Journal of Materials Chemistry C
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2026
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IF 5.1
Jiacheng Cao,Min Zhu,Xuefeng Lu,Xiaonan Chen
Oxide thermoelectric materials demonstrate superior structural stability and environmental compatibility; however, their practical applications are limited by relatively low figure-of-merit (ZT) values. This study overcomes this limitation in strontium barium niobate (SBN) through entropy-mediated Pb doping, achieving a record ZT of 0.42 at 1073 K – the highest reported for SBN-based ceramics. By designing a medium-entropy (ΔS = 1.30R) (Sr0.5Ba0.3La0.2)1−xPbxNb2O6−δ system, electron–phonon transport properties are effectively optimized. Pb doping enhances carrier concentration while maintaining a high Seebeck coefficient, attributed to the contribution of Pb orbitals. Simultaneously, lattice thermal conductivity (κlat) is reduced through dislocation engineering and induced strain fields, as verified by geometric phase analysis. The performance improvement is further supported by local distortions of NbO6 octahedra, as well as the formation of lead and oxygen vacancies. This work not only demonstrates the potential of SBN as a promising oxide thermoelectric material but also presents a broadly applicable doping strategy for developing high-performance oxide energy conversion materials.
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高影响因子
JOURNAL OF CHEMICAL RESEARCH
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2022
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IF 1.097
Zhicheng Fan,Chuwu Xing,Yi Tan,Jinxia Xu,Lingyun Liu,Yuanming Zhou,Yan Jiang
Black-phase formamidinium lead iodine with 1.48 eV bandgap is considered to be the most promising material for improving the near-theoretical limit efficiency of perovskite solar cells, but at room temperature, black-phase formamidinium lead iodine easily transforms into the yellow non-perovskite phase formamidinium lead iodine. Here, different ratios of Cs+-incorporated formamidinium lead iodine prepared by one-step processing with the stability and power conversion efficiency of formamidinium lead iodine perovskite solar cells are investigated. FA0.85Cs0.15PbI3 shows the highest power conversion efficiency of 10.63% (Voc = 1.04 V, Jsc = 16.81 mA cm−2, and fill factor = 0.60), and the unencapsulated device maintained 60% of the initial power conversion efficiency after storage in air with 40% humidity for 186 h with an active area of 0.1 cm2, when the ratios of Cs+ reached 15% (x = 0.15) in formamidinium lead iodine. However, the efficiency of perovskite solar cell–based formamidinium lead iodine is still low. In this work, a simple but an effective strategy was carried out to rapidly and fully oxidize hole transport layer solution by doping CO2 or O2 under ultraviolet light irradiation to increase the conductivity of hole transport layer, thereby improving the power conversion efficiency of solar cells. The results show that FA0.85Cs0.15PbI3 solar cells by CO2-doped hole transport layer for 90 s exhibited the highest power conversion efficiency of 16.11% (VOC = 1.11 V, JSC = 19.73 mA cm−2, and fill factor = 0.74). The improved photovoltaic performance is attributed to CO2-doped spiro-OMeTAD increasing charge carrier density and accelerating charge separation, thereby inducing higher conductivity. CO2 or O2 doped can rapidly and fully oxidize spiro-OMeTAD, and reduce the solar cell fabrication time; it is beneficial to the commercial use of perovskite solar cells.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2012
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IF 2.098
Sheng-Gui Liu,Lin-Ping Zhang,Jian Liu,Wen-Yi Su,Xiao-Bo Shi
Two cadmium complexes, Cd(bpbp)Cl 2 (complex 1 ) and [Cd(bpbp) 2 ](ClO 4 ) 2 (complex 2 ), based on 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine (bpbp), were synthesized and characterized by X-ray single crystal structure analyses. For complex 1 : crystal system, monoclinic, space group, C2/c, a = 27.427(3) Å, b = 13.4495(15) Å, c = 14.8381(17) Å, β = 106.635(2)°, V = 5244.4(10) Å 3 , Z = 8. It is a neutral complex. The Cd(II) ion distorted trigonal bipyramidal geometry is five-coordinated by three nitrogen atoms from ligand (bpbp) and two chlorine ions. For complex 2 : crystal system, triclinic, space group, P-1, a = 13.4791(15) Å, b = 13.8506(16) Å, c = 16.5839(19) Å, α = 94.202(2)°, β = 106.948(2)°, γ = 94.872(2)°, V = 2935.3(6) Å 3 , Z = 2. It is an ionic complex. The Cd(II) ion octahedral geometry is six-coordinated by six nitrogen atoms from two ligand (bpbp). Both complexes emit blue luminescence with emission peaks at 420 and 430 nm in solid state and with emission peaks at 415 and 425 nm in DMF solution. In complex 1 absorption spectra, there is not only the free ligand absorption peak at 310 nm, but also shows strong Cd–Cl charge transfer peak at 350 nm in DMF solution.
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Acta Biomaterialia
·
2026
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IF 10.4
Yihui Sun,Yingshuai Wang,Qianbo He,Min Zhao,Jiaru Guo,Chunjie Xu,Qiupeng Yan,Yanchun Chen,Bingqiang Zhang,Hongmei Du,Jing Huo,Yong Zhang,Haoyun Zhang,Yingjun Guan,Qianjun He
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration in the brain and spinal cord, with mutant superoxide dismutase 1 (SOD1) induced oxidative stress and neuroinflammation as key pathogenic drivers. Here, we uncover that mutant SOD1 is both a Fenton-like agent able for catalytical generation of ·OH and a hydrogenation catalyst for H 2 scavenging reactive oxygen species. To enhance the bioavailability of H 2 , we develop an orally administered Mg 2 Si nanosheets based feed for sustained release of high-amount H 2 . On an ALS model of hSOD1 G93A transgenic mice, Mg 2 Si feed remarkably delays ALS progression, improves the motor performance of ALS mice, and extends their lifespan. Histopathologically, oral Mg 2 Si treatment ameliorates motor neuron degeneration, misfolded SOD1 aggregation and reactive gliosis in spinal cord, while protecting neuromuscular junctions and ameliorating muscle atrophy during disease progression. Transcriptomic analysis demonstrates the H 2 -mediated down-regulation of both oxidative stress and neuroinflammatory pathways in response to the suppression of NLRP3 inflammasome activation. The proposed strategy of catalyzed hydrogen therapy offers an inspiration for metalloproteases-related neurodegenerative diseases treatment. Statement of Significance Amyotrophic lateral sclerosis (ALS) is an incurable and devastating neurodegenerative disease lacking effective clinical interventions. Although hydrogen gas (H 2 ) exhibits promising neuroprotective potential, conventional H 2 therapy is severely limited by unstable and transient H 2 release, failing to sustain long-term treatment requirements for chronic ALS pathogenesis. To overcome this bottleneck, we engineer oral administrable Mg 2 Si nanosheets that enable sustained H 2 release via gastrointestinal retention, achieving stable long-term hydrogen supplementation in vivo . Mechanistically, Mg 2 Si-derived H 2 efficiently eliminates excess free radicals triggered by toxic mutant SOD1, and further disrupts the pathological crosstalk between oxidative stress and neuroinflammation in ALS. In transgenic ALS mice, dietary Mg 2 Si intervention markedly ameliorates motor dysfunction and effectively delays disease progression. Collectively, this study firstly applies Mg 2 Si nanomaterial-based sustained hydrogen therapy for ALS treatment, establishes a novel gastrointestinal hydrogen delivery strategy, and provides an innovative and clinically translatable paradigm for the design of hydrogen delivery systems against neurodegenerative disorders. Download: Download high-res image (244KB) Download: Download full-size image
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高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Kunqi Liu,Junxia Wang,Jin Wang,Long Kang,Jun Li,Die Liu,Yuan Liu,Qing Tao
To explore the application potential of ceramic waste forms for immobilizing multiple nuclides in high-level waste, a systematic study was conducted on (1- x )Sr 0.5 Zr 2 (PO 4 ) 3 - x Ce 0.5 Sm 0.5 PO 4 ( x = 0, 0.5, and 1) ceramics, focusing on their chemical and irradiation stability. The composite ceramics can simultaneously immobilize multiple nuclides (Sr, Ce, and Sm), while retaining a homogeneous microstructure and high relative density (>97%). Static leaching experiment indicated low normalized leaching rates: LR Sr ∼ 10 -4 -10 -3 g·m -2 ·d -1 , LR Ce ∼ 10 -8 -10 -7 g·m -2 ·d -1 , and LR Sm ∼ 10 -7 -10 -6 g·m -2 ·d -1 . Different leaching behaviors of nuclides (Sr, Ce, Sm) were further identified using the de Groot and van der Sloot model. With 5 MeV Xe 20+ irradiation at a fluence of 2.5×10 15 ions/cm 2 , Sr 0.5 Zr 2 (PO 4 ) 3 phase in the composite ceramics can still maintain part of its crystal structure, while Ce 0.5 Sm 0.5 PO 4 phase tends to amorphize. Interestingly, subsequent TEM observation further vitrificated the Xe 20+ -induced amorphous Ce 0.5 Sm 0.5 PO 4 phase recrystallizes under electron-beam (e-beam) irradiation.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
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IF 2.4
Yuexin Chu,Xianming Zhang,Guojun Ji,Yunfei Wang,Ruifeng Wang,Yongli Wu,Jianmin Wang,Hongyu Peng
The production of C8 linear α-olefins via Fischer–Tropsch (F-T) synthesis represents a promising alternative approach. However, purifying α-olefins from F-T synthesis oil presents considerable technical challenges, particularly with respect to the removal of oxygenated compounds. In this work, propylene carbonate (PC) was used as extractant, and 1-pentanol, n-valeraldehyde, 2-hexanone, and ethyl acetate were selected as representative substances of oxygenated compounds. Liquid–liquid equilibrium (LLE) for the binary system of 1-octene + PC, and the ternary systems of 1-octene + 1-pentanol + PC, 1-octene + n-valeraldehyde + PC, 1-octene + 2-hexanone + PC, and 1-octene + ethyl acetate + PC were measured at 298.15, 303.15, and 313.15 K under 101.3 kPa using a jacketed equilibrium cell. The phase diagrams for the ternary systems were classified as Treybal’s Type I behavior. The distribution coefficient (D) and selectivity (S) were calculated to investigate the efficiency of PC as an extractant. Moreover, the temperature dependencies of D and S were investigated in this study. The experimental LLE data were correlated using the NRTL and UNIQUAC models with the interaction parameters optimized. The RMSD values between the experimental and calculated data indicate that these models can accurately correlate the experimental data for the study systems.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Xiaoqiong Li,Yunruo Xu,Luming Xu,Qilin Li,Yiwei Zhao,Chunyu Wei,Yuyu Li,Lin Wang,Zheng Wang
Surgery is the mainstay of treatment for patients with solid tumors. However, the intricate inflammatory and immunosuppressive tumor microenvironment after surgery is recognized as a primary cause of tumor recurrence and metastasis. Here, we design and construct an in situ injectable therapeutic hydrogel encapsulating 1-methyl-d-tryptophan (1-d-MT), a small-molecule competitive inhibitor of indoleamine 2,3-dioxygenase, and meloxicam, a selective inhibitor of cyclooxygenase-2 (Ge1MT/Mel hydrogel) to prevent postoperative tumor metastasis and relapse. In this hydrogel system, 1-d-MT increases cytotoxic T lymphocytes and decreases regulatory T cells, thereby reversing the tumor immune tolerance microenvironment, while released meloxicam reduces inflammation caused by postoperative trauma via the COX-2/PGE2 pathway. When delivered into the resected tumor cavity, the hydrogel system mimics a “hot” tumor-immunity niche to attack residual tumor cells and significantly suppresses the postoperative recurrence of colorectal cancer. In the model of postoperative breast cancer and colorectal cancer recurrence and metastasis, the Ge1MT/Mel hydrogel substantially reduces the volume of recurrent tumors and demonstrates 85.1% and 66.7% inhibition rates of metastases, respectively. Importantly, the Ge1MT/Mel hydrogel markedly stimulates a potent antitumor immune response in the cancer lesion microenvironment, increasing antitumor immune cells including CD8+ T cells, as well as elevating antitumor cytokines such as interferon-γ. Overall, combination immunotherapy via the Ge1MT/Mel hydrogel after surgery represents a promising strategy to minimize residual tumor burden and reduce recurrence risk following tumor resection.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Zemin Li,Rongbo Li,Benxing Li,Yuqi Zhu,Jiale Lin,Chongqing Wang,Rujing Hou,Yichang Pan
The separation of hexane isomers in petrochemical engineering is energy-intensive, driving the need for membrane-based alternatives to conventional thermal processes. Mixed-matrix membranes (MMMs) offer a material platform by combining the processability of polymer matrices with the high structural tunability of porous fillers. In this work, we fabricate UiO-66-Tix/tPIM-1 MMMs by incorporating Ti-regulated bimetallic Zr/Ti-UiO-66 fillers into a thermally treated polymer of intrinsic microporosity (tPIM-1) matrix. At low Ti contents, the UiO-66-type crystallinity is largely preserved, while Ti introduction produces measurable changes in the pore characteristics and nHex/22DMB adsorption kinetics. Membrane-level sorption measurements show preferential nHex uptake, while adsorption-kinetic analysis and molecular dynamics simulations of both the isolated frameworks and the UiO-66-Ti 0.2 /tPIM-1 composite environment indicate stronger diffusion restriction toward bulky 22DMB than toward linear nHex. Collectively, these results support an adsorption–diffusion transport mechanism for the observed separation behavior. Among the Ti contents and filler loadings investigated, the selected 5 wt% UiO-66-Ti 0.2 /tPIM-1 membrane achieves a flux of 515 g·m −2 ·h −1 and a separation factor of 7.9 for nHex/22DMB separation. The membrane also maintained relatively stable performance during 84 h of continuous operation and preferentially enriched nHex from multicomponent C6 isomer mixtures, showing competitive separation performance among reported MMMs for hexane isomer separation. These results indicate that controlled Ti introduction provides a route to modify the pore characteristics of UiO-66 and improve nHex/22DMB discrimination in thermally treated PIM-1-based MMMs.
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高影响因子
ACS Nano
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2025
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IF 16
Xiao Sun,Yufang Gong,Haiyan Ge,Guiqi Ma,Tianxing Yang,Mengyao Mu,Le Zhang,Chenyu Wang,Bowen Shen,Xiaohui Dai,Zhengyan Wu,Xinyu Zhang,Qing Fan,Hongzan Sun
Visualizing tumor programmed cell death ligand 1 (PD-L1) expression and synchronously using this target for effective tumor therapy present great prospects for clinical application. In this study, a gadolinium-hybridized platinum nanoplatform with dimeric PD-L1-antagonistic affibody (ZPD-L1) (GPPZ) was constructed. Leveraging the specific binding between ZPD-L1 and the tumor surface, ZPD-L1 could endow this nanoplatform with efficient PD-L1 targeting, enabling the efficient magnetic resonance imaging (MRI) visualization of PD-L1 expression. GPPZ, through its catalase- and peroxidase-like activities, can catalyze the production of O2 and the production of •OH, respectively, sensitizing radiotherapy and enhancing immunogenic cell death. In addition, ZPD-L1 can also terminate T cells’ immune suppression by effectively inhibiting interactions of PD-1/PD-L1 to further enhance tumor immunotherapy. Systemic delivery of GPPZ resulted in MRI contrast enhancement of tumors with high levels of PD-L1 expression. Importantly, no obvious side effects can be observed in both histological and hematology examination. Therefore, this nanoplatform demonstrated promise for enhanced MRI visualization of tumor PD-L1 level and synergistic radio immunotherapy.
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高影响因子
Stem Cell Research & Therapy
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2026
·Vol. 17
·期 1
·123
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IF 7.8
Du Mengxian,Guo Fengyi,Liu Xinna,Zhang Shiqi,Zhang Di,Qiu Leyi,Zhang Jingyang,Li Baoqiang,Yuan Huiping
Background Normal tension glaucoma (NTG) causes progressive retinal ganglion cell (RGC) loss without elevated intraocular pressure, and currently lacks effective neuroprotective therapies. OPTN(E50K) mutation, a pathogenic gene of NTG, compromises paracrine trophic capacity in bone marrow (BM) stem cells. Allogeneic young BM stem cells can provide trophic support and exhibit therapeutic potential; however, their clinical application is limited by immunogenic rejection and tumorigenic risks, prompting a renewed interest in rejuvenate autologous BM stem cells strategy. Methods To address these challenges, we developed a composite chitosan-rapamycin (RAPA) carbon dots (CRCD) to restore the reparative potential of autologous BM stem cells. BM stem cells from aged OPTN(E50K) mice were isolated, clustered and treated with CRCD before validated their changes of neurotrophic factors expression as well as oxidative stress and autophagy indicators. Then we assessed their impact on co-cultured retinas in vitro. Transplantation were performed into lethally irradiated age-matched OPTN(E50K) hosts with CRCD-pretreated autologous BM stem cells via tail vein injection, and generated stable chimeric models. Neurotrophic factors and neuron apoptosis analyses were performed, followed by the visual behavioral tests. Results Our results demonstrated that CRCD pretreatment enhanced autophagy, reduced oxidative stress, and augmented paracrine neurotrophic release. In vitro, these cells reduced retinal ganglion cell apoptosis and promoted neurotrophic factor expression in co-cultured retinal explants. In vivo, comparative analysis revealed that CRCD intervention significantly elevated neurotrophic factor expression in retinal tissues compared to RAPA-treated and untreated chimeras. Functional assessments further confirmed superior visual performance in CRCD-Sca-1 + chimeras, correlating with improved RGC survival. Conclusion These findings suggest that CRCD improved paracrine neurotrophic support of autologous BM stem cells by enhancing their autophagy and paracrine functions, leading to structural and functional rescue of the glaucomatous retina. This approach offered a clinically relevant strategy for NTG, providing sustained neuroprotection while avoiding the risks of allogeneic transplantation and repeated intravitreal drug delivery. Graphical The alternative text for this image may have been generated using AI.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2023
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IF 6.8
Rui Yan,Jie Ding,Qianlei Yang,Xiaoyun Zhang,Junyu Han,Tingxu Jin,Shudi Shi,Xirui Wang,Yu Zheng,Heran Li,Hengdong Zhang,Yan An
Skeletal system toxicity due to lead exposure has attracted extensive attention in recent years, but few studies focus on the skeletal toxicity of lead in the early life stages of zebrafish. The endocrine system, especially the GH/IGF-1 axis, plays an important role in bone development and bone health of zebrafish in the early life. In the present study, we investigated whether lead acetate (PbAc) affected the GH/IGF-1 axis, thereby causing skeletal toxicity in zebrafish embryos. Zebrafish embryos were exposed to lead PbAc between 2 and 120 h post fertilization (hpf). At 120 hpf, we measured developmental indices, such as survival, deformity, heart rate, and body length, and assessed skeletal development by Alcian Blue and Alizarin Red staining and the expression levels of bone-related genes. The levels of GH and IGF-1 and the expression levels of GH/IGF-1 axis-related genes were also detected. Our data showed that the LC50 of PbAc for 120 h was 41 mg/L. Compared with the control group (0 mg/L PbAc), after PbAc exposure, the deformity rate increased, the heart rate decreased, and the body length was shortened at various time periods, in the 20-mg/L group at 120 hpf, the deformity rate increased by 50 fold, the heart rate decreased by 34%, and the body length shortened by 17%. PbAc altered cartilage structures and exacerbated bone loss in zebrafish embryos; in addition, PbAc exposure down-regulated the expression of chondrocyte ( sox9a , sox9b ), osteoblast ( bmp2 , runx2 ) and bone mineralization-related genes ( sparc , bglap ), and up-regulated the expression of osteoclast marker genes ( rankl , mcsf ). The GH level increased and the IGF-1 level declined significantly. The GH/IGF-1 axis related genes ( ghra , ghrb , igf1ra , igf1rb , igf2r , igfbp2a , igfbp3 , igfbp5b ) were all decreased. These results suggested that PbAc inhibited the differentiation and maturation of osteoblasts and cartilage matrix, promoted the formation of osteoclasts, and ultimately induced cartilage defects and bone loss by disrupting the GH/IGF-1 axis.
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高影响因子
COMBUSTION AND FLAME
·
2023
·
IF 4.4
Jinhu Liang,Ruining He,Shashank S. Nagaraja,A. Abd El-Sabor Mohamed,Haitao Lu,Yousef M. Almarzooq,Xiaorui Dong,Olivier Mathieu,William H. Green,Eric L. Petersen,S. Mani Sarathy,Henry J. Curran
2,3-Dimethyl-2-butene (TME) is a potential fuel additive with high research octane number (RON) and octane sensitivity ( S ), which can improve internal combustion engine performance and efficiency. However, the combustion characteristics of TME have not been comprehensively investigated. Thus, it is essential to study the combustion characteristics of TME and construct a detailed chemical kinetic model to describe its combustion. In this paper, two high-pressure shock tubes and a constant-volume reactor are used to measure ignition delay times and laminar flame speeds of TME oxidation . The ignition delay times were measured at equivalence ratios of 0.5, 1.0, and 2.0 in “air”, at pressures of 5 and 10 bar, in the temperature range of 950 – 1500 K. Flame speeds of the TME/ “air” mixtures were measured at atmospheric pressure, at a temperature of 325 K, for equivalence ratios ranging from 0.78 to 1.31. Two detailed kinetic mechanisms were constructed independently using different methodologies; the KAUST TME mechanism was constructed based on NUIGMech1.1, and the MIT TME mechanism was built using the Reaction Mechanism Generator (RMG). Both mechanisms were used to simulate the experimental results using Chemkin Pro. In the present work, reaction flux and sensitivity analyses were performed using the KAUST mechanism to determine the critical reactions controlling TME oxidation at the conditions studied.
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危险品化学品经营许可证（带存储）