Bio-Design and Manufacturing
·
2024
·
IF 8.1
Jing Luyi,Xu Zhaojie,Fan Penghui,Lu Botao,Mo Fan,Hu Ruilin,Xu Wei,Shan Jin,Jia Qianli,Zhu Yuxin,Duan Yiming,Wang Mixia,Wu Yirong,Cai Xinxia
The subthalamic nucleus (STN) is considered the best target for deep brain stimulation treatments of Parkinson’s disease (PD). It is difficult to localize the STN due to its small size and deep location. Multichannel microelectrode arrays (MEAs) can rapidly and precisely locate the STN, which is important for precise stimulation. In this paper, 16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (MWCNT/PEDOT:PSS) nanocomposites were designed and fabricated, and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain depths. These results showed that nuclei in 6-hydroxydopamine hydrobromide (6-OHDA)-lesioned brains discharged more intensely than those in unlesioned brains. In addition, the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the STN. Moreover, higher values of spike firing rate, spike amplitude, local field potential (LFP) power, and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain, and may therefore be biomarkers of STN localization. Compared with the STNs of unlesioned brains, the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned brains. This may be a cause of sleep and motor disorders associated with PD. Overall, this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei. Graphic abstract
✓ 已验证
产品关联
DOI
高影响因子
MONATSHEFTE FUR CHEMIE
·
2024
·
IF 1.7
Qiu Shengzhou,Wu Chenxi,Akter Sima,Hong Shaoli,Liu Huihong,Mahmud Sakil
Addressing the challenges of tuberculosis drug detection, this study investigates the application of copper(II) oxide modified screen-printed carbon electrodes (CuO/SPCEs) for the electrochemical detection of rifampicin, a critical drug in the treatment of tuberculosis and mycobacterial infections. The CuO/SPCE was fabricated via a constant potential electrodeposition technique and characterized using voltammetry. The bare SPCE surface exhibited a rough, porous structure, whereas the electrodeposition of CuO resulted in a smoother CuO/SPCE surface. The sensor exhibited high sensitivity with a detection limit of 2.89 μM for rifampicin and demonstrated excellent stability with a relative standard deviation of 3.5% over 10 measurements. The reproducibility was confirmed with an RSD of 4.2% across different electrodes. It also showed a linear response to rifampicin concentrations ranging from 10 to 200 μM. The real sample analysis showed a linear relationship between rifampicin concentration and peak current ( I = 0.739 + 0.008 c ), with a high correlation coefficient ( R 2 = 0.995). This electrochemical sensor’s simplicity, cost-effectiveness, and rapid response make it a promising tool for point-of-care applications in tuberculosis management. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
TRANSACTIONS OF TIANJIN UNIVERSITY
·
2024
·Vol. 30
·期 3
·238-249
·
IF 6.7
Ji Jiankun,Gu Yarong,Zhang Jianning,Yu Chongwen,Hu Xiao,Bao Yueping,Song Yujie
A major challenge is to construct ceramic membranes with tunable structures and functions for water treatment. Herein, a novel corrosion-resistant polymer-derived silicon oxycarbide (SiOC) ceramic membrane with designed architectures was fabricated by a phase separation method and was applied in organic removal via adsorption and oxidation for the first time. The pore structure of the as-prepared SiOC ceramic membranes was well controlled by changing the sintering temperature and polydimethylsiloxane content, leading to a pore size of 0.84–1.62 μm and porosity of 25.0–43.8%. Corrosion resistance test results showed that the SiOC membranes sustained minimal damage during 24 h exposure to high-intensity acid–base conditions, which could be attributed to the chemical inertness of SiOC. With rhodamine 6G (R6G) as the model pollutant, the SiOC membrane demonstrated an initial effective removal rate of 99% via adsorption; however, the removal rate decreased as the system approached adsorption saturation. When peroxymonosulfate was added into the system, efficient and continuous degradation of R6G was observed throughout the entire period, indicating the potential of the as-prepared SiOC membrane in oxidation-related processes. Thus, this work provides new insights into the construction of novel polymer-derived ceramic membranes with well-defined structures and functions.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Zhao Fengju,Guo Hui,Yang Wei,Guo Lili,Li Jiaxin,Chen Hanqi
Acetylcholinesterase (AChE) plays an important role in the treatment of human diseases, environmental security and global food supply. In this study, the simple fluorescent indicators and MnO 2 nanosheets were developed and integrated to establish a ratiometric fluorescence sensing system for the detection of AChE activity. Two fluorescence signals could be recorded independently at the same excitation wavelength, which extended the detection range and enhanced the visibility of results. Fluorescence of F-PDA was quenched by MnO 2 nanosheets on account of inner filtering effect. Meanwhile, the nonfluorescent OPD was catalytically oxidized to 2,3-diaminophenazine by MnO 2 nanosheets. The acetylcholine (ATCh) was catalytically hydrolyzed by AChE to enzymatic thiocholine, which decomposed MnO 2 to Mn 2+ , recovered the fluorescence of F-PDA and reduced the emission of ox-OPD. Utilizing the fluorescence intensity ratio F 468 /F 558 as the signal readout, the ratiometric fluorescence method was established to detect AChE activity. Under the excitation wavelength of 410 nm, the ratio F 460 /F 558 against the AChE concentration demonstrated two linear relationships in the range 0.05 -1.0 and 1.0–50 U·L − 1 with a limit of detection (LOD) of 0.073 U·L − 1 . The method was applied to the detection of AChE activity and the analysis of the inhibitor Huperzine-A. Due to the advantages of high sensitivity and favorable selectivity, the method possesses an application prospect in the activity deteceion of AChE and the screening of inhibitors. Graphical Abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Carbon Letters
·
2024
·
IF 5.5
Chen Jinghong,Xie Huan,Lin Yuyin,Tan Zhenxing,Zheng Mingchen,Yuan Yong,Zhou Lihua
Ibuprofen (IBU), a common pharmaceutical and personal care product (PPCP), is a pervasive water pollutant with adverse ecological and human health effects after transformation and accumulation. In this study, we synthesized Fe, N-doped carbon quantum dots (Fe, N-CQDs) using pig blood and FeCl 3 as a precursor via a one-step hydrothermal method. TEM, XRD, XPS, and UV–Vis were used to characterize the physical and chemical properties of Fe, N-CQDs. We investigated the feasibility of Fe, N-CQDs in activating peroxymonosulfate (PMS) for IBU degradation under visible light. The experimental results revealed that Fe in Fe, N-CQDs predominantly formed a stable complex through Fe–N and Fe-OH, with a high degree of graphitization and a sp 2 -hybridized graphitic phase conjugate structure. The Fe, N-CQDs/Light/PMS system exhibited strong activity, degrading over 87% of IBU, maintaining a wide pH range (3–10) adaptability. Notably, Fe, N-CQDs acted as visible-light catalysts, promoting Fe 3+ /Fe 2+ cycling and PMS activation, generating both free radicals (SO 4 •– , ·OH) and non-radicals ( 1 O 2 , h + ) to effectively degrade IBU. This study presents an innovative approach for the sustainable utilization of pig blood as a biomass precursor to synthesize Fe- and N-doped carbon materials. This study provides a new approach for the sustainable and value-added utilization of natural wastes and biomass precursors of Fe- and N-doped carbon materials, which can be used to treat pollutants in water while treating discarded pig blood. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS LETTERS
·
2024
·
IF 2.3
Xiong Ying,Jia Yushan,Yang Ruixi,Wang Peng,Feng Xiaogeng,Cui Junshuo,Lou Zhenning,Shan Weijun,Yu Haibiao
In this paper, the foam-like multi-stage porous 3wt%Al-KIT-6-4T(WI) catalyst was prepared and employed for efficient catalyzing biomass-derived GVL to butene. It is found that the prepared 3wt%Al-KIT-6-4T(WI) catalyst possess abundant mesoporous and presented the foam-like microstructure. Due to this, the 3wt%Al-KIT-6-4T(WI) catalyst has large specific surface area (517.09 m 2 ·g −1 ) and adequate amount of surface acid sites (both Brønsted and Lewis acid site). The special microstructure further improves the mass transfer efficiency of reactants and products. Under the optimized reaction conditions, the butene yield over the 3wt%Al-KIT-6-4T(WI) catalyst can up to 93.78% at 300 °C, after reacting 240 min. Moreover, the 3wt%Al-KIT-6-4T(WI) catalyst still showed excellent regeneration stability, and above 72% butene yield can be maintained after 7th cycle tests. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Ma Fen,Wang Weibiao,Wang Mei,Zhang Weiman,Zhang Shuxian,Wilson Gidion,Sa Yuping,Zhang Yue,Chen Guoning,Ma Xueqin
Given the inherent complexity of natural medicines, finding a straightforward and efficient method for identifying active ingredients remains a significant challenge, yet it is of paramount importance. Influenza virus neuraminidase (NA), a primary target for anti-influenza drug development, plays a crucial role in the infection process, making it essential to develop rapid and facile methods for screening NA inhibitors. Herein, we developed a novel and efficient analytical technique for the identification of NA inhibitors from complex herbal medicines by integrating dual sensing with affinity chromatography. This approach simplifies the experimental process and highlights the benefits of being quicker, more sensitive, and cost-effective. Regarding the biosensing section, the innovative concept of a 4-methylumbelliferyl-N-acetylneuraminic acid-NA-based fluorescence paper sensor strategy enables the rapid detection of NA inhibitors in complex herbal samples. In affinity chromatography, bioactive compounds were precisely captured, separated, and identified. The efficacy and reliability of the developed method were confirmed using both negative and positive controls. Then, the method was applied to screen for NA inhibitors in 20 different herbal medicines. The results revealed that Bupleurum chinense DC. exhibited the most pronounced inhibitory effect on NA. Subsequent analysis utilizing affinity chromatography identified three bioactive compounds, namely saikosaponin a, saikosaponin d, and baicalin, as the active agents responsible for this inhibitory effect, with IC 50 values of 177.3 μM, 262.9 μM, and 241.4 μM, respectively. Molecular docking studies further indicated that these three bioactive compounds exhibit a strong binding affinity with NA. This research provides novel insights into the screening of enzyme inhibitors within herbal medicines. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Ma Qing,Gao Yongjun,Sun Bo,Du Jianlong,Zhang Hong,Ma Ding
Both plastics and CO 2 are waste carbon resources, and their accumulation in nature has led to severe environmental pollution. However, simultaneously converting plastic waste and CO 2 into value-added chemicals remains a challenge. Here we demonstrate a catalytic reforming process that converts plastics and CO 2 into syngas over an electrified FeCrAl heating wire. The temperature of the electrified heating wire can quickly exceed 800 °C, facilitating the decomposition of polyethylene into gaseous hydrocarbons. The high-temperature heating wire promote the CO 2 deoxygenation, resulting in the generation of CO, as well as the dehydrogenation of gaseous hydrocarbons. Significantly, the additional O species from CO 2 and the carbon species from hydrocarbons can react to form CO, maintaining the high catalytic activity of the electrified heating wire. This novel approach is of paramount to achieving a circular economy in addressing the ongoing environmental crisis caused by the accumulation of plastic waste and excessive CO 2 emissions.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Minerals Metallurgy and Materials
·
2025
·Vol. 32
·期 3
·668-677
·
IF 7.2
Huo Yuying,Wang Zhengyan,Zhang Yanlan,Wang Yongzhen
High-entropy design is attracting growing interest as it offers unique structures and unprecedented application potential for materials. In this article, a novel high-entropy ferrite (CoNi) x /2 (CuZnAl) (1− x )/3 Fe 2 O 4 ( x = 0.25, 0.34, 0.40, 0.50) with a single spinel phase of space group \(Fd\bar{3}m\) was successfully developed by the solid-state reaction method. By tuning the Co–Ni content, the magnetic properties of the material, especially the coercivity, changed regularly, and the microwave absorption properties were improved. In particular, the effective absorption bandwidth of the material increased from 4.8 to 7.2 GHz, and the matched thickness decreased from 3.9 to 2.3 mm, while the minimum reflection loss remained below −20 dB. This study provides a practical method for modifying the properties of ferrites used to absorb electromagnetic waves.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2024
·
IF 1.5
Guo Dingge,Xiao Jing,Ning Yang,Yu Hongchao,Jin Tianxiang,Huang Bin,Qian Yong
The efficient removal of thorium from the environment is critical due to the risks it poses to organisms. Metal–organic frameworks are favored by scholars because of their potential to effectively adsorb a variety of heavy metal ions in wastewater treatment. In this work, the interaction of UiO-66-NH 2 surface with graphene, enhances adsorption capacity of MOFs. Optimal adsorption conditions have been identified, and a detailed adsorption mechanism has also been comprehensively discussed. The theoretical maximum adsorption capacity exhibited by UiO-66-GO is 119.57 mg g −1 . Moreover, it shows a fast adsorption rate and reached equilibrium within 20 min. The development of materials with good adsorption performance and fast adsorption for Th(IV) plays an important role in the development of Th(IV) adsorption in the future.
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-13
·
IF 3.8
Dezhakam Ehsan,Vayghan Roya Faraghi,Dehghani Sarina,Kafili-Hajlari Taha,Naseri Abdolhossein,Dadashpour Mehdi,Khalilzadeh Balal,Kanberoglu Gulsah Saydan
Nowadays, rapid and facile diagnosis of cancer using user friendly processes has attracted much attention. In this regard, an electrochemical (EC) biosensor with high sensitivity was fabricated by merging MIL156 MOF@COF nanocomposite with Au nanoparticles for the detection of CA15-3. Herein, metal clusters of MIL-156 as a Metal organic frameworks (MOF) were coated by a crystalline covalent organic frameworks (COF) through covalent bonding and created core-shell-like structures. The active part of the working electrode was modified in two consecutive steps. First, MIL-156 MOF@COF and then Au nanoparticles were electrodeposited on the glassy carbon electrode (GCE). The porosity of nanocomposite has significantly increased the surface area and improved the conductivity. Au nanoparticles also form an acceptable substrate for bonding antibodies due to their high affinity with amino groups. In addition, Au nanoparticles amplify the EC signal of the biosensor with their undeniable conductivity. Nanocomposite was characterized with XRD, SEM, and EDAX techniques. To investigate the proposed biosensor, differential pulse voltammetry (DPV) was used as an analytical technique. The CA15-3 calibration provided a linear range between concentrations of 30 and 100 nU/mL, thus expressing the powerful diagnostic potential of the designed biosensor. Furthermore, the suggested biosensor has been used in serum samples and discriminate breast cancer sufferers from healthy individuals with high confidence levels.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·
IF 3.8
Sun Baohong,Cui Xin,Zhang Jiachen,Tang Yawen,Sun Hanjun
Hydrolytic nanozyme–based visual colorimetry has emerged as a promising strategy for the detection of aluminum ions. However, most studies focus on simulating the structure of natural enzymes while neglecting to regulate the rate of hydrolysis-related steps, leading to low enzyme-like activity for hydrolytic nanozymes. Herein, we constructed a ruthenium dioxide (RuO 2 ) in situ embedded cerium oxide (CeO 2 ) nanozyme (RuO 2 /CeO 2 ) with a Lewis acid–base pair (Ce–O-Ru-OH), which can simulate the catalytic behavior of phosphatase (PPase) and can be quantitatively quenched by Al 3+ to achieve accurate and sensitive Al 3+ colorimetric sensing detection. The incorporation of Ru into CeO 2 nanorods accelerates the dissociation of H 2 O, followed by subsequent combination of hydroxide species to Lewis acidic Ce–O sites. This synergistic effect facilitates substrate activation and significantly enhances the hydrolysis activity of the nanozyme. The results show that the RuO 2 /CeO 2 nanozyme exhibits a limit of detection as low as 0.5 ng/mL. We also demonstrate their efficacy in detecting Al 3+ in various practical food samples. This study offers novel insights into the advancement of highly sensitive hydrolytic nanozyme engineering for sensing applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）