DIAMOND AND RELATED MATERIALS
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2025
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IF 5.1
Chenxi Wu,Mohammad Jahidul Alam,Shengzhou Qiu,Sima Akter,Shaoli Hong,Kazi N. Islam,Huihong Liu,Sakil Mahmud
Hydrochlorothiazide (HCT), a widely used thiazide diuretic, faces detection challenges due to low sensitivity, interference, and complex analysis methods. This study explores an innovative electrochemical sensor based on cobalt oxide-modified screen-printed carbon electrodes (CoO/SPCE) to enhance HCT detection. CoO was electrodeposited onto SPCE, optimizing parameters like the CoO concentration and electrodeposition time through cyclic voltammetry. Microscopic analysis confirmed smoother CoO/SPCE surfaces, indicative of improved structural integrity. The modified electrode demonstrated an oxidation peak at 0.242 V with a current of 5.8 μA for HCT, outperforming unmodified electrodes. Electrochemical impedance spectroscopy revealed a 495-fold decrease in charge transfer resistance after modification, underscoring enhanced electron transfer. The sensor exhibited a low limit of detection, minimal relative standard deviation for signal stability (RSD = 3.38 %), and consistent multi-electrode performance (RSD = 3.32 %). The linear relationship between peak current and HCT concentration, I = 0.01941c + 0.4319 (R 2 = 0.996), confirms the reliability of the method. This CoO/SPCE sensor offers simplicity and rapid detection, marking a significant advancement for in-field HCT analysis.
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ACS Nano
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2025
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IF 16
Jia Liu,Liuting Zheng,Xinyue Li,Wei Tang,Manyu Guo,Yuxing Wang,Xiaoqi Tan,Jiajia Chang,Huiyue Zhao,Dongsheng Zhu,Yu-qiang Ma,Da Huo
Understanding the interaction between nanomaterials and cellular structures is crucial for nanoparticle applications in biomedicine. We have identified a subtype of stress granules, called nanomaterial-provoked stress granules (NSGs), induced by gold nanorods (AuNRs). These NSGs differ from traditional SGs in their physical properties and biological functions. Uptake of AuNRs causes reactive oxygen species accumulation and protein misfolding in the cell, leading to NSG formation. Physically, NSGs have a gel-like core and a liquid-like shell, influenced positively by HSP70 and negatively by HSP90 and the ubiquitin-proteasome system. AuNRs promote NSG assembly by interacting with G3BP1, reducing the energy needed for liquid–liquid phase separation (LLPS). NSGs impact cellular functions by affecting mRNA surveillance and activating Adenosine 5′-monophosphate (AMP)-activated protein kinase signaling, crucial for a cellular stress response. Our study highlights the role of LLPS in nanomaterial metabolism and suggests NSGs as potential targets for drug delivery strategies, advancing the field of nanomedicine.
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Jingyao Li,Huixi Yi,Yuanyuan Fu,Jiani Zhuang,Zhixiong Zhan,Liyou Guo,Ji Zheng,Xiyong Yu,Dong-Yang Zhang
Hypoxia, which is a common characteristic of most solid tumors, not only contributes to the immunosuppressive nature of the tumor microenvironment (TME) but also reduces the efficacy of many oxygen-depleting therapies, including photodynamic therapy (PDT). In this study, we developed acidity-responsive biodegradable iridium-coordinated (IPC) nanodrugs consisting of iridium ions, the photosensitizer chlorin e6 (Ce6), and polyvinylpyrrolidone to potentiate the effects of PDT and immunotherapy by modulating the TME. IPC nanodrugs that accumulate at high levels in tumors catalyze excess hydrogen peroxide to produce oxygen while depleting glutathione levels within cancer cells; thus, the released Ce6 is more efficient at producing reactive oxygen species (ROS) in response to laser irradiation. In addition, IPC nanodrugs alleviate tumor hypoxia, induce more immunogenic cell death by amplifying PDT responses, and synergistically inhibit tumor growth by initiating robust antitumor immunity and reversing the immunosuppressive nature of the TME. As a result, IPC nanodrugs exert pronounced combined therapeutic effects in vitro and in vivo , without obvious toxic effects due to acidity-responsive degradation. These iridium-coordinated nanodrugs have the potential to modulate the TME, amplify the effects of PDT, and substantially inhibit tumors, and they are expected to provide novel ideas for combination therapy of hypoxic cancer.
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JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
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2024
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IF 1.1
Zhenni Ji,Chang Liu,Fa Xu,Yi Wang,Dongyu Gu,Yun Huang,Yi Yang
Blaps rynchopetera Fairmaire is a medicinal insect with a wide range of biological activities. Some of its activities, including anti-cancer and anti-inflammatory activities, are closely related to antioxidant capacity. In this study, a method was established to investigate components and theoretical mechanism of antioxidant from B. rynchopetera . As a result, two antioxidants were obtained by bioassay-guided separation and identified as 4-(2-hydroxyethyl)-1,2-benzenediol and 4-ethylbenzol-1,3-diol. Their EC 50 were 20.20 ± 0.30 μM and 22.90 ± 1.30 μM for ABTS· + scavenging, and 153.00 ± 2.00 μM and 301.00 ± 3.00 μM for DPPH· scavenging, respectively. The thermodynamic investigation indicated that the 2-OH of 4-(2-hydroxyethyl)-1,2-benzenediol and the 1-OH of 4-ethylbenzol-1,3-diol were more susceptible to be attacked by free radicals. They tended to exert antioxidant effects via the sequential proton loss electron transfer mechanism in polar media, whereas the hydrogen atom transfer mechanism was more likely to occur in non-polar media. In addition, frontier molecular orbital theory and energy barrier analysis suggested that 4-(2-hydroxyethyl)-1,2-benzenediol was more likely to react with DPPH·. These results confirmed that 4-(2-hydroxyethyl)-1,2-benzenediol had better antioxidant potential.
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ACS Applied Materials & Interfaces
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2025
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IF 8.2
Jing Zhang,Yang Xue,Lan Zhang,Jun Chen,Dayan Ma,Yingang Zhang,Yong Han
Bacterial infections seriously retard skin wound healing. To enhance the antibacterial efficiency and subsequent skin regeneration, a core–shell structured therapeutic platform, named FZAM, was designed with multiple antimicrobial pathways. FZAM consists of nanosized Fe3O4 as the core and ZIF-8 loaded with Au nanoparticles (NPs) and maltodextrin as the shell. Fe3O4 and Au NPs form a heterojunction that generates hyperthermia and abundant reactive oxide species (ROS) under near-infrared (NIR) irradiation. This heterojunction also exhibits outstanding peroxidase-like activity. When bacteria invade, maltodextrin plays a targeting effect to increase the interaction between FZAM and bacteria, and with the synergistic action of NIR-induced hyperthermia and ROS as well as Zn2+ from ZIF-8, FZAM kills more than 99% of bacteria at 200 μg mL–1. Fortunately, FZAM is cytocompatible and even promotes the biofunctions of fibroblasts and endothelial cells. In infected skin wound models, FZAM sterilizes bacteria with NIR irradiation and subsequently reduces the inflammatory response and accelerates skin regeneration. This work provides a core–shell structured therapy platform for treating infection with the assistance of NIR irradiation and helping skin wound healing.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Wenlong Huang,Bo Jin,Haobing Gong,Nawab Ali,Duoduo Jiang,Tongtong Shan,Liangshun Zhang,Jia Tian,Weian Zhang
Photothermal therapy (PTT) has gained significant attention as a non-invasive treatment in clinical oncology. However, the translation of PTT into clinical practice remains constrained by three fundamental limitations: acquired thermal tolerance in tumor cells, restricted light penetration depth in biological matrices, and insufficient therapeutic outcomes from single-modality treatment. To address these issues, a strategy for forming in situ complexes between near-infrared-II (NIR-II) photothermal agents and proteins is developed, aimed at damaging protein conformation and enhancing PTT effectiveness. We developed a nanoplatform called PCy-SF, consisting of the NIR-II photothermal polymer (PCy) and sorafenib (SF). PCy-SF responds to the tumor microenvironment (TME), specifically releasing Cy-CHO and sorafenib from the assemblies. The released Cy-CHO covalently binds to proteins, forming Cy-Protein complexes that activate NIR-II fluorescence, facilitating NIR-II imaging-guided photothermal therapy. Concurrently, the released SF intensifies microvascular damage, synergizing with PTT for enhanced therapeutic efficacy. Notably, PCy-SF induces a strong anticancer immune response, effectively suppressing tumor recurrence and metastasis. This study introduces a promising protein deactivation strategy for achieving mild-temperature PTT, offering broader applicability of PTT and insights for sensitizing tumors to photothermal therapy. Together, this innovative approach combining NIR-II photothermal agents with protein complexation and a responsive nanoplatform enhances PTT precision and efficacy, demonstrating significant potential in the field of cancer nanomedicine.
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Science China-Chemistry
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2025
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IF 9.7
Shi Quan,Xu Yun-Hao,Chen Ming-Hui,Zhao Peng,Deng Wen-Bo,Xiong Ji,Guo Kai,Feng Ya-Qing,Zhang Bao
Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application prospects. However, due to the unpredictable formation of the nodes, it is still challenging to design novel RE-MOFs. A novel versatile strategy was developed employing a RE-acetate complex (RE 2 (CH 3 COO) 6 ·4H 2 O) as a precursor to construct RE-MOFs. 2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H 2 DBP and tetracarboxylic porphyrin ligands H 2 TCPP, respectively. Ten RE-MOFs were further synthesized to verify the universality of the methodology. Highly crystalline RE-MOFs could also be prepared at room temperature via the developed strategy, which could significantly promote large-scale preparation and practical application of RE-MOFs. As proof of the concept, the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO 2 with epoxides. Among the RE-DBP(Co) MOFs, Tb-DBP(Co) exhibited the best photocatalytic performance, which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer process. This work not only provides a novel versatile strategy to design and develop RE-MOFs, but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.
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International Journal of Electrochemical Science
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2024
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IF 1.3
Yun Xue,Yan Wu,Xiaoxu Zhang,Jun Yan,Zhangde Long,Feihu Xi,Dongsheng Luo,Qibin Liu,Lei Guo,Yanqiu Jing,Liang Zhang
An electrochemical sensor for nicotine determination in heated tobacco products (HTPs) was developed using biosynthesized AuNPs from Ceiba pentandra leaf extract. The biosynthesis process was optimized by investigating the effects of HauCl 4 concentration, extract volume, reaction temperature, and time on the formation of gold nanoparticles (AuNPs). The biosynthesized AuNPs were characterized using various techniques, confirming their crystallinity, spherical morphology, and uniform size distribution with an average diameter of 19.8 ± 3.6 nm. The AuNP modified glassy carbon electrode (AuNP/GCE) exhibited enhanced electrochemical performance compared to the bare GCE, facilitating efficient oxidation of nicotine. The AuNP/GCE sensor demonstrated a wide linear range of 0.02–280 µmol L −1 and a low limit of detection of 0.01 µmol L −1 for nicotine determination. The sensor showed excellent selectivity towards nicotine in the presence of common interfering substances, with negligible responses (<5 % change) to uric acid, paracetamol, glucose, melamine, L-cysteine, and dopamine. The AuNP/GCE sensor's applicability was validated by analyzing nicotine levels in real HTP samples, with excellent recovery rates (97.6–102.4 %) and good agreement with the HPLC (R 2 = 0.998). The biosynthesized AuNP-based electrochemical sensor offers a rapid, sensitive, eco-friendly, and cost-effective approach for nicotine determination in HTPs, providing a valuable tool for quality control and regulatory purposes.
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MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Meichen Ying,Gang Zhu,Wangdong Zhou,Liangqin Zhu,Jianfei Wang,Dexiang Feng,Yan Wei
A novel non-enzyme glucose sensor based on functionalized copper metal–organic framework composite material, AuNPs@MoS 2 /Cu-MOF, was developed for rapid glucose analysis. Cu-MOF nanomaterial was prepared via a hydrothermal method, followed by the surface loading of core–shell structured AuNPs@MoS 2 to synthesize AuNPs@MoS 2 /Cu-MOF composite material. Consequently, a novel gold nanoparticle @ molybdenum disulfide/copper metal–organic framework (AuNPs@MoS 2 /Cu-MOF/GCE) non-enzyme glucose sensor was constructed. Scanning electron microscopy (SEM), energy dispersive spectrometer (EDS) and X-ray powder Diffraction (XRD) was used to verify that the non-enzyme glucose sensor had been constructed effectively. Traditional electrochemical characterization methods were employed to study the electrocatalytic performance of the AuNPs@MoS 2 /Cu-MOF/GCE sensor and its catalytic oxidation of glucose. The experimental results demonstrated a good linear correlation between the concentration of glucose and the peak current within the range of 0.05–14.85 mM, with a detection limit of 16.7 μM. The AuNPs@MoS 2 /Cu-MOF/GCE sensor exhibited rapid electrochemical response to glucose (within 0.5 s), along with long-term stability and excellent selectivity. This is because Cu(II) in Cu-MOF can serve as active sites for the electrocatalytic oxidation of glucose, while the core–shell structure of AuNPs@MoS 2 with excellent conductivity can lower the energy barrier in the reaction, further accelerating this catalytic reaction. The AuNPs@MoS 2 /Cu-MOF/GCE sensor is cost-effective, easy to operate, and suitable for accurate rapid quantification of glucose.
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Advanced Science
·
2024
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IF 14.3
Yunyun Liu,Lihua Xiang,Yitong Li,Shen Zhang,Ying Zhang,Hui Shi,Hui Liu,Dou Du,Bangguo Zhou,Beibei Ye,Shaoyue Li,Haohao Yin,Huixiong Xu,Yifeng Zhang
Pyroptosis, an inflammatory cell death, has attracted great attention for potentiating a strong immune response against tumor cells. However, developing powerful pyroptosis inducers and then activating specific pyroptosis still remains challenging. Herein, a PEG-CuP-COF@∆St nanosystem is rationally designed, consisting of PEG-CuP-COF nanozyme pyroptosis inducers and tumor-targeting bacteria of the Salmonella Typhimurium strain VNP20009 (ΔSt), with an affinity for the tumor hypoxic microenvironment. The PEG-CuP-COF nanozymes possessed excellent sonodynamic performance and multienzyme-mimicking activities to generate reactive oxygen species (ROS) and then induce potent pyroptosis. The superoxide dismutase- and peroxidase-mimicking activities of PEG-CuP-COF catalytically produced hydrogen peroxide (H 2 O 2 ) and hydroxyl radicals (•OH) which have important value in triggering acute inflammatory responses and pyroptosis. Moreover, PEG-CuP-COF showed outstanding glutathione peroxidase-mimicking activities, impairing the antioxidant defense in tumor cells and enhancing sonodynamic efficiency by making them more vulnerable to ROS-induced damage. During in vivo studies, PEG-CuP-COF@∆St nanosystem with its self-driven property exhibited impressive tumor-targeting capability and activated Caspase-3/gasdermin E-dependent pyroptosis to inhibit tumor growth. More importantly, it induced a powerful immune memory effect to prevent bone metastasis. In summary, this study introduces an innovative approach for combinatorial sono-catalytic immunotherapy using bacteria-mediated tumor-targeting delivery of nanozymes as specific pyroptosis inducers.
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Biomedical Materials
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2024
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IF 3.9
Xin Hao,Ting Du,Feng Yang,Yilan Wang,Huatao He,Menghan Yang,Meiying Hong,Guanxiong Wang,Deqing Huang,Yaolei Wang
Recently, in vitro models of intestinal mucosa have become important tools for drug screening and studying the physiology and pathology of the intestine. These models enable the examination of cellular behavior in diseased states or in reaction to alterations in the microenvironment, potentially serving as alternatives to animal models. One of the major challenges in constructing physiologically relevant in vitro models of intestinal mucosa is the creation of three-dimensional (3D) microstructures that accurately mimic the integration of intestinal epithelium and vascularized stroma. Here, core-shell alginate (Alg) microspheres were generated to create the compartmentalized extracellular matrix (ECM) microenvironment needed to simulate the epithelial and vascularized stromal compartments of the intestinal mucosa. We demonstrated that NIH-3T3 and human umbilical vein endothelial cells (HUVECs) embedded in the core of the microspheres can proliferate and develop a vascular network, while human colorectal adenocarcinoma cells (Caco-2) can form an epithelial monolayer in the shell. Compared to Caco-2 monolayer encapsulated within the shell, the presence of the vascularized stroma enhances their proliferation and functionality. As such, our core-shell Alg microspheres provide a valuable method for generating in vitro models of vascularized intestinal mucosa with epithelial and vascularized stroma arranged in a spatially relevant manner and demonstrating near-physiological functionality.
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DYES AND PIGMENTS
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2024
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IF 4.1
Xiqi Su,Le Wang,Xiao Zhang,Jin-Hua Xie,Yi Qu,Di Zhang,Li-June Ming
The extensive use of tetracycline antibiotics (TCs) renders their widespread in the environment that may cause bacterial resistance. Thus, detection of residual TCs and understanding of their broader roles and impacts in the environment and soil ecology are is of critical significance. This paper describes the investigation of a Mg (II)-specific fluorescent micro-probe (PCC–Mg) based on cyclotriphosphazene (Cpz) and curcumin for classical TC•HCl sensing with a low detection limit of 29 nM and a fast response time of less than 10 s. The sensing mechanism is presumably attributed to specific Mg 2+ binding with TCs since the fluorescence enhancement is not observed in the absence of Mg 2+ and not influenced by the presence of several metal ions and anions. The binding of Mg 2+ to curcumin/TC and the formation of TC-metal-curcumin ternary complex can be concluded with NMR and mass spectrometry . Moreover, for the purpose of easy applications, test strips are made to render visual detection of TC with noticeable and selective fluorescence enhancement. The formation of the ternary complex between Cur from the popular herb Curcuma longa and TC from Streptomyces spp. mediated by metal ions also hints a potential role of microbiolochemical-phytochemical interactions in maintaining biodiversity and equilibria in soil microecology.
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