NEW JOURNAL OF CHEMISTRY
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2017
·Vol. 41
·期 9
·3308-3319
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IF 3.269
Qiang Jia,Yinxian Peng,Jianming Pan,Xiaobin Huang,Xiangheng Niu,Tao Zhang
Magnetic microspheres (Fe3O4@PVIM@Zn(II)) composed of a high magnetic-response Fe3O4 core and a Zn(II)-immobilized cross-linked polyvinyl imidazole (PVIM) shell via reflux-precipitation polymerization and metal-ion affinity strategy were fabricated. Integrating the advantages of specific uptake and fast separation, Fe3O4@PVIM@Zn(II) was adopted as an ideal pathway for luteolin (LTL) recognition. As-prepared Fe3O4@PVIM@Zn(II) possessed core–shell structure, uniform size (200 nm), high magnetic responsiveness (32.6 emu g−1), and a very easy synthesis process. X-ray photoelectron spectroscopy (XPS) suggested a strong interaction between the nitrogen heterocyclic ring of PVIM and Zn(II), which produced abundant binding sites for LTL. The batch mode experiments can be well described by pseudo-first-order kinetic models and a Langmuir isotherm. A rapid binding equilibrium (within 45 min) and large monolayer adsorption capacity (23.92 mg g−1) at 298 K were also observed. In addition, Fe3O4@PVIM@Zn(II) displayed remarkable selectivity to LTL; the purification process using Fe3O4@PVIM@Zn(II) can make purified LTL from approximately 85% to 94.26%. The antibacterial activity of purified LTL was outstanding by means of a Staphylococcus aureus (ATCC29213) resistance experiment. Considering its multiple merits, Fe3O4@PVIM@Zn(II) exhibited great potential for specific binding with natural products, such as flavonoids.
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Analytical Methods
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2024
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IF 2.7
Shouhui Chen,Dan Zhou,Qinghao Xiong,Yinan Yang,Mingyang Zhang,Shoulin Chen
Nowadays, many people are turning to medications that can help them stay calm during surgeries and their daily lives. As an anesthetic that reduces the excitability of nerve cells, propofol can achieve sedative with the advantages of fast onset and short half-life. The development of propofol sensors has tremendous application potential because they can help healthcare professionals dynamically regulate the concentration of propofol in the blood, not only to achieve painless surgeries that patients want, to maintain the sedation that surgeons desire, but also to prevent the respiratory failure that may occur during the patient's daily sleep aids. In this paper, we prepared Fe3O4/C/CB nanocomposites by doping carbon black on the surface of the pyrolyzed product of MIL-88B. The nanocomposites-modified glassy carbon electrodes were used to detect propofol in phosphate buffer solution. The porous nanocomposites with high electrical conductivity promoted the charge transfer on the electrode surface, improving the performance of the modified electrodes. After optimization, the linear range, the detection limit, and the sensitivity for propofol were 5.0~205 μM, 0.102 μM, and 2.850 μA cm-2 μM-1, respectively. The electrochemical sensing of propofol in medical propofol emulsion injection and normal human serum showed that the method was rapid and repeatable.
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CARBON
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2024
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IF 10.5
Huiliang Wen,Wei Xu,Sen Lin,Aiguo Guan,Yingna Zhang,Xin Li,Chongbo Liu
As a representative magnetic oxide absorber, Fe 3 O 4 has attracted considerable research attention owing to its remarkable magnetic saturation strength as well as semiconducting properties. Doping Fe 3 O 4 with La 3+ leads to 3d-4f magnetic coupling and ion distribution changes due to the unique electron configuration and large ionic radius of La 3+ , thereby greatly enhancing the magnetic performance. However, high density, low dielectric loss, and low permeability at high frequencies inhibit the electromagnetic wave absorption (EMWA) performance of ferrites. In this study, stick-shaped Sn metal-organic framework (MOF) is in-situ grown on La 3+ -doped Fe 3 O 4 using a surfactant. After high-temperature annealing, the SnO 2 /porous carbon composites derived from Sn-MOF wrap the ferrite, forming a core-shell heterostructure, which not only prevents oxidation but also enhances the EMWA performance. Among the prepared La x Fe 3-x O 4 /SnO 2 /C (LFSC) samples, LFSC-2 (with La x Fe 3-x O 4 to Sn-MOF ratio of 1:2) exhibits strong absorption performance with a minimum reflection loss ( RL min ) of −44.1 dB. Furthermore, the gradient metamaterial based on LFSC-3 shows ultra-broadband EMWA with an effective absorption bandwidth ( RL min ≤ −10 dB) of 13.17 GHz. In addition, the LFSC-2 sample demonstrates excellent radar stealth capability in the radar cross section (RCS) far-field response, achieving an RCS reduction value of 20.4 dB∙m 2 .
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ACS Biomaterials Science & Engineering
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2024
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IF 5.4
Shichao Zhang,Yijiang Liu,Yuhan Xie,Chenchun Ding,Renjie Zuo,Zhenzhen Guo,Shiyong Qi,Tingting Fu,Weibin Chen
Breast cancer represents a substantial contributor to mortality rates among women with cancer. Chemical dynamic therapy is a promising anticancer strategy that utilizes the Fenton reaction to transform naturally occurring hydrogen peroxide (H2O2) into hydroxyl radicals (•OH). Additionally, cancer immunotherapy using immune drugs, such as imiquimod (R837), has shown promise in activating T cells to kill tumor cells. In this study, we proposed a Fe3O4@R837 smart nanoplatform that can trigger the Fenton reaction and induce immune responses in breast cancer treatment. Furthermore, we performed transcriptome sequencing on breast cancer samples and used the R package (limma) to analyze differential expression profiles and select differentially expressed genes (DEGs). We obtained clinical information and RNA expression matrix data from The Cancer Genome Atlas database to perform survival analysis and identify prognostic-related genes (PRGs) and molecular subtypes with distinct prognoses. We used the TIMER 2.0 web and other methods to determine the tumor immune microenvironment and immune status of different prognostic subtypes. We identified DPGs by taking the intersection of DEGs and PRGs and performed functional analyses, including gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis, to elucidate potential mechanisms. Subsequently, we constructed a protein–protein interaction network using the STRING database to visualize the interactions between the DPGs. We screened hub genes from the DPGs using the Cytoscape plugin and identified six hub genes: CD3E, GZMK, CD27, SH2D1A, ZAP70, and TIGIT. Our results indicate that these six key genes regulate immune cell recruitment to increase T-cell cytotoxicity and kill tumors. Targeting these key genes can enhance immunotherapy and improve the breast cancer prognosis.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Lixiao Bi,Shiji Jia,Wenshuang Zhang,Yikun Zhu,Yiwei Gao,Chongbin Wang,Yuanyuan Feng
Inserting metal–organic frameworks into polymer matrix to prepare mixed matrix membranes (MMMs) is a promise strategy for the preparation of organic solvent nanofiltration (OSN) membranes. However, MMMs prepared via traditional physical blending strategy exhibits the disadvantage of uneven dispersion of MOFs particles, resulting in a decrease in organic solvent resistance and membrane performances. In this work, the magnetically responsive nanomaterials (Fe 3 O 4 @ZIF8) were successfully prepared via growing ZIF8 functional layer upon Fe 3 O 4 nanoparticles. Then, the OSN membranes were fabricated via embedding the Fe 3 O 4 @ZIF8 into polymer matrix under a magnetic condition during non-solvent induced phase separation. The magnetically responsive Fe 3 O 4 @ZIF8 particles were compelled to segregate and enrich in membrane surface, optimizing the arrangement of Fe 3 O 4 @ZIF8 within the membrane. This strategic modification significantly improves the porosity and solvent resistance property of membrane. The optimized M−Fe 3 O 4 @ZIF8(0.3)/PAN membrane exhibited an increased permeance of methanol from 40.5 m -2 h −1 bar −1 to 55.5 m -2 h −1 bar −1 compared to the pristine PAN membrane while the retention to Congo Red increased above 99 %. The M−Fe 3 O 4 @ZIF8(0.3)/PAN membrane also possesses excellent permeation of organic solvent and a selectivity (NaCl/Congo Red) of 232, which makes these MMMs promising for salt/dye separation in organic solvent nanofiltration.
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BIOMATERIALS
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2024
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IF 12.8
Yiqun Zhang,Ni Zhang,Jianghao Xing,Yiwei Sun,Xu Jin,Cailiang Shen,Liang Cheng,Yuanyin Wang,Xianwen Wang
Chemodynamic therapy (CDT) involving the use of metal nanozymes presents new opportunities for the treatment of deep-seated tumors. However, the lower ROS catalytic rate and dependence on high H 2 O 2 concentrations affect therapeutic efficacy. To address this issue, a hydrogel was constructed for the treatment of osteosarcoma by combining Cu–Fe 3 O 4 nanozymes (NCs) and artemisinin (AS) coencapsulated in situ with sodium alginate (ALG) and calcium ions. This hydrogel can release nanoparticles and AS within tumor tissue for an extended period of time, utilizing the multienzyme activity of NCs to achieve ROS accumulation. The carbon radicals (•C) generated from the interaction of Fe 2+ /Cu 2+ with AS amplify oxidative stress, leading to tumor cell damage. Simultaneously, the NCs activate ferroptosis via the GPX4 pathway by depleting GSH and activate cuproptosis via the DLAT pathway by causing intracellular copper overload, enhancing therapeutic efficacy. In vitro experiments confirmed that the NCs-AS-ALG hydrogel has an excellent tumor cell killing effect, while in vivo experimental results demonstrated that it can effectively eliminate tumors with excellent biocompatibility , providing a new approach for osteosarcoma treatment.
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Materials Today Communications
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2024
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IF 3.7
Xuyan Yue,Meichen Liu,Yanzhi Xia,Zhong Xiong
Nanocomposite hydrogels enable augmented properties, functions, and responsive behaviors. In the field of stereolithography 3D printing of the photothermal responsive nanocomposite hydrogel, the influence of the size of nano-Fe 3 O 4 on 3D printing properties is significant due to the sedimentation, but the relevant research is rare. In this study, for the fabrication of photothermal responsive hybrid hydrogel, poly( N -isopropylacrylamide-acrylamide)/nano-Fe 3 O 4 [P(NIPAM-AM)/nano-Fe 3 O 4 ] gel photoresist was prepared and digital light processing (DLP)-based 3D printing as one of the popular stereolithography 3D printing technology was utilized. The influences of two sizes of Fe 3 O 4 nanoparticles (10 and 50 nm) denoted as nano-Fe 3 O 4 (10) and nano-Fe 3 O 4 (50) on DLP 3D printing properties of the gel photoresist were investigated in detail. The results reveal that the gel photoresist with nano-Fe 3 O 4 (10) obtained long exposure time for the basic prototype, low overcuring degree ( O d ), and good uniformity of nanoparticles in hybrid hydrogels, while those with nano-Fe 3 O 4 (50) had the merits of printing high 3D sample due to the low release fore. Unfortunately, the gel photoresist with a high content of nano-Fe 3 O 4 such as 3.11 wt% failed in 3D printing of a high and uniform gel cylinder. A strategy of preparing P(NIPAM-AM)/nano-Fe 3 O 4 gel photoresist with mixed nano-Fe 3 O 4 (10) and (50) for 3D printing was proposed. Using the gel photoresist (nano-Fe 3 O 4 content: 3.11 wt%) with two sizes of nano-Fe 3 O 4 mixed with 50% each and the exposure time of 8 s, a gel cylinder with a height of 1 cm was successfully printed with uniform nano-Fe 3 O 4 distribution and low O d values (≤ 1.17%). Further, a biomimetic hydrogel octopus was 3D printed by using the gel photoresist with mixed nano-Fe 3 O 4 and thereafter a near-infrared-light-driven waving motion of octopus tentacle was achieved successfully.
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ACS Applied Materials & Interfaces
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2024
·
IF 8.3
Congyi Yang,Weiwen Yuan,Guoxing Liao,Zhe Tang,Tong Zhu,Yifan Jia,Qianqian Yu,LinGe Wang
Vascular defects caused by trauma or vascular diseases can significantly impact normal blood circulation, resulting in serious health complications. Vascular grafts have evolved as a popular approach for vascular reconstruction with promising outcomes. However, four of the greatest challenges for successful application of small-diameter vascular grafts are (1) postoperative anti-infection, (2) preventing thrombosis formation, (3) utilizing the inflammatory response to the graft to induce tissue regeneration and repair, and (4) noninvasive monitoring of the scaffold and integration. The present study demonstrated a basic fibroblast growth factor (bFGF) and oleic acid dispersed Ag@Fe3O4 core–shell nanowires (OA-Ag@Fe3O4 CSNWs) codecorated poly(lactic acid) (PLA)/gelatin (Gel) multifunctional electrospun vascular grafts (bAPG). The Ag@Fe3O4 CSNWs have sustained Ag+ release and exceptional photothermal capabilities to effectively suppress bacterial infections both in vitro and in vivo, noninvasive magnetic resonance imaging (MRI) modality to monitor the position of the graft, and antiplatelet adhesion properties to promise long-term patency. The gradually released bFGF from the bAPG scaffold promotes the M2 macrophage polarization and enhances the recruitment of macrophages, endothelial cells (ECs) and fibroblast cells. This significant regulation of diverse cell behavior has been proven to be beneficial to vascular repair and regeneration both in vitro and in vivo. Therefore, this study supplies a method to prepare multifunctional vascular-repair materials and is expected to represent a significant guidance and reference to the development of biomaterials for vascular tissue engineering.
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International Journal of Electrochemical Science
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2024
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IF 1.3
Bin Li,Pingxia Wang
Dexamethasone, a potent synthetic glucocorticoid, is widely used for its anti-inflammatory and immunosuppressive properties. However, its misuse as a performance-enhancing drug in sports has raised concerns among regulatory authorities. To address this issue, an electrochemical sensor based on Fe 3 O 4 /polyaniline (PANI)-Cu(II) microspheres and hematite nanoparticles was developed for the sensitive and selective detection of dexamethasone. The sensor exhibited excellent electrocatalytic activity towards the oxidation of dexamethasone due to the synergistic effect of the high conductivity and large surface area of the Fe 3 O 4 /PANI composite microspheres, the electrocatalytic properties of the loaded copper(II) ions, and the enhanced electron transfer of the hematite nanoparticles. Under optimized conditions, the sensor showed a wide linear range of 0.05–50 μM, with a detection limit of 0.015 μM. The sensor also demonstrated good selectivity, reproducibility (RSD = 3.2 %, n = 5), and long-term stability (92 % retention after 4 weeks). Furthermore, the sensor was successfully applied for the determination of dexamethasone in spiked human serum and urine samples, with recoveries ranging from 97.5 % to 103.5 % and RSDs less than 3.5 %.
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MRS Energy & Sustainability
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2024
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IF 3.3
Oubla M’hamed,Idrissi Siham,Edfouf Zineb,Dinia Selma,Elouadi Brahim
Abstract The growing request of enhanced lithium-ion battery (LIB) anodes performance has driven extensive research into transition metal oxide nanoparticles, notably Fe 3 O 4 . However, the real application of Fe 3 O 4 is restricted by a significant fading capacity during the first cycle, presenting a prominent challenge. In response to this obstacle, the current research centers on the development of Fe 3 O4@rGO (with rGO is reduced graphene oxide) nanocomposite through a new two-step soft sol–gel method, incorporating a slight proportion of rGO. This targeted approach aims to resolve issues linked to the electrochemical stability of Fe 3 O 4 anode. The structure and morphological characterizations techniques confirmed the spinel crystalline structure of Fe 3 O 4 as well as the distinctive aggregate morphology of the nanoparticles, highlighting a regular arrangement of rGO-coated nanoparticles. The lithium-ion storage properties of the Fe 3 O 4 @rGO anode were examined through exhaustive electrochemical analyses. A minor irreversible capacity stands out as a particularly noteworthy feature in the Fe 3 O 4 @rGO anode. This characteristic is of paramount interest, given that the anode exhibits high specific capacity along with a high cycling stability and an outstanding rate capability. These remarkable outcomes can be directly linked to the superior morphological characteristics attained through the two-step sol–gel method. Graphical Abstract
Highlights
The Fe 3 O 4 @rGO nanocomposite, resulting from a novel two-step mild sol–gel method, exhibits a unique and promising structure for LIB technologies.
Regarding storage performance as an anode, the prepared nanocomposite exhibited a minor irreversible capacity, high reversible capacity, as well as good coulombic efficiency.
The incorporation of rGO improved the electrical conductivity and played a crucial role in facilitating Li-ion diffusion, overcoming challenges associated with volume changes during the cycling process.
Discussion
Transition metal oxide (TMO)-based anodes hold promise for future LIB technologies owing to their substantial theoretical capacities. However, the material’s tendency to expand dramatically during use, leading to electrode deterioration and capacity fade. To address this challenge, researchers have explored incorporating rGO into TMO composites.
rGO’s unique properties, including high conductivity and mechanical flexibility, effectively mitigate volume expansion and enhance electrochemical performance. The two-step soft sol–gel method could be a promising solution for fabricating rGO-TMO nanocomposites. However, further optimization and large-scale fabrication are necessary for practical applications.
Despite these challenges, the combination of TMOs and rGO could create high-performance and durable anodes for LIB. Further research should focus on optimizing material composition and fabrication processes to realize the full potential of this technology.
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Acta Biomaterialia
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2024
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IF 9.4
Jiale Li,Bo Li,Feng Liu,Ming Deng,Ziying Zhang,Yutao Ran,Bing Wang
The significance of the tumor microenvironment (TME) in tumor initiation and progression is increasingly acknowledged. Conventional therapeutic approaches face limitations within the complex TME, including the restrictions imposed by hypoxia on photodynamic therapy (PDT) and the deficiency of endogenous H₂O₂ affecting chemodynamic therapy (CDT). In response to the TME's characteristics of high metabolism, hypoxia, and weak acidity, a multifunctional nanosystem MNPs/GOD@CS/IR820, which synergistically integrates CDT and PDT, has been developed. This system can actively accumulate at tumor sites under an external magnetic field and release active components in response to the weakly acidic TME. It mitigates the limitations imposed by hypoxia and endogenous H₂O₂ deficiency on PDT and CDT, respectively, thereby enabling synergistic treatment. Additionally, the system's multimodal imaging capabilities facilitate precise tumor localization and real-time, non-invasive in vivo assessment via fluorescence imaging and MRI. In vitro and in vivo evaluations demonstrate significant antitumor efficacy, effectively inhibiting tumor growth and improving survival rates. By comprehensively addressing the challenges posed by the complex TME and enhancing real-time monitoring capabilities, our nanosystem paves the way for personalized and precise cancer treatment. Statement of Significance This study introduces an innovative MNPs/GOD@CS/IR820 nanosystem that represents a significant advancement in cancer nanomedicine by addressing critical limitations of conventional photodynamic therapy (PDT), particularly in hypoxic tumor microenvironments. By synergistically integrating chemodynamic therapy (CDT) with PDT and incorporating MRI and fluorescence dual-modal imaging capabilities, this multifunctional platform offers enhanced therapeutic efficacy and real-time monitoring. The system's ability to generate oxygen in situ overcomes hypoxia-induced limitations, while its multimodal mechanism of action induces tumor cell apoptosis through multiple pathways. In vitro and in vivo studies demonstrate remarkable antitumor efficacy across diverse cancer types, significantly inhibiting tumor growth and improving survival rates. This comprehensive approach to cancer diagnosis and treatment not only advances precision medicine for targeted, multimodal cancer management but also provides a promising foundation for future clinical applications, potentially transforming cancer treatment strategies and improving patient outcomes.
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CHEMICAL ENGINEERING JOURNAL
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2011
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IF 3.074
Wenlu Guo,Wei Hu,Jianming Pan,Hongchun Zhou,Wei Guan,Xue Wang,Jiangdong Dai,Longcheng Xu
Magnetic molecularly polymers (MMIPs) based on kaolinite/Fe 3 O 4 composites were successfully synthesized for the selective adsorption and separation of bisphenol A (BPA) from aqueous solutions. During polymerization, the modified kaolinite/Fe 3 O 4 (KLT/Fe 3 O 4 ) not only was used as supporter but also functional monomer. The properties of MMIPs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) analysis, and thermogravimetric analysis (TGA) and so on. The SEM graphs showed that much of KLT/Fe 3 O 4 was successfully coated by the imprinted layer, TGA analysis suggested the grafting yield of imprinted layer to KLT/Fe 3 O 4 was 72.51 wt%. The effects of pH, initial BPA concentration, contact time and temperature of the medium on the adsorption were studied by the batch mode experiment. The equilibrium data was well described by the Langmuir isotherm model. The kinetics of adsorption followed the pseudo-second-order model and the rate constant decreased with the increase of temperature, indicating exothermal nature of adsorption process. For desorption studies, the highest desorption efficiency (95.75%) was obtained using methanol and acetic acid as eluting solution (v:v = 8:2). Moreover, the selectivity of MMIPs was further demonstrated through HPLC analysis of the stimulant water samples, the result showed that MMIPs could effectively recognize BPA in mixed solution.
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