FOOD RESEARCH INTERNATIONAL
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2020
·
IF 4.972
Jia-Nan Yan,Bin Nie,Xin-Yu Jiang,Jia-Run Han,Yi-Nan Du,Hai-Tao Wu
The complex coacervation between scallop Patinopecten yessoensis male gonad hydrolysates (SMGHs) and κ -carrageenan ( κ -C) as influenced by ionic strength (NaCl and KCl) were monitored by using turbidimetric analysis at pH 1–12. The optical density of SMGHs/ κ -C complexes initially increased at lower ionic strength (0–0.5 M) whereas decreased at higher ionic strength (0.5–1.5 M) as a result of the salt-enhanced and salt-reduced effect, respectively. Both of pH c and pH φ1 exhibited ionic strength-dependent behavior that firstly shifted to acidic pH followed by an increase as salt increasing. Moreover, salt addition strongly promoted the gelation of SMGHs/ κ -C which was mainly driven by electrostatic forces, as reflected by increasing storage modulus G' from 3621 to 6559 Pa, 2681–25631 Pa at 0.1 Hz and decreasing T 23 relaxation time from 349.10 to 296.89 ms, 241.07–186.89 ms by 0–0.5 M NaCl/KCl, respectively. Furthermore, the rheological and relaxation time T 2 data were well associated with microscopy images that SMGHs/ κ -C gels with NaCl/KCl showed a denser network with more flocculation formation and larger pore sizes with thicker network wall, especially in KCl group, which indeed supported the gel elasticity. Taken together, this study could provide theoretical and methodological basis for new functional hydrogel products with modified gel strength and microstructure by understanding the complex coacervation in gel system.
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PubMed
高影响因子
JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2022
·Vol. 46
·期 12
·e17177
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IF 2.609
Xue-Chen Wang,Xiao-Fan Cui,Yi-Nan Du,Shi-Qi Xu,Yu-Qiao Wang,Hai-Tao Wu
The gel properties and microstructure of scallop male gonad hydrolysates (SMGHs) were investigated by combing with κ-carrageenan (κ-C) and locust bean gum (LBG). It was shown that the initial elastic module of SMGHs/κ-C 0.1 Hz got marked improvement from 202.3 Pa to 326.7 Pa and the melting temperature also increased 6°C with the addition of LBG. According to the data of low-field nuclear magnetic resonance, the relaxation time T 23 markedly reduced in SMGHs/κ-C/LBG, representing the migration of water might result in a strong bind among SMGHs, κ-C, and LBG. Fourier transform infrared spectroscopy showed the existence of hydrogen bonding between LBG and SMGHs/κ-C. Low-temperature scanning electron microscopy showed that the SMGHs/κ-C/LBG ternary complexes possessed smaller voids and more dense network structures. These results could provide more possibilities for the application of SMGHs and polysaccharide complexes in functional hydrogel development. Novelty impact statement We evaluated the gel and microstructure properties of ternary composite gel consisted of protein hydrolysates from male gonad of scallop ( Patinopecten yessoensis ) (SMGHs), κ-carrageenan (κ-C), and locust bean gum (LBG). The results showed that the addition of κ-C and LBG significantly improved the gel properties of SMGHs.
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Materials Science & Engineering C-Materials for Biological Applications
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2020
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IF 5.88
Rijian Song,Xuan Mao,Shunqing Tang
Here we prepared a low-degree-sulfated κ/β-carrageenan oligosaccharide (L-DS-KOS) by DMSO-methanol desulfation method, and fabricated a sponge dressing for the wound healing of diabetic rats. The immunomodulatory effects of L-DS-KOS on M1-like macrophages were evaluated. Results showed that L-DS-KOS could effectively promote the secretion of anti-inflammatory factors and accelerate polarization of LPS-activated macrophages from M1 to M2 type. The gross examination result showed that the sponge dressing with the mass ratio of L-DS-KOS: collagen = 3: 7 could effectively accelerate the repair process of the full-thickness excisional wound in diabetic rats; and H&E and Masson staining results disclosed that the L-DS-KOS/collagen dressing could better shorten the inflammation period of the wound site, and improve the process of collagen deposition and epithelial formation, thereby promote the repair of skin wounds in diabetic rats. These results demonstrate that L-DS-KOS has potential to be used as a new type of immunomodulatory biomaterial for diabetic wound dressings.
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高影响因子
CARBOHYDRATE POLYMERS
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2025
·
IF 12.5
Yajuan Hu,Wen Bao,Huaqing Zhang,ChunLing Liu,Fan Wang,Xieraili Maimaitiyiming
Polymer hydrogels have been widely studied for their conductivity, adhesiveness, and 3D printing properties, but preparing hydrogels with both adhesion and printing capabilities remains a challenge. This study reports the one-pot synthesis of a Gelatin/Agar/κ-carrageenan (Gel/Agar/κ-CA) ternary network hydrogel with simultaneous printability, adhesiveness. By leveraging metal-ligand bonds, it overcomes the compatibility challenge of multi-functional components, offering a new paradigm for 3D-printed flexible devices. Enabled by metal-ligand interactions, the hydrogel adheres to diverse substrates, withstands 20 kg ferrous materials at 1.4–25 °C, and supports both planar and 3D printing. A hydrogel-based supercapacitor exhibits stable cycling performance after 38,000 charge/discharge cycles. This work not only develops a strongly adhesive hydrogel but also provides new pathways for 3D-printed flexible sensors and energy storage devices. As a thermoreversible gel, agar maintains fluidity at 60 °C during printing and rapidly gels upon cooling, ensuring high-fidelity fabrication. Amino groups in gelatin form hydrogen bonds with hydroxyl and sulfate groups of κ-carrageenan, enabling multi-substrate adhesion. Sulfate groups in κ-carrageenan immobilize cations to form conductive pathways, while protonated amino groups in gelatin form ion pairs with chloride ions to enhance ion mobility, collectively supporting sensing and energy storage applications.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2014
·
IF 3.785
Chenxi Li,Chunyan Li,Zheshuo Liu,Qiuhong Li,Xueying Yan,Yu Liu,Weiyue Lu
The objective of this study was to construct a new in situ gel system based on the combination of poloxamer 407 and carrageenan (carrageenan–poloxamer 407 hydrogel, CPH) for intranasal delivery of ketorolac tromethamine . CPH showed potassium ion concentration - dependent erosion characteristics which ensured slow erosion in aqueous environment containing potassium ion at the physiological level. Loading with ketorolac tromethamine influenced erosion, drug release and thermosensitive properties of CPH. CPH containing 15% ketorolac tromethamine showed suitable gelation temperature (near 35 °C) and in vitro sustained release profiles. Pharmacokinetic study of intranasal CPH containing 15% ketorolac tromethamine in rats demonstrated enhanced absolute bioavailability (68.8 ± 23.3%) and prolonged mean residence time (8.8 ± 3.5 h) in comparison with the intranasal solution group (24.8 ± 13.8%, 3.9 ± 0.6 h). Nasal ciliotoxicity evaluation on an in situ toad palate model preliminarily showed the safety of CPH for intranasal use. All results suggested the potential of CPH as a new sustained - release platform for the intranasal delivery of ketorolac tromethamine.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Hongrui Dong,Jinhong Huang,Chengpeng Li,Mengyuan Pang,Zhang Hu
CS-TMG/O-Car/SPH hydrogel was constructed via dynamic imine bonds and physical interactions. • CS-TMG/O-Car/SPH exhibits excellent physical properties and strong antibacterial activity. • The hydrogel shows excellent biocompatibility and is a promising antibacterial biomaterial. Facing the challenges of bacterial infection and antibiotic resistance, the development of biomaterials with both excellent antibacterial properties and biocompatibility is of great significance. Using chitosan (CS) and κ-carrageenan (Car) as raw materials, tris(hydroxymethyl)methylglycine-modified chitosan (CS-TMG) and oxidized carrageenan (O-Car) were respectively synthesized. And then by incorporating sea cucumber protein peptides (SPH), a multi-network CS-TMG/O-Car/SPH hydrogel was successfully prepared. Characterization by UV, FTIR, 1 H NMR, XPS and XRD confirmed the successful grafting of TMG onto CS, the formation of aldehyde groups in Car, and the network structure stabilized by dynamic imine bonds and multiple physical interactions. CS-TMG/O-Car/SPH hydrogel exhibited a lamellar porous morphology and a high swelling ratio (2199%), coupled with good self-healing properties, injectability, and sustained-release characteristics (73.12% of SPH cumulative release within 72 h). Antibacterial tests revealed that CS-TMG/O-Car/SPH possessed significant antibacterial activities against both Staphylococcus aureus and Escherichia coli . Assessment of the biosafety revealed that CS-TMG/O-Car/SPH had a low hemolysis rate and negligible cytotoxicity, showing excellent biocompatibility. Consequently, CS-TMG/O-Car/SPH hydrogel is a promising candidate as an antibacterial biomaterial in the fields of wound healing and tissue engineering.
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高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2026
·
IF 4.4
Nana Lei,Junyan Liu,Wenjing Guo,Bowen Liu,Liming Fan
Color-tunable luminescent hydrogels were assembled from naturally derived sodium alginate (AG) and κ-carrageenan (κ-Car). • The hydrogels were formed through coordination interaction between Eu 3+ /Tb 3+ ions and the carboxylate groups of AG, together with a 3D hydrogen-bonding network. • The hydrogel beads and films were fabricated by the droplet method and the immersion/ion diffusion method, respectively. To develop biocompatible optical materials with high transparency, tunable emission, and information encryption capability, color-tunable luminescent hydrogels were prepared using naturally derived sodium alginate (AG) and κ-carrageenan (κ-Car) as a composite polysaccharide matrix. The hydrogels were formed through coordination interaction between Eu 3+ /Tb 3+ ions and the carboxylate groups of AG, together with a three-dimensional hydrogen-bonding network from AG and κ-Car. 2,6-Pyridinedicarboxylic acid (DPA) was introduced as an antenna ligand to sensitize the characteristic emission of rare-earth ions. Luminescent hydrogel beads and films were fabricated by the droplet method and the immersion/ion diffusion method, respectively, and then their photoluminescence properties, microstructures, and information encryption behaviors were systematically investigated. The obtained hydrogels remained highly transparent under visible light and exhibited intense emission under UV excitation. DPA markedly enhanced the characteristic emission of Eu 3+ , and continuous color tuning from red to green was achieved by varying the Eu 3+ /Tb 3+ molar ratio. SEM and FT-IR analyses revealed that the hydrogel films possessed a layered microstructure and that carboxylate groups were involved in coordination with rare-earth ions. Taking advantage of the optical feature of being hidden under visible light and revealed under UV light, array-based and multilevel responsive information encryption models were constructed, enabling the visual readout of concealed information. This work provides a facile and environmentally benign strategy for constructing rare-earth luminescent hydrogels and expands their potential applications in anti-counterfeiting and information encryption. Color-tunable luminescent hydrogels for information encryption were assembled from naturally derived sodium alginate (AG) and κ-carrageenan (κ-Car) via Eu 3+ /Tb 3+ ions coordination, sensitized by 2,6-pyridinedicarboxylic acid (DPA). The hydrogel beads and films were fabricated by the droplet method and the immersion/ion diffusion method, respectively. Download: Download high-res image (113KB) Download: Download full-size image
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Ruike Wu,Liurong Huang,Lihong Chen,Yunliang Li,Ronghai He
This study investigates the impact of different gelation methods on the physicochemical properties and release behavior of whey protein isolate (WPI)/κ-carrageenan gels loaded with curcumin. Various gelation methods, including enzymatic methods, chemical methods, and their combinations, were employed to prepare the gels. The results indicate that among the six gelation methods, the gels obtained through transglutaminase and glucono-δ-lactone (TG/GDL) treatment exhibited the highest hardness, measuring 264.4 g. Structural analyses and release properties revealed that a more compact cross-linked network gels was formed with TG/GDL treatment. The GDL and TG/GDL gels also exhibited higher curcumin encapsulation efficiency (75.43 % and 72.47 %) and sustained release properties during in vitro digestion. Kinetic modeling indicated a non-Fickian diffusion mechanism for curcumin release from GDL and TG/GDL gels, suggesting enhanced controlled release behavior. This research provides insights into optimizing protein-polysaccharide gel systems for functional food and pharmaceutical applications.
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高影响因子
POLYMER BULLETIN
·
2023
·Vol. 81
·期 2
·1373-1388
·
IF 3.2
Jin Yu,Lu Zhenbang
Market demand for food packing bags is large. However, low mechanical properties and strong electrostatic damage limit their use. In this work, carrageenan/konjac glucomannan/graphene oxide (GO) nanocomposite films were prepared by solution casting. First, Hummers method was used to obtain GO nanosheets. Then, GO-filled composites (various GO dosages) were fabricated. Surface morphology of films was investigated. After that, stress–strain curves of films were determined, and mechanical properties of films after 80 °C thermal aging were studied. In the end, electrical and thermal conductivities of films were measured. GO can play an important role in improving mechanical, antistatic and heat-conducting performances of films. The optimal composite (3.6 wt% GO) can exhibit promising features including a high breaking strength of ~ 130 MPa (~ 65 MPa after 80 °C thermal aging for 30 min), high electrical conductivity of ~ 0.01 S m −1 at 20 Hz under 1 V and high thermal conductivity of ~ 0.74 W m −1 K −1 at room temperature. This research will favor a large-scale fabrication of functional and environmental composites for food packaging.
研究领域:
材料科学
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纳米技术
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高分子科学
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食品包装
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机械工程
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高影响因子
FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Nan Wang,Jie Tian,Li Guo,Xueting Chen,Bingbing Hu,Shuang Song,Chengrong Wen
The effects of the differently charged anions, NaCl, NaBr, NaI, Na 2 SO 4 , and Na 3 PO 4 on the gel properties and structure of the fucoidan/κ-carrageenan mixed gel (FC) were investigated using the rheometer, texture analyzer, LF-NMR, Cryo-SEM, FT-IR, and XRD. At a certain concentration, Cl − and Br − could stabilize the helical conformation of the gel through electrostatic shielding. The addition of SO 4 2− and PO 4 3− would reduce the strength of the gel. And I − would soften the gel. With increasing anion concentration, the electrostatic repulsion between FUC and KC was gradually enhanced. The FUC dispersions remained liquid after the addition of anions, while FC gelled depending on the type and concentration of anions. The elastic modulus increased with increasing concentration of NaCl and NaBr, but decreased with increasing concentration of NaI, Na 2 SO 4 , and Na 3 PO 4 . Moreover, the addition of anions promoted the water migration of FC, as reflected by the T 23 relaxation time changing from high to low and the significantly higher migration of NaCl and NaBr than NaI and Na 2 SO 4 . The pores of the gel microstructure change from disordered to uniform. The FT-IR and XRD results were well related to the structural changes. There is electrostatic repulsion between anion and FC, and the binding ability of FC to monovalent anions and trivalent anions is better than that of divalent anions. Overall, this study could provide a theoretical basis for the design and development of FUC-based gels.
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FOOD RESEARCH INTERNATIONAL
·
2020
·
IF 4.972
Junhua Li,Lilan Xu,Yujie Su,Cuihua Chang,Yanjun Yang,Luping Gu
In this study, the influence of NaCl on the flocculation behavior and gel properties of egg yolk/κ-carrageenan mixed dispersions or emulsions were studied. As a result of NaCl incorporation, there was a decrease in the mean droplet size, zeta potential, degree of flocculation and viscosity of the mixed dispersions/emulsions, and the onset point of gelation was also brought forward. Increasing the concentration of NaCl led to a significant increase in gel strength and decrease in gel cohesiveness. Results from low field nuclear magnetic resonance (LF-NMR) confirmed that the addition of NaCl could significantly reduce the hydration ability of gel molecules and increase the content of immobilized water of hydrogels as the gel strength increased, while the water holding capacity of emulsion gels was depressed with the incorporation of oil. These findings suggested the flocculation state and gel properties of egg yolk/κ-carrageenan mixed dispersions/emulsions can be tailored by adjusting NaCl for food formulations.
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高影响因子
FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Qiaoyan Wang,Changyu Zhou,Qiang Xia,Daodong Pan,Lihui Du,Jun He,Yangying Sun,Fang Geng,Jinxuan Cao
In order to investigate the effect of pH treatments on the coacervation mechanism of fibrinogen hydrolysates and carrageenan complex, the cold-set hydrogels of carrageenan and fibrinogen hydrolysates derived from the hydrolysis of chymotrypsin, alcalase and flavourzyme were prepared under different pH; mechanical strength, rheological properties, gelling structure, morphological observation, and chemical action force were investigated, and the antioxidant capacity of the hydrogels was further evaluated in meat preservation model. The results indicated that the hydrogels of carrageenan and fibrinogen hydrolysates derived from the hydrolysis of alcalase (AHs) showed the largest gel strength and the best viscoelasticity at pH 7.0 compared with other pH and hydrolase treatments. FTIR spectrum revealed that AHs showed more β-sheet and β-turn at pH 7.0 among all treatments. The interaction forces of these hydrogels showed various under different pH and hydrolase treatments, and the network of AHs hydrogels at pH 7.0 was mainly stabilized by electrostatic interaction and hydrophobic interaction. SEM and AFM demonstrated that the more regular three-dimensional network with smaller pore sizes was formed in AHs at pH 7.0 compared with pH 5.0 and pH 9.0. The AHs showed the largest scavenging ability for DPPH radicals (72.4%) at pH 7.0 in vitro , and the coated meat samples with AHs significantly increased the preservation times of fresh pork and dry-cured ham during the storage by inhibiting the increase of TBARS, TVB-N, and metmyoglobin. The finding of this work is expected to broaden the application of fibrinogen hydrolysate hydrogels into the field of food industry.
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高影响因子
危险品化学品经营许可证（带存储）