FOOD CHEMISTRY
·
2025
·
IF 9.8
Li Xia,Zhina Chen,Hui Liu,Ying Xue,Hualin Wang
In recent years, there has been an increasing focus on the development of active films for monitoring and maintaining food freshness. However, its further functional diversification remains highly desirable. In this study, the active polycaprolactone (PCL) based membranes loaded with carvacrol (CA) are fabricated via electrospinning technique for grape preservation. Upon touching with ethanol exudate, the resulting membrane is capable of changing from opaque to a reversible transparent packaging (RTP) through interfibrillar fusion during food storage. The RTP exhibits good reusability with light transparency above 80 % after 10 cycles. CA is well-dispersed in the fiber matrix by hydrogen bonding and enriching the membrane with strong antibacterial activity. Furthermore, the release of CA from film matrix is well controlled and predominantly governed by Fickian diffusion. In addition to freshness monitoring, PCL-CA15 can effectively extend the shelf life of grape by about 4 days at 25 °C.
研究领域:
食品科学
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材料科学
·
生物学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2026
·
IF 4.7
Lei Kang,Chunquan Ma,Xiajie Hu,Xudong Wu,Rong Shan,Fuxiang Song
Bone tissue engineering scaffolds are used to repair dimensional alveolar crest defects resulting from etiologies such as trauma, infection, or tumor resection, thereby enabling a more accurate, efficient, and predictable dental diagnosis and treatment. In this study, cone beam computed tomography (CBCT) data from patients with alveolar crest defects were utilized to design a personalized scaffold. Subsequently, the 3D PCL/β-TCP scaffold was successfully fabricated based on this design using 3D printing technology. In parallel, a comprehensive series of assays were conducted to evaluate the properties of the 3D PCL/β-TCP scaffold, including its ability to promote MC3T3-E1 cell adhesion and proliferation in vitro. Furthermore, its capacity to induce bone formation was assessed in an in vivo animal model. The results demonstrated that the scaffold exhibited excellent biocompatibility, as evidenced by CCK-8 and live/dead (AM/PI) fluorescence staining assays, and significantly facilitated the adhesion and proliferation of MC3T3-E1 cells. Additionally, ALP and Alizarin Red staining experiments indicated that the 3D PCL/β-TCP scaffold significantly enhanced ALP expression and calcified nodule formation. Finally, the in vivo experiments in rats with skull defects confirmed that the 3D PCL/β-TCP scaffold contributed to accelerated bone formation. In summary, owing to numerous favorable properties such as personalized customization, biomimetic porous architecture, and excellent osteogenic ability, the 3D PCL/β-TCP scaffold was confirmed to be an advantageous candidate, offering ideas and effective methods for the precise repair of the alveolar crest.
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DOI
PubMed
高影响因子
POLYMER
·
2019
·
IF 3.771
Lan Du,Jiang Dai,Zhi-Yuan Xu,Ke-Ke Yang,Yu-Zhong Wang
Shape memory polymers have been widely applied in actuators and space deployable materials due to the shape-change feature under external stimuli. Actually, it will show greater potential in smart materials if the shape memory technique creatively combined with other functions. Herein, a shape and color memory material was prepared by incorporating a photochromic molecule spiropyran into the shape memory poly( ε -caprolactone) network. Integrating shape memory effect with color variance in this network, we firstly mimic a blooming rose with color change as it warms through specific assembly and procedures. Assisted with dynamic bond exchange of urethane and ester linkages, surface patterning, and molding technology, a series of application models can execute SME accompanied with color change were demonstrated, including high security information storage material, anti-counterfeit label and encryption label.
研究领域:
材料科学
·
智能材料
·
化学工程
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DOI
高影响因子
BIOMATERIALS
·
2014
·
IF 8.312
YuJun Wang,LiJuan Chen,LiWei Tan,Qian Zhao,Feng Luo,YuQuan Wei,ZhiYong Qian
In this study, a composite drug delivery system was developed and evaluated for oral delivery of docetaxel: docetaxel-loaded micelles in pH-responsive hydrogel (DTX-micelle–hydrogel). Docetaxel was successfully loaded in micelles with small particle size of 20 nm and high drug loading of 7.76%, which contributed to the drug absorption in the intestinal tract. The experiments of cytotoxicity on 4T1 cells demonstrated the effective antitumor activity of DTX micelles. Meanwhile, a pH-responsive hydrogel was synthesized and optimized for incorporating the docetaxel micelles. The pH-responsiveness and reversibility of the hydrogel were investigated under the pH conditions of the gastrointestinal tract . Furthermore, the DTX-micelle–hydrogel system showed much quicker diffusion of micelles in simulated intestinal fluid than in simulated gastric fluid, which was mainly caused by the change of pH value. The docetaxel released from the micelle–hydrogel system quite slowly, so it had little influence on the absorption of DTX micelles in small intestine . More important, the pharmacokinetic study revealed that the DTX-micelle–hydrogel significantly improved the oral bioavailability of docetaxel (75.6%) about 10 times compared to DTX micelles, and this increase in bioavailability was probably due to the small intestine targeting release of the pH-responsive hydrogel. Consequently, the oral DTX-micelle–hydrogel system was effective in inhibiting tumor growth in subcutaneous 4T1 breast cancer model, and decreased systemic toxicity compared with intravenous treatment. The apoptosis cells in the immunofluorescent studies and the proliferation-positive cells in the immunohistochemical studies were also consistent with the results. Therefore, the DTX-micelle–hydrogel system might be a promising candidate oral drug for breast cancer therapy.
研究领域:
药剂学
·
肿瘤学
·
生物材料
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 21
·7158
·
IF 4.927
Lu Pan,Jiahao Yang,Lan Xu
Simvastatin (SIM) particles are liposoluble drugs with large particle sizes, resulting in poor compatibility with electrospun polycaprolactone (PCL)/polyethylene glycol (PEG) nanofibers, so that part of them will be exposed to the electrospun nanofiber surface, which is easy to cause the burst release of drugs. Therefore, in this paper, stearic acid (SA) with good biocompatibility was innovatively added to increase the dispersion uniformity of SIM in the spinning solution, thus improving the performances of SIM-loaded PCL/PEG nanofiber membranes (NFMs). Accordingly, the effects of SA addition on the morphologies, mechanical properties, wettability, and drug release properties of the SIM-loaded NFMs were studied. The results showed that after SIM was dissolved in SA solution, the particle size of SIM was significantly reduced and could be evenly dispersed in the polymer spinning solution, thus obtaining the SIM-loaded composite NFMs with the best morphology and performance.Keywords:electrospinning;simvastatin;composite nanofiber membranes;drug release
研究领域:
药学
·
材料科学
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Yajuan Wang,Yuxin Chen,Wenshuo Wang,Xiaofan Zheng,Shiping Chen,Shengzhang Wang,Fujun Wang,Lu Wang,Yongtai Hou,Chaojing Li
The heart valve is a key structure for human blood circulation, and the development of artificial heart valves (AHVs) has become one of the research hotspots in the field of cardiovascular diseases. Compared to the vulnerability of biological valves to compression damage in transcatheter aortic valve replacement surgery (TAVR), polymer valves have shown superior performance in research. However, its structural differences from natural valves have limited its development. In this study, polycaprolactone gelatin (PCL-Gel) co-spinning directional nanofibers (FIB) were used to construct a three-layer structure of orientation layer-random layer-orientation layer imitating natural valves. Then, PCL-Gel/PAAm-co-PAA-Fe composite (COM-Fe) was prepared by iron ion crosslinking the oriented fiber membrane wrapped by polyacrylamide polyacrylic acid copolymer hydrogel (COM). The COM-Fe material has anisotropy similar to that of native valves and fully meets the thickness requirements for transcatheter surgery. In vitro simulated compression results showed that the COM-Fe material has no significant structural or strength loss after short-term curling compression. In vitro fluid dynamics results showed that the COM-Fe samples could fully achieve the parameters specified in ISO 5840-3:2021. In addition, COM-Fe materials showed excellent biocompatibility both in vitro and in vivo, and demonstrated anti-inflammation potential in a rat subcutaneous embedding model. It can be seen that biomimetic COM-Fe composite materials with good curling compression resistance and valve function have great potential for application in the direction of transcatheter AHVs.
研究领域:
心血管医学
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生物材料学
·
组织工程学
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DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2018
·Vol. 25
·期 4
·1-10
·
IF 1.434
Zhang Haoruo,Heng Zhengguang,Chen Yang,Zou Huawei,Liang Mei,Zeng Zhong
The curing kinetics of epoxy system modified with Poly(ε-caprolactone)-block-Polystyrene (PCL- b -PS) diblock copolymer was investigated by differential scanning calorimetry(DSC). PCL- b -PS was synthesized Via the combination of ROP and ATRP, then incorporated into epoxy to access the nanostructured thermosets. The results of TEM, SAXS and DSC demonstrated the occurrence of Reaction-induced Micro-phase Separation. Kinetic studies showed that the PCL- b -PS block copolymer delayed the curing reactions of epoxy system. The occurrence of Reaction-induced Micro-phase Separation had no significant effect on the total heat of reaction ∆H and the total activation energy, but resulted in a higher activation energy at the beginning of curing. The increase in activation energy at the initial stage of curing was related to the size and distribution of the dispersed phase. It is expected that the investigation of cure kinetics of EP/PCL- b -PS could provide more theoretical basis for the preparation of block copolymer modified epoxy resin.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 10
·5338-5346
·
IF 3.049
Jingqi Ma,Lili Lin,Yi Zuo,Qin Zou,Xin Ren,Jidong Li,Yubao Li
In the study, a specific material system that contains poly-(ε-caprolactone) (PCL), polyvinyl acetate (PVAc) and hydroxyapatite (HA) was used to fabricate porous scaffolds employing a 3D printing technique for bone regeneration. Four groups of 3D printing scaffolds were fabricated: PCL, PCL/PVAc, PCL/HA and PCL/PVAc/HA for comparision. The morphologies, mechanical properties and biological characteristics of these scaffolds were analyzed using SEM, a material testing machine, in vitro cell culture and in vivo animal experiments. The results showed that these 3D printed scaffolds possessed porous channel structures with a hole size of 375–475 μm and porosity of 74.1–76.1%. The compressive moduli of the scaffolds increased with the addition of HA and decreased with the addition of PVAc. The PCL/PVAc/HA scaffold exhibited higher cell proliferation and bone formation rates than other groups (p < 0.001), which could be attributed to the synergistic effect of PAVc and HA components. Two types of new bone formation patterns in the scaffold were found in this study: one is the new bone formed directly on the grid matrix, and the other is the new bone initially formed in the center of the scaffold channel and then remolded to concentric circles. The osteogenesis pattern of the latter is analogous to the osteon structure of a cortical bone. The 3D printed scaffold based on PCL/PVAc/HA tri-component system is a promising prospect for future individualized bone repair applications.
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DOI
PubMed
高影响因子
POLYMER
·
2026
·
IF 5.1
Tianyu Liu,Xuening Li,Yunhan Wu,Yunjie Cai,Tong Shen,Mingmei Wang,Xinping Zhang,Zezhong Lin,Rongchao Xue,Chong Wang,Guiying Zhu
PVC as an important plastic material, has gained widespread application due to its excellent physical properties, good heat and chemical resistance, as well as low cost. By incorporating plasticizers and other plastic additives, rigid PVC can be extended to applications in the flexible PVC field. However, conventional low-molar-mass phthalate plasticizers tend to migrate from the PVC matrix to the external environment during long-term use. This migration not only deteriorates the physical properties of PVC but also poses risks to human health and the environment. Therefore, improving the stability of plasticizers in PVC materials is of great significance.In this study, two structurally different plasticizers were prepared by hydroxyl-initiated ring-opening polymerization of ε-caprolactone. The mechanical properties of PVC plasticized with Lignin-PCL, C 5 H 12 O-PCL, and the conventional plasticizer DOP were compared. The results show that PVC plasticized with Lignin-PCL exhibited improved mechanical properties compared to those plasticized with the conventional plasticizer. Interestingly, the hyperbranched plasticized PVC demonstrated higher modulus, strength, and toughness than its linear counterpart. The resulting plasticized PVC materials exhibited a high modulus of approximately 30 MPa while ensuring an elongation at break exceeding 300%. The migration rates of all Lignin-PCL-PVC samples were below 5%, which is only 0.026 times that of DOP-PVC. Moreover, as both lignin and PCL are degradable and environmentally friendly materials, the degradation performance of the materials was also investigated. The study found that the hyperbranched plasticizer Lignin-PCL could be degraded by more than 80%, which is crucial for the development of environmentally friendly flexible PVC materials.
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DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2020
·
IF 3.862
Muhammad Zaheer,Jinxian Yang,Xu Wang,Lianwei Li
This work aims to systematically elucidate the biodegradation and crystallization behaviors of the model hypergraft systems made of poly( ε -caprolactone) (PCL) and poly[tri(ethylene glycol) methyl ether acrylate] (PTEGMA) blocks. A series of hyperbranched PCL (HB-PCL n ) with varied subchain lengths were synthesized using AB 2 -type macromonomers with different degrees of polymerization ( DP s). The HB-PCLs were grafted with linear PTEGMA chains to prepare amphiphilic hypergraft copolymers (HB-PCL n - g -PTEGMA m ) to eventually get self-assembled structures through micellization. The DP of PTEGMA was also varied to get two sets of samples with varied sub-chain lengths of the hyperbranched core and the linear corona within each individual set to systematically study the crystallization and biodegradation behaviors of PCL. Differential scanning calorimetric (DSC) measurements of both hypergrafts and linear precursors were compared in order to get insights into the crystallization pattern of PCL. We found that the degree of crystallization in PCL can be controlled from ~0 (lowest limit) to ~52% (highest limit) by structural regulation. Biodegradation studies were performed in aqueous medium with Lipase from Pseudomonas using dynamic light scattering (DLS). A model was proposed to correlate the sub-chain length of core, the chain length of corona with the biodegradation rate of PCL, which reveals that an increase of PCL content in HB-PCL n - g -PTEGMA m increases the crystallinity while decreases the rate of biodegradation in a predictable manner.
研究领域:
材料科学
·
生物学
✓ 已验证
DOI
高影响因子
Advanced Science
·
2025
·
IF 14.1
Lingling Fan,Weiliang Dong,Jianqi Lu,Yujia Peng,Bin Xie,Ping Wei,Min Jiang,Su Chen
Uncontrolled degradation of wound dressings may result in residues, causing several negative effects on wound healing, such as secondary damage, undesirable inflammation, and scar skin formation. Here, an available strategy associated with the synthesis of enzyme-loaded ( Burkholderia cepacia lipase, BCL) polycaprolactone (PCL) nanofiber scaffolds, aligning with wound healing effects is reported. These scaffolds are fabricated via fiber microfluidic electrospinning degradation-control technique. The obtained scaffolds exhibit tunable degradation rates, achieving complete degradation within 12–72-h cycles. The acidic degradation products are further elucidated and reveal the potential degradation mechanism. The acidic degradation products create an optimal microenvironment during the hemostasis and inflammation stages of wound healing. Notably, in vivo experiments demonstrate the enzyme-loaded scaffolds effectively promote angiogenesis, reduce inflammatory responses, mitigate collagen deposition, and regulate fibroblast differentiation. This promotes rapid wound healing with a remarkable scarless rate of over 99% by day 21. New guidelines for scar-free healing dressings are proposed, which carry out faster degradation without microplastics (MPs) and toxic byproducts before scar formation. These principles might provide valuable insights and promise for developing more effective wound dressings.
研究领域:
生物材料学
·
组织工程
·
再生医学
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DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 3.6
Ying Wang,Haoyou Jiang,Botian Zhu,Hualin Zhang,Mengmeng Zhao,Yeheng Cao,Fuming Wang,Xuyang Feng,Junru Wang
Wound ulceration induces inflammation, delays tissue repair, and may trigger systemic infections, thereby endangering bodily health. Hydrogel films are capable of accelerating wound healing processes. This study fabricated polyvinylpyrrolidone/polycaprolactone (PVP/PCL) nanofiber-hydrogel membranes via juxtaposed electrospinning, overcoming the limitations of traditional electrospinning techniques. Hydrophilic PVP (15% w/v in ethanol with 0.03% DAS) and hydrophobic PCL (15% w/v in chloroform/ N , N -dimethylformamide (CF/DMF) 4:1) were employed, with PVP/PCL ratios precisely regulated. The optimal VC-8/2 (PVP/PCL = 8:2) exhibited excellent performance, featuring a viscosity of 176.5 cp, a smooth, bead-free morphology prior to swelling (diameter: 718.22 ± 142.96 nm), and a twisted structure post-swelling (diameter: 268.71 ± 94.21 nm)—all enabled by optimized solvents and juxtaposed electrospinning that eliminated phase separation. Additionally, the VC-8/2 demonstrated a tensile strength of 1.16 ± 0.10 MPa, an elongation at break of 94.35% ± 5.64%, and a 40% water absorption rate after 12 h. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) confirmed the successful cross-linking of PVP, while CCK-8 assays revealed high L929 cell viability (87.23%–91.44%), exceeding the 85% non-cytotoxic threshold. These biocompatible membranes integrate the exudate absorption capacity of PVP and the mechanical support of PCL, rendering them highly promising for advanced wound dressing applications. Graphical Wound ulceration endangers health by inducing inflammation, delaying tissue repair, and triggering systemic infections, while hydrogel films accelerate wound healing. This study fabricated polyvinylpyrrolidone/polycaprolactone (PVP/PCL) nanofiber-hydrogel membranes via juxtaposed electrospinning (overcoming traditional electrospinning limitations) using hydrophilic PVP (15% w/v in ethanol with 0.03% DAS) and hydrophobic PCL (15% w/v in CF/DMF 4:1). The optimal VC-8/2 (PVP/PCL = 8:2) showed a smooth pre-swelling morphology (718.22 ± 142.96 nm) and twisted post-swelling structure (268.71 ± 94.21 nm), with 1.16 ± 0.10 MPa tensile strength, 94.35% ± 5.64% elongation at break, 40% 12-h water absorption, successful PVP cross-linking (ATR-FTIR), and high L929 cell viability (87.23%–91.44%). Integrating PVP's exudate absorption and PCL's mechanical support, the membranes are promising for advanced wound dressings.
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DOI
高影响因子
危险品化学品经营许可证（带存储）