JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Xiang Wang,Yejun Deng,Junhao Wan,Caihong Zhang,Yong Liu,Yuechao Zhang,Jiekang Tian,Pujun Xie,Lixin Huang
Inhibition of α-glucosidase and improvement of insulin resistance (IR) are key strategies for treating type 2 diabetes mellitus (T2DM). Our previous work obtained a novel α-glucosidase inhibitory peptide, FAPSW. However, its activity was weaker than acarbose. To further enhance its activities, 17 novel peptides were constructed by amino acid substitution using FAPSW as a template. Among them, YAPSW (IC50 = 0.126 ± 0.008 mM) exhibited stronger α-glucosidase inhibition than FAPSW and acarbose. Molecular docking suggested that hydrogen bonds were not the sole determinants of peptide-mediated α-glucosidase inhibition, while molecular dynamics simulations revealed that the enhanced inhibitory activity of YAPSW primarily resulted from its more stable binding to 3A4A. Moreover, FAPSW and YAPSW could improve IR and YAPSW exhibited stronger effects on IRS-1/PI3K/AKT signaling pathway than FAPSW. This study provides insights into optimizing α-glucosidase inhibitory peptides and supports the potential application of YAPSW as a multifunctional food ingredient for T2DM management.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Zeen Zhang,Tiantian Chu,Yangcheng Lu
Revealed Al/Ni and catalyst concentration effects on polymer structure. • Clarified how propagation, chain walking, and transfer determine conversion, branching degree and molecular weight. • Developed a mechanism-inspired model for polyethylene property prediction. • Enabled inverse design for target-oriented polyethylene synthesis. Ethylene homopolymerization catalyzed by an α-diimine nickel/MAO system was investigated in toluene using a microflow platform. The effects of catalyst concentration and Al/Ni ratio on polymerization behavior and polymer structure were systematically examined. Increasing catalyst concentration enhanced the overall polymerization capability but also intensified chain-transfer effects, while the Al/Ni ratio exhibited an optimal window governed by the balance between catalyst activation and activity suppression at excessive MAO levels. Based on the chain-walking mechanism, polymer structure formation was interpreted as a dynamic competition among chain propagation, chain walking, and chain transfer, which mainly determined conversion, branching degree, and molecular weight. A mechanism-inspired apparent model was established by combining variable transformations, a third-order polynomial response surface, and Ridge regularization, enabling simultaneous prediction of key polymer properties. Furthermore, an inverse design model was developed for identifying feasible reaction conditions toward target-oriented polyethylene synthesis. Download: Download high-res image (140KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Dan Li,Yue Su,Yuhang Meng,Cuicui Duan,Fumin Ma,Byung-Hoo Lee,Xiaolei Li
Mutants E395D and S321D showed 1.6× and 1.3× higher catalytic efficiency than BlGBE. • S321D/E395D-modified pea starch had further reduced retrogradation and digestibility. • E395D/S321D increased DP 2 and 3 short branches, reduced R₁₀₄₇/₁₀₂₂ and crystallinity. • S321D-modified cake had further improved slowly digestible starch and reduced hardness. • S321D/E395D had enhanced substrate binding and stabilized transition-state by H-bonds. The 1,4-α-glucan branching enzyme found in Bifidobacterium longum can modify the physicochemical properties of starch by forming denser and shorter branches. To enhance its activity and modification function with regard to pea starch, ten mutants were engineered using site-directed mutagenesis based on multiple sequence alignment, molecular docking, and dynamic simulation. The mutants E395D, S321D and M509L exhibited specific activities 1.32-, 1.23- and 0.81-fold higher than the wild type (WT). The catalytic efficiencies of S321D and E395D were 18.36 and 14.00 mg −1 ·min −1 ·mL, respectively, which were significantly higher than the WT's efficiency of 11.19 mg −1 ·min −1 ·mL. Docking analysis revealed that the mutations reorganised the hydrogen-bonding and electrostatic microenvironment at the active site, producing mutation-specific effects on substrate binding and transition-state stabilisation. These locally altered polar and nucleophilic properties ultimately dictated the catalytic efficiency of each mutant. Compared with WT, E395D and S321D increased DP 2 and 3 short branches, reduced FT-IR R₁₀₄₇/₁₀₂₂ and XRD crystallinity at 200–800 U/g starch, which expanded the amorphous region of starch. After seven days' storage at 4 °C, the retrogradation enthalpy of S321D-modified starch was 0.63 J/g lower than that of WT-modified starch of 0.71 J/g. Glucose release from S321D-modified starch was significantly lower than from WT-modified starch at the level of small intestinal α-glucosidase. The slowly digestible fraction of S321D-modified starch was 38.51%, significantly higher than the 29.19% observed in WT-modified starch. Fresh and stored pea cake modified by S321D had significantly lower hardness and higher slowly digestible properties than the WT-modified equivalent. Download: Download high-res image (208KB) Download: Download full-size image
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Metabolites
·
2026
·Vol. 16
·期 8
·551
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IF 4.5
Haiyan Cui,Yue Guo,Wang Xin,Dan Shao,Meng Hu,Tao Wang,Dan Zhang,Zhiwen Wei,Keming Yun
HighlightsWhat are the main findings?Metabolomic pathway analysis of plasma from α-amanitin-poisoned mice preliminarily reveals that plasma metabolites follow a temporally dynamic progression across seven different groups.PTGS2 emerges as a potential candidate target; propionylcarnitine and 2-arachidonoylglycerol (2-AG) are the key associated metabolites.What are the implications of the main findings?Similar to the clinical symptomatology, α-amanitin-induced liver and kidney injury follows a temporally dynamic evolutionary process, which may inform reference criteria for poisoning treatment.By integrating untargeted metabolomics with network toxicology, this study couples the phenotypic endpoints represented by differential metabolites with the regulatory networks mediated by potential candidate targets. This approach enables a multi-level elucidation of the mechanisms underlying α-amanitin-induced hepatorenal injury, which might provide a reference basis for early toxicity warning and precision intervention.Background/Objectives: Mushroom poisoning is a leading cause of death from foodborne illness, and α-amanitin is its most potent toxin. However, the mechanisms and biomarkers of α-amanitin-induced hepatorenal injury remain inadequately understood.Methods: First, the potential candidate targets and metabolic pathways were identified using network toxicology. Subsequently, untargeted metabolomics was employed to screen for potential metabolic markers of poisoning in α-amanitin-treated mice across eight time groups: 0 h, 3 h, 8 h, 12 h, 24 h, 2 d, 4 d, and 7 d. Following this, a compound–reaction–enzyme–gene network was constructed based on the differential metabolites to identify relevant genes, which were integrated with the core candidate target genes derived from network toxicology. The findings were further validated by molecular docking and immunohistochemistry.Results: Network toxicology identified eight candidate targets associated with α-amanitin-induced combined hepatic and renal injury. Metabolomic analysis revealed that α-amanitin-induced hepatorenal injury followed a temporally dynamic progression, and that propionylcarnitine was the common differential metabolite across all time points. Integration of the network toxicology and untargeted metabolomics results indicated that PTGS2 served as a potential candidate target and 2-arachidonoylglycerol (2-AG) was selected as a potential differential metabolite in the combined hepatic and renal injury caused by α-amanitin.Conclusions: By integrating network toxicology and untargeted metabolomics, this study preliminarily reveals that α-amanitin-induced hepatorenal injury follows a temporally dynamic progression, which is consistent with the toxicological injury–response–adaptation model. PTGS2 is tentatively annotated as the potential candidate target, while propionylcarnitine and 2-AG are the potential candidate metabolites. These findings may provide valuable guidance for poisoning treatment and identification in cases of mushroom poisoning caused byAmanitaspecies.
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Journal of Energy Storage
·
2025
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IF 9.8
Yuanting Wu,Bocheng Zhang,Xuhua Liu,Jingyue Hu,Yunlong Xue,Ou Hai,Hulin Liu,Xinmeng Zhang
The low specific capacity of capacitor electrode materials has been the main problem restricting their development. Compared with β-phase CoNi LDH, α-phase CoNi LDH has high specific capacity and cycling stability, and has broad application prospects, but there are fewer related studies. In this paper, the preparation of α-phase CoNi LDH is realized by introducing Cl − and WO₄ 2− intercalation into CoNi LDH, and the mechanism of the intercalation ions on the enhancement of the electrochemical properties of the LDH is deeply investigated. Different charge densities and ionic radii of the intercalation anions affect the valence states of the cations in the main LDH layer as well as the spacing of the LDH layers, and phase structure. Cl − possesses a smaller ionic radius and lower charge density than WO 4 2− , and changed the electronic as well as the phase structure of LDH by bonding with doped Co atoms, which induces the formation of interlayer water molecule chains, facilitating electron transfer and structural stabilization. Remarkably, the specific capacity of CoNi-Cl LDH/NF (Cl − inserted CoNi LDH) electrode at 1 A g −1 (2828.74 F g −1 ) is 4 times that of CoNi LDH/NF and 1.9 times that of CoNi-W LDH/NF (WO 4 2− inserted CoNi LDH) respectively, and remained 88.7 % constant after 5000 cycles at 10 A g −1 . This study provided a new idea for the use of anionic intercalated LDH to modulate the phase structure to enhance the electrochemical performance of electrode materials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Kunshan Wang,Yingao Zhai,Zenghui Yu,Xuan Zhang,Suzhen Zhou,Jinbo Fan
To mitigate postprandial hyperglycemia, acarbose's excessive α-amylase (AMY) inhibition causes gastrointestinal side effects. Baicalein (Bai), genistein (Gen), and isoliquiritigenin (Isl), featuring 5,6-dihydroxyflavone structures, mildly inhibit AMY. In this study, the inhibitory mechanism of Bai, Gen, and Isl on AMY was determined by integrating multiple analytical techniques and molecular simulation technologies. The results showed that Bai/Gen/Isl exhibited strong inhibitory activity against AMY with IC 50 values of 22.44 ± 0.92 μmoL·L −1 , 24.78 ± 1.91 μmoL·L −1 , and 26.78 ± 1.79 μmoL·L −1 , respectively, which belonged to the mixed inhibition type dominated by competitive inhibition. The three form a ground state complex with AMY through a static quenching mechanism, and the order of binding constants is Bai > Gen > Isl. Their binding significantly changed the microenvironment polarity of Trp residues in AMY and induced secondary structure rearrangement. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscopy (SEM) showed that the relative crystallinity of AMY increased, forming dense aggregates and increasing thermal stability. Molecular simulation showed that the interactions between AMY and Bai/Gen were dominated by van der Waals forces or hydrogen bonds, while the interactions with Isl were dominated by hydrophobic interactions. By employing a novel integrative approach combining fluorescence/UV–Vis/FTIR spectroscopy, DSC-XRD-SEM characterization, and 120 ns molecular dynamics simulation, this study overcomes the single-technique limitations of previous research and provides a theoretical basis for the development of blood glucose control agents based on natural products.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 12.6
Jinming Tian,Zeyu Zhang,Chao Cheng,Fei Yu,Tao Wang,Bin Cui,Ye Peng,Shuang Qiu,Fuming Wang,Weijing Cheng,Rong Luo,Guorong Jia,Changjing Zuo
Transarterial radioembolization (TARE) with β-emitting radionuclides is widely used for hepatocellular carcinoma (HCC), but its clinical efficacy remains to be further improved. α-particle-emitting radionuclides possess high linear energy transfer (LET) and unique advantages in cancer therapy, motivating α-particle based composite platform. Accordingly, we engineer the first clinically mimetic α-TARE microsphere by in-situ ²²³Ra-doped calcium-alginate composite microsphere (²²³Ra/Ca-ALG MS) using a hydrogel matrix, in which alginate "egg-box" coordination captures Ra²⁺ to provide stable radiolabeling, delivered via selective hepatic arterial injection to HCC. The microspheres exhibited excellent radiolabeling stability (88% retention after 384 h) and potent, dose-dependent cytotoxicity against HCC cells under hypoxia. In an orthotopic rat HCC model, 223 Ra/Ca-ALG MS-based TARE achieves precise intratumoral localization and sustained retention on SPECT/CT; ¹⁸F-FDG PET/CT and histopathology indicate a robust antitumor response, while serum biochemistry and histology support a favorable safety profile. Moreover, ²²³Ra/Ca-ALG MS provide powerful immune-activating capacity. Transcriptomics reveals activation of DNA-damage response, immunogenic cell death, and antigen-presentation pathways, flow cytometry and immunohistochemistry show increased dendritic-cell maturation and CD8⁺ T-cell infiltration. Collectively, 223 Ra/Ca-ALG MS demonstrates hypoxia-tolerant cytotoxicity, immune-activating potential, offering new insights for the development of immune-based TARE strategies in HCC and showing promising prospects for clinical translation.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 1
·120898
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IF 7.2
Jing Wang,Guangxi Wang,Xiaoyan Ji,Zhiwen Chang,Yu Wang,Wenguang Chen,Leilei Zhang,Shuwen An,Yi Gu,Jun Liu
The mining, processing, and refining of rare-earth ores generate Th-rich radioactive wastewater, making its effective treatment critical for environmental protection and public health. In this study, mesoporous MoX 2 -α-ZrP (X = S, Se) composite powders were synthesized for Th(IV) adsorption from aqueous solutions. Under the conditions of [Th(IV)] initial = 50 ± 2 mg·L −1 , pH initial = 3, temperature = 298 K, and a contact time = 1440 min, the larger pore volume and pore width of the composites, compared with α-ZrP, enhanced the adsorption capacity ( q e ) of MoSe 2 -α-ZrP and MoS 2 -α-ZrP to 146.3 ± 7.4 mg·g −1 and 143.7 ± 2.5 mg·g −1 , respectively. Higher pH, [Th(IV)] initial, and temperature further enhanced Th(IV) adsorption. Notably, MoX 2 -α-ZrP removed Th(IV) from simulated leaching solution of monazite or bastnaesite and selectively adsorbed Th(IV) in the presence of co-existing ions. Thermodynamic and kinetic analyses confirmed a spontaneous, endothermic, and homogeneous chemisorption behavior. The Thomas and Yoon-Nelson models accurately described dynamic column Th(IV) adsorption, and increases in adsorbent mass, together with decreases in influent Th(IV) concentration, and reduced flow rate extended both breakthrough and saturation times. Mechanistic studies revealed Th(IV) coordination with oxygen-containing groups, ion exchange with -OH, and electrostatic interaction with phosphate groups. Results from our study can help explore the adsorption behaviors and mechanisms of Th(IV) on potential MoX 2 (X = O, S, Se)-based or α-ZrP-based materials for treating Th-rich radioactive wastewater.
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FOOD CHEMISTRY
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2026
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IF 10.4
Meiyu Chen,Sunning Lan,Tianyi Yan,Tengyue Wu,Guruprasad Kori Yatheshappa,Tin Nyawe Nyawe Hlaing,Xiangyu Wang,Yucheng Zou,Hui Zhang
Emulsion-electrospinning strategy encapsulated ALA in gelatin-based nanofibers. • Core-shell structure effectively shielded the lipid within the nanofiber matrix. • Cinnamaldehyde crosslinking enhanced physicochemical properties of nanofibers. • Crosslinked fibers enabled the sustained release of ALA during digestion. • Bioaccessibility of ALA increased from 29.5% to 78.2% with the optimized system. The application of α-linolenic acid (ALA) is hindered by oxidative instability and poor bioaccessibility. Herein, ALA was encapsulated in core-shell gelatin nanofibers via emulsion electrospinning, integrated with in situ cinnamaldehyde (CA) crosslinking for the first time. Increasing the emulsion-to-gelatin ratio from 1:2 to 1:6 reduced droplet size from 2.86 to 1.83 μm, yielding uniform nanofibers (135.8–347.6 nm). CA-crosslinking reinforced the structural network through localized coalescence. Microscopy confirmed distinct core-shell nanofibers with ALA shielded within the gelatin matrix. Spectroscopy and molecular docking revealed CA-induced Schiff base reactions and hydrogen bonding, which increased mechanical strength from 3.67 to 6.66 MPa. CA treatment also improved surface hydrophobicity and reduced water solubility. The optimized formulation EG14A achieved high encapsulation efficiency (92.3%), sustained release during in vitro digestion, and elevated ALA bioaccessibility to 78.2%, while maintaining good biocompatibility. This integrated approach provides a novel, food-grade platform for stabilizing and delivering sensitive bioactive lipids. Download: Download high-res image (158KB) Download: Download full-size image
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FOOD RESEARCH INTERNATIONAL
·
2023
·
IF 8.1
Siyi Peng,Jiajia Zhao,Yaru Wang,Fang Chen,Xiaosong Hu,Lingjun Ma,Junfu Ji
L-menthol-containing food products generally show the flavor loss during storage due to their high volatility. The hydrophobicity of L-menthol also causes the inadequate flavor release during rehydration. In this study, the stability of L-menthol was enhanced by microencapsulation and the effect of different powder drying techniques was also investigated. The highest efficiency (76.58–78.66 %) and loading content (18.58–28.35 mg/g) of encapsulations were obtained by using a mass ratio of 2:1(α-LA: GA). Then they were dried by non-thermal spray freeze drying (SFD) technique compared to spray drying (SD) and freeze-drying (FD) process. The SFD particles were shown to be spherical and porous with the highest porosity (86.82 %). α-LA/GA based microparticles with spherical shapes were demonstrated to largely enhance flavor retention during high humidity storage. In addition, the porous structures of SFD powders could cause rapid rehydration in liquid models, and the release behaviors of loaded L-menthol followed the Fickian diffusion. Consequently, the SFD technique shows great potential to produce microparticles by regulating the release behaviors of L-menthol during storage and rehydration.
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CARBOHYDRATE POLYMERS
·
2023
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IF 11.2
Xinxin Yang,Bowen Zhang,Jingjing Li,Minggui Shen,He Liu,Xu Xu,Shibin Shang
Self-healing, self-adhesive, and stretchable bio-based conductive hydrogels exhibit properties similar to those of biological tissues, making them an urgent requirement for emerging wearable devices. The primary challenge lies in devising straightforward strategies to accomplish all the aforementioned performances and achieve equilibrium among them. This study used the natural compound thioctic acid (TA) and modified cellulose to prepare conductive hydrogels with stretchability, healing, and self-adhesion through a simple one-step strategy. Metastable poly(TA) was obtained through ring-opening polymerization of lithiated TA, followed by the introduction of dopamine-grafted cellulose nanofibers (DCNF) to stabilize poly(TA) and prepare PTALi/DCNF hydrogels with the aforementioned properties. The hydrogels demonstrated remarkable conductivity, attributed to the existence of Li + ions, with a maximum conductivity of 17.36 mS/cm. The self-healing capacity of the hydrogels was achieved owing to the presence of disulfide bond in TA. The introduction of DCNF can effectively stabilize poly(TA), endow the hydrogel with self-adhesion ability, improve the mechanical properties, and further enhance the formability of hydrogels. Generally, bio-based PTALi/DCNF hydrogels with stretchability, self-healing, self-adhesion, and conductivity are obtained through a simple strategy and used as a sensor with a wide response range and high sensitivity. Hydrogels have significant potential for application in wearable electronic devices, electronic skins, and soft robots.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Long Cheng,Jiale Bai,Mingyu Wei,Shuaiqi Zhao,Aihua Xu,Xiaoxia Li
Transition metal oxides and carbon can activate peroxymonosulfate (PMS) to decompose organic contaminants. The combination of two materials can facilitate the adsorption of oxidants and pollutants on the catalyst and improve electron transfer efficiency. In this study, carbon nanoparticles-MnO 2 composites (IC-MnO 2 ) were synthesized by coating carbon ink on α-MnO 2 and applied in PMS activation for acid orange 7 (AO7) degradation. The results showed that carbon nanoparticles were uniformly loaded on the α-MnO 2 surface. Complete degradation of AO7 (20 mg/L) can be achieved in 15 min in the IC-MnO 2 /PMS system with a first-order kinetic rate constant of 0.22 min −1 . Electrochemical analysis , quenching experiments, electron paramagnetic resonance , PMS decomposition, and removal of various contaminants demonstrated that AO7 could be efficiently degraded via a direct electron transfer pathway. A galvanic oxidation system containing the salt bridge and two separate cells was further established to confirm the electron transfer mechanism of the catalytic system. The study expands MnO 2 applications by compositing nanocarbon materials in advanced oxidation processes and sheds light on the direct electron transfer mechanism.
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