MOLECULAR IMAGING AND BIOLOGY
·
2023
·Vol. 25
·期 5
·875-886
·
IF 3.1
Hui Xin,Wang Yanxing,Li Wenjing,Yuan Ying,Tao Xiaofeng,Lv Ruichan
In this research, we designed a novel NIR II luminescence imaging probe with targeting effect to accurately track oral squamous cell carcinoma (OSCC) cells. Massive gene expression data were processed by weighted gene co-expression network analysis to establish a network of relationships between genes. After clustering, correlation of clinical information, and gene functional enrichment analysis, MMP1 was predicted to be a biomarker/therapeutic target for OSCC cells. To obtain rare-earth probes with better luminescence in the NIR II region, we adjusted the doping ratio of the rare-earth element (Nd, Gd, Er, and Yb) fraction of the Nd-Mn molecular cluster to optimize its luminescence properties. The results of in vitro targeting experiments showed that Nd-Mn-MMP1Ab can target Cal-27 cells, demonstrating at the cellular level that the MMP1 gene is a biomarker for oral cancer, which also proves that the cancer targets predicted by the bioinformatics approach are correct.
研究领域:
生物信息学
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癌症研究
·
分子影像学
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Qinghong Meng,Yuning Zhang,Xuejiao Wang,Xiangming Li,Wanjun Yu,Zhijun Xu,Ji-Guang Li
Broadband near-infrared (NIR) emission phosphor with combined high external quantum efficiency (EQE, >30%) and excellent thermal stability requires further inquiry. The crystal/band structure analysis using X-ray diffraction (XRD), diffuse reflectance spectra, and density functional theory (DFT) calculation for the Y 2 CaAl 4− x Ga x ZrO 12 garnets yielded a suitable x = 4.0 host for the exploration of the novel Y 2 CaGa 4− y ZrO 12 : y Cr 3+ (YCAGZO:Cr) NIR phosphors. The comprehensive investigation using Rietveld refinement and photoluminescence spectroscopy produced the optimal YCAGZO:Cr ( x = 4.0, y = 0.04) phosphor with wideband NIR emission (center at ∼764 nm, bandwidth ∼137 nm), high EQE= 32.0% (absorption efficiency ∼43.3%), and outstanding thermal stability ( I 423 K / I 298 K =90.0%, Δ E a =0.36 eV). Further, the satisfactory luminescence (NIR output power of 34.78 mW and photoelectric conversion efficiency of 12.42% at 100 mA) and imaging performance of the fabricated pc-NIR-LED using this optimal garnet phosphor prove that this newly developed phosphor is a promising choice for constructing the pc-NIR-LED devices used in scenarios such as food quality detection, noninvasive medical inspection, and night vision.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Yingjie Feng,Yu lv,Fujia Dong,Yue Chen,Hui Li,Argenis Rodas-González,Songlei Wang
Norfloxacin is an antibacterial compound that belongs to the fluoroquinolone family. Currently, hyperspectral imaging (HSI) for the detection of antibiotic residues focuses mostly on individual systems. Attempts to integrate different HSI systems with complementary spectral ranges are still lacking. This study investigates the feasibility of applying data fusion strategies with two HSI techniques (Visible near-infrared and near-infrared) in combination to predict norfloxacin residue levels in mutton. Spectral data from the two spectral techniques were analyzed using partial least squares regression (PLSR), support vector regression (SVR) and stochastic configuration networks (SCN), respectively, and the two data fusion strategies were fused at the data level (low-level fusion) and feature level (middle-level fusion, mid-level fusion). The results indicated that the modeling performance of the two fused datasets was better than that of the individual systems. Mid-level fusion data achieved the best model based on uninformative variable elimination (UVE) combined with SCN, in which the determination coefficient of prediction set (R 2 p ) of 0.9312, (root mean square error of prediction set) RMSEP of 0.3316 and residual prediction deviation (RPD) of 2.7434, in comparison with all others. Therefore, two HSI systems with complementary spectral ranges, combined with data fusion strategies and feature selection, could be used synergistically to improve the detection of norfloxacin residues. This study may provide a valuable reference for the non-destructive detection of antibiotic residues in meat.
研究领域:
食品科学
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分析化学
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生物医学工程
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CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Guotao Xiang,Zhen Liu,Menglin Yang,Yongxi Ding,Lu Yao,Yongjie Wang,Xianju Zhou,Li Li,Li Ma,Xiaojun Wang,Jiahua Zhang
The development of photothermal therapy (PTT) agents possessing temperature self-response ability and working in the deep tissues is an urgent need for noninvasive cancer treatment. Herein, a nanocomposite material hexagonal phase NaLuF 4 : Yb 3+ /Nd 3+ @SiO 2 @Cu 2 S is successfully constructed for the purpose of meeting the above demands. Under the irradiation of 980 nm near-infrared (NIR) light, the prepared nanocrystals (NCs) exhibit good photothermal conversion capacity and ultrasensitive temperature sensing properties along with remarkable resolution. The optical thermometry is realized by the fluorescence intensity ratio of Nd 3+ : 4 F j (j = 7/2, 5/2, and 3/2) levels, of which the NIR emission intensities are strongly enhanced with the increasing temperature due to the phonon-assisted energy transfer mechanisms between Yb 3+ and Nd 3+ . As the excitation and emission wavelength of the sample are all located in the biological window, its penetration depth in the biological tissues can be reached to 8 mm. The adsorptive Cu 2 S NCs on the surface of NaLuF 4 : Yb 3+ /Nd 3+ @SiO 2 provide the required light-to-heat conversion capacity, which has been investigated in detail through the laser-irradiated and bactericidal experiment respectively. These findings provide a feasible strategy to design high-performance PTT agents integrated with precise temperature self-measurement function for deep-tissue therapy.
研究领域:
生物医学工程
·
纳米医学
·
光学成像
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DOI
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Lina Wu,Xuan Pei,Ping Song,Zhen Tan,Jiabao Nie,Wei Wei,Changchun Zhou,Zi Chen,Yujiang Fan,Xingdong Zhang
Near-infrared (NIR) light, compared with ultraviolet (UV) light, has a stronger tissue penetration ability and is widely used in the medical field. However, few hydrogels can be triggered by NIR. Here, a modular polymer-nanosheet (metal disulfide) (PNS) hydrogel system was proposed, which can be photo-crosslinked through photothermal conversion under NIR light. MoS2, a transition-metal dichalcogenide, was used as a crosslink center in PNS hydrogels. Mo and S (from thiolated polymers), which are essential for gelation, were discovered to have new bonds. Furthermore, 3D printing of NIR-triggered PNS hydrogels was achieved conceptually with masked NIR. Moreover, multiple hydrogels and metal disulfides were applicable in this modular gelation system. This study indicated that these PNS hydrogels have great potential in many smart biomedical applications, including wearable sensors, noninvasive in vivo 3D bioprinting, and tissue repair substitutes.
研究领域:
生物医学工程
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材料科学
·
组织工程
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MATERIALS RESEARCH BULLETIN
·
2026
·
IF 5.8
Yanxin Hu,Chengyan Gao,Qiufeng Shi,Haijie Guo,Lei Wang,Jianwei Qiao
Blue-light-excitable NIR-II/III emission. • Ni 2+ occupies ScO 6 octahedral sites. • Sc substitution enables 1570–1690 nm tuning. • Zr 4+ charge compensation boosts emission 5-fold. • NIR-LED for night-vision and bioimaging. Long-wavelength NIR luminescent materials provide essential support for optoelectronic devices, yet realizing blue-light-pumped broadband emission across the NIR-II/III windows remain challenging. Herein, we successfully synthesized a series of Sr 2 Ga 1- x Sc x SbO 6 :Ni 2+ phosphors with tunable emission from 1570 to 1690 nm under 435–465 nm excitation. Corroborating evidence from DFT calculations, XANES spectroscopy, and structural refinement consistently confirms that the doped Ni 2+ ions occupy Ga/ScO 6 octahedron rather than SbO 6 sites. Furthermore, the introduction of Zr 4+ as a charge compensator effectively mitigates lattice defects induced by aliovalent substitution, leading to a remarkable enhancement in luminescence intensity across the entire composition series. The NIR pc-LED fabricated by integrating the optimized Sr 2 ScSbO 6 :Ni 2+ , Zr 4+ phosphor with commercial GaN chip exhibits promising performance for applications in night-vision imaging and chemical composition analysis. This work proposes a lattice-site engineering strategy to achieve ultralong-wavelength NIR emission and optimize luminescence performance, thereby establishing a new design paradigm for next-generation NIR phosphors. Download: Download high-res image (160KB) Download: Download full-size image Ga-site crystal-field engineering enables broadband NIR emission (1570–1690 nm), while Zr 4+ defect compensation enhances luminescence intensity, offering a new design paradigm for blue-light-excited NIR-II/III phosphors.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Yajing Liu,Shaojia Zhu,Kaizhi Gu,Zhiqian Guo,Xiaoyu Huang,Mingwei Wang,Hesham M. Amin,Weihong Zhu,Ping Shi
Theranostic prodrug therapy enables the targeted delivery of anticancer drugs with minimized adverse effects and real-time in situ monitoring of activation of the prodrugs. In this work, we report the synthesis and biological assessment of the near-infrared (NIR) prodrug DCM-S-PPT and its amphiphilic copolymer (mPEG-DSPE)-encapsulated nanoparticles. DCM-S-PPT is composed of podophyllotoxin (PPT) as the anticancer moiety and a dicyanomethylene-4H-pyran (DCM) derivative as the NIR fluorescent reporter, which are linked by a thiol-specific cleavable disulfide bond. In vitro experiments indicated that DCM-S-PPT has low cytotoxicity and that glutathione (GSH) can activate DCM-S-PPT resulting in PPT release and a concomitant significant enhancement in NIR fluorescence at 665 nm. After being intravenously injected into tumor-bearing nude mice, DCM-S-PPT exhibited excellent tumor-activated performance. Furthermore, we have demonstrated that mPEG-DSPE as a nanocarrier loaded with DCM-S-PPT (mPEG-DSPE/DCM-S-PPT) showed even greater tumor-targeting performance than DCM-S-PPT on account of the enhanced permeability and retention effect. Its tumor-targeting ability and specific drug release in tumors make DCM-S-PPT a promising prodrug that could provide a significant strategy for theranostic drug delivery systems.
研究领域:
药学
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生物医学工程
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癌症研究
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纳米技术
·
药物递送系统
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Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 31
·6155-6162
·
IF 6.331
Liguo Jin,Yinyin Wang,Huan Ouyang,Yu Liu,Zhenling Zhu,Shuhua Wang,Hongbo Xin,Xiaolei Wang
The limited depth of the near infrared (NIR) response is one of the major flaws of the present photothermal therapy (PTT). In this article, thermosensitive polyurethane urea (TPUU) was synthesized by polymerization. Subsequent experiments showed that, compared with classical photosensitizers, TPUU has higher photothermal effects and lower cytotoxicity. These valuable properties could make the present PTT research provide more therapeutic options among different tissues and organs. As a practical example, TPUU was applied to regulate the intestinal flora through external NIR irradiation, which implied its promising expanded applications in deeper tissues.
研究领域:
生物医学工程
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材料科学
·
治疗学
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高影响因子
Journal of Biophotonics
·
2016
·Vol. 10
·期 8
·1034-1042
·
IF 3.818
Huanhuan Li,Quansheng Chen,Jiewen Zhao,Khulal Urmila
Lanthanide-doped upconversion nanoparticles (UCNPs) have attracted widespread interests in the field of biomedicine because of their unique upconverting capability by converting near infrared (NIR) excitation to visible or ultraviolet (UV) emission. Here, we developed a novel UCNP-based substrate for dynamic capture and release of cancer cells and pathogenic bacteria under NIR-control. The UCNPs harvest NIR light and convert it to ultraviolet light, which subsequently result in the cleavage of photoresponsive linker (PR linker) from the substrate, and on demand allows the release of a captured cell. The results show that after seeding cells for 5 h, the cells were efficiently captured on the surface of the substrate and ˜89.4% of the originally captured S. aureus was released from the surface after exposure to 2 W/cm 2 NIR light for 30 min, and ˜92.1% of HepG2 cells. These findings provide a unique platform for exploring an entirely new application field for this promising luminescent nanomaterial.
研究领域:
生物医学工程
·
纳米材料科学
·
细胞生物学
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Advanced Optical Materials
·
2026
·Vol. 14
·期 17
·e71226
·
IF 7.2
Jinwei Liu,Jiaxin Li,Guojun Zheng,Chuan Liao,Jianhong Wu,Jianrong Qiu,Wenge Xiao
Cr 3+ emission can well cover the NIR-I region (700–950 nm), while Ni 2+ emission typically extends across the NIR-II region (1000–1700 nm), making the Cr 3+ –Ni 2+ co-doped phosphors among the most promising ultrabroadband NIR emitters for phosphor-converted light-emitting diodes (pc-LEDs). However, a pronounced gap or even spectral discontinuity between the two emission bands results in a severely imbalanced photon flux across the spectrum, thereby degrading multicomponent spectral detection accuracy and significantly limiting the practical applications of such NIR pc-LED devices. Here, we report a superstoichiometric spinel MgO· n Ga 2 O 3 :Cr 3+ ,Ni 2+ ( n > 1) phosphor, in which the excess Ga 2 O 3 increases the degree of cation inversion to achieve a long-wavelength Cr 3+ emission at 895 nm, substantially elevating the spectral gap height to a state-of-the-art value of ≈36%. Moreover, efficient energy transfer from Cr 3+ to Ni 2+ enables the optimized MgO·1.2Ga 2 O 3 :Cr 3+ ,Ni 2+ phosphor to demonstrate a high internal quantum efficiency of 97% and excellent thermal stability. Finally, the as-fabricated NIR pc-LED delivers an exceptional photoelectric efficiency of 21% at 20 mA and a maximum NIR output power of 62 mW at 350 mA. This work establishes a new pathway toward next-generation compact ultrabroadband NIR pc-LEDs featuring unprecedented spectral flatness and superior optoelectronic performance.
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ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 32
·期 46
·2208028
·
IF 19.924
Jian He,Shiyuan Hua,Dongxiao Zhang,Kai Wang,Xiaoyuan Chen,Min Zhou
Molecular imaging-guided precision photothermal therapy has shown tremendous potential for invasively thermal ablation with solid tumors. However, it is still a pressing clinical need to develop precise and deep-tissue multi-scale imaging technologies easily integrated into a single system to boost accurate photothermal treatments. Herein, a SERS/NIR-II optical nanoprobe assembled by gold nanostars, Raman molecular tags, and silver sulfide quantum dots through silica bridges (named AuDAg 2 S) is reported that allows the combination of the fingerprint-style surface-enhanced Raman scattering (SERS) imaging and second region near-infrared (NIR-II) in-depth biological fluorescence imaging. It can also yield strong localized surface plasmon resonance for a satisfactory photothermal conversion efficiency of 67.1% at 1064 nm to effectively kill CT26 colon cancer cells. Moreover, the AuDAg 2 S nanoprobes can enhance the detection sensitivity up to the picomolar level and increase the depth of the NIR-II fluorescence signal up to 1 cm under the excitation of the near-infrared laser. As a result, the AuDAg 2 S nanoprobes can achieve multidimensional tumor imaging in levels of living subjects, histology, and single cell, and further guided deep NIR-II photothermal anti-tumor therapy in vivo. This study offers a promising approach for SERS/NIR-II whole optical imaging for deep tumor photothermal treatment in future clinical applications.
研究领域:
分子影像
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癌症治疗
·
纳米技术
·
生物医学工程
·
光学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Fengmei Zhu,Yuan Gao,Chunli Zhao,Jiacheng Pi,Jianbei Qiu
Near-infrared phosphor-converted light-emitting diodes (NIR pc-LEDs) offer numerous advantages, including compact size, tunable emission spectra, energy efficiency, and high integration potential. These features make them highly promising for various applications, such as night vision monitoring, food safety inspection, biomedical imaging, and theragnostics. All-inorganic halide double-perovskite materials, known for their large absorption cross section, excellent defect tolerance, and long carrier diffusion radius, serve as unique matrices for constructing near-infrared fluorescent materials. In this study, we successfully prepared the all-inorganic metal halide double-perovskite Cs2NaYCl6:Cr3+ using a grinding–sintering method. A small fraction of the [YCl6] octahedra within the host material’s lattice was substituted with Cr3+ ions, resulting in the creation of the Cs2NaYCl6:Cr3+ phosphor. When excited with λ = 310 nm UV light, the phosphor exhibited a broad emission range spanning from 800 to 1400 nm, covering the NIR-I and NIR-II regions. It had a broad bandwidth emission of 185 nm and achieved a fluorescence quantum yield of 20.2%. The unique broadband emission of the phosphor originates from the weak crystal field environment provided by the Cs2NaYCl6 host matrix, which enhances the luminescence properties of the Cr3+ ions. To create NIR pc-LEDs, the phosphor was encapsulated onto a commercially available UV LED chip operating at 310 nm. The potential application of these NIR pc-LEDs in night vision imaging was successfully validated.
研究领域:
材料科学
·
光学
·
生物医学工程
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PubMed
高影响因子
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