Advanced Composites and Hybrid Materials
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2024
·Vol. 7
·期 6
·1-16
·
IF 23.2
Zuo Shixiang,Wang Chunyu,Alshammari Nawaa Ali Husaykan,El-Bahy Salah Mohamad,Xu Rong,Li Saijie,Wang Lei,Yao Chao,El-Bahy Zeinhom Mohamad,Gui Haoguan
Efficient separation of emulsified oil is urgently needed to repair the ecological environment, given the explosive development in modern industrial civilization. Herein, Janus porous composites were constructed using two different paraffin oil-in-dimethylsulfoxide (DMSO) gel emulsions. One of the gel emulsions contained graphene oxide (GO) within the DMSO phase, while the other continuous phase was dissolved with triarm hydroxyl-terminated poly( ε -caprolactone) (PCL-triol). To create Janus porous composites, the gel emulsions were overlaid and solidified with poly[(phenyl isocyanate)- co -formaldehyde] through step-growth polymerization. The resultant GO/PCL Janus porous composites exhibited an asymmetric double-layer structure with a tightly bonded interface. GO/PCL Janus porous composites displayed asymmetric surface wettability, functioning as a liquid diode and enabling effective separation of oil-in-water (O/W) miniemulsion. Under simulated 1.2 sun irradiation, the separation efficiency remained above 95%, and the flux increased to nearly four times that observed without solar irradiation. Furthermore, the Janus porous composite demonstrated excellent reusability, maintaining efficacy after ten cycles of separating emulsified oil. These Janus porous composites demonstrated excellent performance in oil-water separation, making them an ideal candidate for such applications.
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Advanced Composites and Hybrid Materials
·
2024
·Vol. 8
·期 1
·1-19
·
IF 23.2
Liu Yang,Deng Zongyi,Zhang Wei,Jiang Guoqin,Cao Wenjing,Huang Zhixiong,Shi Minxian,Li Jian
Lightweight ablative materials are commonly utilized as thermal protection materials for hypersonic vehicles. Ceramizable phenolic aerogel/carbon fiber (PA/CF) composites modified with TiB 2 and B 4 C were fabricated, which had the characteristics of lightweight, high strength, and low thermal conductivity. The acid-catalyzed phenol-aldehyde polymerization reaction was used to significantly shorten the gelation time, which facilitated the uniform distribution of ceramic fillers. The oxygen-consuming, oxygen-blocking, and carbon-fixing synergistic effects of TiB 2 and B 4 C high-temperature ceramic reactions, as well as the multiphase ceramic structure (C-B 2 O 3 -TiO 2 -TiC) formed, conferred excellent thermal stability (the residual weight of 58.8% at 1200 °C), oxidation resistance (the residual strength of 3.44 MPa after static ablation), and ablation resistance (the linear and mass ablation rates as low as 0.045 mm/s and 0.0115 g/s) on the composites. The lightweight, high-strength materials with anti-thermal insulation properties demonstrate significant competitiveness and application potential in the field of thermal protection.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-25
·
IF 10.6
Zhou Shiqi,Xiao Cairong,Fan Lei,Yang Jinghong,Ge Ruihan,Cai Min,Yuan Kaiting,Li Changhao,Crawford Ross William,Xiao Yin,Yu Peng,Deng Chunlin,Ning Chengyun,Zhou Lei,Wang Yan
The treatment of critical-size bone defects with irregular shapes remains a major challenge in the field of orthopedics. Bone implants with adaptability to complex morphological bone defects, bone-adhesive properties, and potent osteogenic capacity are necessary. Here, a shape-adaptive, highly bone-adhesive, and ultrasound-powered injectable nanocomposite hydrogel is developed via dynamic covalent crosslinking of amine-modified piezoelectric nanoparticles and biopolymer hydrogel networks for electrically accelerated bone healing. Depending on the inorganic-organic interaction between the amino-modified piezoelectric nanoparticles and the bio-adhesive hydrogel network, the bone adhesive strength of the prepared hydrogel exhibited an approximately 3-fold increase. In response to ultrasound radiation, the nanocomposite hydrogel could generate a controllable electrical output (-41.16 to 61.82 mV) to enhance the osteogenic effect in vitro and in vivo significantly. Rat critical-size calvarial defect repair validates accelerated bone healing. In addition, bioinformatics analysis reveals that the ultrasound-responsive nanocomposite hydrogel enhanced the osteogenic differentiation of bone mesenchymal stem cells by increasing calcium ion influx and up-regulating the PI3K/AKT and MEK/ERK signaling pathways. Overall, the present work reveals a novel wireless ultrasound-powered bone-adhesive nanocomposite hydrogel that broadens the therapeutic horizons for irregular bone defects.
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高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-15
·
IF 3.8
Zhang Chenxu,Ji Zhangxin,Xu Na,Yuan Jingjing,Zeng Wen,Wang Yadong,He Qing,Dong Jiaxing,Zhang Xinyu,Yang Dongmei,Jiang Wei,Yan Yibo,Shang Wencui,Chu Jun,Chu Quangen
Diabetes mellitus (DM) is a chronic metabolic disease that is highly susceptible to kidney injury. Di’ao XinXueKang capsules (DXXK) is a novel Chinese herbal medicine that has been used in clinical trials for the therapy of DM and kidney disease, but the underlying pharmacological mechanism remains unclear. This study aims to integrate network pharmacology, molecular docking and in vivo experiments to explore the potential mechanisms of DXXK in the treatment of diabetic kidney injury. The chemical constituents of DXXK were extracted from the ETCM and Batman-TCM databases, and then evaluated for their pharmacological activity via the Swiss ADME platform. Multiple disease databases were searched and integrated for DM-related targets. Overlapping targets were then collected to construct a protein–protein interaction (PPI) network. KEGG and GO enrichment analyses were performed based on the Metascape database, and molecular docking was performed using AutoDock Vina software. The main components in DXXK were analyzed by HPLC. The results of network pharmacology and molecular docking were validated in an animal model of DM induced by the combination of a high-fat diet (HFD) and streptozotocin (STZ). We screened and obtained 7 ingredients and identified dioscin, protodioscin, and pseudoprotodioscin as the major components of DXXK by HPLC. A total of 2,216 DM-related pathogenic genes were obtained from DrugBank, GeneCards, OMIM, and DisGeNET databases. KEGG and GO enrichment analyses indicated that the TGF-beta signaling pathway is a critical pathway associated with DM therapy. Molecular docking revealed that the ingredients in DXXK bind to the pivotal targets TGFβ1, Smad2, and Smad3. In diabetic mice, we found that DXXK alleviated diabetic symptoms, lowered blood glucose, improved insulin tolerance, and modulated lipid metabolism. Furthermore, DXXK attenuated renal lesions and fibrosis by downregulating TGFβ1, Smad2, and Smad3. Collectively, our results suggest that DXXK has the potential to regulate glucolipid metabolism in DM, and it may serve as a viable therapeutic option for renoprotection by inhibiting of the TGF-β1/Smad2/3 pathway.
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高影响因子
CHROMATOGRAPHIA
·
2024
·Vol. 87
·期 6
·407-418
·
IF 1.2
Hong Lei,Mao Huihui,Huang Xiaowei,Fu Xinyang,Lin Yanfang
To analyze 1-methyladenosine (m1A) and 1-methylinosine (m1I) in urine samples obtained from patients with breast cancer and healthy people, we used magnetic dispersive solid-phase micro-extraction (MDSPME) combined with high-performance liquid chromatography. The structure and morphology of magnetic nanoparticles, Fe 3 O 4 @GO, were investigated by FT-IR, XRD, TEM, and TGA. m1A and m1I in urine samples were enriched by the solid phase micro-extraction technology of Fe 3 O 4 @GO. Several parameters affecting the extraction efficiency, including adsorption time, pH, ionic strength, mass of adsorbent, extraction time, eluent solvent, elution time, and elution temperature, were researched and optimized. Under the optimized conditions, the corresponding linearity range of the two analytes showed a good linearity ( r 2 > 0.9998) and significant addition recoveries ranging from 88.50 to 109.38%, while the limit of detection was between 0.10 and 0.11 ng/mL. The enrichment factors of m1A and m1I were 108 and 134, respectively. The method was simple, sensitive, and reliable for the detection and purification with good detection limit, and it was suitable for the detection of m1A and m1I in urine samples. In addition, the analysis of modified nucleosides is of great value for the early diagnosis of patients with breast cancer.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Du Shuxian,Huang Hao,Lan Zhineng,Cui Peng,Li Liang,Wang Min,Qu Shujie,Yan Luyao,Sun Changxu,Yang Yingying,Wang Xinxin,Li Meicheng
The commercialization of perovskite solar cells is badly limited by stability, an issue determined mainly by perovskite. Herein, inspired by a natural creeper that can cover the walls through suckers, we adopt polyhexamethyleneguanidine hydrochloride as a molecular creeper on perovskite to inhibit its decomposition starting from the annealing process. The molecule possesses a long-line molecular structure where the guanidinium groups can serve as suckers that strongly anchor cations through multiple hydrogen bonds. These features make the molecular creeper can cover perovskite grains and inhibit perovskite decomposition by suppressing cations’ escape. The resulting planar perovskite solar cells achieve an efficiency of 25.42% (certificated 25.36%). Moreover, the perovskite film and device exhibit enhanced stability even under harsh damp-heat conditions. The devices can maintain >96% of their initial efficiency after 1300 hours of operation under 1-sun illumination and 1000 hours of storage under 85% RH, respectively.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·
IF 0
Peng Jun,Xiao Qian,Wang Ziwei,Zhou Fang,Yu Junxia,Chi Ruan,Xiao Chunqiao
For the serious situation of heavy metal pollution, the use of cheap, clean, and efficient biochar to immobilize heavy metals is a good treatment method. In this paper, SA@ZIF-8/BC was prepared for the adsorption of Pb 2+ in solution using sodium alginate (SA) and zeolitic imidazolate framework-8 (ZIF-8) modified corn cob biochar. The results showed that the specific surface area of modified biochar was greatly improved, with good adsorption capacity for Pb 2+ , strong anti-interference ability, and good economy. At the optimal adsorption pH of 5, the adsorption model of Pb 2+ by SA@ZIF-8/BC was more consistent with the pseudo-second-order kinetic model and Langmuir isotherm model. This indicates that the adsorption of Pb 2+ by SA@ZIF-8/BC is chemisorption and monolayer adsorption. The maximum adsorption of modified biochar was 300 mg g −1 , which was 2.38 times higher than that of before modified BC (126 mg g −1 ). The shift in binding energy of functional groups before and after adsorption of SA@ZIF-8/BC was studied by XPS, and it was found that hydroxyl and carboxyl groups played an important role in the adsorption of Pb 2+ . It was demonstrated that this novel adsorbent can be effectively used for the treatment of Pb pollution in wastewater.
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Tungsten
·
2024
·
IF 5.6
Zhang Zhi-Qi,Yang Liu,Luo Wen,An Vladimir,Li Jing,Liu Bao-Dan
The design and synthesis of vanadium-based denitration catalysts with low-temperature activity pose significant challenges in the field of toxic gas catalysis. In this study, we have developed a novel approach to fabricate highly efficient V 2 O 5 -WO 3 /TiO 2 monolithic mesh catalysts for NO x reduction at low temperatures. First, TiO 2 nanosheets with strong adhesion and large surface area were grown on Ti mesh using plasma electrolytic oxidation technology and hydrothermal method. Then, super-small traces of WO 3 and V 2 O 5 active nano-species were subsequently deposited on TiO 2 nanosheets using the deposition–precipitation method. Compared to traditional ceramic-based V 2 O 5 -WO 3 /TiO 2 catalysts, our V 2 O 5 -WO 3 /TiO 2 monolithic mesh catalyst exhibits superior mechanical performance, excellent thermal conductivity, lower pressure drop, higher utilization of active components, and stronger synergistic effects. Significantly, the V 2 O 5 -WO 3 /TiO 2 monolithic mesh catalysts exhibited excellent low-temperature catalytic activity with 98% of NO x conversion at 220 ℃, and remarkable long-term SO 2 tolerance and water resistance in the selective catalytic reduction (SCR) of NO x with NH 3 . The SCR reaction of tiny V 2 O 5 and WO 3 active species supported on TiO 2 nanosheets directly demonstrated to follow the Eley–Rideal mechanism by in situ infrared spectra.
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Cancer Nanotechnology
·
2024
·Vol. 15
·期 1
·1-21
·
IF 4.5
Huang Yilong,Shen Shasha,Xiao Jie,Luo Cici,Ma Jiyao,Huang Xin,Qi Tianfu,Gao Chao,Li Guiyun,Li Fan,He Bo,Chen Bingdi,Han Dan
Background Mesothelin (MSLN) has been implicated in cancer migration, invasion, and prognosis, making it a potential tumor marker. However, the precise role of MSLN in the migration and invasion of malignant pleural mesothelioma (MPM) remains elusive, and effective noninvasive methods for assessing MSLN status are currently lacking. In this study, we focused on MSLN expression and elucidated the underlying mechanisms by which MSLN regulates migration and invasion in MPM. Building upon this knowledge, we developed an MRI nanoprobe that targets MSLN to assess its status in vitro and in vivo by comparing T2 signal intensity and T2 values on magnetic resonance imaging examinations. This nanoprobe combines the anatomical information obtained from MRI with biological information obtained from MSLN for comprehensive evaluation of MPM. Results Notably, we observed that MSLN expression in the epithelial type of MPM was higher and increased continuously with tumor growth than that in other types. In addition, MSLN upregulation promoted N-cadherin, matrix metalloproteinase-7, and MMP9 expression and resulted in higher migration/invasion ability and shorter survival. We synthesized MSLN-targeted nanoprobes (Fe 3 O 4 @SiO 2 -PEG-MSLN, FSPM) to assess MSLN expression by comparing the T2 signal intensity and T2 value of different cell lines and mice after 14, 28, and 42 days of modeling. Remarkably, MSLN-targeted nanoprobes demonstrated excellent targeting capabilities. In vitro studies revealed a pronounced reduction in T2 signal intensity and T2 values of the epithelial type as the probe concentration increased. In addition, in vivo experiments demonstrated a gradual decline in these parameters over time, particularly in the epithelial type as compared to the biphasic type, corresponding to the dynamic expression patterns of MSLN during different growth stages. Conclusion Our comprehensive research succeeded in confirming the regulatory mechanisms by which MSLN influences migration and invasion. Moreover, we introduced a promising method for monitoring MSLN expression that may help in facilitating the early detection, histological subtype identification, and assessment of migration, invasion, and prognosis in MPM.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·Vol. 416
·期 29
·7043-7062
·
IF 3.8
Liu Wen-Ya,Xu Di,Meng Hui-Hui,Wang Cheng-Yao,Feng Xin,Wang Jun-Song
Cucurbitacin B (CuB) is a natural triterpenoid with diverse pharmacological effects including potent anticancer activity. However, its oral bioavailability is hampered by limited metabolism in vivo. We characterized CuB’s in vivo metabolism in rats to uncover bioactive metabolites retaining therapeutic potential, using a robust UHPLC-Q-TOF–MS/MS workflow. This workflow combined molecular networking, fragmentation filtering, and mass defect filtering to identify CuB metabolites in rat urine, plasma, and feces following oral administration. Thirteen metabolites were identified and seven were confirmed. Major phase I transformations involved hydrolysis, reduction, epoxidation, and amination. Phase II conjugation included cysteine, glutathione, glucuronide, and gluconic acid conjugates. Notably, one of the main metabolites formed was the cysteine conjugate CuB-Cys. CuB-Cys maintained similar in vitro antiproliferative activity to CuB on HepG2, MCF-7, and PANC-1 cancer cell lines. However, it demonstrated lower cytotoxicity towards non-cancerous L02 cells, highlighting improved therapeutic selectivity. Mechanistically, CuB-Cys induced greater apoptotic signaling in HepG2 cells than CuB via enhanced caspase activation and disrupted BAX-Bcl-2 balance. This represents the first systematic characterization of CuB’s in vivo metabolic pathway. The identification and confirmation of CuB-Cys provide insight for drug development efforts aiming to maintain therapeutic efficacy while reducing toxicity, via metabolite-based approaches. Our findings shed light on strategies for improving CuB’s clinical potential. Graphical Abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Mei Liang,Sun Mingzi,Yang Ruijie,Zhang Yaqin,Zhang Yuefeng,Zhang Zhen,Zheng Long,Chen Ye,Zhang Qinghua,Zhou Jiang,Zhu Ye,Leung Kenneth M. Y.,Zhang Wenjun,Fan Jun,Huang Bolong,Zeng Xiao Cheng,Shin Hyeon Suk,Tang Chuyang Y.,Gu Lin,Voiry Damien,Zeng Zhiyuan
Two-dimensional (2D) materials, as adsorbents, have garnered great attention in removing heavy metal ions (HMIs) from drinking water due to their extensive exposed adsorption sites. Nevertheless, there remains a paucity of experimental research to remarkably unlock their adsorption capabilities and fully elucidate their adsorption mechanisms. In this work, exceptional lead ion (Pb 2+ ) (a common HMI) removal capacity (up to 758 mg g −1 ) is achieved using our synthesized metallic 1T/1T′ phase 2D transition metal dichalcogenide (TMD, including MoS 2 , WS 2 , TaS 2 , and TiS 2 ) nanosheets, which hold tremendous activated S chemisorption sites. The residual Pb 2+ concentration can be reduced from 2 mg L −1 to 2 μg L −1 within 0.5 min, meeting the drinking water standards following World Health Organization guideline (Pb 2+ concentrations <10 μg L −1 ). Atomic-scale characterizations and calculations based on density functional theory unveil that Pb 2+ bond to the top positions of transition metal atoms in a single-atom form through the formation of S-Pb bonds. Point-of-use (POU) devices fabricated by our reported metallic phase MoS 2 nanosheets exhibit treatment capacity of 55 L-water g −1 -adsorbent for feed Pb 2+ concentration of 1 mg L −1 , which is 1-3 orders of magnitude higher than other 2D materials and commercial activated carbon.
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JOURNAL OF MATERIALS SCIENCE
·
2024
·
IF 3.5
Qin Kaili,Zhao Yingzhu,Zhang Yuqi,Zhu Huirui,Chang Bingmei,Zhai Xiang,Wang Xiaoyu,Gong Tao,Guo Rui
Nano targeted therapy has been widely used in cancer treatment research by surface modification to increase the delivery of smart nanomedicine to specific target tissues, thereby reducing the toxic side effects of drugs on normal tissues. At present, a number of targeting ligands have been used for surface modification of nanomedicine, such as folic acid (FA) and hyaluronic acid (HA). Methotrexate (MTX), as a folic acid analog, has a strong tumor inhibition effect, which is expected to be used as a novel targeting ligand for tumor targeted therapy. However, the study of MTCATX as a nanomedicine carrier targeting ligand is rarely reported. And cholic acid is expected to be as a targeting ligand to liver cancer cells based on the specific binding effect of cholic acid on hepatocyte surface receptors. In addition, synergistic therapy has shown great potential in the treatment of hepatocellular carcinoma. Herein, a novel multi-targeting nano-drug carrier MGO-TCA-MTX (MTM) was constructed by functionalizing the surface of graphene oxide (GO) with Fe 3 O 4 , methotrexate (MTX) and triformylcholic acid (TCA) for synergistic chemo-phototherapy of hepatocellular carcinoma. The anti-tumor drug doxorubicin (DOX) was loaded onto nano-drug carrier MTM through hydrogen bonding and π–π stacking to form nanocomposite MGO-TCA-MTX@DOX (MTM@DOX) for enhanced chemo-photothermal therapy. The MTM@DOX with multiple tumor-targeting, near-infrared light (NIR) and pH triggered drug release, and high photothermal conversion efficiency exhibited an excellent tumor inhibitory effect on hepatocellular carcinoma in vitro and in vivo.
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