CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Chenchen Qin,Bianjing Sun,Xinyu Chen,Du Ping,Wuxin Bai,Lin Shi,Ahsan Nazir,Chuntao Chen,Dongping Sun
A novel graft copolymer BC-g-PCL was synthesized and characterized by integrating bacterial cellulose (BC) with polycaprolactone (PCL) to improve mechanical performance and sustainability. Molecular dynamics simulations reveal that hydrogen bonding is crucial for improving the strength and toughness of the material, with temperature fluctuations affecting the interactions of the polymer chains. The BC-g-PCL exhibits notable water plasticity and solvent responsiveness, enabling reversible transitions between dry and wet states due to the high surface wettability from exposed hydroxyl groups. Mechanical testing demonstrates that BC-g-PCL retains excellent ductility and strength across varying humidity conditions due to the dynamic formation of hydrogen bonds. Furthermore, recyclability and biodegradability assessments indicate substantial stability against organic solvents and successful regeneration via N , N -dimethylacetamide (DMAC)/lithium chloride (LiCl) dissolution, while maintaining robust mechanical properties even after multiple recycling cycles. These results make BC-g-PCL a promising eco-friendly alternative to traditional plastics, highlighting its potential for advanced functional materials and sustainable engineering applications derived from biological resources.
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高影响因子
Journal of Materials Chemistry B
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2025
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IF 5.7
Zi Fu,Yan Zhou,Ziyi Liu,Zhe Chen,Qiang Fu,Shiqun Lin,Rongping Dai,Huade Zheng
Pathological myopia, characterized by excessive axial elongation, posterior staphyloma (PS) and retinal-choroidal degeneration underlies sight-threatening conditions such as myopic traction maculopathy (MTM) and macular atrophy. Macular buckling (MB) surgery has demonstrated significant efficacy in managing MTM-associated pathologies, including macular schisis, macular holes, and macular retinal detachment. However, its widespread clinical adoption remains limited due to suboptimal material properties and geometrical design constraints of existing buckling devices. Advancements in imaging modalities-such as spectral-domain optical coherence tomography (SD-OCT), swept-source OCT (SS-OCT), ultrawidefield fundus imaging, and three-dimensional magnetic resonance imaging (3D-MRI)-have substantially enhanced the understanding and evaluation of MTM biomechanics. The future development of MB may lie in identifying superior biomaterials and creating customized buckling devices tailored to individual ocular morphology. Here, we developed a photo-curable polycaprolactone (PCL)-based non-isocyanate polyurethane acrylate (NIPUA) resin (PCL-NIPUA) for one-piece J-shaped 3D-printed MB devices. Structural characterization via Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectroscopy (FTIR), and Mass Spectrometry (MS) confirmed successful synthesis. Photocuring kinetics under 465 nm visible light achieved an optimal storage modulus within 82 s, coupled with minimal curing shrinkage (7.2%). By tuning flexible PCL segments, the material exhibited a tensile strength of 25 MPa and elongation at break of 32%, balancing strength and elasticity. The resin demonstrated environmental stability (water contact angle: 72°; water absorption: 8.8%; thermal decomposition: 420°C) and exceptional biocompatibility (hemolysis rate <0.5%; cell viability >97%). Liquid crystal display (LCD) 3D printing produced cost-effective MB devices that provided stable scleral indentation in rabbit models, with few complications, and no pathological structural changes in the optic nerve and retina，showing good biocompatibility and safety. This work establishes PCL-NIPUA as a synergistic platform combining green chemistry, rapid photocuring, mechanical adaptability, and biosafety, offering a clinically translatable solution for customized 3D-printed implants in MB surgery.
研究领域:
眼科
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生物材料
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组织工程
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转化医学
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生物医学工程
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眼底病学
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高分子医学材料
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PubMed
高影响因子
Materials Today Communications
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2024
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IF 3.7
Yang Liu,Run Liu,Wenxian Nie,Leiting Yu,Shaoyuan Lyu,Qi Han,Yun Zhao,Minfang Chen
In this study, a composite coating of polycaprolactone layer and polydopamine-cyclodextrin (β-CD)/naringenin (NG) was prepared on the surface of a micro-arc oxidized (MAO) pretreated magnesium alloy by a two-step method. The findings demonstrate that the composite coating exhibits favorable corrosion resistance, biocompatibility, photo-thermal antimicrobial, and bone-enhancing characteristics. Compared with the MAO coating, the corrosion rate of the composite coating was significantly reduced from about 0.087 mm/y to 0.066 mm/y. The antimicrobial efficiency of the coating against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) under 808 nm laser irradiation was found to reach 93 % and 99 %, respectively. Furthermore, in vitro cytotoxicity assays, dead and live cell staining, and immunoblotting analysis showed that the coating exhibited favorable biocompatibility and osteogenic activity. This novel coating may have good application prospects in the treatment of osteoporosis-related fractures.
研究领域:
材料科学
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生物医学工程
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高影响因子
CARBOHYDRATE POLYMERS
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2014
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IF 3.916
Zesheng Lv,Longlong Chang,Xingwen Long,Jianping Liu,Yuzhang Xiang,Jinjian Liu,Jianfeng Liu,Hongzhang Deng,Liandong Deng,Anjie Dong
In this work, a new hydrogel was constructed using poly(ɛ-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)–poly(ethylene glycol)–poly(ɛ-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) tri-block copolymers (PECT) with hyaluronic acid (HA) in order to expand application scopes of PECT hydrogel. The rheological and sol–gel phase transition behaviors were investigated by rheometer and test tube inversion method, and the interior morphologies of hydrogel systems were observed by scanning electron microscope (SEM). With the introduction of HA, certain properties of PECT hydrogel, such as viscosity and morphology, have present trends with regularity. Furthermore, with the participation of HA, the degradation and release of acetylsalicylic acid was slightly affected, however, the drug release mechanism of hydrogel has not been changed. PECT/HA hydrogel is confirmed to be non-toxic through a test to NIH3T3 cells. In conclusion, blending with HA is a feasible and safe method to tune properties of PECT hydrogel.
研究领域:
生物材料
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高分子科学
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药物递送
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组织工程
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生物医学工程
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DOI
高影响因子
POLYMER
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2025
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IF 4.5
Hengyu Yan,Mingjie Zhang,Qing Tang,Chao Long,Hecheng Wu,Ao Wang,Nan He,Wenkai Liu,Zhen Li,Feng Luo,Jiehua Li,Hong Tan
Recent advances reported polyurethanes with hard-segment main chains and soft-segment side chains. However, fundamental understanding of their aggregation structures, deformation mechanisms, and potential applications remained limited. Besides, existing designs were confined to polyether or zwitterion side chains, with polyester-based variants unexplored. Herein, we synthesized a kind of novel comb polyurethanes with polycaprolactone (PCL) sidechains attached to hard backbone (SPPU). Comprehensive characterizations revealed distinct aggregation structures in SPPU compared to linear PCL-based polyurethanes (PPUs) from different aspects. Strain-dependent analysis was first applied to uncover the distinctive deformation mechanism of SPPUs in this study. While PPUs’ deformation was mainly driven by soft-segment elongation, low hard-segment SPPUs underwent whole-chain slippage-dominated deformation (enhancing chain mobility) and high hard-segment SPPUs demonstrated hard-segment elongation-based deformation (reinforcing rigidity). SPPUs exhibited enhanced room-temperature loss modulus and absolute damping capacity compared to PPU. Low hard-segment SPPU exhibited significantly higher loss factor and displayed superior impact protection performance. High hard-segment SPPUs exhibited substantially increased modulus than linear PUs. SPPUs also exhibited improved acid/alkali corrosion-resistance, extending the service life in corrosive environments. Superior melt flowability of SPPUs at high temperature highlighted the topological design in improving processability. The synergy of tunable stiffness, optimized damping and durability positioned SPPUs as transformative materials for optimization of conventional linear PCL-based PUs. This work afforded the first polyester-based comb PU system and crucial molecular design insights for advanced high-performance polyurethane materials.
研究领域:
高分子科学
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材料工程
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大分子化学
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材料力学性能
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软物质物理
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DOI
高影响因子
Frontiers in Chemistry
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2020
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IF 3.693
Pang Zekun,Zhou Jiayan,Sun Chunyang
The development of the nanosized delivery systems with targeting navigation and efficient cargo release for cancer therapy has attracted great attention in recent years. Herein, a folic acid (FA) modified PEGylated polycaprolactone containing ditelluride linkage was synthesized through a facile coupling reaction. The hydrophobic doxorubicin (DOX) can be encapsulated into the polymeric micelles, and such nanoparticles (F-TeNPDOX) exhibited redox-responsive drug release under abundant glutathione (GSH) condition due to the degradation of ditelluride bonds. In addition, flow cytometric analyses showed that the FA ligands on F-TeNPDOX could facilitate their cellular uptake in 4T1 breast cancer cells. Therefore, F-TeNPDOX led to the promoted drug accumulation and enhanced growth inhibition on 4T1 tumor in vivo. The obtained results suggest F-TeNPDOX excellent potential as nanocarriers for anticancer drug delivery.
研究领域:
纳米技术
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癌症研究
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聚合物化学
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药物递送系统
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DOI
PubMed
高影响因子
BIOMACROMOLECULES
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2013
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IF 5.371
Yang Zhu,Zhengwei Mao,Changyou Gao
Gradient biomaterials can offer progressively changing signals to specific tissue interface, and thereby modulate the conjunction between different tissues. A linear density gradient of alendronate (Aln), a molecule that is capable of promoting osteogenic differentiation of bone mesenchymal stem cells (BMSCs), was created on an aminolyzed poly(ε-caprolactone) (PCL) membrane. X-ray photoelectron spectroscopy and quartz crystal microbalance with dissipation revealed the linear increase of the Aln amount as a function of the position on the PCL membrane. By contrast, the surface wettability and energy were kept unchanged. The surface-grafted Aln showed a stronger ability to induce the osteogenic differentiation of rat BMSCs than its counterpart in culture medium of the same amount, and the osteo-inductive culture medium. On the Aln-grafted gradient surface, the BMSCs showed gradient osteogenic differentiation as a function of membrane position in terms of cell morphology, alkaline phosphatase activity, calcium deposition, and the expression of osteogenesis marker proteins including collagen type I (COL I), Runt-related transcription factor 2 (Runx2), and osteocalcin (OCN).
研究领域:
生物材料
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干细胞生物学
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组织工程
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材料科学
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DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
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2019
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IF 3.621
Guohui Zhang,Panpan Wang,Xiaoxiao Zhang,Chunhui Xiang,Lili Li
Hydrophobic polycaprolactone (PCL) membranes with hierarchical structure were fabricated via one-step electrospinning technique. Meanwhile, the addition of the liquid methyl silicone oil (MSO) and hydrophobic silica (SiO 2 ) nanoparticles in the PCL membrane were expected to improve the hydrophobicity of PCL membranes. FE-SEM images showed the microsphere-fiber interlinked hierarchical morphology of PCL/MSO/SiO 2 composite fiber. FT-IR confirmed the formation of PCL/MSO/SiO 2 composite fibers. XPS approved its hierarchical structure of the composition. By comparing with pure PCL membrane which the water contact angle (WCA) was 132.2 ± 1.2°, the WCAs of PCL/MSO and PCL/SiO 2 membrane increased to 143.3 ± 1.2° and 141.7 ± 1.9°, respectively. It was worth noting the WCA of PCL/MSO/SiO 2 composite mat could reach 151.6 ± 1.7° and the sliding angle was 7.4 ± 1.2°. The excellent surface roughness and air-pocket capacity on the hierarchical membranes were believed to contribute to the superhydrophobicity of PCL/MSO/SiO 2 membrane. The unique microsphere-fiber interlinked hierarchical structure and superhydrophobicity of membrane could provide adequate support for oil adsorption and oil-water separation. The maximum n-hexane adsorption capacity of PCL/MSO/SiO 2 membrane was 41.37 g g −1 . Separation efficiency for n-hexane-water mixture of PCL/MSO/SiO 2 membrane was as high as 99.92%. The PCL/MSO/SiO 2 hierarchical superhydrophobic mats indicate the potential applications of environmental-friendly biopolymers as separator.
研究领域:
材料科学
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环境工程
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纳米技术
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高分子科学
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DOI
高影响因子
Advanced Composites and Hybrid Materials
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2022
·Vol. 5
·期 2
·991-1002
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IF 11.806
Xu Pei,Huang Bincheng,Tang Ruobing,Wang Zhenfeng,Tu Jiaying,Ding Yunsheng
The functionalization and distribution of conductive fillers and the interfacial compatibilization of polymer blends is the basic scientific problem of electromagnetic interference (EMI) shielding composites. Polylactic acid/polycaprolactone (PLA/PCL)-based nanocomposites containing polymerizable ionic liquid copolymer of poly(methoxy poly(ethylene glycol) monomethacrylate-co-1-vinyl-3-ethylimidazolium bromide) (PILs) and multi-walled carbon nanotubes (CNTs) were fabricated by the melt blending. The high affinity of MEPGMA segments of PILs for both phases and the interaction between the imidazole group of PILs and CNTs improved the dispersion and compatibility of CNTs in the matrix. PILs could expand to the interfacial layers as compatibilizers because of the high affinity of MEPGMA groups for polymer phases. The migration of CNTs from PLA to PCL phase was realized by the kinetic control and PIL-modified CNTs were selectively distributed at the co-continuous PLA/PCL interface and PCL phase of the PLA/PCL/4PIL/8CNT-6 m composite with blending time of 6 min. The selective localization of CNTs at interphase significantly can form effective conductive networks at the interface for PLA/PCL/4PIL/8CNT-6 m composite, which increase the electrical conductivity of the composite. The EMI shielding efficiency of the PLA/PCL/4PIL/8CNT-6 m composites, which can reflect and absorb microwaves with multiple times, reaches up to the maximum value 41 dB. Graphical abstract
The selective localization of CNTs at interphase forms effective conductive network. EMI SE of the PLA/PCL/4PIL/8CNT-6 m composite displays 41 dB.
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高影响因子
ACS Applied Polymer Materials
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2023
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IF 5
Jianing Lv,Anying Wang,Yinwen Li,Shoufang Xu,Xingjian Li
Beyond self-repairability and reprocessability, permanent shape reconfigurability in thermadapt shape memory polymers (TSMPs) is a prominent functionality in dynamic covalent polymer networks. The design and synthesis of TSMPs with a wide range of tunable macroscopic properties that do not require sophisticated chemistry or modification are highly desirable for real-world device applications but are a significant challenge. Herein, we present a straightforward yet efficient strategy to prepare TSMPs with adjustable properties, good reconfigurability, and self-repairability via ester–ester exchange. The class of TSMPs is engineered as the architecture of AB copolymer networks (AB-CPNs), which are composed of the semicrystalline polycaprolactone (PCL) as the A-segment and the poly(butyl acrylate) (PBA) as the B-segment. Regulating the weight content of the PCL segment in the thermadapt shape memory PCL-co-PBA networks can govern the network rearrangement kinetics, thermal properties, thermomechanical properties, switching temperature, and shape memory properties. The thermadapt shape memory AB-CPNs with ester–ester exchange do not require the introduction of extra hydroxyl groups, and their network structure is readily adjusted, allowing for considerable flexibility in the structure design and property adjustment. It is anticipated that a large family of thermadapt shape memory AB-CPNs with widely tunable macroscopic properties and the commercial availability of precursors will contribute significantly to real-world applications of SMP devices.
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高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2021
·Vol. 306
·期 12
·2100587
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IF 4.367
Yang Wang,Maoli Ying,Meng Zhang,Xuehong Ren,Ick Soo Kim
Wound dressings are usually employed to maintain suitable conditions around the injured skin to accelerate wound healing. This paper aims to report functional composite dressings combined with polycaprolactone (PCL) nanofibers, self-assembly zein coating and modified ZnO nanoparticles (ZnO NPs) for wound management. The synthetic compounds and prepared composite dressings are characterized by Fourier infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy. Meanwhile, the water vapor transmission rate, hemostatic performance, antibacterial activity, and cytocompatibility of the composite dressings are systematically tested to evaluate their applicability in wound treatment. The results show that the multilayer dressings can retain moisture and prevent excessive dehydration of wound. In vitro hemostatic test is conducted, and the enhanced blood clotting capacity and the activation of platelets indicate that the desired dressings are able to control hemorrhaging from wound. Meanwhile, the composite dressings with excellent biocidal efficacy against Gram-positive Staphylococcus aureus (6.01 Log within 30 min) and Gram-negative Escherichia coli O157:H7 (6.04 Log within 30 min) can effectively prevent wound infection. Furthermore, the dressings show no toxicity which are evidenced in hemolysis and cytocompatibility evaluation, and have potential application for wound healing.
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高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2018
·
IF 1.551
Ju Lv,Xueqiong Yin,Rongguo Li,Junhua Chen,Qiang Lin,Li Zhu
Superhydrophobic composite nanofibrous membranes(PP) were prepared from polycaprolactone (PCL)/polystyrene (PS) through solution blow spinning with an airbrush for oil adsorption. PP membranes were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, water contact angle, X-ray Photoelectron Spectroscopy, X-ray diffractometer, and thermogravimetric analysis instrument. The effects of mass ratio of PCL and PS on the morphology, porosity, density, cyrstallinity, thermal stability, and oil adsorption ability were investigated. PP membranes had higher density than PCL and PS, while better hydrophobicity. The saturation adsorption capacity of PP to peanut oil, motor oil, and diesel oil is 16.89 g/g, 20.33 g/g, and 12.17 g/g, respectively. After 6 cycles of reutilization, the adsorption capacity to peanut oil, motor oil, and diesel oil remained at 6.16, 7.46, and 5.33 g/g, respectively, higher than that of pure PCL membrane.The water/oil adsorption selectivity of PP was about 7:100. PP had higher oil adsorption capacities and better water/oil adsorption selectivity than the commercial oil absorbent polypropylene. PP membrane could be prepared and used in situ to separate oil from oil/water mixture. POLYM. ENG. SCI., 59:E171–E181, 2019. © 2018 Society of Plastics Engineers
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高影响因子
危险品化学品经营许可证（带存储）