FIBERS AND POLYMERS
·
2026
·
IF 3.1
Cui Jie,Deng Hangjun,Qi Dongming,Zhou Guiyang,Chen Tao
To enhance the surface hydrophilicity of polyphenylene sulfide (PPS) fibers and expand their industrial applications in fire-resistant/radiation-resistant workwear, water electrolysis hydrogen production diaphragms, and fiber paper, this study modified PPS nonwovens using three polyphenols: dopamine, gallic acid, and tannic acid. Specifically, the catechol groups in polyphenols were utilized to adsorb hydrolyzed titanium dioxide (TiO 2 ) from an aqueous solution of ammonium hexafluorotitanate, thereby forming polyphenol/PPS/TiO 2 composites materials. The physicochemical properties (e.g., morphology, elemental composition) and surface properties (e.g., hydrophilicity, mechanical performance, etc.) of modified and unmodified fabrics were characterized using a suite of analytical techniques, including Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), contact angle measurement, water absorption testing, thermogravimetric analysis (TGA), and stress–strain testing. Additionally, the effects of polyphenol type, polyphenol concentration, and reaction time on hydrophilicity of the modified nonwovens were investigated to determine the optimal modification conditions. Results showed that polyphenol modification, combined with subsequent TiO 2 treatment, significantly improved the surface hydrophilicity of PPS nonwovens while preserving their favorable mechanical properties and friction resistance. Among the three polyphenols, the dopamine/PPS/TiO 2 composite exhibited the best wettability: when 2% dopamine (mass concentration) and subjected to 18 h of deposition, the water contact angle decreased from 146.0° (for unmodified PPS) to 51.9°, and the water absorption capacity of the PPS nonwovens increased to 508.4 mL/m 2 /s.
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DOI
高影响因子
SYNLETT
·
2024
·
IF 1.7
Jun Zeng,Yajie Li,Feiyan Li,Sisi Zhou
Theaflavins (TFs) contribute greatly to the colour and flavor of black tea, and have various bioactivities beneficial to human health. This research compared the activity for enzymatic production of TFs from tea polyphenols by recombinant polyphenol oxidase (Malus domestica, GenBank login number LT718523.1, MdPPO2) versus commercial enzyme (Agaricus bisporus, AbPPO) in both free and immobilized form. It describes the difference in activity for TFs production between recombinant and natural polyphenol oxidase. Enzyme assays by LC-MS revealed that the TFs production by AbPPO was almost 5 times as high as recombinant MdPPO2 in free enzyme. When immobilized on mesoporous silica, the activity of recombinant MdPPO2 increased significantly, while AbPPO almost lost its activity. By comparing relative enzyme activity, the immobilization of recombinant MdPPO2 has the highest relative enzyme activity, which was above 6 times higher than free AbPPO. Among these TFs, TF3 was the most abundant, followed by TF2a, TF1 and TF2b.
研究领域:
食品科学
·
生物化学
·
酶学
·
茶叶技术
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DOI
高影响因子
MATERIALS & DESIGN
·
2022
·
IF 9.417
Xiao Yang,Ning Zhang,Gen Li,Mingzhe Zhang,Chunli Pang,Shenzhen Ren,Hailong An
Recently, the development of multifunctional nanoplatforms for synergistic therapy is highly attractive in cancer treatment. Herein, a cancer cell membrane-coated biomimetic nanoplatform (termed as mPAGT) was designed through a simple and versatile polyphenol-mediated coating strategy for a catalytic cascades-enhanced tumor targeted combination therapy. Porphyrin MOFs (PCN) were selected as a nano-photosensitizer and then an endogenous nitric oxide (NO) donor l -arginine ( l -Arg) was loaded into the framework to obtain PA nanoplatforms; Subsequently, glucose oxidase (GOx) was coated on the surface through the interactions between protein and polyphenol and the purified murine breast cancer cell membrane was further decorated to form the resulting nanoplatforms mPAGT NPs. The prepared nanoplatforms exhibited an excellent drug loading capability (9.59% for l -Arg and 33.75% for GOx) and homologous targeting ability. Meanwhile, the mPAGT NPs could initiated a cascade reaction included GOx catalyzed oxidation of glucose, nano-photosensitizer based 1 O 2 -producing, and ROS-mediated the release of NO, and induce an obvious apoptosis with the highest apoptotic ratio of 86.2%. Moreover, the in vivo experimental results further confirmed that our multifunctional nanoplatforms possessed negligible systemic toxicity and promising potential for the treatment of tumor through the catalytic cascades-enhanced synergistic therapy.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物化学
·
药学
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DOI
高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Min Mu,Yuelong Wang,Shasha Zhao,Xiaoling Li,Rangrang Fan,Lan Mei,Min Wu,Bingwen Zou,Na Zhao,Bo Han,Gang Guo
Chemotherapy works against tumors by inducing cell apoptosis; however, evasion of apoptosis is recognized to result in resistance to anticancer therapy. Ferroptosis is an iron-dependent cell death pathway that differs from apoptosis in morphological, biochemical, and genetic levels. Combined ferroptosis and apoptosis may shed light on strategies for cancer treatment. Therefore, we have designed a nanoparticle (NP) that can simultaneously cause tumor cell apoptosis and ferroptosis. This NP is composed of epigallocatechin gallate (EGCG) and Fe3+ through a simple and green process and can be used to deliver doxorubicin hydrochloride (DOX) and iron ions to the tumor site at the same time. DOX/Fe3+/EGCG (DF) NPs display a great resolubility and long-term storage stability, and efficient DOX and Fe3+ release is realized after cellular internalization under the high level of glutathione and acidic nature in tumor. EGCG is likely to chemically reduce the released Fe3+ to Fe2+. The generated Fe3+/Fe2+ converts intracellular H2O2 to hydroxyl radicals (•OH) via the Fenton reaction. In addition, the generated •OH subsequently induces lethal ferroptosis to improve DOX-induced apoptosis. In vitro and in vivo investigations indicate that a great therapeutic effect was achieved, suggesting that the formation of the DF NP delivery system is a promising strategy to fight against tumors by an apoptosis and ferroptosis combination modality.
研究领域:
纳米技术
·
癌症生物学
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药学科学
·
材料科学
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DOI
PubMed
MOLECULES
·
2023
·Vol. 28
·期 9
·3831
·
IF 4.6
Ying Huang,Changzheng Gao,Wei Song,Wanqing Wei,Xiulai Chen,Cong Gao,Jia Liu,Jing Wu,Liming Liu
Theaflavins (TFs) are good for health because of their bioactivities. Enzymatic synthesis of TFs has garnered much attention; however, the source and activity of the enzymes needed limit their wide application. In this study, a microbial polyphenol oxidase fromBacillus megateriumwas screened for the synthesis of theaflavin-3,3′-digallate (TFDG). Based on structural and mechanistic analyses of the enzyme, the O-O bond dissociation was identified as the rate-determining step. To address this issue, a transition state (TS) conformation optimization strategy was adopted to stabilize the spatial conformation of the O-O bond dissociation, which improved the catalytic efficiency of tyrosinase. Under the optimum transformation conditions of pH 4.0, temperature 25 °C, (−)-epigallocatechin gallate/epicatechin gallate molar ratio of 2:1, and time of 30 min, Mu4(BmTyrV218A/R209S) produced 960.36 mg/L TFDG with a 44.22% conversion rate, which was 6.35-fold higher than that of the wild type. Thus, the method established has great potential in the synthesis of TFDG and other TFs.Keywords:polyphenol oxidase;protein engineering;transition state;theaflavin-3,3′-digallate
研究领域:
生物化学
·
酶学
·
蛋白质工程
·
食品科学
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PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Sainan Wang,Pengchang Liu,Yongmei Qin,Zhijun Chen,Jiacong Shen
In this report, a rapid approach for the synthesis of protein conjugated gold nanoclusters under heating condition (AuNCs-protein(p)-heating(h)) was proposed. These AuNCs-p-h were synthesized within 3 min at approximately 100 °C and contain remarkable peroxidase-like activity. Notably, in the presence of tea polyphenols (TPs), the peroxidase-like activity of AuNCs-p-h is restrained, which is likely due to the TP-induced aggregation. A facile approach for TP sensing based on the inhibition effect of TPs towards the peroxidase mimic activity of AuNCs-p-h has been developed. Tea is one of the most popular and health beneficial beverages, the favourable effect of which attributes greatly to its key component, TPs. TP detection thus becomes an important task for various food and beverage companies. This novel TP colorimetric detecting method exhibits a linear response in the concentration range of 10 nM to 10 μM with detection limit of 10 nM as well as prominent selectivity towards various TP related molecules including tyrosol, protocatechuate, chlorogenic acid, theophylline, l -theanine, and l -norepinephrine hydrochloride. Comparing with the traditional tartaric acid colorimetric approach (Tac), this new system shows basically identical experimental results but with much higher sensitivity. AuNCs-p-h can be readily used for TP quantification from real tea samples.
研究领域:
纳米技术
·
分析化学
·
食品科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Shao-Peng Zhao,Yi-Zi Wang,Han-Qiao Zhang,Mianzhi Chen,Dacheng Jiang,Yu Han,Yue Ren,Fengyuan Yang,Chuntai Liu,Changyu Shen
Oral delivery of probiotics is fundamentally constrained by the trade-off between gastrointestinal protection and therapeutic activity at inflamed intestinal sites. Here, we report a polyphenol-regulated mineralization strategy that programs a hierarchical petaloid mineral shield on probiotic surfaces through a mild one-pot process. Epigallocatechin gallate (EGCG) directed calcium phosphate assembly into a stacked petaloid shield on Limosilactobacillus reuteri , providing protection during fabrication and gastrointestinal transit while preserving bacterial proliferative capacity. The petaloid shield also enabled immobilization of hyaluronic acid and enhanced retention at inflamed intestinal sites. Partial shield disintegration released EGCG for reactive oxygen species scavenging and local microenvironment modulation alongside liberated probiotics. In a dextran sulfate sodium–induced colitis model, the engineered probiotics reduced disease activity, attenuated inflammatory responses, repaired intestinal barrier integrity, and improved gut microbiota homeostasis. This work provides a polyphenol-regulated mineralization strategy to engineer multifunctional probiotic shields for oral delivery of living therapeutics.
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高影响因子
Foods
·
2026
·Vol. 15
·期 11
·1897
·
IF 6
Jiayi Zhang,Shengyang Shi,Yingxi Chen,Sufang Zhang,Chaofan Ji
Kombucha quality is largely governed by polyphenol transformation during fermentation. However, interaction between substrate composition and microbial communities regulating phenolic transformation and quality formation remains unclear. In this study, six tea substrates (white, green, yellow, black, oolong, and mint tea) were fermented using three defined microbial communities (SMC1-SMC3) and a traditional symbiotic culture of bacteria and yeast (SCOBY) to evaluate carbon metabolism, phenolic transformation, antioxidant activity, and sensory quality. After 10 d of fermentation, SMC2 and SMC3, containing acetic acid bacteria, showed stronger acidification (pH 2.2–2.5) and lower ethanol (0.34–0.52 mg/mL) than SMC1 (13.09–15.88 mg/mL). Phenolic transformation was substrate-dependent: total phenolics and flavonoids decreased in green tea, both increased in white tea, while flavonoids increased in oolong and black tea. Meanwhile, rutin decreased in white and green tea, whereas gallic acid accumulated in yellow, black, and oolong teas and was positively correlated with antioxidant activity. Sensory evaluation showed SMC3 achieved higher overall acceptability in most substrates, whereas SCOBY performed best in mint tea. These findings indicate substrate-microbiota interactions play a key role in phenolic transformation and quality formation in kombucha. Rational matching of tea substrates with defined microbial communities enables coordinated optimization of antioxidant activity, ethanol control, and sensory quality.
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DOI
PubMed
高影响因子
JOURNAL OF ADHESION
·
2021
·
IF 2.917
Lei Wang,Bo Zhang,Xue Li,Wencai Wang,Ming Tian,Zhaodong Fan,Liqun Zhang
In this work, a green and efficient method for the surface modification of aramid fibers is proposed, aiming to enhance their adhesion property with rubber matrix. The surface of the aramid fibers was pre-deposited with a polyphenol-metal complex coating via rapid (1 min) complexation between FeIII ions and tannic acid (TA), followed by silane grafting. The influences of reactant concentration and reaction temperature on the grafting efficiency of bis-(γ-triethoxysilylpropyl)-tetrasulfide (Si69) were also characterized. The adhesion force of the modified aramid fibers/rubber composites showed a maximum improvement of 73.6% compared to that of untreated aramid fibers/rubber composites. This approach showed great potential in rubber industry due to its low-cost and high-efficiency.
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高影响因子
FOOD CHEMISTRY
·
2026
·
IF 9.8
Xinhui Wang,Junjun Zhou,Bing Qi,Zhou Chen,Siting Li,Aijin Ma,Yingmin Jia
This study developed an edible chitosan-based coating incorporating the main polyphenols from walnut kernel seed coats (gallic acid, ferulic acid, and ellagic acid) to enhance the oxidative stability and sensory quality of fresh walnut kernels during roasting. SEM and AFM analysis revealed that gallic acid-loaded chitosan films exhibited a uniform yet rough morphology, while zeta potential measurements (36–41 mV) confirmed improved film stability. The gallic acid-loaded film demonstrated superior wettability (contact angle: 21.45°) and low water vapor permeability (2.87 × 10 −3 g/(mm∙h∙kPa)), ensuring strong adhesion. FTIR and UV–Vis analyses confirmed hydrogen-bonded crosslinking between polyphenols and chitosan. Thermal stability increased, with DSC and TGA peaks at 181.97 °C and 343 °C for the gallic acid-loaded film. Coated kernels exhibited significantly lower oxidation, with peroxide and acid values (0.04 g/100 g, 0.5 mg/g) outperforming uncoated samples. These findings suggested that gallic acid-loaded chitosan coatings effectively improve walnut kernel quality during roasting.
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DOI
PubMed
高影响因子
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
·
2012
·Vol. 234
·期 4
·607-616
·
IF 1.566
Zheng Yongju,Shi Junling,Pan Zhongli
Polyphenol oxidase (PPO) was isolated from Thompson seedless grape ( Vitis vinifera ‘Thompson Seedless’ ), and its biochemical characteristics were studied. The PPO showed activity to catechol and D, L-DOPA, but not towards monophenol l -Tyrosine, diphenols guaiacol and caffeic acid, and triphenols pyrogallic acid and gallic acid. Apparent Michaelis–Menten constant ( K
m ) and maximum velocity of the reaction ( V
max ) values were 45.0 ± 0.05 mM and 500.0 ± 15.3 OD 400 nm /min for catechol, and 34.6 ± 0.03 mM and 384.6 ± 11.7 OD 478 nm /min for D, L-DOPA, respectively. The obtained similar specificity values of V
max / K
m ratio of catechol and D, L-DOPA indicated their similar affinity to Thompson seedless PPO. The most effective inhibitor was l -cysteine, followed in decreasing order by ascorbic acid, sodium metabisulfite, EDTA, NaCl, and citric acid. It was discovered that metal ions of Mg 2+ and Cu 2+ increased, while Zn 2+ and K + reduced the PPO activity. Sugars showed inhibition on the PPO activity, with higher effect by sucrose and lower effect by fructose and glucose. Optimum pH and temperature for grape PPO activity were 6.0 and 25 °C with 10 mM catechol as substrate. The enzyme was heat stable between 10 and 25 °C, but showed significant activity loss at temperatures higher than 40 °C and completely inactivation at 70 °C for 10 min. Thermal inactivation of PPO showed a first-order kinetic with an activation energy ( E
a ) of 146.1 ± 10.8 kJ/mol at pH 6.0.
研究领域:
食品科学
·
生物化学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Xi Zhang,Yan Lv,Hao-Cheng Yang,Yong Du,Zhi-Kang Xu
Thin-film composite (TFC) nanofiltration membranes are prepared via interfacial polymerization with a polyphenol coating as an interlayer for the thin and smooth polyamide selective layer. The polyphenol interlayer is simply fabricated by the codeposition of tannic acid and diethylenetriamine without changing the surface morphology of the polysulfone ultrafiltration substrate. An interfacial polymerization is conducted from piperazidine and trimesoyl chloride on the polyphenol interlayer to construct the polyamide selective layer. The as-prepared TFC nanofiltration membranes show nearly tripled fold of water permeation flux as compared with those prepared at the same condition without an interlayer. They also exhibit a high rejection to Na2SO4 (>98%) because the thin and defect-free polyamide selective layer is formed on the polyphenol interlayer. These nanofiltration properties have high reproducibility, which means the TFC nanofiltration membranes are suitable for scale-up industrial applications.
研究领域:
材料科学
·
环境工程
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）