POULTRY SCIENCE
·
2025
·
IF 4.2
Xirui Xia,Huifang Zhao,Yaxi Li,Xiangyang Long,Xuezhen Liu,Mingyang Bai,Youzhi Tang,Xiangguang Shen,Huanzhong Ding
Mycoplasma gallisepticum ( M. gallisepticum , MG ) is the primary pathogen of chronic respiratory disease ( CRD ) in chickens and leads to pneumonia and air sacculitis in infected chickens and a corresponding economic loss for the poultry industry. The pleuromutilins have excellent anti-mycoplasmal activity and we evaluated the in vivo activity of a new derivative 22-((4-((2-furan-1-yl)acetamido)phenyl)thio) deoxypleuromutilin ( p- furoylamphenmulin ) against M. gallisepticum . A plasma pharmacokinetic ( PK ) study and an in vivo pharmacodynamic ( PD ) study of p -furoylamphenmulin were performed using an M. gallisepticum -infected chicken model. Based on the PK/PD results, a preliminary recommended dose was calculated. The minimum inhibitory concentration ( MIC ) of p -furoylamphenmulin against M. gallisepticum was 0.001953125 μg/mL. PK results indicated that the absorption half-life ( T 1/2ka ) in infected chicks was 0.10 h, elimination half-life ( T 1/2kel ) was 4.23 h. The areas under the concentration-time curve at 24h ( AUC 24h ) for 5, 40, and 80 mg/kg single-dose injections were 1.49, 10.15, and 18.56 μg·h/mL, respectively. The peak concentrations ( C max ) of 5, 40, and 80 mg/kg were 0.56, 5.79, and 9.53 μg/mL, respectively. The PD results indicated that at doses of 70 and 80 mg/kg, the mycoplasmal counts in lungs decreased by 3.39 and 3.28 Log 10 CFU/mL, respectively, achieving a bactericidal effect. Through PK/PD fitting, the target values corresponding to reducing the lung mycoplasma load by 3 Log 10 CFU/mL of AUC 24h /MIC and C max /MIC were 8288.29 h and 4299.30, respectively, and the calculated dosage using formula (2) was 62.64 mg/kg, under the regimen of intramuscular injection once every 24 h for 3 consecutive days. In addition, the effect of high-dose p -furoylamphenmulin on the relief of air sac lesions was significant. These results provide a basis for developing and applying p -furoylamphenmulin and provide a preliminary medication regimen.
研究领域:
兽医学
·
药理学
·
感染病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2024
·
IF 3.3
Nan Wang,Yuanyuan Huang,You Zi,Mengke Wang,Weichun Huang
A practical and regioselective direct N-alkylation of 2-pyridones is enabled by use of α-keto esters in the P(NMe2)3-mediated deoxygenation process. The reaction proceeds under mild conditions to produce N-alkylated 2-pyridones with high selectivity and generality, and the protocol is shown to be applicable for the scale-up synthesis, which makes it promising for practical applications.
研究领域:
有机化学
·
合成化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CATALYSIS
·
2023
·
IF 7.3
Tian-Hong Jing,Kai-Chun Zhao,Guang-Hui Shi,Yi-Ying Zhuang,Xiao-Chao Chen,Xiao-Li Zhao,Yong Lu,Ye Liu
A series of bis-P,O-hybrid ligands ( L1–L4 ) were synthesized and characterized. The crystal structures demonstrated that the ligand of L2 , 1,4-bis((2-(diphenylphosphaneyl)phenoxy)methyl)benzene, not only acted as a typical trans -positioned diphosphine as observed in the complexes Pd( L2 )(OAc) 2 and Pd( L2 )Cl 2 , but also potentially as a P,P,O-tripodal pincer. As a result, under mild conditions (80 °C, 0.5–3.0 MPa), L2 enabled Pd(OAc) 2 to exhibit remarkable performance in terms of high activity and excellent regioselectivity ( l / b > 97/3) in the alkoxycarbonylation of vinyl arenes with the isolated yields of 57–91 %.
研究领域:
有机化学
·
催化化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Zheng Zhou,Zhao Zhang,Qilong Zhang,Hui Yang,Yulu Zhu,Yuanyu Wang,Lu Chen
Piezoelectric nanogenerators (PENGs), as a promising solution to harvest mechanical energy from ambient environment, have attracted much attention over the past decade. Here, the core–shell structured BaTiO3@Carbon (BT@C) nanoparticles (NPs) were synthesized by a simple surface-modifying method and then used to fabricate the efficient PENGs with poly[(vinylidene fluoride)-co-trifluoroethylene] (P(VDF-TrFE)). The carbon shell with the uniform thickness of 10–15 nm can increase the content of the polar β phase in P(VDF-TrFE) and significantly enhance the interfacial polarization between BT NPs and the polymer matrix during the poling process. Out of all compositions, the 15 wt % BT@C/P(VDF-TrFE) PENG exhibited the optimal piezoelectric performance with an output voltage of ∼17 V and a maximum power of 14.3 μW under bending–releasing mode. More importantly, the PENG can also efficiently harvest other types of mechanical energy from human activities and exhibits stable output after 1500 bending–releasing cycles. When the PENG was bent and beat by bicycle spokes, a peak voltage of 16 V was generated, which can light up 12 white LEDs directly and charge the commercial capacitors. Our research provides a new strategy to fabricate flexible and efficient PENGs from a nanoscale viewpoint; it can be hopefully applied in energy-harvesting systems and wearable electric sensors.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS CHEMISTRY
·
2011
·Vol. 21
·期 18
·6736-6741
·
IF 5.101
Xiwei Zhang,Jiansheng Jie,Zhi Wang,Chunyan Wu,Li Wang,Qiang Peng,Yongqiang Yu,Peng Jiang,Chao Xie
Single-crystal p-type ZnSe nanowires (NWs) with zinc blende structure and [21–1] growth direction were synthesized by using bismuth (Bi) as dopant via a thermal co-evaporation method. The ZnSe : Bi NWs showed evident p-type conductivity with hole concentration up to 4.1 × 1018 cm−3 after the acceptor activation. Negative photoconductivity was first investigated in the p-ZnSe NWs, i.e., the conductivity of the NWs under light was dramatically lower than that in the dark. Surface effects arising from oxygen absorption and photo-desorption were suggested to be responsible for this. By using Al as the Schottky gate, high-performance nano-metal-semiconductor field-effect transistors (nanoMESFETs) were constructed, and measurements on the Al/p-ZnSe NW Schottky diode also revealed the bias-dependent photoresponse. It is expected that the p-type ZnSe : Bi NWs will have great potential in nano-optoelectronic applications.
研究领域:
材料科学
·
半导体物理
·
纳米技术
·
光电子学
·
凝聚态物理
✓ 已验证
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2020
·Vol. 31
·期 9
·2020-2030
·
IF 2.578
Shijun Long,Di Qiu,Ren Long,Xun Li,Hanyu Chen,Yiwan Huang,Xuefeng Li
In order to improve the performance of inorganic/organic composites, aluminum trihydroxide (ATH) core composites with a styrene-ethylene-butadiene-styrene block copolymer grafted with maleic anhydride (MAH- g -SEBS) shell phase, and P-N flame retardant as a synergistic agent, were prepared through an interface design. The effects of polyethylene glycol (PEG) content on the interfacial interaction, flame retardancy, thermal properties, and mechanical properties of high-density polyethylene (HDPE)/ATH composites were investigated by small angle X-ray diffraction, rotational rheometer, limiting oxygen index, thermogravimetric analysis (TGA), and tensile testing. The ATH synergistic effects of P-N flame-retardant improved the combustion performance of HDPE/ATH/PEG(3%)/MAH- g -SEBS/P-N (abbreviated as HDPE/MH3/M- g -S/P-N) composite by forming more carbon layer, increased the elongation at break from 21% to 558% compared to HDPE/ATH, and increased the interface thickness from 0.447 to 0.891 nm. SEM results support the compatibility of ATH with HDPE increased and the interfacial effect was enhanced. TGA showed the maximum decomposition temperature of the two stages and the yield of the residue at high temperature increased first and then decreased with the increase of PEG content. Rheological behavior showed the storage modulus, complex viscosity, and the relaxation time initially increased and then decreased with the increase of PEG content indicating PEG, M- g -S, and ATH powder gradually formed a partial coating, then a full coating, and finally an over-coated core-shell structured model.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2013
·
IF 3.777
Heng Zhang,Yi Lu,Chang-Dong Gu,Jian-Bin Cai,Xiu-Li Wang,Jiang-Ping Tu
Amorphous Ni–P–C films are fabricated by combining the electrodeposition of Ni–P films from a eutectic-based ionic liquid and the direct current magnetron sputtering of amorphous carbon top-layer. The carbon top-layer with a thickness of about 10 nm is homogeneously coated on the surface of the Ni–P films. A comparison study is undertaken between Ni–P and Ni–P–C films to evaluate the microstructure and the electrochemical performances of the composite films as anode materials for lithium ion batteries , which allow the decoupling of the effect of the carbon layer . It is found that at lower discharge–charge current densities, the cyclability of both Ni–P and Ni–P–C films is similar. As the discharge–charge current density increases, the Ni–P–C film exhibits improved capability and reversibility over the Ni–P film. The Ni–P–C film delivers an initial discharge capacity of 1060 mAh g −1 at 250 mA g −1 and the capacity retention after 50 cycles is 62%, much higher than that of the Ni–P film (51%). The cyclability of Ni–P–C film at different discharge–charge current densities from 200 to 500 mA g −1 is also much better than those of Ni–P film. This study indicates that the introduction of a carbon top-layer on Ni–P film could significantly improve the electrochemical performances due to the decreased interface electric resistance and the structure stability.
研究领域:
材料科学
·
电化学
·
纳米材料
·
能源存储
·
薄膜技术
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2020
·
IF 16.683
Tongdong Shen,Wentao Su,Qiangqiang Yang,Jun Ni,Shaoping Tong
MgM x O y (M = Fe, Mn) powders prepared by the sol-gel method were used as the catalysts for ozonation of p -hydroxybenzoic acid ( p -HBA) and acetic acid (AcOH) (20 mg/L) at a neutral pH for 9 min. The study aims to bring an insight into the synergetic mechanism for basic and acid sites of MgM x O y in heterogeneous catalytic ozonation. 84.8 %, 88.2 %, 86.7 % p -HBA were removed by ozonation catalyzed by MgFe x O y , MgMn x O y and MgO, respectively. 49.3 %, 65.8 %, 64.3 % AcOH were removed by ozonation catalyzed by the three catalysts, respectively. MgMn x O y exhibited the highest catalytic activity in ozonation of p -HBA and AcOH owing to the action of acid sites of MgMn x O y for additional ozone decomposition. The increase of solution pH, the protonation of surface hydroxyl groups and the electron transfer on acid sites induce ozone decomposition into reactive oxygen species in MgM x O y catalytic ozonation.
研究领域:
环境科学
·
催化化学
✓ 已验证
DOI
高影响因子
Materials Today Energy
·
2021
·
IF 7.311
J. Yang,F. Mo,L. Huang,H. Liang,G. Sun,S. Peng
Black phosphorus/natural graphene (BP/NG) composite electrode material for all-solid-state lithium-ion batteries (ASSLIBs) was fabricated by a facile ball milling method. A C-P bond with characteristics of high ion and electron transfer was constructed, which unlocked the reversible cycling and rate performance of phosphorus. In addition, compounding black phosphorus (BP) with natural graphene (NG) can relieve the large internal stress caused by volume change during cycling and improve the stability of the long cycling and high-rate performance. At current density of 0.5 A g −1 , a high specific capacity of 750 mAh g −1 remained after 100 cycles, whereas at high current density of 1 A g −1 , the BP/NG anode material delivered a reversible capacity of ~300 mAh g −1 . Furthermore, the reaction controlling step of Li x P delithiation was revealed by kinetic measurement. In addition, when coupling BP/NG anode material with TiS 2 to assemble a full solid-state cell, it delivered a high capacity of 400 mAh g −1 after 30 cycles, indicating a potential of further application. This work expanded the candidate of anode materials for ASSLIBs and provided aid for the further application of all-solid-state batteries.
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
高影响因子
CANCER RESEARCH
·
2024
·
IF 12.5
Fang Liang,Zhang Li,Wang Mengran,He Yuhao,Yang Jiao,Huang Zengjin,Tan Ying,Fang Ke,Li Jun,Sun Zhiyuan,Li Yanping,Tang Yisen,Liang Weizheng,Cui Huanhuan,Zhu Qionghua,Wu Zhe,Li Yiming,Hu Yuhui,Chen Wei
Epithelial-mesenchymal transition (EMT) is a fundamental cellular process frequently hijacked by cancer cells to promote tumor progression, especially metastasis. EMT is orchestrated by a complex molecular network acting at different layers of gene regulation. In addition to transcriptional regulation, post-transcriptional mechanisms may also play a role in EMT. Here, we performed a pooled CRISPR screen analyzing the influence of 1547 RNA binding proteins (RBPs) on cell motility in colon cancer cells and identified multiple core components of P-bodies (PBs) as negative modulators of cancer cell migration. Further experiments demonstrated that PB depletion by silencing DDX6 or EDC4 could activate hallmarks of EMT thereby enhancing cell migration in vitro as well as metastasis formation in vivo. Integrative multi-omics analysis revealed that PBs could repress the translation of the EMT-driver gene HMGA2, which contributed to PB-meditated regulation of EMT. This mechanism is conserved in other cancer types. Furthermore, endoplasmic reticulum (ER) stress was an intrinsic signal that induced PB disassembly and translational derepression of HMGA2. Taken together, this study has identified a function of PBs in regulation of EMT in cancer.
研究领域:
癌症生物学
·
分子生物学
·
细胞生物学
·
遗传学
✓ 已验证
DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2023
·
IF 5.2
Ne Ni,Xiuzhi Gao,Enhui Xing,Yuan Zhu,Jianqiang Liu,Mudi Xin,Ying Ouyang,Yibin Luo,Xingtian Shu
The promotional effects of phosphorous modification on ZSM-5 zeolites by phosphorus oxyacids (H 4 P 2 O 7 , H 3 PO 4 , H 3 PO 3 , and H 3 PO 2 ) with different molecular sizes were investigated with catalytic cracking of n -tetradecane as the probe reaction. It was verified that the diffusion of P precursor molecules into ZSM-5 channels was important to prevent aggregation of P species for better stabilization on tetra-coordinated framework aluminum . Meanwhile, the P–Al interaction was proposed based on results of 27 Al, 31 P, and 29 Si MAS NMR. With H 3 PO 2 as the P precursor, easy diffusion into ZSM-5 channels contributed to less formation of polyphosphates, homogeneous distribution of P species, better reserved crystallinity, microporous area and acidic sites for improving cracking performance of n -tetradecane.
研究领域:
化学工程
·
催化
·
材料科学
✓ 已验证
DOI
高影响因子
LANGMUIR
·
2021
·
IF 3.882
Aling Chen,Qingfeng Yi,Kuang Sheng,Yuebing Wang,Jiangchuan Chen,Qiaoli Zhang,Kaiwen Xiang,Guanghua Tan
Development of high-efficiency oxygen reduction reaction (ORR) catalysts under neutral conditions has made little research progress. In this work, we synthesized a three-dimensional porous N/P codoped carbon nanosheet composites (CNP@PNS) by high-temperature thermal treatment of dicyandiamide, starch, and triphenylphosphine and subsequent porous structure-making treatment using the NaCl molten salt template. In the neutral solution, the electrocatalytic performance of the CNP@PNS-4 catalyst exhibits an onset potential of 0.98 V (vs reversible hydrogen electrode) and a half-wave potential of 0.91 V for ORR, which greatly surpasses commercial Pt/C (40%). Three kinds of neutral metal–air batteries (Zn–air, Al–air, and Fe–air) using the prepared samples as cathodic catalysts were constructed, corresponding to the maximum power density of 120.2, 78.3, and 18.9 mW·cm–2, respectively. Also, they reveal outstanding discharge stability under different current densities. The density functional theory calculation depicts the reduction of the free energy of the determining step and subsequent decline of the overpotential for ORR.
研究领域:
材料科学
·
电化学
·
能源科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）