ORGANOMETALLICS
·
2020
·
IF 3.804
Liangwei Zhang,Long Liu,Tianzeng Huang,Qizhi Dong,Tieqiao Chen
A palladium-catalyzed cyclobutanation of aryl sulfonates with strained alkenes has been developed. The methodology is featured to achieve the cleavage of both C–O and C–H bonds of phenol derivatives in one pot. Under the reaction conditions, in addition to reactive triflates, the relatively inactive tosylates and mesylates can also be transformed into the corresponding benzocyclobutanes in high yields. This reaction can be carried out in gram-scale experiments with a low loading of the palladium catalyst and is applicable to the cyclobutanative modification of bioactive molecules, highlighting its synthetic value in organic synthesis.
研究领域:
有机化学
·
催化化学
·
合成化学
✓ 已验证
DOI
高影响因子
Food Analytical Methods
·
2018
·Vol. 12
·期 2
·544-557
·
IF 2.245
Al-Dalali Sam,Zheng Fuping,Sun Baoguo,Chen Feng
Zhenjiang aromatic vinegar is one of the most popular vinegars in China, which can be produced by either traditional or modern techniques. Aroma profiles of the traditional Zhenjiang aromatic vinegar (TZAV) and the modern Zhenjiang aromatic vinegar (MZAV) at different stages of their aging were analyzed by headspace solid-phase microextraction (HS-SPME) with an aid of DVB/CAR/PDMS fiber combined with gas chromatography-mass spectrometry (GC-MS) and gas chromatography-olfactometry (GC-O). A total of 53 volatile compounds were identified. Among them, 43 aromas were positively identified after comparison with their corresponding authentic compounds. Two volatiles, including isopentyl alcohol and butyl benzoate, were only identified in TZAV, while propiophenone was only identified in MZAV. In addition, some volatiles were found to be generated during the aging period, which included isopentyl alcohol, 3-(methylthio)propyl acetate, and 2-acetoxy-3-butanone in the TZAV samples, and 2-ethyl-1-hexanol, octanoic acid, propiophenone, and dimethyl trisulfide in the MZAV samples. The total amount of volatile compounds in the MZAV was greater than its counterpart TZAV. Moreover, 29 odor-active compounds were recognized by GC-O analysis, while 25 of them were confirmed by their authentic compounds, and their perceived odors included sweet, acid, buttery, floral, herbal, fruit, fresh, pungent, almond, and geraniol notes.
研究领域:
食品科学
·
分析化学
·
农学
✓ 已验证
DOI
高影响因子
Nano Energy
·
2021
·
IF 17.881
Zhen Liu,Di Jiang,Linjing Yang,Jiayuan Yu,Xiao Li,Xiaoyan Liu,Lili Zhao,Xiao Li Zhang,Feng Han,Weijia Zhou,Hong Liu
How do the synergistic effects work and which dominate the distribution of active sites, that's an interesting question in mang plasmon-enhanced catalysis. Herein, we put a deep insight into the distribution of active sites and the mechanism of charge transfer at the noble metal-metal oxide interface for accelerating the hydrogen evolution reaction (HER) kinetics. A heterostructure of Au loaded MoO 2 nanosheets (Au-MoO 2 ) is prepared by the light-reduction method. EXAFS analysis demonstrates the tight coupling at Au-MoO 2 interface through the Au-O bond. An enhanced HER activity is observed with an overpotential decrease of (Δη) 176 mV and Tafel slop down to 52.5 mV/dec. KPFM measurement and FEM simulation verify the high local field enhancement at the junction. This field induces the concentrated surface charge through the Au-O bond. DFT calculation confirms the upraises filling of Op orbital in the Au-O bond, thus degrading the hydrogen adsorption energy level for HER kinetics.
研究领域:
催化化学
·
纳米材料科学
·
表面科学
·
物理化学
·
能源化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Qianyu Zhao,Hua Zhang,Haitian Zhao,Jia Liu,Jingyi Liu,Zilong Chen,Bin Li,Xiaojun Liao,Joe Mac Regenstein,Jing Wang,Xin Yang
Seven magnetic covalent organic framework molecularly imprinted polymers with magnetic responsiveness, large specific surface area, and molecular recognition ability were successfully synthesized, suitable for the separation of cyanidin-3-O-glucoside from complex samples. Using a room-temperature synthesis strategy, covalent organic frameworks accompanied by imprinted sites were formed in one step on the functionalized magnetic nanoparticles with 1,6-hexanediamine. The composite materials were easy to prepare and showed high adsorption capacity (127 mg g–1) together with favorable adsorption selectivity for cyanidin-3-O-glucoside over other flavonoids and phenolic acids. Magnetic covalent organic framework molecularly imprinted polymers exhibited good stability in 10 adsorption–desorption cycles. This work established a new method of extracting and separating high-purity anthocyanins and even unstable natural compounds.
研究领域:
材料科学
·
分析化学
·
天然产物研究
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Han-Bing Gao,Yue-Lun Wang,Dao-Ran Liu,Jin-Xuan Xie,Le-Le Qiu,Jian Xiao,Jing Liang,Fang-Jing Liu,Yun-Peng Zhao
Achieving high efficiency and selectivity in cleaving aryl C–O bonds is critical for lignin valorization and the production of aromatic chemicals. A green and sustainable approach has been developed using bimetallic Ni–W catalysts, which controlled the hydrogen supply and mediated hydrogen transfer via in situ hydrogen donors. An appropriate W/Ni ratio is essential for enhancing the supply of active hydrogen, the adsorption capacity for reactive molecules, and the efficiency of hydrogen transfer, thereby optimizing the overall catalytic performance. A comprehensive investigation was conducted on the factors influencing the catalytic transfer hydrogenolysis of lignin derivatives, focusing on the reaction temperature, solvent, hydrogen source, pressure, and duration. Under optimal conditions (180 °C, 1.0 MPa N2, and <2.5 h), various lignin-derived aryl ethers achieved complete conversion with 100% monomer selectivity. This study demonstrated the excellent reusability of the Ni–W catalyst for four cycles. More significantly, the mechanisms underlying active hydrogen transfer, transfer hydrogenolysis, and bimetallic interactions were elucidated. The integration of Ni and W species significantly enhanced the synergy among active metal sites, oxygen defects, and acid sites. This synergistic mechanism enabled H• and H+ to function as the primary active hydrogen species. Furthermore, the in situ generation and targeted migration of H• radicals and H+ ions facilitated the preferential cleavage of C–O bonds over the hydrogenation of aromatic units within lignin, leading to the formation of high-value aromatic monomers.
研究领域:
催化化学
·
可再生资源转化
·
绿色化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
·
2022
·Vol. 46
·期 11
·15174-15181
·
IF 4.672
Yang Liu,Xuesong Cai,Dinggui Chen,Yan Qin,Yuan Chen,Jinxiang Chen,Chenglu Liang
Summary The large-scale applications of energy storage system via lithium-ion batteries (LIBs) put forward demands for high capacity, high safety, and low cost of materials. Covalent organic polymers have attracted extensive attention because of their high capacity, flexible structural design, high safety, abundance, and low cost. Here, 2,3,5,6-tetraamino-p-benzoquinone and hexaketocyclohexane octahydrate were chosen as monomers to construct the covalent organic framework (TH-COF) cathode materials with active C=O and C=N groups. The TH-COF was further composed with reduced graphene oxide (rGO) and the prepared TH-COF/rGO cathode provided a capacity of 135 mAh g −1 after 600 cycles at 1 C current density. In addition, after 100 cycles, the cathode delivered capacities of 118 and 73 mAh g −1 at the high current densities of 5 C and 20 C, respectively, displaying superior rate performances. The TH-COF/rGO electrode exhibited high capacity and stability, making it a promising cathode material for the next generation LIBs.
研究领域:
材料科学
·
能量存储
·
电化学
✓ 已验证
DOI
高影响因子
Current Protocols
·
2024
·Vol. 4
·期 1
·e956
·
IF 0
Xuan Chen,Long Xie,Chenglong Zhang,Shen Tian,Zeyu Tang,Ming Xiang,Weiwei Tian,Patrick Lu,Xianbin Yang
The integration of fluorine atoms into biologically active organic compounds has proved to be a vital technique in small molecule drugs. This technique can substantially enhance crucial properties, including metabolic stability, lipophilicity, and bioavailability, often with a mere addition of a single fluorine atom or a trifluoromethyl group. Over the past few decades, this concept has also been applied in nucleic acid chemistry. A commonly employed 2′-OH substitution is the introduction of a 2′-deoxy-2′-fluoro (2′-F) group. The strong electronegativity of fluorine prompts the modified siRNA to readily adopt a C3′- endo conformation, resulting in significant advantages in terms of binding affinity. To enrich the toolbox of chemical modification of oligonucleotides, the replacement of the 2′-OH with the 2′- O -trifluoromethyl group has been developed in RNA analog synthesis. Oligodeoxynucleotides containing the 2′- O -trifluoromethyl group can greatly increase the thermal stability of DNA/RNA duplexes depending on the position and amount of the modification. Moreover, 2′- O -trifluoromethylated oligodeoxynucleotide also exhibited a slightly higher resistance to snake venom phosphodiesterase than the unmodified oligodeoxynucleotide. The 2′- O -trifluoromethylated oligonucleotides can emerge as a label to study RNA structure and function as well, or to develop DNA/RNA-based diagnostics. Hence, it is necessary to report an effective method for the synthesis, deprotection, purification, and characterization of oligonucleotides bearing a 2′ -O -trifluoromethyl group. © 2024 Wiley Periodicals LLC. Basic Protocol 1 : Preparation of 6- N -benzoyl-5′- O -dimethoxytrityl-2′- O -trifluoromethyl adenosine 3′-(2-cyanoethyl N,N -diisopropyl)phosphoramidite Basic Protocol 2 : Preparation of 4- N -acetyl-5′- O -dimethoxytrityl-2′- O -trifluoromethyl cytidine 3′-(2-cyanoethyl N,N -diisopropyl)phosphoramidite Basic Protocol 3 : Preparation of 2- N -isobutyryl-5′- O -dimethoxytrityl-2′- O -trifluoromethyl guanine 3′-(2-cyanoethyl N,N -diisopropyl)phosphoramidite Basic Protocol 4 : Preparation of 5′- O -dimethoxytrityl-2′- O -2-trifluoromethyl uridine 3′-(2-cyanoethyl N,N -diisopropyl) phosphoramidite Basic Protocol 5 : Solid-phase synthesis of 2′- O -trifluoromethylated RNA analogs Basic Protocol 6 : Deprotection and purification of 2′- O -trifluoromethyl-RNAs
研究领域:
生物有机化学
·
核酸化学
·
药物化学
·
RNA生物学
·
分子生物学
·
药学
✓ 已验证
DOI
BIOCHEMICAL PHARMACOLOGY
·
2025
·
IF 5.6
Suiqing Mai,Jiale Ke,Shiqin Lin,Rongrong Huang,Fengxin Zheng,He Jiao,Hong Wang,Shuqin Zhang,Mengying Mao,Qiuping Li,Zean Zhao,Jianxin Pang,Qun Zhang
A high-purine diet is an important factor in the development of hyperuricemia (HUA), in which the intestinal tract is the main site of dietary purine absorption. Inhibition of intestinal concentrative nucleoside transporter 2 (CNT2) can inhibit dietary purine-induced elevation of serum uric acid (sUA) levels. However, there is a lack of research on CNT2 inhibitors for the treatment of HUA. By using high throughput virtual screening from an in-house natural product database, the natural active component 5-methylvisammioside (MeV) in Saposhnikovia divaricata (Turcz.) Schischk was predicted to be an effective CNT2 inhibitor with the highest docking score. In vitro , MeV showed the strongest inhibitory activity against CNT2, with IC 50 value of 11.22 ± 2.18 μM. Moreover, MeV showed little or almost no inhibitory effect on other nucleoside transporters CNT3 and equilibrative nucleoside transporters (ENTs), as well as on uric acid (UA) transporter-related targets. In vivo , MeV significantly reduced sUA, inhibited adenosine uptake, and had an ameliorative effect on pathological changes in the liver, kidney, and intestinal tract. Moreover, MeV improved serum and intestinal indices related to inflammation and oxidative stress in mice, reduced intestinal permeability. Through our further study, we found that MeV inhibited the activation of reactive oxygen species (ROS) and NF-κB P65, reduced the production of the NOD-like receptor protein 3 (NLRP3) inflammasome, and improved intestinal injury in a high UA environment. The study suggests that MeV is a potent CNT2 inhibitor for the treatment of HUA and also protects intestinal function by inhibiting the ROS/NF-κB/NLRP3 pathway.
研究领域:
药理学
·
生物化学
·
分子生物学
·
药物化学
·
营养学
·
胃肠病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Redox Biology
·
2019
·
IF 7.793
Shen-Fei Wang,Xin Liu,Mo-Yu Ding,Shuangcheng Ma,Jing Zhao,Ying Wang,Shaoping Li
Reducing agents are crucial for the management of maladaptive inflammation-induced macrophage death and hematopoietic toxicity of chemotherapy. 2- O - β - d -glucopyranosyl- l -ascorbic acid (AA-2 β G), a unique AA (or vitamin C) derivative identified in Lycium barbarum , exhibited enhanced free radical scavenging activity compared with AA and its synthetic derivative AA-2 α G. AA-2 β G protected hydrogen peroxide-induced cell death in murine macrophage RAW264.7 cells. Treatment with AA-2 β G eliminated oxidative stress and the ratio of cellular glutathione to glutathione disulfide more effectively than AA and AA-2 α G. AA-2 β G also significantly reduced the fluorescent intensity of DCFH-DA triggered by chemotherapeutic agent camptotehcin-11 but not fluorouracil. AA, AA-2 α G, and AA-2 β G significantly decreased Keap-1expression, and increased the expression levels of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1. All compounds triggered the nuclear translocation of Nrf2, while the ability of AA-2 β G to enhance the Nrf2-DNA binding affinity was approximately two fold as those of AA and AA-2 α G. Sodium ascorbate cotransporters (SVCT) inhibitors, sulfinpyrazone, phloretin, and 3- O -methyglucose, potently abrogated the free radical scavenging activities of AA, AA-2 α G, and AA-2 β G. The cellular uptake efficacy of AA-2 α G and AA-2 β G was less than 10% of AA, while the inhibition of SVCT with sulfinpyrazone considerably diminished the uptake efficacy of these compounds. AA-2 α G and AA-2 β G are more stable in the Fenton reagents than AA. In summary, AA-2 β G from L. barbarum with excellent free radical scavenging activity is a promising natural AA derivative for further pharmacological evaluation.
研究领域:
药理学
·
免疫学
·
肿瘤学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Hao Gu,Yi Jiang,Xijia Yang,Yue Yang,Xuesong Li,Liying Wang,Wei Lü
Flexible and wearable pressure sensors have attracted significant attention due to their wide range of potential applications. However, they often suffer from low sensitivity, narrow pressure detection range, and poor mechanical flexibility. In this work, a multifunctional 3D pressure sensor based on a ternary metal oxide@carbon-based sponge (C–NiCoZn–O/CMF) was developed by the hydrothermal method. The pressure feedback layer of the sensor was uniformly coated with C–NiCoZn–O on the surface of the framework, which improved the device’s conductivity, sensitivity, and stability significantly. The sensitivities of 41.99, 23.39, and 11.19 kPa–1 are in the ranges 0–4.01, 4.01–8.39, and 8.39–20.1 kPa, respectively, and the cyclic retention rate exceeded 90% after 2000 cycles. The C–NiCoZn–O/CMF composite demonstrated excellent electrochemical performance as an electrode for supercapacitors, with a high specific capacity of 2030 mF/cm2 at a current density of 1 mA/cm2 and a high capacity retention rate of 81.55% after 4000 cycles. As a multifunctional device, when integrated with a microprocessor, it can easily detect and process a large amount of human physiological signal data in daily work scenarios. Present composites maintain adjustable conductivity and extremely high elasticity even under extreme conditions such as liquid nitrogen and high temperatures up to 85.6 °C. This work is expected to play a great role in polar exploration, volcano survey, deep space exploration, etc.
研究领域:
材料科学
·
传感器
·
纳米技术
·
电化学
·
柔性电子学
·
可穿戴设备
✓ 已验证
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2025
·
IF 3.8
Shuangjiang He,Junchang Wang,Chong Wang,Xiao Zhang,Sen Liang
The Mn-Fe-Co-Zn-O series is a widely used thermistor material, but its thermal stability is compromised by nitrogen glass encapsulation, limiting its application in electrical devices. To address this issue, La 2 O 3 and Y 2 O 3 were used as rare earth oxide dopants, and xR 2 O 3 -Mn 0.76 Fe 0.87 Co 1.07 Zn 0.3 O 4 (x = 0.0025, 0.005, 0.01, 0.02) negative temperature coefficient (NTC) materials were synthesized via solid-state sintering. The effect of rare earth doping on the electrical properties after high-temperature nitrogen annealing was investigated. After annealing at 750°C for 4 h, the variation in resistivity ( ρ 25 ) and material constant ( B 25/50 ) significantly decreases with increasing La doping. For the La-doped sample (x = 0.01), Δρ 25 decreased to 7.77% and ΔB 25/50 to 0.77% (for the Y-doped sample (x = 0.01), Δρ 25 decreased to 22.76% and ΔB 25/50 to 1.91%), compared to the undoped sample, where Δρ 25 reduced by 168.84% and ΔB 25/5 0 by 5.57%. This improvement was attributed to rare earth accumulation at grain boundaries, filling voids and forming R-O bonds, which inhibited oxygen vacancy migration and significantly reduced grain boundary resistance. Rare earth doping effectively improved the thermal stability and electrical consistency of NTC thermistor ceramics in high-temperature nitrogen atmospheres, offering a new strategy for high-temperature encapsulation applications. (Y-doped samples showed similar results, as detailed in the Supplementary Materials.)
研究领域:
材料科学
·
无机非金属材料
·
电子陶瓷
·
热敏材料
·
固态化学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-18
·
IF 15.7
Li Taiguang,Chen Butian,Wang Tenghui,Liu Chong,Yin Wen,Mao Qianjiang,Zhou Dongxu,Hao Yongmei,Liu Xiangfeng
Solid-state sodium metal batteries have attracted great interest because of their improved safety and abundant Na resources. However, the interfacial resistances and instabilities induced by parasitic reactions, together with Na dendrite issues, result in reduced rate capability and poor cycling stability. Here, we address these challenges by intrinsically inhibiting parasitic interfacial redox reactions through enhanced P-O covalency in Na 3 Zr 2 Si 2 PO 12 (NZSP) with Na 2 SiF 6 incorporation, wherein the high electronegativity of F strengthens P-O covalency. Additionally, SnF 2 coating provides a sodiophilic surface and stabilizes the NZSP interface, which is essential for effective electrochemical cycling. This integrated approach significantly reduces interfacial impedance to 2.0 Ω cm 2 , enabling stable Na plating/stripping for 3600 hours at 0.5 mA cm -2 /0.25 mAh cm -2 . The full cell with Na 3 V 2 (PO 4 ) 3 positive electrode demonstrates stable cycling with high-rate capability (87.5% capacity retention after 2500 cycles at 1 C and 96.1% capacity retention after 1200 cycles at 5 C). This study sheds light on the development of high-performance quasi-solid-state sodium batteries.
研究领域:
储能技术
·
材料科学
·
电化学
·
固态电池
·
界面工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）