CHEMICAL ENGINEERING SCIENCE
·
2019
·
IF 3.372
Yuning Tang,Sa Wang,Xin Zhou,Ying Wu,Shikai Xian,Zhong Li
A facile and efficient room-temperature synthesis approach was proposed to prepare MOF material Cu(Qc) 2 (henceforth called RT-Cu(Qc) 2 ) with ultramicropores. RT-Cu(Qc) 2 was successfully synthesized at room-temperature by means of (Zn, Cu) hydroxyl double salt as intermediate within 1–12 h. The resulting RT-Cu(Qc) 2 exhibited excellent water vapor stability and its C 2 H 6 uptake reached 2.19 mmol/g at 288 K and 1 bar. Its C 2 H 6 /C 2 H 4 and C 2 H 6 /CH 4 uptake ratio at 298 K and 1 bar were up to 3.70 and 22.67, superior to benchmark MAF-49, Cu(Qc) 2 and ZIF-7. Its IAST-predicted C 2 H 6 /C 2 H 4 and C 2 H 6 /CH 4 selectivity reached 4.1 (1:1 v:v) and 35.9 (1:9 v:v) at 288 K and 1 bar, higher than most of ethane-capturing MOFs. Molecular simulation revealed well-defined host–guest match between Cu(Qc) 2 and ethane. Fixed bed experiments confirmed that ethane/ethylene or ethane/methane mixtures can be completely separated using RT-Cu(Qc) 2 . RT-Cu(Qc) 2 has great potential for separation of ethane/ethylene and the recovery of ethane from natural gas.
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FEBS Journal
·
2019
·Vol. 287
·期 8
·1666-1680
·
IF 4.739
Chen-Yu Zhang,Jia-Xi Duan,Hui-Hui Yang,Chen-Chen Sun,Wen-Jing Zhong,Jia-Hao Tao,Xin-Xin Guan,Hui-Ling Jiang,Bruce D. Hammock,Sung Hee Hwang,Yong Zhou,Cha-Xiang Guan
Pulmonary fibrosis (PF) is a senescence-associated disease with poor prognosis. Currently, there is no effective therapeutic strategy for preventing and treating the disease process. Mounting evidence suggests that arachidonic acid (ARA) metabolites are involved in the pathogenesis of various fibrosis. However, the relationship between the metabolism of ARA and PF is still elusive. In this study, we observed a disorder in the cyclooxygenase-2/cytochrome P450 (COX-2/CYP) metabolism of ARA in the lungs of PF mice induced by bleomycin (BLM). Therefore, we aimed to explore the role of COX-2/CYP-derived ARA metabolic disorders in PF. PTUPB, a dual COX-2 and soluble epoxide hydrolase (sEH) inhibitor, was used to restore the balance of COX-2/CYP metabolism. sEH is an enzyme hydrolyzing epoxyeicosatrienoic acids derived from ARA by CYP. We found that PTUPB alleviated the pathological changes in lung tissue and collagen deposition, as well as reduced senescence marker molecules (p16 Ink4a and p53-p21 Waf1/Cip1 ) in the lungs of mice treated by BLM. In vitro , we found that PTUPB pretreatment remarkably reduced the expression of senescence-related molecules in the alveolar epithelial cells (AECs) induced by BLM. In conclusion, our study supports the notion that the COX-2/CYP-derived ARA metabolic disorders may be a potential therapeutic target for PF via inhibiting the cellular senescence in AECs.
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PubMed
高影响因子
Biomaterials Science
·
2019
·Vol. 8
·期 5
·1290-1297
·
IF 5.251
Xiao-Xiao Shi,Wei-Min Miao,Di-Wen Pang,Jia-Si Wu,Qi-Song Tong,Jia-Xian Li,Jia-Qi Luo,Wen-Yu Li,Jin-Zhi Du,Jun Wang
Primary central nervous system lymphoma (PCNSL) is a rare brain tumor. Its therapeutic efficacy is much lower than that of traditional lymphoma, largely due to the presence of the blood–brain barrier (BBB), which hinders the effective drug delivery and deposition on the disease site. Angiopep-2 (ANG) can target low-density lipoprotein receptor-related protein (LRP) on the surface of brain capillary endothelial cells (BCECs) and exhibits high BBB transport capability. In this study, we designed an ANG conjugated poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) (APP) nanoparticle to deliver doxorubicin (DOX) for the treatment of PCNSL. Our data indicated that the targeted APP nanoparticles showed significantly increased cellular uptake by BCECs compared with the control nanoparticles. In the intracranial SU-DHL-2-LUC lymphoma xenograft mice model, APP enhanced drug deposition in tumor tissues, and DOX-loaded APP (APP@DOX) exhibited a better therapeutic effect than free DOX and nontargeted PP@DOX, which significantly prolonged the survival time of mice.
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PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 30
·期 20
·18617-18625
·
IF 2.195
Meng Zuchao,Li Mao,Liu Xiang,Lei Zigang
A new hydrazine electrochemical sensor was fabricated based on in situ synthesis of Cu 3 (BTC) 2 /GO nanocomposite. Cu 3 (BTC) 2 /GO composite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared spectrometry (FT-IR). Meanwhile, the electrochemical behaviors of hydrazine on the Cu 3 (BTC) 2 /GO/GCE were studied by cyclic voltammetry and linear sweep voltammetry. Under the optimized conditions, Cu 3 (BTC) 2 /GO/GCE had enhanced electrocatalytic activity toward hydrazine due to synergic catalytic effect between Cu 3 (BTC) 2 and GO. The electrochemical sensor exhibited a wider linear range (1.0 µM to 5000 µM) and a lower detection limit (0.5 μM) as well as good reproducibility and stability. The proposed sensor has also been used for the determination of hydrazine in tap water with satisfactory results.
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RSC Advances
·
2022
·Vol. 12
·期 51
·33056-33063
·
IF 4.036
Bo Huang,Zhihua Zhao,Pu Chen,Baocang Zhou,Zhuo Chen,Yu Fu,Hongyu Zhu,Chen Chen,Shuaiwen Zhang,Anbiao Wang,Pu Shi,Xiaoqing Shen
Ammonia (NH3) is a common air pollutant and is a biomarker for kidney disease. Therefore, the preparation of ammonia gas sensors with high sensitivity, good selectivity and low operating temperature is of great importance for health protection. Using the in situ electrostatic self-assembly approach, a chemoresistive gas sensor based on Co(OH)2/Ti3C2Tx hybrid material was created in this study. The prepared samples were characterized by XRD, XPS, TEM, BET and other testing methods for structure, surface topography and elements. These samples were fabricated into sensors, and the gas sensing properties of the materials were investigated under different test conditions. The results show that the gas response value of the C/M-2 sensor is up to about 14.7%/100 ppm, which is three times the response value of the sensor made of pure MXene to NH3. In addition, the Co(OH)2/Ti3C2Tx hybrid sensors exhibit excellent repeatability, high sensitivity under low concentration (less than 5 ppm), fast response/recovery time (29 s/49 s) and long-time stability, which indicates their promising utility in the IoT field.
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高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2022
·
IF 7.129
Ruifen Kang,Sheng Li,Aneela Perveen,Jiakun Shen,Chunmei Li
T-2 toxin belongs to the trichothecenes group A compound, mainly produced by Fusarium fungi. It has been shown that T-2 toxin could cross the placental barrier and breast milk, thus endangering the health of offspring. The present study aimed to explore the effects of maternal T-2 toxin exposure on the integrity of the intestinal barrier and the intestinal microflora of young mice. From late pregnancy (GD 14) to lactation (LD 21), pregnant mice were given T-2 toxin daily at 0, 0.005, or 0.05 mg T-2 toxin/kg BW. Postnatal day 21 (PND21), PND28, and PND56 young mice were chosen as objects to detect the influences of maternal T-2 toxin exposure to mice on the offspring. The results showed that maternal exposure to T-2 toxin disturbed the balance of the intestinal microbial flora of the young mice. Villous adhesions and fusion of ileum were observed in T-2-treated groups. In addition, supplementation of T-2 toxin significantly decreased the gene expressions of Claudin 1 , Occludin , Tjp1 , Il10 , Il6, and Tnf in PND 21. However, in PND 28, the expressions of Tnf were significantly increased . T he expressions of Claudin 1 , Occludin , Tjp1 , Il10 , Il6 and Tnf were significantly increased after T-2 toxin treatment in PND 56. These results suggested that maternal exposure to T-2 toxin has negative influences on the intestine of young mice, which may be due to the alterations of microbial composition.
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高影响因子
JOURNAL OF FOOD SCIENCE
·
2023
·
IF 3.9
Minmin Tang,Zhihuang Wang,Jiaxin Luo,Tingting Zhu,Fei Song,Hua Chen
Date palm ( Phoenix dactylifera L.) is an important commercial crop extensively consumed as a staple food and has been applied in many ethnomedical systems. Fruit vinegar is a preservative, condiment, and beverage with a spectrum of health benefits. Studies about the preparation, chemical profiles, and bioactivities of date fruit vinegar (DFV) are fundamental requirements for industrialization production. This study focused on the lab-scaled producing conditions, chemical profiles of DFV, and its bioactivities in vitro. According to the results, a date wine containing 9.75% methanol was obtained by yeast fermenting the enzyme-hydrolyzed date juice with 23.11% ± 0.39% of total sugar content. The optimized acidic fermentation conditions were an inoculation amount of 0.02%, a fermentation temperature of 31.14°C, and an initial alcohol content of 7.78%. Total acidity and total phenolic contents of the DFV were 7.74% ± 0.29% and 1.44 mg gallic acid equivalent/mL, respectively. In total, 32 organic acids were quantitated in the unaged DFV, with acetic, L -malic, and oxoglutaric acids as the predominant compounds. A total of 930 volatiles were identified in the DFV, including 186 esters, 177 terpenoids, and 148 heterocyclic compounds. There are 18 phenolic acids presented in the DFV. In addition, 42 flavonoids were quantitated in the DFV, including catechin, taxifolin, and cynaroside. The results of free radical scavenging activities and reducing power demonstrated that the DFV displayed good antioxidant properties. The DFV also acted well on angiotensin-converting enzyme 2 inhibition. These results suggest that the DFV can be industrially developed as a dietary supplement.
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高影响因子
INTERNATIONAL IMMUNOPHARMACOLOGY
·
2026
·
IF 5.6
Guan-feng Xu,Ya-Xuan Wang,Hao-fang Wan,Jia-huan Shen,Yong-qi Li,Jie-hong Yang,Yu He,Hai-tong Wan
ISO induces myocardial injury, collagen accumulation, and cardiac fibrosis. • Luteolin alleviates ISO-induced myocardial fibrosis and Ang II-induced endothelial cell injury. • Luteolin inhibits oxidative stress, apoptosis, EndMT, and extracellular matrix remodeling. • Multi-method analysis identifies the ERK1/2-GATA4 axis as a potential target of luteolin. • Blocking ERK1/2 partly abolishes the protective effects of luteolin against myocardial fibrosis. Introduction Myocardial fibrosis is a common pathological feature of cardiovascular diseases and is closely associated with oxidative stress, apoptosis, extracellular matrix remodeling, and endothelial-to-mesenchymal transition (EndMT). Luteolin (Lut), a naturally occurring flavonoid, exhibits cardioprotective properties; however, its anti-fibrotic effects and underlying mechanisms remain unclear. Methods Myocardial fibrosis was induced in rats by subcutaneous isoproterenol injection for 7 days, followed by Lut treatment. Cardiac function was evaluated by echocardiography, while myocardial injury and fibrosis were assessed by histological and molecular analyses. Potential anti-fibrotic targets of Lut were identified using network pharmacology and validated by molecular docking and molecular dynamics simulation. In vitro , HUVECs were stimulated with angiotensin II (Ang II) and then incubated with Lut. Oxidative stress, mitochondrial membrane potential (MMP), apoptosis, and ERK1/2-GATA4 signaling were examined. The involvement of ERK1/2 was further confirmed using the pharmacological inhibitor PD98059. Results Lut significantly improved cardiac function, alleviated myocardial injury, reduced collagen deposition, and attenuated myocardial fibrosis in ISO-treated rats. In Ang II-induced HUVECs, Lut suppressed ROS generation, preserved MMP, and inhibited apoptosis. Mechanistically, Lut activated ERK1/2 and GATA4 phosphorylation, regulated apoptosis-related proteins, and inhibited EndMT by decreasing α-SMA and FSP-1 while restoring VE-cadherin and CD31 expression. These protective effects were partially abolished by PD98059 both in vivo and in vitro . Conclusion Our findings demonstrate that Lut attenuates myocardial fibrosis by regulating oxidative stress, apoptosis, and EndMT, at least in part, via activation of the ERK1/2-GATA4 phosphorylation axis, suggesting its therapeutic potential for myocardial fibrosis.
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高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Peng Ye,Deming Wu,Manye Wang,Yi Wei,Aihua Xu,Xiaoxia Li
A heterogeneous magnetic CuFe 2 O 4 @OMS-2 catalyst was fabricated through a facile solvent-free process using Mn(CH 3 COO) 2 and KMnO 4 in the presence of CuFe 2 O 4 . It was found that the BET surface area of OMS-2 as well as the ratio of low-valent manganese species significantly increased in the hybrid catalyst, due to interactions between CuFe 2 O 4 and the precursor of amorphous manganese oxide . Acid Orange 7 (AO7) and other organic pollutants could be completely degraded by the CuFe 2 O 4 @OMS-2 catalyst within 30 min in the presence of peroxymonosulfate (PMS), while CuFe 2 O 4 and OMS-2 showed no significant activity for the reaction. The hybrid catalyst also exhibited excellent long-term stability and could be easily recovered with the assistance of an external magnetic field. A possible degradation mechanism for the synergistic effects of different valent metal species and reactive radicals was proposed, which involved the electron transfer from Mn(III) or Mn(II) species to PMS with the generation of sulfate and hydroxyl radicals, and from AO7 and Cu(I) in CuFe 2 O 4 to Mn(IV) and Mn(III) to reduce these Mn species.
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高影响因子
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2023
·
IF 2.7
Zhongying Fang,Xiaolong Liang,Lehui Lu,Wei Chen
The electrocatalytic oxidation of urea (EOU) is an important half-reaction in water splitting, urea fuel cells, and urea wastewater treatment. The anions of nickel-based catalysts can be leached severely in the oxidation potential range. Therefore, the influence of anion on the electrocatalytic performance of Ni(OH) 2 /NiOOH for urea oxidation has not been systematically studied. The present experimental results show that the structure reconstruction of catalyst is a complicated process, specifically including deep penetration by alkaline electrolyte, leaching-induced oxidation by phosphorus or sulfur anions, transformation or cracking of the original structure, and formation of an amorphous layer on the surface. The reconstructed NF-NiP x -R or NF-NiS x -R has a three-layer core-shell structure, with a nickel foam skeleton in the innermost layer, an amorphous NiP x or NiS x layer in the middle layer, the outermost layer of oxygen-containing anion (PO x or SO x ) coordinated Ni(OH) 2 . In the prepared catalyst, the Ni(OH) 2 /NiOOH redox is the real catalytic species for the urea oxidation. It is found that the oxygen-containing anion can enhance the catalytic performance of the Ni(OH) 2 /NiOOH redox, and PO x anion has the best enhancing effect. It is found that the urea molecules are oxidized on the electrocatalyst surface mainly through an indirect pathway.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 51
·2308191
·
IF 19
Jianxi Lu,Songbo Chen,Yuling Zhuo,Xinya Mao,Dong Liu,Zhenbo Wang
Hydrogen production through seawater electrolysis faces several challenges, one of which involves the development of electrocatalysts with high catalytic performance. Here, surface amorphization and morphology engineering are combined to design a novel electrocatalyst for highly-efficient hydrogen evolution reaction (HER). The surface-amorphized MoO 2 /Ni 3 (PO 4 ) 2 microcolumns supported on nickel foam (SA-MoO 2 /Ni 3 (PO 4 ) 2 /NF) display remarkable performance with low overpotentials of 34 and 46 mV at a current density of 10 mA cm −2 in 1 m KOH and alkaline seawater, respectively. In addition, the alkaline electrolysis cell (AEC) integrated with SA-MoO 2 /Ni 3 (PO 4 ) 2 /NF as the cathode and Ni foam as the anode achieves a current density of 100 mA cm −2 at 1.87 V in 6 m KOH seawater at 60 °C, superior to that of industrial NiMo electrode as cathode (2.05 V). DFT calculations demonstrate that the surface amorphous layer (MoO x ) improves the hydrogen adsorption energy of sample and reduces the energy barrier of water dissociation. It is found that substantial improvement in catalytic performance stems from the synergistic effect between surface amorphization and unique microcolumn morphology. These findings may provide insights into combining surface amorphization and morphology engineering strategies to enhance catalytic performance and pave the way for the development of highly efficient seawater HER electrocatalysts.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 40
·18818-18824
·
IF 3.3
Yaoxia Yang,Xingwei Guo,Mi Kang,Dangxia Wang,Zhiwang Yang
Developing efficient and inexpensive catalysts for the hydrogen evolution reaction (HER) is critical for the commercial viability of electrochemical sustainable energy technologies. In this study, a La-CoP/Co(OH)2 nanoarray supported on nickel foam (NF) was successfully prepared using the secondary hydrothermal and low-temperature phosphating method. The as-prepared La-CoP/Co(OH)2/NF material exhibited excellent hydrogen evolution performance in 1 M KOH solution. The overpotential of La-CoP/Co(OH)2/NF was 114 mV at the current density of 10 mA cm−2, and the Tafel slope was estimated to be 99 mV dec−1. The decoration of Co(OH)2 nanosheets on La-CoP nanorods with the textured surface not only provides a large surface area and more active sites but also promotes the transfer of electrons between Co(OH)2 and La-CoP, which accelerates the reaction rate and further improve the HER performance of the composite material. Additionally, the fabricated catalyst exhibits good stability and durability in alkaline media. This approach provides a feasible and effective strategy for exploring electrocatalysts with high efficiency and low prices for the electrolysis of water.
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