RSC Advances
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2016
·Vol. 6
·期 37
·31101-31106
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IF 3.289
Ailing Hui,Shijing Zhu,Huayang Yin,Li Yang,Zheng Zhang,An Zhou,Jian Pan,Wencheng Zhang
A series of ginkgolide B derivatives (GBD) were designed for delivery of ginkgolide B (GB) across the blood–brain barrier to the brain. Three GBD had shown considerable brain-targeting ability in our previous study. Among them, the ginkgolide B pyrazine (PGB) derivative was selected as a promising novel GB derivative because of its highest brain distribution. Further investigations with regard to PGB and GB's effects on inhibiting the expression of P-gp and attenuating the efflux function of P-gp were reported in this study. They were considered a big step towards better understanding the relationship between GBD's brain-targeting behavior and P-gp regulation. Western blot analysis indicated that PGB was more effective in inhibiting the expression of P-gp than GB in rat brain microvessel endothelial cells (rBMECs) and rat cerebral cortexes and hippocampus. Moreover, the efflux function of P-gp via the transportation of rhodamine 123 was significantly inhibited in PGB-treated rat brains. Preventive medication with PGB induced a better protection of the integrity of the BBB in incomplete ischemia mice. Our findings revealed that an attenuated expression level and efflux function of P-gp and improved protective effect could be realized by the ginkgolide B derivative. These investigations will pave the way for designing more efficient brain-targeting derivatives of ginkgolide and some other central nervous system drugs.
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Journal of Analytical Methods in Chemistry
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2016
·
IF 1.369
Lin Liu,Lu Chen,Jiangong Liang,Lingzhi Liu,Heyou Han
A ratiometric probe for determining ferric ions (Fe3+) was developed based on nitrogen-doped carbon dots (CDs) and rhodamine B isothiocyanate (RhB), which was then applied to selective detection of Fe3+ in PB buffer solution, lake water, and tap water. In the sensing system, FePO4 particles deposit on the surface of CDs, resulting in larger particles and surface passivation. The fluorescence (FL) intensity and the light scattering (LS) intensity of CDs can be gradually enhanced with the addition of Fe3+, while the FL intensity of RhB remains constant. The ratiometric light intensity of CDs LS and RhB FL was quantitatively in response to Fe3+ concentrations in a dynamic range of 0.01–1.2 μM, with a detection limit as low as 6 nM. Other metal ions, such as Fe2+, Al3+, K+, Ca2+, and Co2+, had no significant interference on the determination of Fe3+. Compared with traditional probes based on single-signal probe for Fe3+ detection, this dual-signal-based ratiometric probe exhibits a more reliable and stable response on target concentration and is characterized by easy operation in a simple fluorescence spectrophotometer.
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CHINESE JOURNAL OF CHEMISTRY
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2017
·Vol. 35
·期 7
·1109-1116
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IF 1.852
Naixu Li,Jun Yin,Lingfei Wei,Quanhao Shen,Wei Tian,Jing Li,Yong Chen,Jing Jin,Hongcheng Teng,Jiancheng Zhou
We fabricate a novel cellulose acetate (CA) ultrafiltration membrane modified by block copolymer F127-b- PDMAEMA, which is synthesized using F127 and DMAEMA via the ARGET ATRP method. Compared to conventional ultrafiltration membranes, the incorporation of both F127 and PDMAEMA can not only readily increase the hydrophilicity of the membrane, but also exhibit stimuli-responsiveness to temperature and pH. Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (NMR), and gel permeation chromatography (GPC) are employed to analyze the structure of the F127-b-PDMAEMA. The membrane properties are evaluated via scanning electron microscope (SEM) imaging, porosity test, automatic target recognition Fourier transform infrared spectroscopy (ATR-FTIR), water contact angle test and permeation test. The results indicate that the F127-b-PDMAEMA is an excellent pore agent, which contributes to an enhancement of the membrane in sensitivity to temperature and pH. The modified membrane also exhibits lower water contact angle (64.5°), which is attributed to the good anti-fouling performance and high water permeation.
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JOURNAL OF HAZARDOUS MATERIALS
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2024
·
IF 12.2
Xin Mao,Junlong Cai,Fazhi Xie,Pengwei Yan,Bin Liu
Catalytic oxidation pretreatment is a significant focus in the field of membrane fouling control; however, traditional catalytic materials are plagued by limitations in catalytic sites and challenges in recovery. In this study, a novel catalyst, B-doped NiFe 2 O x , was prepared with magnetic recovery capabilities and abundant oxygen vacancies to address landfill leachate treatment and mitigate membrane fouling. The results demonstrated the efficient activation of persulfate (PS) by the catalytic sites on B-NiFe 2 O x , which significantly degraded the complex organic pollutants like conjugated double bonds and aromatic compounds in landfill leachate. A large amount of humic acid and soluble microbial products in the landfill leachate were efficiently degraded upon contact with sulfate and hydroxyl radicals produced by B-NiFe 2 O x /PS, thereby resulting in achieving a chemical oxygen demand removal efficiency of up to 72 % and more than a twofold enhancement in filtration flux. Moreover, the characteristics of the fouled layer reveal that the B-NiFe 2 O x /PS system facilitated the formation of a porous cake layer, maximizing the retention of functional groups on the NF270 membrane surface. Notably, a minor presence of B-NiFe 2 O x is uniformly distributed within the cake layer, indicating the in-situ occurrence of weak catalytic oxidation reactions. This study provides an effective and innovative approach utilizing catalytic oxidation for membrane fouling control.
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Surfaces and Interfaces
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2024
·
IF 5.7
Kuo Yang,Yun Yang,Yifan Jiang,Bingjie Ye,Luowei Li,Wenju Liu,Tong Yan,Wei Li,Shixi Liu
s In this study, a flower-shaped Bi 2 S 3 /g-C 3 N 4 heterostructure was synthesized via a hydrothermal method and utilized as a visible-light-driven photocatalyst for the removal of hexavalent chromium (Cr 6+ ) and Rhodamine B (RhB). Employing an interface electronic engineering strategy with heterostructure nanosheets, the thickness of the nanosheets was adjusted by varying the molecular weight of the structure guiding agent, polyethylene glycol (Mn = 400, 2000 or 4000). Under visible light irradiation for 18 and 60 minutes, the removal efficiencies of Cr 6+ and RhB reached 95.0 % and 99.9 %, respectively, with corresponding rate constants being 8.64-fold and 9.67-fold higher than pure Bi 2 S 3 . The enhanced photocatalytic efficiency may be attributed to the intermediate adsorption states and increased active sites enhancing light absorption and charge separation. Furthermore, species capture studies revealed that electrons (e - ) and superoxide radicals (·O 2 - ) played crucial roles in the reduction of chromium (VI), while holes (h + ) were the primary active species involved in RhB degradation. Density-functional theory (DFT) calculation demonstrated charge redistribution and electron accumulation can be more obviously observed at Bi 2 S 3 /g-C 3 N 4 than Bi 2 S 3 , which proved that g-C 3 N 4 doping effectively improved the electrons transfer efficiency over the Bi 2 S 3 /g-C 3 N 4 surface, thereby enhancing the photocatalytic activity.
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Nanomaterials
·
2024
·
IF 4.4
Fangqin Liu,Mingjie Fan,Xia Liu,Jinyang Chen
A cellulose-based carbon aerogel (CTN) loaded with titanium dioxide (TiO 2 ) and graphitic carbon nitride (g-C 3 N 4 ) was prepared using sol–gel, freeze-drying, and high-temperature carbonization methods. The formation of the sol–gel was carried out through a one-pot method using refining papermaking pulp, tetrabutyl titanate, and urea as raw materials and hectorite as a cross-linking and reinforcing agent. Due to the cross-linking ability of hectorite, the carbonized aerogel maintained a porous structure and had a large specific surface area with low density (0.0209 g/cm 3 ). The analysis of XRD, XPS, and Raman spectra revealed that the titanium dioxide (TiO 2 ) and graphitic carbon nitride (g-C 3 N 4 ) were uniformly distributed in the CTN, while TEM and SEM observations demonstrated the uniformly distributed three-dimensional porous structure of CTN. The photocatalytic activity of the CTN was determined according to its ability to degrade rhodamine B. The removal rate reached 89% under visible light after 120 min. In addition, the CTN was still stable after five reuse cycles. The proposed catalyst exhibits excellent photocatalytic performance under visible light conditions.
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ACS Omega
·
2024
·
IF 3.7
Xinde Jiang,Zhuoru Tan,Guixian Jiang,Chang Liu,Guiqing Gao,Zhanmeng Liu
A magnetic MnFe2O4-modified graphite-like porous biochar composite (MnFe2O4/KFS800) was synthesized by the hydrothermal method, and its catalytic activity was evaluated in the activation of peroxydisulfate toward degradation of Rhodamine B. After characterization by SEM, XRD, and the BET method, the specific surface area and total pore volume of the MnFe2O4/KFS800 catalyst reached 121 m2/g and 0.263 m3/g, and exhibited plate-like morphology with good crystallinity. The degradation rate of Rhodamine B by the obtained composite was more than 91.1% when the initial concentration of RhB was 10 mg/L, the dosage of MnFe2O4/KFS800 was 0.2 g/L, and the initial pH was 6.7. Then the anti-interference ability of the obtained composite was studied, and it was found that there was a little effect on the degradation of Rhodamine B with the presence of humic acid. Finally, quenching test, EPR research, and XPS analysis were conducted to reveal the catalytic mechanism, and possible mechanism was a synergistic behavior of free radicals (SO4•–, •OH, O2•–) and nonfree radicals (1O2), and trace amounts of uncarbonized bagasse was also involved in the formation of free radicals.
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NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 4
·2857-2864
·
IF 3.201
Chunxi Zhao,Yang Jiao,Lei Zhang,Yaling Yang
Herein, we report a fast and selective technique for the determination of diethylstilbestrol in milk sample using fluorescent sulfur and boron co-doped carbon dots (S,B co-doped CDs). The S,B co-doped CDs were synthesized by hydrothermal synthesis using poly(sodium-p-styrenesulfonate) and borax as precursors. The as-prepared S,B co-doped CDs possess good stability and fluorescence characteristics and exhibit a fluorescence quantum yield of 25.7%. The fluorescence intensity of the S,B co-doped CDs decreased in the presence of diethylstilbestrol, and a good linear relationship existed between the fluorescence quenching and different concentrations of diethylstilbestrol in the range of 0.1–200 μM with a detection limit of 0.06 μM. Finally, the S,B co-doped CDs were successfully applied in the detection of diethylstilbestrol in milk samples, yielding recoveries between 90.4% and 109.2%.
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Materials Research Express
·
2018
·Vol. 5
·期 3
·035510
·
IF 1.151
Wenxia Wang,Qi He,Kaijun Xiao,Liang Zhu
In the study, a two-major step involving a hydrothermal method and an electrostatic self-assembly method was adopted to synthesis Fe3O4/GO nanocomposites. The Fe3O4 nanoparticles were successfully modified with the 3-aminopropyltrimethoxy-silane and homogeneously deposited onto the surface of GO. They were used as Fenton-like catalyst to degrade Rhodamine B and displayed a higher activity compared with the pristine Fe3O4 nanoparticles, H2O2, Fe3O4/GO nanocomposite and Fe3O4/H2O2 system, demonstrating the synergistic effect between the superior adsorption properties of GO and the excellent catalytic activity of Fe3O4/H2O2 system. Besides, the possible catalytic mechanism and degradation pathway for RhB molecules by Fe3O4/GO nanocomposites and H2O2 was proposed based on the liquid chromatography-mass spectrometry (LC-MS) analysis. The result reveals that the •OH radicals should be the main actives species during catalytic degradation of RhB by the Fe3O4/GO/H2O2 system. In addition, the catalyst is reusable and shows efficiency up to 5 cycles. We believe the strategy in our work can provide insight into designing the novel catalysts for large-scale degradation of organic pollutants in the wastewater.
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Inorganic Chemistry Frontiers
·
2018
·Vol. 5
·期 4
·827-834
·
IF 5.106
Yueyun Fang,Qizhang Huang,Pengyi Liu,Jifu Shi,Gang Xu
Molybdenum disulfide (MoS2) nanoflowers synthesized by a hydrothermal route were successfully grafted on a melamine-formaldehyde sponge through a facile dip-coating method to form MoS2 nanoflowers sponges. The MoS2 sponges exhibited high-efficient adsorption performance to cationic dye, Rhodamine B (RhB), with a maximum adsorption capacity of 104.78 mg RhB g−1 product (equal to 213.84 mg RhB g−1 MoS2 by conversion) within 60 min, which was primarily attributed to the strong electrostatic interactions between electronegative MoS2 nanoflowers and positively charged RhB molecules. The equilibrium adsorption and kinetics data fitted well with the Sips isotherm model and the pseudo-second-order kinetic model, respectively. The recyclability experiments showed that the MoS2 sponge adsorbent could be reused for 10 times with above 86.7% of the adsorption capacity retained. More remarkably, the as-prepared sponge adsorbent can be separated from the dye solution easily through a simple salvage instead of any tedious centrifugation or filtration processes. Thus, the separable MoS2 sponge adsorbent with remarkable adsorption capacity and excellent reusability for organic dyes shows promise for large scale water remediation in the future.
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JOURNAL OF IMMUNOLOGY
·
2024
·
IF 3.6
Gao Along,Lin Yuhua,Chai Yiwen,Han Jugan,Wu Liting,Ye Jianmin
Chemokines play crucial roles in the regulation of immune cell migration and development. The CXCL12/CXCR4 axis has been extensively studied in mammals, but its regulatory mechanism in teleost fish remains unclear. In this study, we used Nile tilapia (Oreochromis niloticus) as a teleost model to investigate the mediation of the CXCL12/CXCR4 axis in IgM+ B cells. Our findings demonstrate that the CXCL12/CXCR4 axis exhibits chemotactic activity on IgM+ B cells and promotes the phagocytosis of IgM+ B cells. Blocking CXCR4 severely impairs the chemotaxis and phagocytosis of IgM+ B cells in vitro and reduces the percentages and numbers of IgM+ B cells that migrate to peripheral blood after pathogen infection in vivo. This reduction in migration leads to a decrease in the inflammatory response, an increase in tissue bacterial load, and a decrease in survival rate. We also discovered that the evolutionarily conserved PI3K-AKT signaling pathway and Girdin are involved in the immune response during Streptococcus agalactiae infection. Inhibitors of the PI3K-AKT signaling pathway prevent the chemotaxis and phagocytosis of IgM+ B cells, impair the expression and phosphorylation levels of related proteins in vitro, and prevent IgM+ B cells chemotaxis into the peripheral blood after pathogen infection in vivo. Furthermore, CXCR4 blocking significantly downregulates the expression of AKT and Girdin. Overall, our study reveals the regulatory mechanism of the CXCL12/CXCR4 axis on IgM+ B cells via the PI3K-AKT signaling pathway in tilapia, suggesting that the functions of the CXCL12/CXCR4 axis in B cells may be conserved between mammals and teleost fish.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Chen-Xuan Li,Rui Wang,Wen Sun,Kangping Cui,Xian-Zhong Fu,Minshu Cui,Yihan Chen,Zhi Guo,Yingying Liu
Advanced oxidation systems (AOS) hold promise for tackling refractory dyes in wastewater, yet the quest for efficient systems tailored to the degradation of dye remains a formidable hurdle. Here, a novel visible-light-driven AOS, consisting of biomimetic Fe(III) salen complex (FeL, salen= N, N-bis(salicylidene)ethylenediamine) and peroxymonosulfate (PMS), was proposed for highly efficient degradation of Rhodamine B (RhB), a model dye. The proposed AOS was capable of degrading 94.8 % RhB in 40 min, outperforming the typical Fe 3+ -based system, which achieved only 52.6 % pollutant degradation under identical conditions. As indicated by experimental results and theoretical calculations, the unique Fe-N 2 O 2 coordination structure of FeL facilitated the adsorption of terminal O (O3) at PMS site, thereby enhancing the heterolysis of the O-O bond and generating high-valent iron-oxo species (i.e., Fe Ⅴ =O) rather than radicals (SO 4 •− , HO • ). The system demonstrated robust resistance to interference from environmental anions (Cl − , NO 3 − , HCO 3 − , SO 4 2− ), pH variations (initial pH 3.0–11.0) and humic acid . More attractively, it achieved 87.3 % chroma and 37.6 % chemical oxygen demand (COD) removal in real dye wastewater samples. This work may shed light on the understanding and development of biomimetic Fe complexes-based AOS for wastewater treatment .
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