can be attributed to the hybrid structure, in which one-dimension α -MnO 2 nanowires provide a super highway for electron and ion transfer and Mn 3 O 4 nanoparticles attached offer the abundant pseudocapacitive sites for charge storage.
研究领域:
材料科学
·
能源存储与转换
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DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Liang Zhang,Puyuan Hu,Wen He,Wenze Wang,Linpin Luo,Qingqing Li,Bing Pan,Jing Sun,Lizhi Liu,Jianlong Wang
To mitigate the decay of fruits and vegetables caused by food-borne microorganisms, this contribution proposed for the first time a novel mild temperature-assisted nanozyme-based antibacterial packaging system with self-activating behavior (MnHC- CS films) through a demand-oriented tailoring process that involved the construction of hollow carbon-supported Mn 3 O 4 fillers (MnHC) and its incorporation in chitosan ( CS ) matrix. In this system, the weak acidity of CS film triggers the self-activation of MnHC nanozyme . Leveraging the synergistic effects of the excellent oxidase-like activity and photothermal properties of MnHC, in conjunction with the inherent bacteria trapping and killing capabilities of CS, the MnHC 0.20 -CS film (The 0.20 represents the amount of MnHC in the film-forming solution) demonstrates remarkable antibacterial and antifungal performances, with high bactericidal rate, short action time, and mild heating temperature. Therefore, the MnHC 0.20 -CS film showcases excellent preservation capabilities, significantly extending the shelf life of kumquats by approximately 2.3 times. Additionally, this film also boasts enhanced mechanical strength, improved barrier properties, and sufficient safety, paving the way for its practical application. These exceptional features underscore the good potential of MnHC 0.20 -CS film in effectively safeguarding perishable products.
研究领域:
材料科学
·
食品科学
·
生物技术
·
纳米技术
·
包装工程
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2018
·
IF 3.779
Xiaoshi Lang,Fang Ge,Kedi Cai,Lan Li,Qiushi Wang,Qingguo Zhang
In this paper, a novel Mn 3 O 4 /MnO nano spherical transition metal compound as bi-functional catalyst for air electrode of lithium-oxygen battery is prepared by vacuum direct current arc method. Through physical property characterization , it shows that the Mn 3 O 4 /MnO particle size can be controlled between 40 and 60 nm and evenly distributed inside the carbon material. In addition, photoluminescence test result indicates that this material has better electronic conductivity and catalytic activity than traditional MnO 2 catalyst owing to some defects in the crystal structure. The cyclic voltammetry results display that the oxidation and reduction reactions are both very obvious even at high scanning rate, although only one kind of catalyst is employed in the air electrode. This proves that the Mn 3 O 4 /MnO nano spherical transition metal compound can be as a bi-functional catalytic material. Electrochemical impedance spectroscopy also displays that the charge transfer resistance of Mn 3 O 4 /MnO catalyst is smaller and the ion diffusion speed is faster. Through charge and discharge test, it can be concluded that the voltage platform of the lithium-oxygen battery with Mn 3 O 4 /MnO as bi-functional catalyst is flat and the discharge voltage can reach 2.7 V. The specific energy can reach 7102 Wh·kg −1 at 0.025 mA cm −2 current density and a capacity limit of 1000 mAh·g −1 , it can carry out the 31 non capacity decay charge and discharge cycles.
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DOI
高影响因子
Biomaterials Science
·
2024
·
IF 5.8
Qin Wang,Xuedan Nie,Yifan Song,Haiyan Qiu,Liting Chen,He Zhu,Xueli Zhang,Mengru Yang,Xiaohui Xu,Peidan Chen,Chao Zhang,Jia Xu,Yeping Ren,Wenting Shang
Immune-mediated glomerular diseases lead to chronic kidney disease (CKD), primarily through mechanisms such as immune cell overactivation, mitochondrial dysfunction and imbalance of reactive oxygen species (ROS). We have developed an ultra-small nanodrug composed of Mn3O4 nanoparticles which is functionalized with biocompatible ligand citrate (C-Mn3O4 NPs) to maintain cellular redox balance in an animal model of oxidative injury. Furthermore, this ultra-small nanodrug, loaded with tacrolimus (Tac), regulated the activity of immune cells. We established a doxorubicin (DOX)-induced CKD model in SD rats using conditions of oxidative distress. The results demonstrate the ROS scavenging capability of Mn3O4 NPs, which mimics enzymatic activity, and the immunosuppressive effect of tacrolimus. This combination promotes targeted accumulation in the renal region with sustained drug release through the enhanced permeability and retention (EPR) effect. Tac@C-Mn3O4 protects the structural and functional integrity of mitochondria from oxidative damage while eliminating excess ROS to maintain cellular redox homeostasis, thereby suppressing the overexpression of pro-inflammatory cytokines to restore kidney function and preserve a normal kidney structure, reducing inflammation and regulating antioxidant stress pathways. This dual-pronged treatment strategy also provides novel strategies for CKD management and demonstrates substantial potential for clinical translational application.
研究领域:
纳米医学
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药理学
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免疫学
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肾脏生理学
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氧化应激研究
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产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Chenghong Sun,Enze Zhu,Chaoyang Shi,Juan Yu,Shubiao Yin,Chunxia Liu,Xiaoying Cui,Weiping Liu,Mingli Xu
The vigorous development of efficient cathode-side oxygen reduction reaction (ORR) catalysts is one of the keys to the practical application of fuel cells and Zn-air batteries (ZABs). Herein, a facile and green photochemical method is developed to synthesize pure-phase Mn 3 O 4 nanoparticles , which are uniformly anchored on nitrogen-doped reduced graphene oxide (N-rGO), followed by simple one-step annealing to highly catalytical active and stable MnO/N-rGO. The resultant MnO/N-rGO exhibits exciting ORR performance in alkaline media. Particularly, both GDE (gas diffusion electrode) half-cell and ZABs assembled from MnO/N-rGO have excellent overall performance and outstanding long-term durability, obviously better than Pt/C-based GDE half-cell and Pt/C + RuO 2 -based ZABs, respectively. It is mainly attributed to the synergistic effect between MnO nanoparticles and N-rGO support, which significantly increases the active sites and facilitates 4-electron transfer. This research paves a way for the green photochemical synthesis of transition metal oxide ORR catalysts at room temperature.
研究领域:
材料科学
·
电化学
·
能源存储
·
催化
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Liang Zhang,Wen He,Yiya Ping,Wenze Wang,Puyuan Hu,Bingzhi Li,Wenxin Zhu,Jing Sun,Yanwei Ji,Jianlong Wang
Confronting the escalating challenges of food waste and safety, primarily attributed to microbial-induced spoilage, this investigation unveils a cutting-edge nanozyme-based antimicrobial packaging paradigm with self-activating mechanism (CMn 0.20 -CS film), employing low-thermal aid to optimize the preservation of fruits and vegetables. At its core, the system amalgamates a carbon nanotube-supported Mn 3 O 4 (CMn) filler within a chitosan (CS) film matrix. The fabrication of the CMn complex involves a dual-stage process, initially focusing on the immobilization of Mn 2+ ions, followed by the wet chemical nucleation of Mn 3 O 4 crystals. A pivotal feature of this construct is the weak acidity of CS matrix, which imparts the CMn 0.20 -CS film with a self-activating capacity, facilitating an optimal environment for the manifestation of oxidase-like activity. The CMn 0.20 -CS film exhibits a synergistic antimicrobial efficacy, derived from the augmented oxidase-mimetic and photothermal characteristics of CMn, in conjunction with the intrinsic microbial capture and killing capabilities of CS. This translates into formidable bactericidal proficiency (exceeding 99.99 % for bacteria and 99.67 % for mold), swift action (within 10 min), and a requirement for minimal auxiliary heat (56.4 ℃). Based on this, the CMn 0.20 -CS film significantly prolongs the shelf life of kumquats, extending its shelf life by 2.3 times. The augmented mechanical strength, improved barrier qualities, and demonstrated safety profile of the film underscore its potential for practical applications. Collectively, the CMn 0.20 -CS film stands out as an exceptionally suitable method for the effective preservation of perishable goods, tackling fundamental concerns in food safety and wastage mitigation.
研究领域:
材料科学
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纳米技术
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食品科学
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生物技术
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化学工程
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 13
·2213364
·
IF 19
Shuya Pan,Guanning Huang,Zhengwei Sun,Xin Chen,Xinli Xiang,Wenxiao Jiang,Yanchao Xu,Tianfeng Chen,Xueqiong Zhu
Developing radiosensitizers based on the characteristics of the tumor microenvironment can improve the effectiveness and overcome the bottleneck of cervical cancer radiotherapy. Herein, an in situ synthesis strategy is demonstrated by using a highly bioactive zeolitic imidazolate framework to cap Mn 3 O 4 and folic acid as targeting molecules (FA-Mn 3 O 4 @ZIF-8) to achieve enhanced radiosensitization against cervical cancer. As expected, the ZIF-8 cap on the surface of Mn 3 O 4 responds more effectively to X-rays. Meanwhile, by facilitating the presence of oxygen vacancies and valence transition of manganese on the surface of Mn 3 O 4 , the ZIF-8 cap on Mn 3 O 4 can increase the catalytic capacity for hydrogen peroxide (H 2 O 2 ) and glutathione as well as produce more singlet oxygen under X-ray, alleviate hypoxia within the tumor microenvironment, and increase reactive oxygen species production. Moreover, FA-Mn 3 O 4 @ZIF-8 shows excellent radiotherapy-sensitizing properties in vitro and in vivo by promoting DNA damage and apoptosis. Collectively, this study suggests that designing and construction of X-ray responsive nanoradiosensitizers could be a good way for future clinical radiotherapy of malignant cervical cancer.
研究领域:
癌症研究
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放射肿瘤学
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纳米技术
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治疗开发
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DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 23
·3661-3669
·
IF 5.047
Dan Ou,Duanping Sun,Xiangan Lin,Zhixian Liang,Yongsheng Zhong,Zuanguang Chen
Developing highly sensitive and selective detection strategies for biomarkers is beneficial for fundamental research and disease diagnosis. Herein, we constructed a sandwich-type electrochemical aptasensor to detect the breast cancer cell biomarker Human Epidermal Growth Factor Receptor 2 (HER2). The aptasensor was a combination of tetrahedral DNA nanostructures (TDNs)–aptamer as recognition probes and flower-like nanozymes/horseradish peroxidase (HRP) as signal nanoprobes. In the process of assembling the biosensor, the TDN–aptamer 1 as a bio-recognition element was immobilized on the gold electrode (GE) surface for capturing the biomarker HER2. The nanozyme Mn3O4 was decorated by Pd@Pt nanozymes which were linked by the aptamer 2 and natural enzyme HRP. The designed Mn3O4/Pd@Pt/HRP nanoprobe (nanoprobe 1) was used to amplify the biosensor signal via catalyzing the oxidation of hydroquinone (HQ) with hydrogen peroxide (H2O2). After binding HER2, an aptamer–protein–nanoprobe sandwich system was fabricated on the GE surface. Lastly, a Pd@Pt/HRP/complementary DNA (cDNA) nanoprobe (nanoprobe 2) was added on the surface of nanoprobe 1 through DNA hybridization of aptamer 2 and cDNA to form a dendritic DNA nanostructure to further amplify the signal significantly. The results indicate that the aptasensor shows a broad linear response from 0.1 to 100.0 ng mL−1 and the low detection limit is 0.08 ng mL−1. The designed approach holds great potential for the construction of various aptasensors for the effective and convenient detection of different biomarkers.
研究领域:
生物医学工程
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分析化学
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纳米技术
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癌症诊断
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）