ChemSusChem
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2019
·Vol. 12
·期 23
·5172-5182
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IF 7.804
Ye Liu,Wenjun Yan,Wei Zhang,Wei Kong,Zhongde Wang,Xiaogang Hao,Guoqing Guan
Although lithium–sulfur batteries are promising environmentally friendly and low-cost energy storage devices with high energy densities, many obstacles such as poor conductivity, volume expansion and the “shuttle effect” still limit their large-scale commercialization. In this work, a 2D sandwich-like α-ZrP/polypyrrole (α-ZrP/PPy) material with a nanosheet structure was designed as a sulfur host. The material can provide unique ion transfer channels for the rapid transfer of Li + ions and catalytically promote the conversion of lithium polysulfides (LiPSs). Moreover, the α-ZrP nanosheets provides a true covalent anchor for sulfur species, whereas the PPy builds a physical barrier and forms a conductive network for accelerating the electron transport and promoting the electrochemical performance. In addition, the moderate catalytic activity and true sulfur confinement effect of α-ZrP were confirmed by experiments and theoretical calculations. The α-ZrP/PPy@S cathode exhibits a highly reversible capacity of 727.2 mAh g −1 even at a high current density of 5 C, offering a novel cathode material for high performance Li–S batteries. Graphical Welcome to the cell : 2D sandwich-like α-ZrP/polypyrrole (α-ZrP/PPy) nanosheets are designed as a sulfur host material. The material has a remarkably enhanced cycling performance, excellent rate capability, and improved coulombic efficiency owing to the true covalent confinement of sulfur and moderate catalytic activity for the conversion of LiPSs. Such α-ZrP/PPy@S composites can be applied as promising cathode materials for Li–S batteries.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Luo Weibin,Hou Jiahui,Fan Jie,Zhuang Xiaoyan,Nie Rui,Yao Zilong,Yu Bin,Wang Jun,Guan Daogang,Jin Jian,Wu Hangtian
Background The treatment of Osteomyelitis (OM) faces challenges due to the harmful cycle of bacterial persistence and pathogen-triggered cytokine storms. Conventional antibiotic therapy centers on eliminating bacteria, yet frequently neglects the immunopathological harm following bacterial breakdown. Therefore, there exists an immediate requirement for dual-action treatments capable of simultaneously alleviating multidrug-resistant infections and hyper-inflammatory reactions. Results In this study, single-cell sequencing highlights a TNF/NF-κB-centered transcriptional network which serves as a crucial molecular switch, propelling M1 polarization in macrophages related to OM. Combination of network toxicology and transcriptomic investigations uncovers the key regulatory function of TNF in LTA-triggered cytokine storms in OM. Metabolic sequencing reveals that LTA triggers reprogramming of pyrimidine metabolism in macrophages and synergistically boosts Tnf-α expression. As a result, we created DB-shTnf-α@Gel, an injectable hydrogel that delivers Dalbavancin and shTnf-α self-assembled nanoparticles. This system demonstrated strong anti- MRSA efficacy and interfered with bacterial resistance genes in vitro. In vivo experiments revealed that DB-shTnf-α@Gel has the capacity to oppose macrophage M1 polarization and notably relieve bone damage. Conclusions By accurately zeroing in on TNF-induced excessive inflammation and eliminating multidrug-resistant infections, this nanoplatform presents a synergistic, phased therapeutic approach to surmount the intricate pathology of OM. Graphical abstract
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 16
·118674
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IF 6.3
Zhiqiang Hou,Yikan Yang,Xing Wei,Yongkai Wang,Yao Tang,Chao Wang,Zhicai Zhang,Hao Li,Jiao Yang,Jun Gao,Rui Fang,Haikuo Wang
Existing polycrystalline stishovite bulk synthesized from traditional strategies generally suffer from low purity, grain coarsening and minuscule sample size. Here, we successfully synthesized millimeter-scale high-performance polycrystalline stishovite with nano-sized grains from microcrystalline α-SiO 2 powder in a large-volume press. An anomalous variation in grain size from micrometer to nanometer is realized by high-pressure transformation of microcrystalline precursors. Remarkably, the sample with an average grain size of 91.6 nm synthesized at 15.6 GPa and 800 °C possesses the highest Vickers and Knoop hardness among reported pure stishovite materials, meanwhile higher indentation crack resistance ( K IC = 3.1 MPa m 1/2 ), about double that of stishovite single crystals. The outstanding mechanical properties stem from the synergistic effects of pure stishovite phase, dense microstructure, fine grain size, and high-concentration dislocations. This work provides valuable approach for synthesizing advanced structural ceramics and next-generation superhard materials by high-pressure transformation of microcrystalline precursors.
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ChemSusChem
·
2026
·Vol. 19
·期 14
·e70876
·
IF 5.9
Fei Fei,Yunxiao Liao,Jie Gao,Yancheng Wang,Yifeng Xu,Xinting Huang,Rui Chen,Pin Zhou,Shubo Wang,Ningyi Yuan
The solution-based fabrication of perovskite solar cells (PSCs) typically relies on high-purity materials, the cost of which limits commercial scalability. Here, we report an efficient strategy for directly synthesizing FAPbI 3 -based perovskite microcrystals (MCs) from industrial-grade precursors using formic acid (HCOOH) as a multifunctional additive and antisolvent in a synergistic process combining inverse temperature crystallization (ITC) and antisolvent-assisted precipitation. In situ grazing-incidence wide-angle X-ray scattering (GIWAXS) analysis reveals that formate anions (HCOO − ) coordinate with Pb 2+ to regulate crystallization, passivate structural defects, and promote the direct formation of α-FAPbI 3 . An optimal HCOOH concentration (40%–60% v/v) was identified, achieving a high microcrystalline yield of 92.83% and effectively suppressing the formation of δ-FAPbI 3 . However, concentrations exceeding this range (>80% v/v) disrupt the precursor stoichiometry, leading to PbI 2 impurity segregation. Thin films fabricated using the optimized microcrystals exhibited improved morphological uniformity, enhanced crystallinity, reduced nonradiative recombination losses, and extended charge carrier lifetimes. As a result, inverted-structure PSCs based on these MCs achieve a champion power conversion efficiency of 25.24% (0.07 cm 2 ). This work presents a cost-effective and scalable route for producing high-quality perovskite materials and provides mechanistic insights into the dual functionality of HCOOH, offering valuable guidance for the advancement of low-cost, high-performance perovskite photovoltaic technologies. Graphical Formic acid serves a dual function as both an additive and antisolvent, directing the direct crystallization of α phase perovskite microcrystals from low purity industrial precursors. This one-step strategy achieves a 92.83% yield, simultaneous defect passivation, and a champion solar cell efficiency of 25.24%.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
·
IF 6.7
Xueying Hu,Yue Sun,Junyu Zhou,Khitab Ur Rahman,Xuan Tang,Yueyuan Chen,Zhifang Cui
Luteolin, a flavonoid, exhibits inhibitory activity against α-glucosidase, an enzyme target relevant to glycemic regulation. This study reports the development of a green extraction process employing deep eutectic solvents (DESs). From a COSMO-SAC (Conductor-like Screening Model for Segment Activity Coefficient)-based screening of 128 candidate DESs, choline chloride/1,4-butanediol was identified as the optimal solvent and experimentally validated. Response surface optimization yielded a maximum luteolin yield of 1.394 mg/g under conditions of 40 mL/g liquid-to-solid ratio, 30% water content, 48 °C, and 30 min, representing 1.37- and 1.34-fold yields of methanol and ethanol, respectively. Molecular dynamic simulations indicated that electrostatic interactions predominantly govern extraction efficiency. Greenness metrics (Modified Green Analytical Procedure Index (MoGAPI) and Analytical GREEnness calculator (AGREE)) confirmed favorable sustainability. The extract displayed notable antioxidant capacity and mixed-type inhibition of α-glucosidase with synergistic potentiation of acarbose. These findings support sustainable luteolin extraction and its further investigation in postprandial glycemic regulation.
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CATALYSIS LETTERS
·
2026
·Vol. 156
·期 7
·214
·
IF 2.5
Yang Shumao,Zhang Minsong,Liu Peng,Kang Linxuan,Cui Jiandong
Cascade catalysis of glutamate oxidase (GLOX) and catalase (CAT) is an important one-pot synthetic route for α-ketoglutarate (α-KG) production. However, as the soluble natural proteins, the instability of free GLOX and CAT and the difficulty of recycling severely limits its application. Here, magnetic dual-enzyme cross-linked enzyme aggregates (combi-CLEAs) of GLOX and CAT were successfully prepared with amino-functionalized Fe 3 O 4 magnetic nanoparticles as the carrier by a macromolecular cross-linking agent. Preparation conditions of the combi-CLEAs were systematically optimized. The highest activity recovery of combi-CLEAs reached 81% under the optimized conditions. Meanwhile, the combi-CLEAs exhibited high stability than free enzymes, including temperature tolerance, pH tolerance, and storage capacity. After incubation at 80 °C for 30 min, the magnetic combi-CLEAs retained 25% of its initial activity whereas the free enzymes maintained only 10%. Moreover, after 6 cycles of use, the combi-CLEAs maintained 74% of its initial activity, indicating excellent reusability. In particular, the combi-CLEAs exhibited high substrate tolerance and conversion efficiency of L-glutamate to α-KG. The total α-KG yield by combi-CLEAs after 6 cycles of use was 5.8 times higher than that of the free enzyme system.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2026
·
IF 4
Jiayi Zhao,Yanling Xu,Lu Liu,Xiaodong Li,Xiuxiu Zhang
BACKGROUND Milk-derived α -glucosidase-inhibiting peptides are attracting increasing attention from the scientific community because of their exceptional biological activity and excellent safety profile. However, the differences in inhibitory activity among peptides from various milk protein sources remain unclear. In this study, a novel α -glucosidase inhibitory peptide was screened from milk protein hydrolysates derived from different sources and subsequently validated in vitro . RESULTS The results obtained indicate that the peptide fraction derived from bovine casein hydrolyzed by alkaline protease exhibited the strongest enzyme inhibitory effect (IC 50 = 0.87 ± 0.02 mg mL −1 ). Through mass spectrometry identification combined with molecular docking and molecular dynamics simulations, it was found that the peptide segment FRQFYQL can stably bind to α -glucosidase via hydrogen bonds and hydrophobic interactions (−11.2 kcal mol −1 ). The in vitro experiments revealed that the inhibitory activity of this peptide (IC 50 = 0.35 ± 0.04 mg mL −1 ) was higher than that of the original hydrolysate. Furthermore, FRQFYQL significantly increased glucose absorption and glycogen production in insulin-resistant HepG2 cells. Network pharmacology analysis suggested that FRQFYQL may improve glucose metabolism-related complications by regulating signaling pathways such as TNF and IL-17, thereby reducing cellular glucose levels and pro-inflammatory factor expression. CONCLUSION The peptide FRQFYQL effectively inhibits α -glucosidase activity, and enhances cellular glucose uptake and glycogen synthesis, thus demonstrating potential as a hypoglycemic component in functional foods and nutraceuticals. © 2026 Society of Chemical Industry.
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ORGANIC & BIOMOLECULAR CHEMISTRY
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2026
·
IF 2.8
Lin Chen,Shuang Xu,Zhiming Chen
Direct α-C(sp3)−H arylation of 4-aminopyrazolones involving arynes, enabled by dual phase-transfer catalysis and ultraviolet irradiation, has been developed. The dual phase-transfer catalytic pathway powered by triaminocyclopropenium salts gave rise to the generation of structurally diverse 4-amino-4-arylpyrazolones in moderate to excellent yields, while the photochemical protocol furnished the products with moderate yields. Notably, these products are tentatively proposed as candidates for carbamate pesticides based on the preliminary structural analysis. The synthetic potentials of the methods were shown by gram-scale reactions, and the possibilities for greater structural diversity of the product were highlighted by derivatizations. The results of control experiments indicated that the timely capture of the transient arynes by the activated 4-aminopyrazolone nucleophiles is the key to the success of the reactions.
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TRIBOLOGY INTERNATIONAL
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2026
·
IF 7.6
Ying Gao,Ru Yan,Hualei Cheng,Ping Wen,Rui Dong,Mingjin Fan
One‑pot cation intercalation and interfacial charge programming for α‑Ni(OH)₂ nanosheets. • Unique intercalation‑ionization dual effects expand interlayer spacing and reverse surface charge polarity. • Central heteroatoms (N vs. P) dictate heterolytic vs. homolytic tribochemical pathways. • Ni‑P additive achieves 64.4% friction reduction, 95.1% anti‑wear and 500 N load‑carrying capacity. Layered metastable α-Ni(OH) 2 is a promising lubricant additive due to its tunable interlayer chemistry, yet its intrinsic thermodynamic instability and weak positive surface charge severely hinder interfacial adhesion, oil dispersion and tribological performance. Herein, we develop a facile one-pot interfacial charge programming strategy via cation engineering to modify α-Ni(OH) 2 nanosheets, using tetrabutylammonium hydroxide (TBAOH) and tetrabutylphosphonium hydroxide (TBPOH) as trifunctional alternatives versus NaOH to accomplish Ni 2 ⁺ precipitation, organic cation intercalation and surface charge polarity transition, simultaneously. Compared to traditionally fabricated Ni-Na, the intercalated Ni-N (TBA + ) and Ni-P (TBP + ) exhibit expanded interlayer spacings, exfoliated thin flexible nanosheets, increased specific surface areas and negative surface potentials. Utilized as additives in PAO 10, the intercalation-ionization dual effects leverage molecular rollers, electrostatic anchoring and tribochemical film formation. Combined with multiple characterizations and theoretical calculation, this work reveals that the distinct chemical and electronic properties of the central N/P atoms in TBA + and TBP + leads to preferential heterolytic cleavage for Ni-N and homolytic cleavage for Ni-P under nanoconfinement, friction, and possible Ni-catalyzed conditions, which governs the evolution pathway and final composition of the interfacial tribofilm. As a result, Ni-P delivers the optimal friction-reducing (64.4%), anti-wear (95.1%), load-carrying capacity (500 N), and long-term durability. This work clarifies the structure-tribology relationship governed by intercalation-ionization dual effects, and provides a novel strategy for designing high-efficiency layered lubricant additives. Download: Download high-res image (327KB) Download: Download full-size image
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FOOD CHEMISTRY
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2026
·
IF 10.4
Ruijie Shi,Zhanmei Jiang,Lixia Yuan,Qingpeng Wang,Zengli Gao,Zhishen Mu
First phase diagram of α-lactalbumin/glycyrrhizin hydrogels defines concentration-dependent gelation windows. • Gy induces controllable hydrophobic exposure and a reduction in antiparallel β-sheet content. • Hydrophobic interactions dominate network assembly. • Gelable systems exhibit shear-thinning rheology, a critical viscosity threshold, and enhanced bound water content. • MD simulations reveal Gy increases α-La–Gy H-bonds and lowers protein/water diffusion coefficients. The non-monotonic concentration-dependent formation mechanism of α-lactalbumin (α-La) and glycyrrhizin (Gy) composite hydrogels was systematically investigated using multi-technique approaches combined with molecular dynamics simulations. Phase diagrams showed that gelation occurred only within specific windows (α-La 0.1–1.0% w / v , Gy 3.0–15.0 mM), with Gy thresholds increasing from 3.0 to 15.0 mM as α-La rose, whereas no gel formed at α-La ≥2.0%. Hydrophobic interactions dominated network assembly (56–79% contribution), accompanied by conformational rearrangements. All gels exhibited shear-thinning rheology and enhanced bound water (LF-NMR). Simulations revealed Gy-dependent increases in H-bonds, and the solvent-accessible surface area of α-La peaked at an optimal Gy number then slightly decreased. Gy also reduced diffusion coefficients of both α-La and water. Overall, gelation relies on moderate hydrophobic exposure within a strict non-monotonic window, excess protein paradoxically inhibits gelation. This finding could provide a molecular foundation for designing green hydrogels with precisely tunable behavior Download: Download high-res image (477KB) Download: Download full-size image
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GREEN CHEMISTRY
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2026
·
IF 10.6
Zhijun Kong,Weihan Sun,Wenjin Dong,Su Song,Li Ma,Shengying Li,Hui Chen
The selective conversion of chemically inert linear alkanes into α,ω-dicarboxylic acids remains a significant challenge in sustainable chemistry. α,ω-Dicarboxylic acids are key building blocks for high-performance polymers and pharmaceuticals, their industrial production relies on energy-intensive, poorly selective multi-step oxidation processes. These limitations stem from the intrinsic inertness of inactivated primary C-H bonds and the difficulty of achieving regioselective dual-terminal C-H bond oxyfunctionalization under mild conditions. Consequently, progress in the conversion of chemically inert linear alkanes into α,ω-dicarboxylic acids hinges on two central challenges: enabling highly regioselective terminal C-H oxidation and developing sustainable transformation pathways. To address these challenges, we developed a multi-enzyme cascade driven by internal cofactor cycling that enables one-pot deep oxidation of dodecane to dodecanedioic acid under mild conditions. In the first stage, a hydrogen-borrowing-based NADH regeneration strategy enables selective oxidative C-H functionalization, converting dodecane to dodecanoic acid. Coupling this step with a second hydrogen-borrowing cycle and in situ elimination of H2O2 further drives terminal oxidation, ultimately affording 1.49 mM dodecanedioic acid. In addition, nonane, decane, undecane, and tridecane were successfully converted into their corresponding α,ω-dicarboxylic acids. Overall, this study establishes a green biocatalytic paradigm for the deep transformation of inert alkanes using molecular oxygen as the sole oxidant, enabled by internal cofactor cycling and in situ reactive oxygen management. This strategy maximizes atom economy and provides an efficient and sustainable route for upgrading linear alkanes into value-added products.
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JOURNAL OF NUTRITIONAL BIOCHEMISTRY
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2026
·
IF 5.2
Yuting Dong,Xiaodan Wang,Shize Wang,Kang Yang,Tong Xu,Hongjin Lin
DEHP induces thymus injury in chickens by activating the NF-κB/TNF-α pathway, triggering oxidative stress and PANoptosis. • QUE can alleviate the activation of the NF-κB/TNF-α pathway, oxidative stress and PANoptosis induced by DEHP in chickens. • QUE exerts a targeted effect on NF-κB, thereby mitigating DEHP-induced thymus injury in chickens. Quercetin (Que), a natural dietary flavonoid, possesses significant antioxidative and immunoregulatory properties. Di(2-ethylhexyl) phthalate (DEHP), a pervasive environmental endocrine-disrupting chemical, triggers oxidative stress (OS) and elicits immunotoxic effects in various species. However, whether Que can target NF-κB to alleviate DEHP-induced OS and PANoptosis in the chicken thymus remains unclear to date. To investigate the mechanism of thymus damage induced by DEHP and the intervention effect of Que, we established an in vivo chicken model treated with DEHP and/or Que. Based on the results of network pharmacology, molecular docking, molecular dynamics simulations, and Cell Thermal Shift Assay (CETSA), we predicted that NF-κB is the key target for the protective effect of Que. Subsequently, through H&E staining, CCK-8, immunofluorescence, Western blot and other techniques, we verified the effects of DEHP and/or Que on OS, the assembly of PANoptosome, and cellular PANoptosis in chicken thymus tissue and chicken lymphocyte cell line (MSB-1). Meanwhile, to clarify the key role of NF-κB in the above regulatory process, we conducted reverse validation experiments by introducing the NF-κB activator Act1 in cellular experiments. The results demonstrated that DEHP exposure markedly induces the upregulation of NF-κB and TNF-α(P<0.05), leading to a pronounced burst of reactive oxygen species (ROS) and consequent OS within the chicken thymus. This process further activates the ZBP1-mediated PANoptosis pathway, ultimately causing damage to chicken thymus tissue. Que intervention effectively suppresses NF-κB activation, blocking the transmission of the NF-κB/TNF-α/ROS signaling axis, thereby reversing DEHP-induced ZBP1-mediated PANoptosis in chicken thymus. Download: Download high-res image (290KB) Download: Download full-size image
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