IONICS
·
2024
·Vol. 30
·期 5
·2783-2791
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IF 2.4
Gu Ning,Li Xiaolin,Gao Miao,Liu Zixuan,Liu Qichao,Cao Yang,Sun Youyi
A new magnetic ionic liquid (MIL) based on 1-methylethyl ether-3-butylimidazole and [FeCl 4 ] − is synthesized for application in electrolyte. It is found that the electrochemical performance of electrochemical cell based on MIL electrolyte can be improved by applying magnetic field. The enhanced electrochemical performance is attributed to formation of micro-domain in the mixed electrolyte under magnetic field. The ions of MIL can align along direction of magnetic field, providing efficient transmission path for migration of Li + and Cl − . Under magnetic control, the MIL-based electrolyte does not only retain its wide electrochemical window characteristics, but also solve problem of limiting high viscosity of IL as electrolyte. The work provides a new method to design and prepare high-performance electrolyte for various electrochemical applications.
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INFLAMMOPHARMACOLOGY
·
2024
·
IF 4.6
Miao Lurong,Yuan Ziqi,Zhang Shijia,Zhang Guangqin
Objective To investigate whether honokiol (HNK) acted as an analgesic in connection with inhibiting the voltage-gated proton channel (Hv1). Methods The model of gouty arthritis was induced by injecting monosodium urate (MSU) crystals into the hind ankle joint of mice. HNK was given by intragastric administration. Ankle swelling degree and mechanical allodynia were evaluated using ankle joint circumference measurement and von Frey filaments, respectively. Hv1 current, tail current, and action potential in dorsal root ganglion (DRG) neurons were recorded with patch-clamp techniques. Results HNK (10, 20, 40 mg/kg) alleviated inflammatory response and mechanical allodynia in a dose-dependent manner. In normal DRG neurons, 50 µM Zn 2+ or 2-GBI significantly inhibited the Hv1 current and the current density of Hv1 increased with increasing pH gradient. The amplitude of Hv1 current significantly increased on the 3rd after MSU treatment, and HNK dose-dependently reversed the upregulation of Hv1 current. Compared with MSU group, 40 mg/kg HNK shifted the activation curve to the direction of more positive voltage and increased reversal potential to the normal level. In addition, 40 mg/kg HNK reversed the down-regulation of tail current deactivation time constant ( τ tail ) but did not alter the neuronal excitability of DRG neurons in gouty mice. Conclusion HNK may be a potential analgesic by inhibiting Hv1 current.
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 2
·1-20
·
IF 21.8
Yan Feihong,Li Ruiyuan,Liu Jiaxin,Yang Lulu,Liu Helin,Zhu Shengcang,Zhang Yuhui,Wang Lijun,Huang Lu,Wang Yu,Qin Yaqiang,Zhang Yuhang,Wang Xin,Wang Yuan,Zhang Jianping,Sha Yinlin,Fu Limin,Liu Zhiyong,Han Rongcheng,Jiang Yuqiang
The development of a multifunctional therapy nanoplatform is of crucial importance to tackle the complex challenges associated with cancer. Despite significant advancements in tumor treatment, the efficacy of these traditional approaches remains insufficient. Recurrence and metastasis following tumor treatment continue to represent a significant contributor to tumor-related mortality. This paper presents an improved, facile, and relatively green fabrication of (5-mercapto-1,3,4-thiadiazol-2-ylthio) acetic acid (TMT)-coated luminescent gold nanoparticles (L-AuNP@TMT), which exhibit highly membrane-targeting capacity and superior photodynamic properties. Furthermore, in vivo tumor-bearing mouse model experiments indicated that the L-AuNP@TMT could be used as a two-photon excited nanomedicine via pyroptosis-mediated anti-tumor immunity for effectively eliminating colorectal cancer (CRC), the third most common malignancy and the second deadliest cancer, without evident toxic side effects or tumor metastasis/recurrence. According to its facile and green fabrication approach, near-infrared light-activatable highly efficient photodynamic cancer therapy, and noninvasive imaging mode, this multifunctional nanoplatform offers significant advantages over traditional monotherapy techniques, providing an alternative for the precise clinical treatment of cancer.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 5
·1-12
·
IF 5.3
Ouyang Ruizhuo,Feng Meina,Liu Jinyao,Wang Caihong,Wang Zhongmin,Hu Xin,Miao Yuqing,Zhou Shuang
Rapid and sensitive detection of carcinoembryonic antigen (CEA) is of great significance for cancer patients. Here, molybdenum (Mo) was doped into bismuth oxide (Bi 2 O 3 ) by one-pot hydrothermal method forming porous tremella Bi 2 MoO 6 nanocomposites with a larger specific surface area than the spherical structure. Then, a new kind of hydrangea-like TiO 2 /Bi 2 MoO 6 porous nanoflowers (NFs) was prepared by doping titanium into Bi 2 MoO 6 , where titanium dioxide (TiO 2 ) grew in situ on the surface of Bi 2 MoO 6 nanoparticles (NPs). The hydrangea-like structure provides larger specific surface area, higher electron transfer ability and biocompatibility as well as more active sites conducive to the attachment of anti-carcinoembryonic antigen (anti-CEA) to TiO 2 /Bi 2 MoO 6 NFs. A novel label-free electrochemical immunosensor was then constructed for the quantitative detection of CEA using TiO 2 /Bi 2 MoO 6 NFs as sensing platform, showing a good linear relationship with CEA in the concentration range 1.0 pg/mL ~ 1.0 mg/mL and a detection limit of 0.125 pg/mL (S/N = 3). The results achieved with the designed immunosensor are comparable with many existing immunosensors used for the detection of CEA in real samples. Graphical abstract
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JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
·
2024
·Vol. 150
·期 7
·1-19
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IF 2.7
Chang Jing-Xia,Zhang Meng,Lou Li-Li,Chu He-Ying,Wang Hua-Qi
Purpose Kinase interacting with stathmin (KIS) is a serine/threonine kinase involved in RNA processing and protein phosphorylation. Increasing evidence has suggested its involvement in cancer progression. The aim of this study was to investigate the role of KIS in the development of lung adenocarcinoma (LUAD). Dual luciferase assay was used to explore the relationship between KIS and SOX4, and its effect on ID1/β-catenin pathway. Methods Real-time qPCR and western blot were used to assess the levels of KIS and other factors. Cell proliferation, migration, and invasion were monitored, and xenograft animal model were established to investigate the biological functions of KIS in vitro and in vivo. Results In the present study, KIS was found to be highly expressed in LUAD tissues and cell lines. KIS accelerated the proliferative, migratory and invasive abilities of LUAD cells in vitro, and promoted the growth of LUAD in a mouse tumor xenograft model in vivo. Mechanistically, KIS activated the β-catenin signaling pathway by modulating the inhibitor of DNA binding 1 (ID1) and was transcriptionally regulated by SOX4 in LUAD cells. Conclusion KIS, a target of SOX4, regulates the ID1-mediated enhancement of β-catenin to facilitate LUAD cell invasion and metastasis.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2024
·Vol. 39
·期 4
·937-944
·
IF 1.3
Tan Yan,Hao Panpan,He Yang,Zhu Rufeng,Wang Yuedan
Poly(3, 4-ethylenedioxyethiophene)-polystyrene sulfonic acid (PEDOT:PSS)/polyallyl dimethyl ammonium chloride modified reduced graphene oxide (PDDA-rGO) was layer by layer self-assembled on the cotton fiber. The surface morphology and electric property was investigated. The results confirmed the dense membrane of PEDOT: PSS and the lamellar structure of PDDA-rGO on the fibers. It has excellent electrical conductivity and mechanical properties. The fiber based electrochemical transistor (FECTs) prepared by the composite conductive fiber has a maximum output current of 8.7 mA, a transconductance peak of 10 mS, an on time of 1.37 s, an off time of 1.6 s and excellent switching stability. Most importantly, the devices by layer by layer self-assembly technology opens a path for the true integration of organic electronics with traditional textile technologies and materials, laying the foundation for their later widespread application.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
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IF 14.7
Peng Yong,Xiong Hanting,Zhang Peixin,Zhao Zhiwei,Liu Xing,Tang Shihui,Liu Yuan,Zhu Zhenliang,Zhou Weizhen,Deng Zhenning,Liu Junhui,Zhong Yao,Wu Zeliang,Chen Jingwen,Zhou Zhenyu,Chen Shixia,Deng Shuguang,Wang Jun
Olefin/paraffin separations are among the most energy-intensive processes in the petrochemical industry, with ethylene being the most widely consumed chemical feedstock. Adsorptive separation utilizing molecular sieving adsorbents can optimize energy efficiency, whereas the size-exclusive mechanism alone cannot achieve multiple olefin/paraffin sieving in a single adsorbent. Herein, an unprecedented sieving adsorbent, BFFOUR-Cu-dpds (BFFOUR = BF 4 - , dpds = 4,4’-bipyridinedisulfide), is reported for simultaneous sieving of C 2 -C 4 olefins from their corresponding paraffins. The interlayer spaces can be selectively opened through stronger guest-host interactions induced by unsaturated C = C bonds in olefins, as opposed to saturated paraffins. In equimolar six-component breakthrough experiments (C 2 H 4 /C 2 H 6 /C 3 H 6 /C 3 H 8 /n-C 4 H 8 /n-C 4 H 10 ), BFFOUR-Cu-dpds can simultaneously divide olefins from paraffins in the first column, while high-purity ethylene ( > 99.99%) can be directly obtained through the subsequent column using granular porous carbons. Moreover, gas-loaded single-crystal analysis, in-situ infrared spectroscopy measurements, and computational simulations demonstrate the accommodation patterns, interaction bonds, and energy pathways for olefin/paraffin separations.
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Carbon Letters
·
2025
·
IF 5.8
Kong Xiangyu,Zhang Xinyang,Zhang Jie,Wang Dewei
Aqueous zinc–iodine batteries (AZIBs) are gaining attention for their ability to store and convert electrical energy. Nevertheless, their performance is hindered by the continual migration of polyiodides towards the zinc anodes, leading to undesirable side reactions, diminished coulombic efficiency, and compromised cycling stability. Traditional carbon materials have proven inadequate in resolving these challenges, mainly due to their limited iodine capacity and weak binding forces. Herein, we explore the use of porous carbon nanosheets (PCNSs) synthesized via the “Pharaoh’s Serpent” reaction as cathode electrodes in AZIBs without pre-load iodine. The PCNSs, characterized by their nanosheet structure and expansive specific surface area, not only facilitate a shorter diffusion path for rapid electrolyte infiltration but also provide numerous sites for ion adsorption and capacitive storage, markedly improving the efficacy of electrochemical reactions and ion migration rates. Utilizing the synthesized PCNSs as the cathode electrode in AZIBs, a specific capacity of 296 mAh g −1 was achieved at 0.3 A g −1 . Even when the current density increased to 30 A g −1 , a specific capacity of 144 mAh g −1 was still attained, with a capacity retention ratio of up to 48.6%, which is competitive with that of supercapacitors. In addition, the AZIBs demonstrated impressive cycling stability, retaining 103% of their capacity after 10,000 cycles, and a notable energy density of 266.4 Wh kg −1 based on the cathode material. These findings significantly broaden the application of carbon materials in AZIBs research, emphasizing their potential in advancing AZIB technology.
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npj Flexible Electronics
·
2025
·Vol. 9
·期 1
·1-13
·
IF 15.5
Hazarika Dinku,Lu Jiaqi,Wu Jianhui,Shah Muhammad Naeem,Li Jie,Zhang Kaihang,Xu Liangquan,Chen Chuanrui,Cao Zhen,Jin Hao,Dong Shurong,Huang Yuhui,Zhang Qilong,Wu Yongjun,Luo Jikui
Organic piezoelectric materials have attracted significant interest for applications in sensing, energy harvesting, and flexible electronics. However, its piezoelectric properties are yet to be improved. This study introduces a facile strategy to fabricate homogenous and dense polyvinylidene fluoride (PVDF) films with high piezoelectric performance via anhydrous CaCl 2 doping. The strong ion–dipole interaction between Ca 2+ and F atoms, along with directional dipole alignment under an electric field at elevated temperature, as verified by molecular dynamics simulations and material characterizations. This results in an impressive β -phase content of 92.78% and a piezoelectric coefficient of 29.26 pm/V. A piezoelectric device fabricated from this PVDF film delivers an output voltage exceeding 12 V under external pressure and maintains stability over 60,000 cycles. When integrated with an LC resonant circuit, it functions as a wireless sensor for real-time motion monitoring. This scalable approach significantly advances piezoelectric polymer performance for practical applications.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Hou Tianyi,Wang Donghai,Jiang Bowen,Liu Yi,Kong Jia,He Yanbing,Huang Yunhui,Xu Henghui
Polyether electrolytes have been widely recognized for their favorable compatibility with lithium-metal, yet they are hampered by intrinsically low oxidation thresholds, limiting their potential for realizing high-energy Li-metal batteries. Here, we report a general approach involving the bridge joints between non-lithium metal ions and ethereal oxygen, which significantly enhances the oxidation stability of various polyether electrolyte systems. To demonstrate the feasibility of the ion-bridging strategy, a Zn 2+ ion-bridged polyether electrolyte (Zn-IBPE) with an extending electrochemical stability window of over 5 V is prepared, which enables good cyclability in 4.5 V Li||LiCoO 2 batteries. Ampere-hour-level quasi-solid-state batteries of SiO-graphite||LiNi 0.8 Mn 0.1 Co 0.1 O 2 (10 Ah, N/P ratio of 1.12, 303 Wh kg −1 at 0.1 C based on the total weight of the pouch cells) and 60 μm-Li||LiNi 0.9 Mn 0.05 Co 0.05 O 2 (18 Ah, N/P ratio of 2.5, 452 Wh kg −1 at 0.33 C based on the total weight of the pouch cells) pouch cells with Zn-IBPE present elevated electrochemical performance, benefiting from adequate interfacial stability. Nail penetration tests evidence high battery safety enabled by Zn-IBPE in 4 Ah graphite||LiNi 0.8 Mn 0.1 Co 0.1 O 2 pouch cells without combustion or smoke. This work offers a pathway for designing high-voltage polymer electrolytes and a general solution for achieving high-performance quasi-solid-state batteries.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Wu Jinxiang,Wang Qianxi,Li Yanhao,He Yi
Three-dimensional covalent organic frameworks are promising multifunctional materials for applications in adsorption, separation, and catalysis. However, despite the continuous synthesis of an increasing number of three-dimensional covalent organic frameworks, little is known about the crystal growth pathways. Here, we report the real-time visual observation of the crystal growth process of COF-300 and LZU-79, two typical three-dimensional covalent organic frameworks, using in situ dark-field optical microscopy. Our dark-field optical microscopy imaging results reveal that two crystal-growth pathways are simultaneously operative during the liquid growth of COF-300 and LZU-79 microcrystals, including classical crystal growth modes and non-classical oriented attachment mechanisms. Specifically, detailed tracking of the trajectories between two rod-shaped single-crystal COF-300 pairs suggests that the oriented attachment process undergoes several distinct stages such as approach, alignment at (021) facets, tip-to-tip attachment, fusion, and shaping. Theoretical simulation results show that (021) facets of COF-300 microcrystals, which have a lower repulsive energy barrier due to steric solvation forces from intervening solvents, are energetically more favorable than (010) facets, inducing the oriented attachment between adjacent facets. This work enables a fundamental understanding of how three-dimensional covalent organic framework microcrystals grow dynamically, which can aid the further design of three-dimensional covalent organic frameworks with enhanced performances.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 4
Jin Guang-Zhi,Chen Le-Hang,Gong Yu-Zhen,Li Peng,Wang Run-Guo,Li Fan-Zhu,Lu Yong-Lai
The fatigue resistance of casting polyurethane (CPU) is crucial in various sectors, such as construction, healthcare, and the automotive industry. Despite its importance, no studies have reported on the fatigue threshold of CPU. This study employed an advanced Intrinsic Strength Analyzer (ISA) to evaluate the fatigue threshold of CPUs, systematically exploring the effects of three types of isocyanates (PPDI, NDI, TDI) that contribute to hard segment structures based on the cutting method. Employing multiple advanced characterization techniques (XRD, TEM, DSC, AFM), the results indicate that PPDI-based polyurethane exhibits the highest fatigue threshold (182.89 J/m 2 ) due to a highest phase separation and a densely packed spherulitic structure, although the hydrogen bonding degree is the lowest (48.3%). Conversely, NDI-based polyurethane, despite having the high hydrogen bonding degree (53.6%), exhibits moderate fatigue performance (122.52 J/m 2 ), likely due to a more scattered microstructure. TDI-based polyurethane, with the highest hydrogen bonding degree (59.1%) but absence of spherulitic structure, shows the lowest fatigue threshold (46.43 J/m 2 ). Compared to common rubbers (NR, NBR, EPDM, BR), the superior fatigue performance of CPU is attributed to its well-organized microstructure, polyurethane possesses a higher fatigue threshold due to its high phase separation degree and orderly and dense spherulitic structure which enhances energy dissipation and reduces crack propagation.
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