FOOD CHEMISTRY
·
2020
·
IF 6.306
Baolei Dong,Hongfang Li,Jiefang Sun,Ghulam Mujtaba Mari,Jun Ai,Diangang Han,Xuezhi Yu,Kai Wen,Jianzhong Shen,Zhanhui Wang
Herein, we proposed a duplex and homogeneous fluorescent immunoassay for the simultaneous detection of amantadine (AMD) and chloramphenicol (CAP) residue in chicken breast with both high sensitivity and short assay time. The immunoassay was based on the fluorescence resonance energy transfer (FRET) between hapten-labeled carbon dots (CDs) and antibody-modified WS 2 nanosheets. To achieve the duplex FRET , polyethyleneimine-functionalized blue and green emissive CDs with separated emission were synthesized via a one-pot hydrothermal method and directly coupled with the haptens of AMD and CAP, serving as the energy donors. The antibodies were modified on the surface of WS 2 nanosheets with high quenching efficiency to construct the energy acceptor. The specific immunoreaction could trigger the efficient FRET between the donors and the acceptors, causing the fluorescence quenching of CDs. The developed immunoassay was applied to simultaneously detect AMD and CAP, having the detection limit of 0.10 ng g −1 and 0.06 ng g −1 , respectively.
研究领域:
分析化学
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纳米技术
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Fei Li,Huanshun Yin,Yan Chen,Siyu Wang,Jingyan Li,Yuemei Zhang,Chunxiao Li,Shiyun Ai
DNA formylation (5-formylcytosine, 5fC) is a major epigenetic modification involved in alterations in the DNA double helix structure and protein identification. Due to the low amount in all mammalian tissues and cells, it is necessary to develop a rapid, sensitive and efficient method for detecting 5fC for further understanding the biological functions of 5fC. Thus, a novel PEC biosensor was constructed using P-g-C 3 N 4 -WS 2 nanocomposite as photoactive material. Firstly, AuNPs/P-g-C 3 N 4 -WS 2 /ITO electrode was prepared as substrate electrode. Secondly, the probe DNA and complementary DNA (containing 5fC base) was modified to the electrode surface based on the formation of Au-S bonds between AuNPs and thiol group on the probe DNA and hybridization, respectively. Finally, the amino functionalized MnO 2 nanoflowers were further modified to the electrode surface by covalent interaction between the aldehyde group on the 5fC and the amino group on MnO 2 nanoflowers. The sensitive and specific detection of 5fC can be achieved by oxidizing ascorbic acid with MnO 2 nanoflowers and quenching the photoactivity of P-g-C 3 N 4 -WS 2 nanocomposite. The sensor has a detection range of 0.01–200 nM and a detection limit of 3.8 pM. Moreover, this sensor has excellent detection specificity, stability and reproducibility.
研究领域:
生物化学
·
分析化学
·
表观遗传学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
Journal of Physical Chemistry C
·
2023
·
IF 3.7
Lei Wang,Shuai Zhang,Long Yan,Xiaohong Ji,Qinyuan Zhang
The electronic and optical properties of two-dimensional transition metal dichalcogenides can be tuned by a doping strategy. Herein, spiral and monolayer Er-doped WS2 (WE) flakes have been synthesized by chemical vapor deposition using ErCl3, WO3, and S as precursors. The growth and properties of WE flakes have been systematically studied based on experimental and theoretical analysis. The morphology, size, and thickness of WE flakes can be regulated by adjusting the molar ratio of ErCl3/WO3 and the growth time. It has been found that the ErCl3 precursor not only acts as the promoter of the WE flakes during the growth but also drives the formation of screw dislocations owing to the internal strain in the lattice induced by Er3+ doping. The WE flakes exhibit near-infrared (NIR) emission at ∼1530 nm under 980 nm excitation, which corresponds to the energy transition from 4I13/2 to 4I15/2 of the Er3+ dopants. In addition, the WE-based device exhibits improved NIR photoresponse with a 16.9-fold enhancement in photocurrent compared with that of the WS2-based device. Our work provides a simple method for the preparation of highly crystalline WE flakes with NIR emission and enhanced NIR photoresponse.
研究领域:
材料科学
·
光电子学
·
纳米技术
·
半导体物理
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Qimin Peng,Xue Shao,Chuan Hu,Zuyang Luo,Tayirjan Taylor Isimjan,Zhifeng Dou,Ruobing Hou,Xiulin Yang
Developing the earth-abundant transition metal-based bifunctional electrocatalysts for water splitting and renewable energy devices has attracted much attention. Herein, we report a 1 T-WS 2 in ultrathin nanosheet arrays grafted with Co 4 S 3 on conductive carbon cloth (CC) (1 T-Co 4 S 3 -WS 2 /CC) through a feasible in-situ growth and vulcanization. The optimized 1 T-Co 4 S 3 -WS 2 /CC catalyst exhibits an impressive electrocatalytic activity and remarkable stability with the oxygen/hydrogen evolution reaction (OER/HER: 278/75 mV for 10 mA cm −2 ). It also showed the small Tafel slope values of 61.7 and 58.4 mV dec −1 , respectively. Additionally, the 1 T-Co 4 S 3 -WS 2 /CC (−/+) achieved 1.59 V@10 mA cm −2 in alkaline media superior to the most previously reported non-precious metal electrocatalysts. The outstanding performance could be attributed to the synergy between heterostructures of Co 4 S 3 and 1 T-WS 2 modifying the electronic structure to accelerate water splitting kinetics. Thus, this work presents a rational design of scalable, high-efficiency, stable water splitting electrocatalysts based on WS 2 .
研究领域:
材料科学
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电化学
·
可再生能源
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Yuan Tan,Mingshi Li,Xiaoxue Ye,Zhengguo Wang,Yanying Wang,Chunya Li
Ionic liquid functionalized tungsten disulfite nanosheets (IL-WS 2 ) were prepared by using 1-vinyl-3-(3-aminopropyl)-imidazolium bromide (VAPimBr) ionic liquid as an auxiliary reagent to exfoliate WS 2 bulk crystals in N-methyl pyrrolidone with ultrasonication. Hollow gold nanospheres (HGNs) were controllably synthesized by using 1,3-di(3-bromopropyl)-imidazolium bromide ionic liquid as the functional monomer. HGNs were integrated onto IL-WS 2 nanosheet surface to fabricate a HGNs/IL-WS 2 nanocomposite through the interaction between S and Au atoms. VAPimBr ionic liquid and HGNs can significantly enhance the photocurrent response of IL-WS 2 nanosheets. Human epididymis protein 4 antibody (anti-HE4) was immobilized onto the HGNs/IL-WS 2 nanocomposite modified glassy carbon electrode (GCE) surface. Followed by being treated with glutaraldehyde vapor and bovine serum albumin (BSA), a photoelectrochemical immunosensor for human epididymis protein 4 (HE4) was successfully constructed and denoted as anti-HE4/HGNs/IL-WS 2 /GCE. The photoelectrochemical variation upon interacting with HE4 was used for the quantitative assay. Experimental conditions including the exfoliation time, the amount of VAPimBr ionic liquid, HGNs size, ascorbic acid concentration, incubation time, incubation temperature have been optimized. Under optimal conditions, HE4 was determined by using the photoelectrochemical immunosensor in a dynamic linear range from 0.1 pg mL −1 to 10 ng mL −1 with a detection limit of 0.03 pg mL −1 (S/N = 3). HE4 in clinical serum samples were also accurately determined with satisfied results.
研究领域:
纳米技术
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分析化学
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生物传感器
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2021
·
IF 6.057
Qian Wang,Huanshun Yin,Jia Ding,Xi Fang,Yunlei Zhou,Shiyun Ai
The endogenous epigenetic marker 5-formylcytosine (5 fC) is introduced by 5-methylcytosine (5 mC) oxidation under action of enzyme oxidation, and plays an important role in many life activities. Since the content of 5 fC in mammalian tissues and cells is very low, it is necessary to exploit a sensitive and specific detection method to further understand the function of 5 fC. In this work, a sensitively and selectively photoelectrochemical (PEC) biosensor was developed for 5-formyl-2′-deoxycytidine (5fdC) detection. CuBi 2 O 4 /ZnPc@WS 2 was used as photoactive material, where the formed ternary heterojunction structure greatly enhanced the PEC response and increased the detection sensitivity. Positively charged polyethyleneimine (PEI) was employed as 5fdC recognition and capture unit, where the amine group on PEI specifically reacted with aldehyde group of 5fdC to form stable amide bond. 4-Carboxyphenylboronic acid (4-CPBA) was adopted as crosslinker for 5fdC and amino functionalized CuBi 2 O 4 based on the covalent interaction between 1,3-diol bond on 5fdC and boric acid structure on 4-CPBA, and the covalent interaction between –COOH on 4-CPBA and –NH 2 on amino functionalized CuBi 2 O 4 . On the basis of the positive synergistic effect of ZnPc and CuBi 2 O 4 on improving the photoelectric performance of WS 2 , the separation of photo-generated electron-hole pairs in semiconductors were promoted, and the examination range was expanded from 0.1 to 500 nM, and the detection limit was 0.0483 nM (3σ). Based on the unique covalent reaction between –NH 2 and –CHO, the PEC biosensor has excellent detection sensitivity, and can even separate 5fdC from 5-methylcytosine deoxyribonucleoside and 5-hydroxymethylcytosine deoxyribonucleoside. The effect of antibiotics and heavy metals on the 5fdC content in wheat tissue genome has also been further investigated using this sensor.
研究领域:
分析化学
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生物化学
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材料科学
·
纳米技术
✓ 已验证
DOI
高影响因子
Nanoscale
·
2023
·Vol. 15
·期 39
·16131-16143
·
IF 6.7
Jingzhi Wang,Mei Li,Zhiliang Jin
Dynamics and morphology play a crucial role in the field of photocatalytic hydrogen production. Regulating the transfer of photogenerated charges is an effective way to improve the catalytic activity. In this paper, 1T-WS2 is introduced into a p–n heterostructure, ZnCdS/NiV-LDH, as a metalloid electron pump to transfer photogenerated electrons from semiconductors with larger work functions to metalloid materials with smaller work functions, effectively to attract photogenerated electrons, and promote charge rearrangement at the p–n heterostructure interface, so as to achieve the best utilization efficiency of photogenerated charges. Second, adjusting the morphology to increase the light absorption area of the catalyst is also a way to improve the photocatalytic activity. Two different nanosheet structures dispersed heavily stacked ZnCdS, increasing the light absorption area of the system. The optimal catalyst ratio achieves a hydrogen evolution rate of 22.37 mmol g−1 h−1, achieving 7.98% AQE and 2.12% STH conversion efficiency at 450 nm. The potential mechanism was demonstrated through in situ XPS. This study provides new insights into adding “electron pumps” to heterostructures to enhance photocatalytic activity.
研究领域:
材料科学
·
催化
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纳米技术
·
光化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2017
·Vol. 9
·期 17
·5551-5564
·
IF 7.367
Jinping Wang,Xiaojuan Pang,Xiaoxiao Tan,Yilin Song,Li Liu,Qing You,Qi Sun,Fengping Tan,Nan Li
In this study, we report a strategy for integrating hyaluronic acid (HA), polyaniline (PANI), WS2 nanodots (WS2), and chlorin e6 (Ce6) into a single nanoplatform (HA-WS2@PANI/Ce6) for fluorescence, photoacoustic, and computed tomography multi-modality imaging-guided trimodal photothermal/radiation/photodynamic combination therapy of tumors. The WS2 nanodot core is used as the radiosensitizer with the PANI shell as the hyperthermal agent and the photosensitizer reservoir. HA and Ce6 were adsorbed on the outer shell for tumor targeting and photodynamic therapy, respectively. The in vivo trimodal imaging uncovered that HA-WS2@PANI/Ce6 nanoparticles showed enhanced tumor uptake and diagnosis effects after intravenous injection. More importantly, in the in vitro and in vivo experiments, the nanoparticles exhibited an evident near-infrared induced photothermal effect, which remarkably improved the radiation and photodynamic therapy efficiency by accelerating the blood flow and subsequently increasing oxygen supply in the tumor. The nanohybrids were found to be safe to cells in vitro and organs in vivo. Taken together, our current work demonstrates a nanoplatform for multimodal imaging guided targeted triple-therapy, which reveals a potential strategy for tumor treatment.
研究领域:
纳米技术
·
生物医学工程
·
癌症治疗
·
医学成像
✓ 已验证
DOI
PubMed
高影响因子
Nanoscale
·
2025
·Vol. 17
·期 39
·23129-23138
·
IF 5.1
Mengya Li,Xinhui Yang,Chang Lu,Meili Long,Zhihui Chen,Haitao Chen,Xiaoming Yuan,Jun He
Anisotropic van der Waals (vdW) heterostructures are crucial for smart optoelectronic device development. Although transition metal dichalcogenides (TMDCs) like WS2 hold great potential for high-performance optoelectronic devices, their C3 rotational symmetry restricts polarization-sensitive applications. Crystal symmetry breaking of TMDCs by forming heterostructures is a powerful approach for achieving anisotropic optoelectronic properties. Considering the promising potential of the WS2/Te p–n heterostructure in broad photoresponse and enhanced nonlinearity, we successfully fabricated this heterostructure and investigated its anisotropic optical properties. The formation of the heterostructure induces interfacial symmetry breaking, and the interface shows twofold symmetry as confirmed by polarization-dependent second-harmonic generation (SHG) measurements. Moreover, the WS2/Te heterostructure exhibits enhanced SHG signals across the 850–1064 nm wavelength range. The interlayer anisotropic moiré potential induced by symmetry breaking leads to anisotropic Raman scattering and exciton emission with degrees of polarization (DOP) of 0.268 and 0.310. Furthermore, the heterostructure formation reduces intervalley scattering, enhancing valley polarization in WS2. In particular, the valley polarization degree of the trion in the heterostructure is 0.495 at 93 K. These results demonstrate the potential of the WS2/Te heterostructure for strong nonlinear optical responses and anisotropic optoelectronic properties, establishing a foundation for their broad application in next-generation photonic devices.
研究领域:
光电子学
·
纳米光子学
·
材料科学
·
非线性光学
·
凝聚态物理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Yinshuang Song,Hai-Cai Huang,Wenhui Lu,Nianlu Li,Jie Su,Shi-Bo Cheng,Yongchao Lai,Jing Chen,Jinhua Zhan
Novel SERS substrates is urgently in demand for rapid and sensitive analysis of toxic agrochemicals from food. In this work, a monodispersed tungsten disulfide quantum dots modified silver nanosphere (Ag@WS 2 QD) was prepared and used as SERS substrate. Ag@WS 2 QD generated uniform and stable SERS signals within 2 min, displaying great promise in “mixing and reading” detection. Compared to unmodified colloidal silver nanoparticles, 4 times higher analytical enhancement factor was found in Ag@WS 2 QD. Density functional theory calculation verified the enhanced charge transfer within the coupling systems of molecule-Ag@WS 2 QD. Besides, the unique surface properties are beneficial for the enrichment of specific molecule. Both the chemical extraction and enhanced charge transfer contributes to rapid and sensitive SERS detection of Ag@WS 2 QD. A “mixing and reading” SERS method for thiram from honey and four kinds of juice was developed from Ag@WS 2 QD, showing great promise for rapid and direct SERS detection for toxic agrochemicals and further applications.
研究领域:
分析化学
·
材料科学
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Horizons
·
2022
·Vol. 9
·期 9
·2416-2424
·
IF 15.717
Xing Xin,Yanmei Zhang,Jiamei Chen,Mao-Lin Chen,Wei Xin,Mengfan Ding,Youzhe Bao,Weizhen Liu,Haiyang Xu,Yichun Liu
Defects, such as uncontrollable vacancies, will intensively degrade the material properties and device performance of CVD-grown transition metal dichalcogenides (TMDs). Although vacancies can be repaired by some post-processing measures, these treatments are usually time-consuming, complicated and may introduce uncontrollable chemical contaminants into TMDs. How to efficiently suppress the uncontrollable defects during CVD growth and acquire intrinsic high-quality CVD-grown TMDs without any after-treatment remains a critical challenge, and has not yet been well resolved. Here, an alternate-growth-etching (AGE) CVD method was demonstrated to fabricate defect-suppressed submillimeter-scale monolayer WS2 single crystals. Compared with normal CVD, the grain size of the as-grown WS2 can be enlarged by 4–5 times (∼520 μm) and the growth rate of ∼14.4 μm min−1 is also at a high level compared to reported results. Moreover, AGE-CVD can efficiently suppress atomic vacancies in WS2. In every growth-etching cycle, the etching of WS2 occurs preferentially at the defective sites, which will be healed at the following growth stage. As a result, WS2 monolayers obtained by AGE-CVD possess higher crystal quality, carrier mobility (8.3 cm2 V−1 s−1) and PL quantum yield (QY, 52.6%) than those by normal CVD. In particular, such a PL QY is the highest value ever reported for in situ CVD-grown TMDs without any after-treatment, and is even comparable to the values of mechanically exfoliated samples. This AGE-CVD method is also appropriate for the synthesis of other high-quality TMD single crystals on a large-scale.
研究领域:
材料科学
·
纳米技术
·
凝聚态物理
·
半导体材料
·
光电子学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Qian Wang,Huanshun Yin,Yunlei Zhou,Jun Wang,Shiyun Ai
As an important epigenetic modification, 5-formylcytosine (5fC) plays a vital role in cell differentiation, genomic DNA structure and function regulation. Its low abundance in all suckler tissues and cells and high structural similarity with cytosine (C) and its derivatives, the sensitive and selective detection method for 5fC is required. In this work, a photoelectrochemical biosensor was constructed using BiIO 4 -WS 2 composite as photosensitive material, the synergy of ternary heterojunction of BiIO 4 -WS 2 /CuO as signal amplification technology and 5-formylcytosine deoxyribonucleoside (5fdC) as target. Firstly, the ITO electrode modified by BiIO 4 -WS 2 was aminated by (3- aminopropyl) triethoxysilane. 5fC was captured on the electrode surface with amidogen as recognition reagent, based on the amide bond formed between amidogen and aldehyde group. Then, 4-carboxyphenylboronic acid (4-CPBA) was linked by covalent reaction between boronic acid and O -diol of 5fdC. Finally, the signal amplification material of amino-functionalized CuO was deposited on the electrode surface through the formation of amide bond based on −COOH of 4-CPBA and –NH 2 on CuO. In view of the constitution of a ternary heterojunction between CuO and BiIO 4 -WS 2 , the photoactivity of BiIO 4 -WS 2 was greatly enhanced, which also increased the detection sensitivity with the wide examination area from 0.005 to 200 nM and low limit of detection was 0.38pM (3σ). Based on the specific covalent identification pattern, this method showed high selectivity for 5fC, even discriminating 5fC with C and 5hmC. The impacts of antibiotics and heavy metals on 5fdC content change in genomic DNA of wheat tissues were investigated, and thus the feasibility of this work was evaluated.
研究领域:
分析化学
·
生物化学
·
材料科学
·
生物技术
·
表观遗传学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）