FOOD CONTROL
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2026
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IF 7
Yangchun Ge,Zhuochao Shen,Yuying Xie,Jiangkuan Tang,Haohua Zhang,Yupeng Qiu,Xuqiang Peng,Lanlan Zhai,Zhongyu Li
This study reports the rational design and fabrication of an intelligent, self-healing hydrogel tailored for fruit preservation via the dynamic cross-linking of chitosan (CS) with a synthesized phenylboronic acid-based crosslinker (DMSA-PBA). The strategic introduction of dynamic boronate ester bonds as the key crosslinking nodes is pivotal, granting the material not only rapid gelation (<60 s) and autonomous self-healing capabilities but also dual responsiveness to pH and reactive oxygen species (ROS). The resulting hydrogel network exhibits a suite of exceptional properties: superior mechanical robustness, a high swelling ratio (∼1000%), and outstanding water vapor barrier performance. Furthermore, the inherent synergistic antibacterial activity, stemming from the chitosan and the DMSA-PBA components, was confirmed. When evaluated as a protective coating on mangoes, this multifunctional hydrogel significantly delayed quality deterioration during ambient storage, effectively reducing weight loss and decay incidence while maintaining firmness and acidity. This work underscores the immense potential of dynamic covalent chemistry in designing advanced coatings for sustainable food preservation, presenting a feasible and eco-friendly strategy grounded in a well-defined material design.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Jing Zhang,Yiming Chen,Wenya Meng,Huifang Liu,Jing Li,Long Yu,Ping Dong
The biomedical potential of chitosan (CS) in wound healing is constrained by poor solubility and processability. Herein, we report a green and efficient route to synthesize water-soluble sulfated chitosan (SCS) with controlled sulfation patterns, using a sulfamic acid-urea deep eutectic solvent (DES). Comprehensive characterization (FTIR, 13 C and HSQC NMR, HPSEC-MALLS-RI, and elemental analysis) verified tunable sulfation and molecular weights, with zeta potential further delineating the corresponding surface properties. Biological evaluations demonstrated that SCS possesses excellent biocompatibility, promotes cell migration, enhances TGF-β1/VEGF secretion, and facilitates angiogenesis, collagen deposition, and extracellular matrix remodeling. Structure-activity analysis revealed sulfation patterns determined bioactivity, with 6-O-sulfated SCS demonstrating superior wound closure rates (96.2% in 6-O-SCS vs. 88.6% in control group on 12 day post-treatment). This study provides a sustainable approach to SCS production and highlights its therapeutic potential in wound management.
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PubMed
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APPLIED CLAY SCIENCE
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2026
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IF 5.2
Nan Liu,Xu Zhang,Xuemei Sun,Na Meng,Bingnan Du
Traditional wound dressings lack antibacterial properties and may cause wound damage during dressing changes, impairing healing. Therefore, single-function dressings cannot meet the multifaceted requirements of modern wound healing processes. This study successfully prepared a Cu 2 O/PDA-MMT by loading cuprous oxide nanoparticles (Cu 2 O NPs) onto polydopamine (PDA)-modified montmorillonite (MMT), which was then incorporated with chitosan (CS)/polyvinyl alcohol (PVA) via a one-step blending method to fabricate CS/PVA/Cu 2 O/PDA-MMT hydrogels. Characterization techniques including XRD, FTIR, TG, and SEM confirmed the successful preparation of the material, while systematic evaluation demonstrated its physicochemical properties such as gel fraction, porosity, and mechanical performance. Antimicrobial experiments, cell compatibility tests, mouse tail-amputation hemorrhage models, and full-thickness skin wound infection models demonstrated that the 1% CS/PVA/Cu 2 O/PDA-MMT hydrogel not only exhibited over 95% antimicrobial inhibition rates against both test bacterial strains but also possessed excellent biocompatibility. It significantly reduced blood loss in rat tail hemorrhage models. When treating full-thickness skin wounds, this hydrogel effectively controlled infection, accelerated healing, achieved a wound healing rate exceeding 97% by day 12, and promoted tissue regeneration. These outstanding properties position it as a wound dressing material with significant clinical application potential.
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高影响因子
Biomolecules
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2026
·Vol. 16
·期 8
·1140
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IF 5.6
Xinyu Lyu,Xiaotong Xu,Mengqi Shi,Rui Wang,Xiaoqing Yu,Yan Liu,Xiangyu Xue,Fengmin Zhang,Xiuhong Wang
Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by immune dysregulation, microbiota imbalance, and intestinal barrier damage. Unconjugated bilirubin (UCB) shows promise in treating UC due to its anti-inflammatory properties but is limited by poor solubility and potential toxicity. This study developed a chitosan-based controlled-release microsphere (CBMS) treatment to overcome these issues. CBMS utilizes the mucoadhesive properties of chitosan to achieve targeted, controlled UCB release in the colon, enhancing its stability and bioavailability. In a DSS-induced UC mouse model, CBMS alleviated clinical symptoms, reduced colon shortening, and improved histological outcomes, including reduced inflammation and enhanced mucosal repair. The mechanism involves CBMS retention in the intestinal lumen, UCB inactivation of digestive proteases, and restoration of microbiota balance, suppressing pro-inflammatory pathways. CBMS offers a promising new therapeutic strategy for UC and insights into polysaccharide-based drug delivery systems.
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高影响因子
EUROPEAN POLYMER JOURNAL
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2026
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IF 6.8
Jingjing Ning,Jie Hu,Qing Li,Chen Xu,Su Chen
Hydrogel is increasingly appreciated as a reliable dressing for wound repair and regeneration due to the established favorable microenvironment for healing. Thus, hydrogel with multiple synergistic functions are of particular interest in biomedicine. Herein, we develop a double network hydrogel with low swelling property, outstanding adhesive capacity, good biocompatibility, excellent anti-bacterial and ROS scavenging capacity, which shows potential for accelerating wound healing. Quaternized chitosan serves as the first network to endow the hydrogel with anti-bacterial capacity (75.18% for E. coli and 93% for S. aureus ). Zwitterionic monomer is copolymerized with acrylic acid to form the second network, which improves the mechanical properties and reduces the swelling behavior (ultralow swelling ratio of 2.42%). Tannic acid and dihydrocaffeic acid contribute excellent tissue adhesion (adhesion strengths of 124.4 kPa to pig skin) and antioxidant capacity (ROS scavenging rate of 96%). Based on these advantages, the hydrogel greatly facilitates the wound closure, as well as promotes epithelialization, collagen deposition and neovascularization.
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CHEMICAL ENGINEERING SCIENCE
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2026
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IF 5.1
Ju Lv,Lang Pan,Yawei Zhu,Xinyue Zhang,Xueqiong Yin
Conventional solar evaporators often suffer from salt accumulation, biofouling, and structural instability, limiting their practical use in sustainable freshwater production. Herein, a lightweight, self-floating chitosan/polyvinyl alcohol/genipin aerogel (CPG) was developed through an eco-friendly, photosensitizer-free crosslinking and aerogelation strategy for solar-driven desalination and wastewater purification. The optimized CPG aerogel combines broadband optical absorption of 97 %, robust mechanical stability, and an interconnected macroporous network, enabling rapid water replenishment, vapor transport, and salt rejection. Under 1 sun irradiation, CPG achieved a high evaporation rate of 3.85 kg·m −2 ·h −1 and maintained stable performance in hypersaline brine containing 25 wt% NaCl. During real seawater desalination, the evaporation–condensation process effectively rejected non-volatile ions, producing purified water that met WHO drinking water standards. CPG also generated dye-free condensates from dye-containing wastewater through distillation separation and interfacial retention, rather than direct dye degradation. In addition, the aerogel exhibited stable evaporation performance across pH 2–12 and light-enhanced antibacterial activity with > 99.9 % bacterial inactivation. This integrated self-floating aerogel design provides a promising platform for durable solar desalination and wastewater purification.
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高影响因子
Journal of Bioresources and Bioproducts
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2026
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IF 19.9
Yusi Bu,Guoxi Xia,Minglei Zhang,Jiabo Wang,Qiuhua Chen,Guoxiang Wang,Xiaolian Shi,Fang Sui
The development of robust biomimetic interfaces remains challenging due to the inherent instability of native cell membranes when integrated into functional devices. Herein, we reported a bio-based functional composite in which a chitosan-derived conductive hydrogel served as a multifunctional matrix to achieve unprecedented stabilization of red blood cell membranes (RBCMs). Leveraging the three-dimensional polycationic network and abundant amino groups of this natural polysaccharide, the hydrogel electrostatically anchored RBCMs while preserving their native fluidity and membrane-bound acetylcholinesterase conformation-overcoming a long-standing bottleneck in biomembrane-based material engineering. Integration of carboxylated multi-walled carbon nanotubes endowed the composite with efficient electron transfer capability without compromising biocompatibility. The resulting biomimetic interface retained 85.8% of its initial electrochemical response after 7 days of continuous operation and enabled sensitive detection of organophosphate pesticides in real agricultural samples (apples, oranges, and tomatoes). This work established chitosan hydrogel as a versatile bio-based platform for constructing stable biomembrane composites, expanding the application scope of natural polysaccharides in functional material design for environmental monitoring.
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高影响因子
ACS Biomaterials Science & Engineering
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2026
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IF 6
Weng Sheji,Lin Zhongqin,Tan Kai,Long Zhengyang,Yang Lei,Chen Bin,Zhang Qin,Chen Weikai
Conventional wound dressings often fail to integrate rapid hemostasis, antibacterial protection, and a pro-regenerative microenvironment, leading to persistent infection and delayed healing in complex wounds. Herein, we report a multifunctional self-adhesive hydrogel for integrated hemostatic, antibacterial, and regenerative wound management with a synergistic dual-crosslinked network. The hydrogel is composed of methylacrylamide-modified type I collagen (ColMA), o -nitrobenzene-modified hyaluronic acid (HANB), and methylacrylamide-modified chitosan (CSMA), and can rapidly form in situ under UV irradiation through free-radical polymerization of methacrylamide groups and Schiff base reactions between HANB and amino groups on ColMA/CSMA. Once applied to infected wounds, the hydrogel rapidly seals the wound bed and adheres tightly to the tissue, where HANB contributes hemostatic and adhesive properties, CSMA provides intrinsic antibacterial activity to inhibit bacterial colonization, and ColMA offers extracellular matrix-mimicking cues to support cell adhesion and tissue regeneration. Through this coordinated mechanism, the hydrogel not only controls bleeding and reduces infection risk at the early stage but also promotes the growth of granulation tissue, re-epithelialization, and matrix reconstruction during the subsequent repair phase. This platform integrates wound closure, antibacterial defense, and tissue regeneration into a single dressing system, acting as a promising strategy for the treatment of infected wounds.
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PubMed
高影响因子
FOOD HYDROCOLLOIDS
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2026
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IF 13.8
Wei Wan,Aijun Jian,Lingyi Gao,Jiaxuan Qu,Xiaokang Na,Ming Du,Jianyu Zhu,Beiwei Zhu,Chao Wu
Orchestrating hierarchical protein assembly is pivotal for tailoring plant-based food textures. This study elucidates a skeleton-filler mechanism by modulating chitosan oligosaccharide (COS) chain length during preheated soy protein isolate gelation. Spectroscopic and microscopic analyses revealed that long-chain COS induced substantial unfolding, increasing ordered β-sheets to 59.2% and promoting denser aggregate assembly. Critically, analyses of ultracentrifugation fractions confirmed that long-chain COS facilitated the formation of disulfide-crosslinked large aggregates (LAs). These LAs, serving as rigid skeletons, exhibited larger hydrodynamic radii but reduced surface hydrophobicity due to hydrophilic COS shielding, while small aggregates acted as interstitial fillers. This architectural optimization accelerated mesoscopic dynamics and elevated the storage modulus by 2.3-fold. Furthermore, low-field nuclear magnetic resonance and magnetic resonance imaging demonstrated restricted water mobility within this dense network, evidenced by a shortened relaxation time of immobilized water (shifted to 166 ms). These findings confirm that manipulating COS chain length regulates aggregate subpopulations, offering a targeted strategy for fabricating mechanically robust plant protein gels.
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Journal of Functional Biomaterials
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2026
·Vol. 17
·期 4
·177
·
IF 5.9
Jingwen Yang,Zihao Zhao,Zengtao Song,Lei Cao,Xifan Mei,Xing Zhang
Segmental bone defects are large, non-healing injuries characterized by insufficient structural support and limited bioactivity, posing a significant clinical challenge. In this study, we developed biomimetic chitosan/polyvinyl alcohol–glycerol (CS/PG) scaffolds inspired by porcupine quills, which were fabricated via fused deposition modeling and unidirectional freeze casting. The as-prepared scaffold featured a dense outer layer of polyvinyl alcohol–glycerol (PG) with high compressive strength (24.21 ± 0.11 MPa at 25% strain) and an oriented inner foam of chitosan (CS). The CS foam was further incorporated with poly (3,4-ethylenedioxythiophene) polystyrene sulfonic acid (PEDOT:PSS, denoted as PP) and amorphous zinc phosphate (AZP) to form PP-AZP-CS/PG, aimed at enhancing neural conductivity and stimulating blood vessel formation, respectively. The in vitro results indicated that the biomimetic scaffolds exhibited excellent biocompatibility while significantly enhancing angiogenesis and osteogenesis capabilities. In a rabbit radial segmental defect model, PP-AZP-CS/PG achieved robust bone regeneration, attaining a bone volume/total volume of approximately 26.22% after implantation for 8 weeks. Overall, this biomimetic scaffold demonstrated that integrating hierarchical design with additional bioactive components enhanced mechanical support while promoting new bone regeneration, addressing critical challenges in segmental bone defect repair.
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PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 4
·169
·
IF 3.5
Pan Chang,Miao Yanting,Zhai Guangchao,Zhou Xinyue,Xing Zheng
Hydrogels possess high water content, tunable mechanical properties, and excellent biocompatibility, making them promising candidates for surface protective materials for jade artifacts. However, the rapid dehydration rate and inherent brittleness of traditional hydrogels restrict their widespread application in the protection of fragile cultural relics. Herein, polyacrylamide/chitosan (PAM/CS) dual-network hydrogels with enhanced water retention, adhesion, and toughness were fabricated by the introduction of aluminum ions (Al 3+ ) and ethylene glycol (EG). The Al 3+ ions form coordination cross-links with the polymer network, while the EG molecules reconstruct the hydrogen bonding system, significantly improving the moisture-locking capability and mechanical stability of the hydrogel. The optimized PAM/CS hydrogel exhibited a maximum lap shear strength of 23.2 kPa on metal substrates and maintained excellent flexibility and transparency at -20 °C. Furthermore, the modification with EG endowed the hydrogel with superior anti-drying properties and high toughness, effectively addressing the issues of desiccation and cracking. Finally, the hydrogel was applied as a fully wrapping coating for fragile Xiuyan jade artifacts, demonstrating remarkable capabilities in moisturizing, buffering against impact from a 2-meter free fall, and removing surface dust. Consequently, this study not only promotes the broader use of hydrogels in artifact conservation but also offers a feasible solution for the effective protection of other soft jade materials, holding profound significance for the inheritance of Chinese jade culture.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Shibing Shi,Xin Lu,Hongni Chen,Jian Li,Zhanguo Li,Mengfei Gao,Xin Gao,Yaping Zhang,Junfang Yan,Yi Wang
A green chitosan/gelatin hydrogel was developed via a facile one-pot strategy without chemical crosslinkers. • The hydrogel achieved >90% uranyl removal on non-porous surfaces and 70.7% on porous cement. • Synergistic chemisorption (–NH₂/–COOH) and physical encapsulation (gelatin 3D network) enable high decontamination. In recent years, the expansion of nuclear energy infrastructure has intensified demand for efficient surface decontamination technologies. Hydrogels have emerged as promising candidates for surface decontamination owing to their high radionuclide removal efficiency and compatibility with heterogeneous substrate geometries. In this study, a natural polymer hydrogel based on chitosan and gelatin was developed, achieving high removal rates of uranyl contaminants from various substrates. The hydrogel exhibits advantages including a facile one-pot synthesis, biodegradability, and compliance with green chemistry principles. Glycerol was introduced as a plasticizer to enhance film flexibility and crack resistance, while titanium dioxide (TiO 2 ) nanoparticles were incorporated as rigid nanofillers to reinforce the mechanical strength of the gel network. Rheological characterization revealed that the precursor solution exhibits shear-thinning behavior, facilitating uniform application onto contaminated surfaces via brushing or spraying. High strength, high toughness, and high removal efficiencies can be achieved simultaneously by optimizing the concentration, temperature, and decontamination time during material design. Decontamination efficiencies reached 99.4% (stainless steel), 94.1% (glass), 98.8% (rubber), 96.0% (painted board), 91.3% (ceramic), and 70.7% (cement), substantially surpassing the performance of commercial decontaminants such as DeconGel. XPS confirmed that amino (-NH₂) and carboxyl (-COO⁻) groups from chitosan and gelatin, respectively, engage in inner-sphere coordination with UO 2 2 + , forming stable chelate complexes. Concurrently, the thermoreversible gelation of gelatin establishes a dense 3D network, which—upon solvent evaporation—physically entraps uranyl ions, thereby confirming a synergistic physicochemical decontamination mechanism. Owing to the abundance, low cost, and biodegradability of its constituents, along with the use of glycerol and TiO 2 as functional additives, this hydrogel system represents a green and sustainable alternative for surface decontamination in nuclear accident response and facility decommissioning scenarios. Download: Download high-res image (269KB) Download: Download full-size image
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