LASER PHYSICS LETTERS
·
2018
·Vol. 15
·期 5
·055701
·
IF 2.235
Xi Liu,Meizhen Huang,Jie Chen,Lili Kong,Keihui Wang
A simple method, based on a roll-to-roll ultraviolet micro-pyramid imprinting technique and a nanoparticle self-assembling process in aqueous solution, to fabricate a large-area, flexible surface-enhanced Raman scattering (SERS) polyethylene glycol terephthalate substrate is proposed. The SERS substrate is demonstrated to be of high sensitivity. The detection concentration of Rhodamine 6G (R6G) measured by a portable Raman spectrometer is down to 10−9 mol l−1. The relative standard deviation values of different spots and different substrates are less than 13%. In addition, the feasibility for rapid detection of dye in herbal tea based on this SERS substrate and a portable Raman spectrometer is investigated. Three industrial dyes are employed to simulate the dyeing process. It is presented that R6G of 4.8\times {{10}^{-7}} g ml−1, malachite green of 10−6 g ml−1 and Auramine O of 10−6 g ml−1 in herbal tea could be detected rapidly. The experimental results imply that this method could be potentially applied in the field of dyed herbal tea detection.
研究领域:
分析化学
·
材料科学
·
食品安全
✓ 已验证
产品关联
DOI
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2020
·Vol. 18
·期 18
·3512-3521
·
IF 3.412
Shijie Wang,Dingyao Gao,Ke Li,Siqin Ye,Qingzhu Liu,Ying Peng,Gaochao Lv,Ling Qiu,Jianguo Lin
Early evaluation of the therapy efficiency can promote the development of anti-tumor drugs and optimization of the treatment method. Caspase-3 is a key biomarker for early apoptosis. Detection of caspase-3 activity is essential for quick assessment of the curative effect. We have reported a PET probe that could image drug-induced tumor apoptosis in vivo. However, high liver uptake limits its application. In order to optimize the pharmacokinetics of the previous probe, we introduced a hydrophilic peptide sequence to minimize liver uptake. The structure of the new probe was confirmed by mass spectrometry and nuclear magnetic resonance. This probe was able to cross the cell membrane freely and could be converted into a dimer through the condensation reaction of 2-cyano-6-aminobenzothiazole (CBT) and cysteine in response to intracellular activated caspase-3 and glutathione (GSH). The hydrophobic dimers further self-assembled into nanoparticles, which could enhance the probe aggregation in apoptotic tumor tissues. In vivo experiments showed that the tumor uptake of the new probe was higher than that of the previous probe, while the liver uptake of the new probe was significantly reduced. The new probe might be promising in imaging apoptotic tumors with suitable pharmacokinetics.
研究领域:
放射药理学
·
医学影像
·
肿瘤学
·
药物动力学
✓ 已验证
DOI
PubMed
高影响因子
APPLIED ENERGY
·
2023
·
IF 11.2
Ali Reza Kamali,Siyuan Li
Polyethylene terephthalate (PET) is one of the most widely used plastic materials, and therefore, its clean, efficient and low-cost valorization into high-value materials is of substantial economic and environmental interest. Here, for the first time, the utilization of molten salts for the facile, scalable and fast depolymerization of PET into terephthalic acid (C 8 H 6 O 4 ) is reported. It is asserted that the simple heat-treatment of PET in molten KCl-LiCl containing SnCl 2 in air leads to the green preparation of nanocrystalline terephthalic acid embedded with SnO 2 nanocrystals, with an excellent performance as the anode of lithium ion batteries (LIBs). The structural, morphological, thermal, surface, electrical and electrochemical characteristics of plastic-derived nanocomposites are evaluated by various techniques. The sample prepared at 500 °C (PDN-500) contains 28.3 wt% SnO 2 , and exhibits an enhanced bulk electrical conductivity of 447.3 S m −1 , and an excellent Li-ion storage capacity of 498 mAh g -1 after 500 cycles, corresponding to 1657 mAh per gram of SnO 2 . This performance is accompanied by an enhanced lithium ions diffusion coefficient of 8.51 × 10 −10 cm 2 s −1 recorded after 300 cycles, and a capacitive storage contribution of above 42 %. The sustainability of the presented molten salt approach is discussed from two complementary points of view, in terms of the clean conversion of waste plastics into high-performance anode materials for LIBs, as well as the facile and scalable depolymerization of PET, reducing the waste plastics in our environment. This article proposes an efficient and green strategy for the valorization of waste plastics into nanostructured SnO 2 @terephthalic acid for energy storage applications .
研究领域:
材料科学
·
能源存储
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-15
·
IF 12.6
Wang Xingyi,Fang Hanyi,Hu Wenzhu,Feng Yuan,Zhou Zhangyongxue,Hu Mengyan,Jiang Dawei,Zhang Yongxue,Lan Xiaoli
Limited treatment response and inadequate monitoring methods stand firmly before successful immunotherapy. Recruiting and activating immune cells in the hypoxic tumor microenvironment is the key to reversing immune suppression and improving immunotherapy efficacy. In this study, biomimetic oxygen-delivering nanoparticles (CmPF) are engineered for homologous targeting and hypoxia alleviation within the tumor environment. CmPF targets the tumor microenvironment and delivers oxygen to reduce hypoxia, thereby promoting immune cell activity at the tumor site. In addition, granzyme B-targeted positron emission tomography (PET) imaging is employed to monitor immune cell activity changes in response to immunotherapy efficacy in vivo. The combination of CmPF with carboplatin and PD-1 inhibitors significantly suppresses tumor growth by 2.4-fold, exhibiting the potential of CmPF to enhance the efficacy of immunotherapy. Immunohistochemistry further confirms increased expression of key immune markers, highlighting the reprogramming of the tumor microenvironment. This study demonstrates that hypoxia alleviation enhances tumor immunotherapy efficacy and introduces a non-invasive PET imaging method for dynamic, real-time assessment of therapeutic response.
研究领域:
肿瘤学
·
免疫学
·
纳米技术
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Guoqiang Zhang,Jieke Du,Chengsong Zhang,Zhiyi Zhao,Yuexing Chen,Mingyu Liu,Jianwei Chen,Guangyi Fan,Li Ma,Shengying Li,Kun Liu
Widespread use of polyethylene terephthalate (PET) plastics and their recycling challenges have led to substantial accumulation of PET wastes in global environments, with inevitable consequences for their entry into the food chains. Recent studies have increasingly documented the ingestion of microplastics by humans through food and beverages. However, the fate of these microplastics within the gastrointestinal tract, particularly the role of the human gut microbiota, remains inadequately understood. To address this knowledge gap, we employed a bioinformatics workflow integrated with functional verification to investigate the PET digestion/degradation capabilities of intestinal microorganisms. This approach identified a novel PET hydrolase—HGMP01 from the human gut metagenome, which exhibits the capacity to hydrolyze PET nanoparticles. Moreover, comprehensive exploration for HGMP01 homologues in the human gut metagenome and metatranscriptome unveil their distribution in diverse intestinal microorganisms. This study provides biochemical evidence for an unforeseen role of human gut microbiome in plastic digestion, thus holding substantial implications for human health.
研究领域:
环境科学
·
微生物学
·
生物化学
·
人类健康
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2018
·
IF 8.173
Jintao Cai,Tao Chen,Yuanhong Xu,Shuang Wei,Weiguo Huang,Rui Liu,Jingquan Liu
Molecularly imprinted technique (MIT) has proven to be a significant tool in the analyzing area in virtue of its obvious advantages such as specific recognition, favorable stability to high temperature and higher sensitivity. Electrochemiluminescence (ECL) technology has also been receiving enormous attention as a powerful tool in sensing fields. However, sensors based on the combination of MIT and ECL technologies have seldom been reported yet. Herein, we find that Ru(bpy) 3 2+ cannot only work as an efficient catalyst for photo-induced electron transfer–reversible addition–fragmentation chain transfer (PET-RAFT) polymerization, but also as a sensing probe for ECL sensor. Based on this, we successfully construct ECL sensors via the combination of MIT and ECL techniques. In details, poly(methacrylic acid) (PMAA) and cross-linked PMAA were synthesized first via a well-controlled PET-RAFT polymerization using Ru(bpy) 3 2+ as catalyst under illumination of visible light with a wavelength of 460 nm, as confirmed by 1 H NMR and gel permeation chromatography (GPC). Then, negatively-charged Au nanoparticles (AuNPs) with average sizes of 20 nm were prepared and modified with Ru(bpy) 3 2+ via electrostatic incorporation. MIPs were prepared on the surface of AuNPs using melamine (MEL) as the template via PET-RAFT controlled cross-linking polymerization. The MIPs modified AuNPs (AuNPs-MIPs) were then fixed on the surface of working electrode with Nafion to achieve a solid-state ECL sensing platform employing Ru(bpy) 3 2+ as the ECL probes. The as-prepared sensor showed a wide detection range of 5.0 × 10 –13 − 5.0 × 10 −6 mol/L and a low detection limit of 1.0 × 10 –13 mol/L (S/N ≥ 3) was reached in the detection of MEL. Moreover, further tests for analyzing MEL structural analogues proved that the constructed ECL sensing platform could be utilized to detect various substances via specific recognitions.
研究领域:
分析化学
·
传感技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Ying Wang,Tengfei He,Jingguo Cao,Ke Li,Chengqian Wang,Qun Liu,Yu Zhang
This study demonstrates a sustainable strategy for synthesizing MIL-53(Al) and ZSM-5 zeolite through dual-waste synergy using coal fly ash (CFA) and waste polyethylene terephthalate (PET). A sequential alkaline fusion-acid leaching protocol selectively fractionated CFA into aluminum-rich solutions and silica residues, while alkaline hydrolysis of PET liberated terephthalic acid (PTA) as organic ligands. The Al 3+ -PTA coordination under solvothermal conditions produced MIL-53(Al)(CFA-PET) exhibiting well-defined 1D rhombic channels with a high BET surface area (1303 m 2 ·g −1 ), whereas hydrothermal crystallization of silica residues yielded ZSM-5(CFA), which formed spherical aggregates composed of 100 nm nanosheets with 89.9 % yield and a surface area of 311 m 2 ·g −1 . Structural advantages were evidenced by exceptional adsorption performance: MIL-53(Al)(CFA-PET) achieved 96.24 % methylene blue removal at pH 7 (250 mg·L −1 ), outperforming rhodamine B (30.8 %) and methyl orange (66.4 %), as well as reagent-synthesized MIL-53(Al) Che (91.99 %). Both materials demonstrated exceptional CO 2 capture capacities (4.23 mmol·g −1 for MIL-53(Al)(CFA-PET) vs. 2.37 mmol·g −1 for ZSM-5(CFA) at 273 K/1 bar), attributable to MIL-53′s flexible framework enabling dynamic pore adjustment and ZSM-5′s rigid microporous channels favoring molecular sieving. This work establishes a closed-loop strategy for converting industrial and plastic wastes into functionally differentiated porous materials through element-targeted process design.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Xiao Ma,Chen Zhu,Mingyue Li,Wenyuan Hu,Mei Hong,Fuping Qian
With the rapid advancement of urbanization, individuals spend over 90 % of their time in indoor environments, where prolonged exposure to indoor air pollutants particularly particulate matters (PMs) poses significant health risks. This highlights the urgent need to develop advanced fiber-based filtration systems that simultaneously exhibit high filtration efficiency and antimicrobial properties. In this study, a multifunctional ZIF-8@PET/CA-PP composite filter material was fabricated using commercial PET membranes as substrates via a combination of electrostatic spraying and self-assembly techniques. The resulting material features a surface-functionalized CA/ZIF-8/PVDF-HFP composite layer. Comprehensive characterization revealed that the optimized filter material achieves exceptional PM2.5 filtration efficiency of 98.52 % (±0.72 %) with a low air resistance of only 57 Pa, while demonstrating antibacterial rates of 93.75 % against Escherichia coli ( E. coli ) and 94.2 % against Staphylococcus aureus ( S. aureus ). The outstanding performance can be attributed to two key factors: (1) the uniform dispersion and dense nanostructure of the functional layer significantly enhances particle capture capacity through combined mechanical and electrostatic filtration mechanisms; (2) the incorporated ZIF-8 nanoparticles provide effective antimicrobial activity by disrupting microbial membranes. Further validation through X-ray micro-CT scanning simulations confirmed the filter material's structural integrity and consistent filtration performance across varying airflow velocities. The ZIF-8@PET/CA-PP composite filter material developed in this work represents a promising candidate for next-generation air filtration applications, offering an optimal combination of low air resistance, high filtration efficiency, and robust antimicrobial properties. These advantages position the material as particularly suitable for improving indoor air quality in urban environments.
研究领域:
材料科学
·
环境工程
·
纳米技术
·
空气过滤
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
NUCLEAR MEDICINE AND BIOLOGY
·
2018
·
IF 2.203
Weiyan Zhou,Weiqi Bao,Donglang Jiang,Yanyan Kong,Fengchun Hua,Xiuhong Lu,Yihui Guan
Introduction The objective of this study was to synthesize an N -methyl- d -aspartate receptor (NMDAR) radiotracer [ 18 F]-GE-179 in one-pot and evaluate its in vivo binding for NMDAR activation after brain ischemia reperfusion injury. Methods [ 18 F]-GE-179 was auto-synthesized using a quick one-pot method from a stable disulfide precursor and purified using semi-preparative high-performance liquid chromatography (HPLC) with ethanol/aqueous NaH 2 PO 4 as the eluent. Dynamic micro-positron emission tomography (PET)/computed tomography (CT) study of [ 18 F]-GE-179 was successfully performed using a rat model of middle cerebral artery occlusion (MCAO, induced by transient occlusion into the left MCA). A simplified reference tissue model method was used to calculate the [ 18 F]-GE-179 non-displaceable binding potential (BPND) for intracranial NMDAR activation assessment. Immunofluorescence staining of NMDAR NR1 subunit in brain slices containing lesion was also performed. Results [ 18 F]-GE-179 was successfully prepared in a yield of 23–30% in a formulation that could be injected directly after dilution. Localized radioactivity accumulation was observed in the animal model of MCAO. Significantly higher ( p = 0.0003–0.0404) BPND relative to equivalent contralateral was found in the ipsilateral caudate putamen , Acb core/shell, cortex cingulate , amygdala , hypothalamus , and superior colliculus . Immunofluorescence staining showed elevated NMDAR expression in the affected hemisphere. Conclusions [ 18 F]-GE-179 was synthesized using a one-pot process with a markedly improved yield. Preliminary in vivo micro-PET study visualized excessive NMDAR stimulation successfully in a rodent model of MCAO, which was consistent with results of in vitro immunofluorescence staining. The study demonstrates that [ 18 F]-GE-179 is a promising PET probe for the detection of functional NMDAR alterations.
研究领域:
神经科学
·
放射学
·
药理学
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR RESEARCH
·
2019
·Vol. 27
·期 11
·1144-1154
·
IF 1.758
Zhou Jinsheng,Lin Yanming,Ye Lin,Wang Ling,Zhou Li,Hu Huiyuan,Zhang Qilong,Yang Hui,Luo Zhongkuan
To solve the biofouling problem of polyvinyl alcohol (PVA) hydrogel as the artificial cornea, glycidyl methacrylate (GMA) and 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC) were grafted on the surface of PVA hydrogel via a new method of photoinduced electron transfer—reversible addition fragmentation chain transfer (PET-RAFT) polymerization and ring-open reaction. Both attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), scanning electron microscope (SEM), and thermogravimetric analysis (TGA) confirmed that GMA and HACC were successfully grafted on the surface of PVA hydrogel. A series of experiments to test the hydrophilicity of PVA hydrogel showed that it became hydrophobic due to the introduction of hydrophobic groups after grafting with GMA and HACC. In addition, cytotoxicity in vitro of PVA-g-p(GMA-HACC) hydrogel could be considered as not cytotoxicity according to ISO 10993-5: 2009. The anti-fouling property of hydrogel decreased after grafting with GMA due to the hydrophobic surface, while increased after grafting with HACC due to the steric repulsion of p(GMA-HACC) polymer brush. It’s no doubt that PET-RAFT was a feasible and reliable surface modification method which could be used in many biomolecules due to the excellent advantages.
研究领域:
生物材料学
·
表面化学
·
医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Qi Zhang,Dong Liu,Wei Pan,Haiyan Pei,Kunlun Wang,Shengang Xu,Yingliang Liu,Shaokui Cao
The multifunctional photoelectronic devices are recently attracting much more attention due to their potential enlarged applications. The flexible stretchable electrothermally/photothermally dual-driven heaters for all-weather wearable thermal management are presented in this work with nano-embedded hierarchical Cu x S-coated PET fabrics. Herein, the hierarchical nano-embedded Cu x S film is fabricated via a simple chemical bath method for high electrical conductivity and highly efficient inelastic collision of electro/photo-generated carriers. The hierarchical nano-embedded Cu x S morphology produces the low sheet resistance of 1.26 Ω sq -1 and the super low total heat transfer coefficient of 3.256 × 10 -5 W/ o C·mm 2 , which lead to the high-efficient electro/photo-dual-driven heating effect in the Cu x S@PET fabrics. The saturated temperature on the as-fabricated flexible wearable heaters reaches up to 172 °C. The thermal conversion devices also bear the excellent stability, reproducibility, stretchability, controllability and corrosion-resistant characteristics. Interestingly, their excellent thermal conversion performance could be achieved by freely exchanging the driving power sources, such as electricity-supplying equipment, 635-nm laser, infrared physiotherapy lamp and solar simulator, which provides a necessary precondition for the all-weather applications of flexible wearable heaters. The as-fabricated electro/photo-dual-driven heaters on the Cu x S@PET fabrics have the promising applications in wearable electronics, all-weather self-heating facilities, out/in-vivo physiotherapy, and so on.
研究领域:
材料科学
·
光电功能器件
·
可穿戴技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemSusChem
·
2023
·Vol. 16
·期 9
·e202300154
·
IF 8.4
Yuheng Lin,Deshuai Yang,Chaoyu Meng,Chunying Si,Quanxing Zhang,Guixiang Zeng,Wei Jiang
Graphical Replace the atom : Ni 2+ -doped MgO catalyst is developed via a combined theoretical and experimental approach, which exhibits excellent performance toward the glycolysis of polyethylene terephthalate (PET) with a bis(hydroxyethyl) terephthalate yield of 93.7 %. Ni 2+ doping is found critical to the generation of O − and deprotonated ethylene glycol which break the PET chain via nucleophilic attack. Developing efficient and eco-friendly catalysts for selective degradation of waste polyethylene terephthalate (PET) is critical to the circular economy of plastics. Herein, we report the first monatomic oxygen anion (O − )-rich MgO−Ni catalyst based on a combined theoretical and experimental approach, which achieves a bis(hydroxyethyl) terephthalate yield of 93.7 % with no heavy metal residues detected. DFT calculations and electron paramagnetic resonance characterization indicate that Ni 2+ doping not only reduces the formation energy of oxygen vacancies, but also enhances local electron density to facilitate the conversion of adsorbed oxygen into O − . O − plays a crucial role in the deprotonation of ethylene glycol (EG) to EG − (exothermic by −0.6 eV with an activation barrier of 0.4 eV), which is proved effective to break the PET chain via nucleophilic attack on carbonyl carbon. This work reveals the potential of alkaline earth metal-based catalysts in efficient PET glycolysis.
研究领域:
材料科学
·
催化
·
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）