ChemNanoMat
·
2024
·Vol. 10
·期 7
·e202400134
·
IF 2.6
Xiaoqian Yao,Feng Teng,Tao Yang,Peng Hu
Over the past few decades, the overuse of antibiotics has raised concerns about drinking water and potential health risks, especially the hydrochloride tetracycline (TC-HCl). Therefore, it is crucial to develop a simple, low-cost and high-efficiency photocatalyst for the degradation of the pollutant. A novel photocatalyst with an S-scheme heterojunction structure of AgIn 5 S 8 and Bi 2 MoO 6 was synthesized by using a solvothermal method. The heterojunction photocatalyst obtained demonstrates superior photocatalytic degradation activity for hydrochloride tetracycline (TC-HCl) under visible light irradiation. It exhibits higher photocatalytic degradation performance than pure AgIn 5 S 8 and Bi 2 MoO 6 under the same conditions. The heterojunction with 3 % AgIn 5 S 8 exhibited the highest degradation efficiency of 63.65 % within 40 minutes. Furthermore, the degradation rate is 6.21 times higher than that of AgIn 5 S 8 and 2.18 times higher than that of Bi 2 MoO 6 . The improved photocatalytic activity is primarily attributed to the enhanced light absorption and the high rate of carrier separation resulting from S-scheme heterojunctions.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
PROCESS BIOCHEMISTRY
·
2013
·
IF 2.414
Yuxiang Tang,Wei Liu,Jiangling Wan,Yuanxin Wang,Xiangliang Yang
We report the selective recovery of S-adenosylmethionine (SAM) from fermentation broths using a two-stage supported liquid membrane system with strip dispersion (SLM-SD). The system utilized two MiniModule ® hollow-fiber membrane modules as microporous supports and an organic membrane solution consisting of the extractants of sodium di-2-ethylhexyl sulfosuccinate (AOT), di-(2-ethylhexyl)phosphoric acid (DEHPA), and trioctylphosphine oxide (TOPO) in the solvent n-octanol. SAM was extracted in the first membrane module. Methionine (Met) was captured by the first stripping solution and further purified in the second membrane module. pH values in the feed phase and the first and second stripping solutions, extractant concentrations, NaCl concentration, and the SAM acceptor in the first stripping solution were optimized. Strip dispersion mixing speed, pressure differences across the membranes, and flow rates of the feed and strip dispersion phases were investigated experimentally. The optimal extractant concentrations were: AOT 2.78 wt%, DEHPA 27.0 wt%, and TOPO 1.61 wt%. The optimal pH values in the feed phase and the first and second stripping solution were 3.0, 2.5, and 1.0, respectively. SAM extraction efficiency of 98.7%, SAM recovery efficiency of 91.8% and Met removal efficiency of 85.4% were achieved within 5 h. Finally, the mass transfer analysis indicated that the mass transfer resistances from the extraction reaction and the membrane phase were predominant.
研究领域:
生物工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
TOXICOLOGY
·
2025
·
IF 4.6
Hua Zhang,Fei Lin,Bo-Han Lin,Xiong-Lin Sun,Qing-Shui Zheng,Rui Gao,Yong Wei,Shao-Hao Chen,Xue-Yi Xue
Bisphenol S (BPS) is widely used in the production of food containers and children's toys and is known to have endocrine-disrupting effects linked to various cancers; however, its role in renal cell carcinoma (RCC) development remains unclear. This study investigates the mechanisms by which BPS may promote RCC progression. The effects of BPS on proliferation and migration were evaluated in HK-2 and 786-O cells using CCK-8, scratch, and Transwell assays. A LASSO regression model and functional analysis were employed to identify candidate genes involved in BPS-related renal cancer progression and to construct a prognostic model, which was validated using Kaplan-Meier and ROC curves. Additionally, the impact of BPS on epithelial-mesenchymal transition (EMT)-related markers was examined. Results showed that BPS did not significantly affect the proliferation of HK-2 and 786-O cells at concentrations of 0-10 μM but significantly enhanced cell migration and invasion, inducing EMT. The LASSO model identified nine key genes associated with BPS-related renal cancer progression, with WNT5A expression positively correlated with BPS concentration. Knockdown of WNT5A significantly inhibited BPS-induced migration of HK-2 and 786-O cells and disrupted the EMT process. These findings demonstrate that BPS promotes HK-2 and 786-O cell migration through the WNT5A-dependent EMT pathway, and inhibition of WNT5A expression can suppress this process. This study provides novel insights into the role of BPS in renal cancer progression and highlights potential therapeutic targets for RCC.
研究领域:
肿瘤学
·
分子生物学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 17
·8203-8214
·
IF 3.925
Lingli Zhang,Han Tao,Chun Ji,Qiaoling Wu,Xiao Wang,Yuangeng Wu
As an alternative to bisphenol A (BPA), bisphenol S (BPS) is widely used in many consumer goods and industrial products. However, BPS has similar genotoxic, reproductive and endocrine disrupting effects to BPA and can enter the body through the food chain or by dermal absorption to endanger human health. This paper presents a rapid and direct electrochemical sensing technique for ultra-trace BPS determination on the basis of the signal amplification of the 1T phase & 2H phase hybrid MoS2 nanosheets (1T&2H-MoS2) and amino-functionalized carbon nanotube (CNTs-NH2) composites. The cooperative electrocatalytic effect and high-electrically active surface area of 1T&2H-MoS2/CNTs-NH2 composites not only facilitated the electron transfer between BPS and the electrode, but also promoted the adsorption of BPS on the electrode. Hence, the 1T&2H-MoS2/CNTs-NH2 modified electrode exhibited excellent electrocatalytic activity with a lower oxidation potential and higher peak current for BPS. Under the optimized conditions, the peak current response of BPS showed a good dose-dependent relationship with its concentration in the range of 0.02–1.0 μM and 1.0–70.0 μM, while the detection limit was as low as 8.6 nM. The proposed method was used to determine BPS in the mineral water bottle and orange juice samples with satisfactory spiked recoveries between 92.31% and 104.20%, demonstrating its reliability and practicality in real sample analysis. Furthermore, the sensing method has the characteristics of facile electrode fabrication, fast response (<4 min) and good reproducibility.
研究领域:
环境科学
·
分析化学
·
毒理学
✓ 已验证
产品关联
DOI
高影响因子
Drug Design Development and Therapy
·
2017
·
IF 2.822
Jingrun Chen,Junjie Liu,Dongxiao Cui,Chaoqun Yan,Liqiang Meng,Liqian Sun,Shurong Ban,Rui Ge,Taigang Liang,Qingshan Li
This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactones. The newly synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C-NMR, mass spectrometry, and elemental analysis. All the derivatives were subjected to in vitro cytotoxicity screening against HEPG-2 (human liver carcinoma), SGC-7901 (human gastric carcinoma), and LS174T (human colon carcinoma), by using the MTT assay. The results revealed that several of the 4-methoxy-substituted compounds exhibited potent cytotoxicity. Among these, compound 12e showed the highest activity against cancer cells which 50% inhibitory concentration (IC50) values were in the range of 6.1–9.2 μM with low toxicity on normal human hepatocyte. Preliminary investigation of possible mechanisms of action of compound 12e against HEPG-2 cells indicated possible induction of apoptosis, as determined by morphological observations and Annexin V/propidium iodide (PI) double staining, in addition to apparent dissipation of mitochondrial membrane potential (MMP), as measured by 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide (JC-1) staining in combination with the activation of caspase-9 and caspase-3 by Western blot analysis. Overall, the data suggest that compound 12e may be a promising potential anti-cancer agent that could act primarily by inducing apoptosis through the mitochondria-mediated intrinsic pathway in human hepatoma cells.
研究领域:
药理学
·
肿瘤学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
POLYHEDRON
·
2018
·
IF 2.067
Dejuan Fa,Mao Zhou,Hui Zhao,Yiwei Jiang,Yuqing Miao
The 3D flower-like Ni–Co–S was synthesized by a typical hydrothermal method in the presence of urea and thioacetamide. As comparison, the urchin-like Ni–Co–O was prepared in the absence of thioacetamide. The former processed higher electrocatalytic activity for methanol oxidation than the latter. Ni–Co–S exhibited the anodic peak current density of 19.23 mA/cm 2 for methanol oxidation, far higher than Ni–Co–O. It also showed the Tafel slopes of 57 mV/dec, much lower than Ni–Co–O. The BET results showed that the surface area and pore volume are 96.373 m 2 /g and 0.367 cm 3 /g for the flower-like Ni–Co–S, which is higher than 88.736 m 2 /g and 0.224 cm 3 /g for the urchin-like Ni–Co–O. As a result, the flower-like Ni–Co–S possessed more electroactive sites for methanol oxidation. The superhydrophobicity of the flower-like Ni–Co–S helps for the formation of micro air film on the surface of flower petals. Such a tri-phase interface of Ni–Co–S solid, reaction solution and air film may help for the electrocatalytic oxidation of Ni–Co–S toward methanol oxidation since the produced CO 2 can leave the surface of Ni–Co–S quickly and enter into solution phase due to the presence of air film and high solubility of CO 2 in aqueous solution.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Zhenlu Liu,Jing Xu,Caijin Xiang,Ye Liu,Lijun Ma,Linying Hu
Semiconductor materials can absorb visible light to become excellent hydrogen-producing materials. When different semiconductors are supported on each other, it can greatly promote the increase of hydrogen production rate. The article uses ZnS and CoMoO 4 to construct a new type of S-scheme heterojunction, and uses related characterization to illustrate the hydrogen production advantages and high performance reasons of the system. The experimental data of photocatalytic hydrogen production concretely proved the high catalytic performance of the composite material. The results shown that when the amount of ZnS loaded on CoMoO 4 was 5%, the adsorption of the composite catalyst and an appropriate amount of sensitizer made the hydrogen production rate reached 1233 μmol/g/h. This study used different characterizations to show the ball-and-stick structure of the composite catalyst and supplements the S-scheme heterojunction mechanism. Based on various studies, ZnS and CoMoO 4 had broad application prospects. The special electron transfer path of the S-scheme heterojunction provided theoretical model support for high-performance hydrogen production.
研究领域:
材料科学
·
能源化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Hongyu Niu,Xing-Bao Wang,Jingjie Luo,Jiaxin Liu,Chuang Li,Wen-Ying Li,Changhai Liang
Desulfurization plays a critical role in refining crude oil to produce fuel and the manufacture of fine chemicals. However, its low efficiency becomes a great challenge for the present desulfurization if only the C-S cleavage is considered a promising approach to reducing hydrogen consumption under atmospheric pressure. Accordingly, we investigate the critical factors necessary to achieve high C-S cleavage of dibenzothiophenes under mild conditions of 0.1 MPa and H 2 /oil = 100. The mechanism of reactive adsorption desulfurization of dibenzothiophenes with or without steric hindrance at atmospheric pressure on Pt/ZnO is proposed by studying the adsorption model of active metal sites, the Pt efficiency in C-S cleavage influenced by the steric hindrance and the structural evolution of Pt active centers in the presence of sulfur adsorption/deposition. Based on both experimental and DFT results, we report C-S cleavage of dibenzothiophenes with (TOF = 15 h −1 ) or without steric hindrance (TOF = 128 h −1 ) that can be highly efficiently fractured (99.9%) by the interface between PtS x and ZnO . This work has great practical significance for developing atmospheric industrial adsorbents for ultra-deep reactive adsorption desulfurization.
研究领域:
化学工程
·
催化材料
·
能源化工
✓ 已验证
产品关联
DOI
高影响因子
CEMENT AND CONCRETE RESEARCH
·
2025
·
IF 13.1
Haochuan Wang,Xin Liu,Chong Wang,Wei Wang,Jinxiang Hong,Pan Feng
Ultra-early mechanical properties are critical for shotcrete performance, significantly influenced by ettringite and calcium silicate hydrate (C-S-H) formed during the initial hydration stage and free water. This study investigates the individual and synergistic effects of these phases on mechanical behavior using equivalent cement pastes. In this system, cement was entirely replaced with dolomite particles of matching size distribution, with the controlled introduction of free water, ettringite, and C-S-H. The validity of these equivalent systems was confirmed through comprehensive characterization. Mechanical performance was subsequently evaluated using compression, shear, Vickers hardness and nanoindentation tests. Results revealed that free water remarkably weakened the mechanical properties, whereas both ettringite and C-S-H enhanced strength by reducing voids and reinforcing weak particle interfaces. Ettringite primarily contributed to interparticle friction, while C-S-H enhanced cohesion at interfaces including dolomite-dolomite, dolomite-ettringite and ettringite-ettringite contacts. When co-existing, C-S-H formed within the porous ettringite network, not only establishing a multi-scale filling structure but also stabilizing the dolomite-ettringite skeleton. These findings advance our understanding of the early-age mechanical development of shotcrete and highlight the potential of equivalent cement systems as robust tools for research into cementitious materials.
研究领域:
土木工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CEMENT AND CONCRETE RESEARCH
·
2024
·
IF 10.9
Binmeng Chen,Xu Fang,Yuyang Zhao,Zongjin Li
In recycling and reusing construction waste, carbonation of recycled concrete fine (RCF) has been successfully applied to produce value-added products, such as silica nanoparticles, via the breaking of calcium silicate hydrate (C-S-H) structure and condensation of silicate chains. However, the intricacies of carbonation of RCF with varying calcium to silicon (C/S) ratios and their implications on the size of generated silica nanoparticles remain unknown. In this work, we developed an optimized carbonation method at high water to solid ratio to fabricate silica nanoparticles from C-S-H with different C/S ratios. The particle size of silica nanoparticles was found to gradually decrease with the increased C/S ratio of C-S-H. Since as C/S ratio increased, silicate in Q 3 state shifted to Q 1 state and the silicate chain became shorter, shifting from long-range, disordered to short-range, ordered. As the disordered self-seeding growth of long silicate chains derived from C-S-H continued, the Si-O-Si network of silica nanoparticles became chaotic, leaving more unreacted Si-OH on its surface. On the contrary, the short silicate chains displayed higher possibility of condensation, making nanoparticles with a smaller diameter.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Jiamin Li,Changheng Chen,Jiangwen Bai,Yuehui Jin,Chongfeng Guo
Although self-polarized piezoelectric semiconductor photocatalysts significantly enhance the separation of internally generated photocarriers, their photocatalytic performance is constrained by insufficient internal polarisation and a wide bandgap. Additionally, the low concentration of oxygen in contaminated water limits the effectiveness of such photocatalysts. To the best of our knowledge, this study was the first to determine that the piezoelectric properties of Bi 2 MoO 6 (BMO), was due to the polarisation displacement of the MoO 6 octahedron that occurred along the x -axis, as revealed through density functional theory (DFT) calculations. Subsequently, the self-polarisation characteristics of BMO were enhanced and the bandgap was reduced through Fe 3+ doping, as confirmed via atomic force microscopy, hysteresis loop measurements and DFT analysis, resulting in an increase in surface potential from 30.41 to 46.80 mV. Furthermore, an S-scheme WO 3 /Bi 2 MoO 6 :Fe 3+ heterojunction was developed to improve the surface separation of photoelectron–hole pairs. The piezoelectric photocatalytic performance of this sample was evaluated through the degradation of rhodamine B (RhB) and oxygen generation. Results indicated that the degradation rate of RhB reached 98.63 % within 25 min under the synergistic influence of light and ultrasound, which was 1.85 and 9.60 times higher than those of Bi 2 MoO 6 and WO 3 , respectively. Furthermore, the optimal oxygen production efficiency was 167.41 µmol·g −1 ·h −1 . This study provides a novel approach for designing more efficient piezoelectric photocatalysts.
研究领域:
材料科学
·
环境科学
·
理论计算
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2021
·
IF 4.939
Qi Zhang,Baolin Huang,Hongjiao Xue,Zimin Lin,Jie Zhao,Zheng Cai
(S)-carvedilol (S-CAR) is the dominant pharmacodynamic conformation of carvedilol, but its further development for extended-release formulation is restricted by its poor solubility. This study aimed to prepare and screen S-CAR salts that could be used to improve solubility and allow extended release. Five salts of S-CAR with well-known acid counterions (i.e., phosphate, hydrochloride, sulfate, fumarate, and tartrate) were produced using similar processes. However, these salts were obtained with water contents of 1.60–12.28%, and their physicochemical properties differed. The melting points of phosphate, hydrochloride, and tartrate were 1.1–1.5 times higher than that of the free base. The solubility of S-CAR salts was promoted to approximately 3–32 times higher than that of the free base at pH 5.0–8.0. Typical pH-dependent solubilities were evidently observed in S-CAR salts, but considerable differences in solubility properties among these salts were observed. S-CAR phosphate and hydrochloride possessed high melting points, considerable solubility, and excellent chemical and crystallographic stabilities. Accordingly, S-CAR phosphate and hydrochloride were chosen for further pharmacokinetic experiments and pharmaceutical study. S-CAR phosphate and hydrochloride extended-release capsules were prepared using HPMC K15 as the matrix and presented extended release in in vitro and in vivo evaluations. Results implied that water molecules in the hydrated salt were a potential threat to the achievement of crystal stability and thermostability. S-CAR phosphate and hydrochloride are suitable for further development of the extended-release formulation.
研究领域:
药学
·
药物化学
·
制药工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）