JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2025
·
IF 3.8
Jimei Xue,Xiaoling Liu,Yuqiu Wang,Hepeng Zhao,Xiaomeng Fan
Oxide ceramic matrix composites (OCMC) have good high-temperature resistance, oxidation resistance, and mechanical properties. However, the microwave absorbing properties of OCMC areinsufficient due to the low dielectric and low loss characteristics of oxide ceramics, so it is urgent to develop a kind of the oxide ceramic matrix with adjustable microstructure and electromagnetic properties. PDC-SiOC ceramics are the optimal oxide ceramics whose component and microstructure can be adjusted by rare earth nitrate modified polysiloxane precursor. For Sc(NO 3 ) 3 modified PDC-SiOC ceramics, rare earth metals not only can react with siloxy groups to form silicates at high temperatures but also can catalyze the formation of SiCnws. Herein, rare earth nitrate modified polysiloxane precursor was pyrolyzed at 900°C, and then annealing at high temperature to form silicate and SiCnws. After annealing at 1400°C, a large amount SiCnws was in situ formed conductive network structure in SiOC ceramic, so the SiOC ceramic with SiCnws had great electromagnetic wave (EMW) absorbing properties, the maximum effective absorption bandwidth (EAB max ) and the minimum reflection coefficient (RC min ) at the thickness of 2.75 mm reach 4.0 GHz and −42.3 dB in X -band, respectively. By the double-layer impedance matching design, the EAB can be effectively improved, which provide a good way for the design and fabrication of OCMC with advanced (EMW) absorbing properties.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
·
2025
·Vol. 39
·期 9
·e70453
·
IF 2.8
Dongfang Hu,Zihui Shen,Xueke Hou,Zhishuai Wan,Xiaoyu Guo,Lingli Chen,Zhihong Yin,Hongmei Ning,Yaming Ge
Florfenicol (FLO), a widely used antibiotic, can cause early embryonic death and impaired angiogenesis. However, the mechanism by which FLO inhibits angiogenesis and its role in FLO-induced embryonic toxicity are not yet fully understood. This study aimed to investigate the effect of FLO on the proliferation and migration of mouse bEnd.3 endothelial cells (bECs) and the underlying mechanism, given the crucial role of endothelial cells in angiogenesis. The results showed that FLO treatment at 7.5–15 μg/mL significantly inhibited proliferation and migration in a time-dependent manner, with stronger effects observed after 48 h compared to 24 h. RNA sequencing analysis identified 1351 genes differentially expressed in response to FLO. Functional analysis indicated that FLO disrupted ATP metabolism, angiogenesis, vasculature development, and actin filament organization. The F-actin cytoskeleton remodeling was morphologically confirmed, and activation of the ROCK/Cofilin signaling pathway was detected. Subsequent experiments demonstrated that pharmacological inhibition of the pathway normalized cytoskeletal rearrangement and promoted angiogenesis, as evidenced by enhanced wound closure and increased cell viability. Our results demonstrated that ROCK-mediated F-actin remodeling plays a crucial role in the FLO-induced inhibition of proliferation and migration in bECs. These findings may explain why FLO inhibited angiogenesis. However, further investigations are necessary to validate our findings in in vivo experiments.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Shao-Kang Ju,Li-Juan Yue,Jian-Yong Yuan,Fei-Long Gong,Ke-Feng Xie,Xuan-Yu Yang,Shao-Ming Fang,Yong-Hui Zhang
Defect sites in heterostructures play a vital role in optimizing interfacial charge separation efficiency and carrier migration behavior, which enhance surface reaction dynamics. However, the effect of defect sites on modulation of electronic structure and oxygen activation is still ambiguous. Herein, we successfully construct in-plane ZnIn 2 S 4 /In 2 O 3 heterostructures by partial in-situ oxidation strategy and the surface properties can be precisely tuned by treating at individual temperatures. Notably, the in-plane ZnIn 2 S 4 /In 2 O 3 heterostructure which is treated in air at 425 °C exhibits outstanding sensing performance towards acetoin (R a /R g = 248.6 for 50 ppm acetoin at 180 °C), a biomarker of Listeria monocytogenes, with rapid response and recovery dynamic (18/183 s), along with excellent reliability and sensing stability. Detailed characterization and DFT calculation indicate that in-plane heterostructures possess numerous grain boundaries, thereby modulating the p-orbitals electronic structure of oxygen atom and promoting the formation of reactive oxygen species (O − (ad)). Moreover, the built-in electric field further also facilitates the electron transfer, further contributing to the enhanced sensing performance for 3-hydroxy-2-butanone.
✓ 已验证
产品关联
DOI
高影响因子
MINERALS ENGINEERING
·
2025
·
IF 5
Na Xue,Yunpeng Zhang,Zongxu Li,Yangge Zhu,Xuejing Liu,Hao Wang,Yimiao Nie,Long Wang
Fluorite often coexists with calcite naturally and the efficient separation of these two minerals has been a long-troubled problem. In this study, the inhibitory action of 3-phosphopropionic acid (3-PPA) in the flotation separation of fluorite from calcite was investigated and its depression mechanism was detailly explored. In single mineral flotation experiments, when the dosage of sodium oleate (NaOL) was 60 mg/L and the dosage of 3-PPA was 90 mg/L at a pH of 7.5, the recovery rates of fluorite and calcite were 92.52 % and 20.51 %, respectively. At this point, in the concentrate obtained from the mixed ore flotation test, the grade and recovery rate of CaF 2 were 76.24 % and 77.78 %, respectively, demonstrating a selective inhibitory effect on calcite. Zeta potential results confirmed that 3-PPA selectively interacted with calcite, impeding the subsequent adsorption of NaOL. Adsorption capacity tests, Fourier transform infrared spectroscopy (FTIR) and atomic force microscope (AFM) tests showed that 3-PPA powerfully and abundantly adsorbed on the calcite through its phosphate and carboxyl groups, while physically adsorbed on the fluorite surface with relatively small adsorption amount. Molecular dynamics (MD) simulations revealed that 3-PPA aggregated on the calcite surface and formed strong chemical and hydrogen bonding interactions with the calcite (1 0 4) surface through its phosphate groups. In contrast, on the (1 1 1) surface of fluorite, 3-PPA was dispersed and the interaction was weak. Therefore, 3-PPA exhibited a selective inhibitory effect on calcite, enabling the separation of fluorite and calcite.
✓ 已验证
产品关联
DOI
高影响因子
Results in Chemistry
·
2025
·
IF 4.2
Worku Lakew Kebede,Molla Tefera,Amogne Wondu,Melesse Ababay,Abrha Berhe,Mengistu Mulu,Atnafu Guadie
Water contamination caused by textile and industrial dyes is currently among the most important issues facing humanity that require urgent attention. Organic pollutants are harmful and can cause cancer in both humans and aquatic life. Even small amounts of these pollutants in water can lead to grave health problems. One promising way to clean up these pollutants is through degradation, using oxysulfide-based photocatalysts. These materials are effective because of their advanced optical and structural properties. The Sn-Mo(O,S) 3 catalysts were prepared through an easy precipitation process conducted at low temperatures. Different techniques were used to examine the catalyst's shape, structure, electrical properties, chemical makeup, and how it interacts with light. The Sn-Mo(O,S) 3 oxy-sulfide nanoparticle was successfully used to break down organic pollutants through photocatalytic processes. Among the samples made, the SMOS-25 catalyst showed the best performance in breaking down methylene blue dye. The effectiveness of the SMOS-25 catalyst was tested by seeing how well they could break down organic dye pollutant when exposed to visible light. The SMOS-25 nanoparticle was able to remove 98.9 % MB dye from water within 105 min under visible light. In this system, the main substance responsible for breaking down the dye is hydroxyl radical ( • OH).
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Energy
·
2025
·
IF 8.6
Xudong Wang,Lei Fu,Yun Huang,Jiepeng Chen,Jiapin Liu,Jie Xiao,Xinyan Xiang,Wenping Zeng,Siming Huang,Xing Li,Mingshan Wang,Bingshu Guo,Yuanhua Lin,Haijun Cao
Sodium super ion conductor (NASICON) structure materials such as Na 3 V 2 (PO 4 ) 3 (NVP) are suitable cathodes for Sodium-ion batteries (SIBs) due to their open three-dimensional structure that can provide fast Na + migration channels. However, low inherent conductivity and capacity restrict the application of NVP. In this paper, NASICON-structured Na 2.25 V 1.25 Ti 0.75 (PO 4 ) 3 @Y (NT 0.75 VP@Y) constructed by yeast with the biological template method is successfully synthesized. Theoretical calculations show that the spherical structure of bio-derived carbon formed after calcination produces a local compressive strain that leads to a uniform distribution of electronic states and stronger adsorption of Na + and NaClO 4 , thus enhancing the electronic and ionic conductivities of the material. NT 0.75 VP@Y exhibits a discharge specific capacity of 135 mAh g −1 at 0.2 C and a capacity retention rate of 94.8 % after 500 cycles. Finally, the full cell and the pouch cell are successfully assembled to verify the practicality of NT 0.75 VP@Y. This paper provides a simple, low-cost, and environmentally friendly way to synthesize high-performance cathode materials for SIBs.
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2013
·
IF 5.437
Yi Huang,Wen Wang,Zou Li,Xiaoli Qin,Lijuan Bu,Zhiyong Tang,Yingchun Fu,Ming Ma,Qingji Xie,Shouzhuo Yao,Jiming Hu
We report here on a facile enzymatic polymerization protocol to prepare enzyme—poly(thiophene-3-boronic acid) (PTBA) polymeric biocomposites (PBCs) for high-performance mono-/bi-enzyme amperometric biosensing. Horseradish peroxidase (HRP)-catalyzed polymerization of thiophene-3-boronic acid (TBA) monomer was conducted in aqueous solution containing HRP (or plus glucose oxidase (GOx)) by either directly added or GO x -glucose generated oxidant H 2 O 2 . The mono-/bi-enzyme amperometric biosensors were prepared simply by casting the dialysis-isolated PBCs on Au-plated Au electrode (Au plate /Au), followed by coating with an outer-layer chitosan (CS) film. The boronic acid residues are capable of covalent bonding with enzyme at the glycosyl sites (boronic acid-diols interaction), which should less affect the enzymatic activity as compared with the common cases of covalent bonding at the peptide chains, and UV–vis spectrophotometric tests confirmed that the encapsulated HRP almost possesses its pristine enzymatic specific activity. The enzyme electrodes were studied by cyclic voltammetry , electrochemical impedance spectroscopy and chronoamperometry in the presence of Fe(CN) 6 4− mediator. The CS/HRP–PTBA/Au plate /Au electrode responded linearly to H 2 O 2 concentration from 1 to 300 μM with a sensitivity of 390 μA mM −1 cm −2 and a limit of detection (LOD) of 0.1 μM. The bienzyme CS/GO x −HRP−PTBA(H 2 O 2 )/Au plate /Au electrode responded linearly to glucose concentration from 5 μM to 0.83 mM with a sensitivity of 75.1 μA mM −1 cm −2 and a LOD of 1 μM, and it is found here that the use of Fe(CN) 6 4− that can only efficiently mediate HRP favorably avoids the “unusual amperometric responses” observed when other mediators that can efficiently turn over both HRP and GO x are used.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY & BIODIVERSITY
·
2024
·
IF 2.3
Yongchang Bi,Jingjun Wang,Xingyu Bian,Mingyue Chen,Guangyuan Zhu,Yumin Zhang,Qiang Gu
An efficient and green method for synthesizing 3-methyl-4-(hetero) arylmethylene isoxazole-5(4 H )-ones was developed using a recyclable and environmental–friendly catalyst, Na 2 S 2 O 3 , and 16 target compounds were successfully synthesized under the obtained optimal reaction condition. Using rifampicin as a positive control, the antibacterial activity of all synthesized compounds was tested by micro dilution method, among them, 3-methyl-4-[(2,4-dimethoxyphenyl) methylene]-isoxazole-5-one ( 4 m ) presented wonderful antimicrobial activity, which may contribute to the development of anti-tuberculosis drugs. Graphical
✓ 已验证
DOI
PubMed
高影响因子
APPLIED THERMAL ENGINEERING
·
2024
·
IF 6.1
Zhao-ran Li,Gao-ning Liang,Yu-dong Ding,Qiang Liao,Xun Zhu,Min Cheng
As an important intermediary between the green energy and human society, the lithium-ion battery has promising prospects in the new energy vehicles, energy storage, and green development fields. However, lithium-ion batteries can generate a large amount of heat during operation. In addition, excess temperature or big temperature difference of the surface of the lithium-ion battery can reduce its performance, which also results in reducing its operational life and even triggers incidents such as fires and explosions. Therefore, studying efficient thermal management methods for lithium-ion batteries is crucial for increasing their application range. This paper proposes a novel thermal management method by combining 3-D finned tubes with PCM. The thermal management system maintains a battery operating temperature less than 45 °C and a maximum temperature difference less than 2.4 °C. The influence of different fin structure parameters on the melting dynamics of PCM and the heat transfer performance is then discussed. The obtained results show that under each solid–liquid ratio of PCM, the heat transfer performance increases with the increases of the fin height, while it initially decreases and then increases with the increase of the width and axial spacing. Moreover, the heat transfer performance of the 3-D finned tube with different PCM liquid–solid ratios is investigated. The obtained results demonstrate that for constant fin parameters, the heat transfer reaches its highest performance for a PCM liquid–solid ratio greater than 2:2. The findings of this study lay a foundation for the design of efficient thermal management systems incorporating PCM applications.
✓ 已验证
DOI
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 47
·22890-22898
·
IF 6.97
Zihua Wu,Yuling Liang,Linqi Cao,Qing Guo,Suju Jiang,Fangfang Mao,Jiarong Sheng,Qi Xiao
Facile synthesis of high quality gold nanorods (AuNRs) with a tunable size is of great value for applications of AuNRs in various fields and for the study of the growth mechanism of such anisotropic nanostructures. However, limitations usually exist in a specific synthetic protocol. In this work, using 3-aminophenol as the reducing agent, we present a AuNR synthetic strategy with an excellent comprehensive performance, which includes an exceptional monodispersity, a AuNR shape purity of around 99%, a conversion ratio of the gold precursor of about 91%, and an easily tuned longitudinal surface plasmon resonance wavelength ranging from 580 to ∼1050 nm. Studies on the impacts of the experimental parameters including silver ions, gold seeds, reducing agent, and cetyltrimethylammonium bromide (CTAB) revealed a profound recognition of the significant effect of the reductive atmosphere, in synergy with other parameters, in directing the growth and structural evolution of the gold seeds, thus deeply affecting the size, shape yield, monodispersity, and morphology of the final structure. These results could be immensely useful for the application and revelation of the growth mechanism of AuNRs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Medicinal Chemistry
·
2023
·Vol. 19
·期 3
·246-262
·
IF 2.3
Lu Jia-Hao,Lai Wu-Ji,Jiang Li-He,Lei Fu-Hou,Shen Li-Qun,Wu Ai-Qun
Survivin is an important member of the antiapoptotic protein family and controls the cell’s life cycle. Overexpression of survivin in tumor cells leads to inhibition of apoptosis, thus contributing to cancer cell proliferation. The largest binding pocket in the survivin dimer
was located in the BIR domain. The key to the efficacy of 3-cyanopyridines was their surface interaction with the survivin amino acid Ile74. Methods: Through the optimization of the 3-cyanopyridine, 29 new compounds with a 3- Cyanopyridine structure were designed, synthesized, and characterized
by NMR, IR, and mass spectrometry. The antitumor activity of the compounds in vitro was detected by the MTT method. Results: In vitro anti-tumor experiments showed that some compounds exhibited good anti-cancer effects. The IC50 values of the compound 2-amino-6-(2,4-difluorophenyl)-4-(4-hydroxyphenyl)
nicotinonitrile (10n) against human liver cancer (Huh7), human glioma (U251), and human melanoma (A375) cells were 5.9, 6.0 and 7.2 μM, respectively. The IC50 values of the compound 6-(2,4-difluorophenyl)- 4-(4-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
(9o) against Huh7, U251 and A375 cells were 2.4, 17.5 and 7.2 μM, respectively, which were better than those of 10- hydroxycamptothecin and 5-fluorouracil. Analysis of the results of molecular dynamics simulation established that the BIR domain is the optimal binding site on the survivin
protein, and the fingerprints of the eight most active compounds and the molecular docking to the survivin protein are analyzed. Conclusion: 3-Cyanopyridine is an excellent backbone for antitumor lead compounds, 10n and 9o, as derivatives of 3-Cyanopyridine are excellent survivin protein-targeting
inhibitors worthy of further study. The key factor in inhibiting survivin protein through the action of amino acid Ile74.
✓ 已验证
DOI
PubMed
高影响因子
Analytical Methods
·
2021
·Vol. 13
·期 14
·1757-1765
·
IF 2.896
Can Zhang,Xiaoxiao Wu,Dongyang Li,Jinnuo Hu,Debin Wan,Zhen Zhang,Bruce D. Hammock
As a major metabolite of pyrethroid pesticides, 3-phenoxybenzoic acid (3-PBA) can be an indicator of health risk and human exposure assessment. Based on nanobodies (Nbs), we have developed a rapid flow-through dot enzyme linked immunosorbent assay (dot ELISA) and gold nanoparticle (GNP) lateral-flow immunoassay for detecting 3-PBA. The limit of detection (LOD) values for detecting 3-PBA by flow-through dot ELISA and GNP lateral-flow immunoassay were 0.01 ng mL−1 and 0.1 ng mL−1, respectively. The samples (urine and lake water) with and without 3-PBA were detected by both nanobody-based flow-through dot ELISA and GNP lateral-flow immunoassay, as well as liquid chromatography-mass spectrometry (LC-MS) for validation. There was good consistency between the results of the immunoassays. This demonstrated that the two developed nanobody-based immunoassays are suitable for rapid detection of 3-PBA.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）