Analytical Methods
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2024
·
IF 2.7
Shouhui Chen,Dan Zhou,Qinghao Xiong,Yinan Yang,Mingyang Zhang,Shoulin Chen
Nowadays, many people are turning to medications that can help them stay calm during surgeries and their daily lives. As an anesthetic that reduces the excitability of nerve cells, propofol can achieve sedative with the advantages of fast onset and short half-life. The development of propofol sensors has tremendous application potential because they can help healthcare professionals dynamically regulate the concentration of propofol in the blood, not only to achieve painless surgeries that patients want, to maintain the sedation that surgeons desire, but also to prevent the respiratory failure that may occur during the patient's daily sleep aids. In this paper, we prepared Fe3O4/C/CB nanocomposites by doping carbon black on the surface of the pyrolyzed product of MIL-88B. The nanocomposites-modified glassy carbon electrodes were used to detect propofol in phosphate buffer solution. The porous nanocomposites with high electrical conductivity promoted the charge transfer on the electrode surface, improving the performance of the modified electrodes. After optimization, the linear range, the detection limit, and the sensitivity for propofol were 5.0~205 μM, 0.102 μM, and 2.850 μA cm-2 μM-1, respectively. The electrochemical sensing of propofol in medical propofol emulsion injection and normal human serum showed that the method was rapid and repeatable.
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Chemosensors
·
2024
·Vol. 12
·期 6
·104
·
IF 3.7
Yanyan Xing,Pingping He,Deyong Wang,Yuan Liang,Xing Gao,Xiaohong Hou
Colorimetric biosensor-based nanozymes have received considerable attention in various fields thanks to the advantages of the simple preparation, good stability, and regulable catalytic activity of nanozymes. In this study, a bimetallic nanozyme Fe3O4@Co3O4/CN was prepared via the high-temperature calcination of Fe3O4-PVP@ZIF-67. The material retained its skeletal structure before calcination, which prevented the aggregation of nanoparticles and exposed more active sites of the nanozyme, substantially enhancing the intrinsic dual enzyme-mimetic activities, including peroxidase- and oxidase-like activities. In particular, Fe3O4@Co3O4/CN with oxidase-like activity catalyzed the colorless tetramethylbenzidine (TMB) to become blue oxTMB with oxygen. Reducing glutathione (GSH) could inhibit the above oxidation reaction. In contrast, with respect to the existence of mercury(II), GSH bound to mercury(II) due to the strong affinity between mercury(II) and -SH, thus eliminating the inhibition and restoring the oxTMB signal. A simple and effective colorimetric sensor was fabricated to detect mercury(II) based on the above principles. The proposed measurement had a linear range of 0.1–15 μM and a limit of detection (LOD) of 0.017 μM. It was shown that the established colorimetric sensing system could be successfully applied to detect mercury(II) in water samples, and the Fe3O4@Co3O4/CN nanozyme proved to be a promising candidate for biosensing application.
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CHEMICAL ENGINEERING JOURNAL
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2011
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IF 3.074
Wenlu Guo,Wei Hu,Jianming Pan,Hongchun Zhou,Wei Guan,Xue Wang,Jiangdong Dai,Longcheng Xu
Magnetic molecularly polymers (MMIPs) based on kaolinite/Fe 3 O 4 composites were successfully synthesized for the selective adsorption and separation of bisphenol A (BPA) from aqueous solutions. During polymerization, the modified kaolinite/Fe 3 O 4 (KLT/Fe 3 O 4 ) not only was used as supporter but also functional monomer. The properties of MMIPs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) analysis, and thermogravimetric analysis (TGA) and so on. The SEM graphs showed that much of KLT/Fe 3 O 4 was successfully coated by the imprinted layer, TGA analysis suggested the grafting yield of imprinted layer to KLT/Fe 3 O 4 was 72.51 wt%. The effects of pH, initial BPA concentration, contact time and temperature of the medium on the adsorption were studied by the batch mode experiment. The equilibrium data was well described by the Langmuir isotherm model. The kinetics of adsorption followed the pseudo-second-order model and the rate constant decreased with the increase of temperature, indicating exothermal nature of adsorption process. For desorption studies, the highest desorption efficiency (95.75%) was obtained using methanol and acetic acid as eluting solution (v:v = 8:2). Moreover, the selectivity of MMIPs was further demonstrated through HPLC analysis of the stimulant water samples, the result showed that MMIPs could effectively recognize BPA in mixed solution.
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Acta Biomaterialia
·
2024
·
IF 9.4
Jiale Li,Bo Li,Feng Liu,Ming Deng,Ziying Zhang,Yutao Ran,Bing Wang
The significance of the tumor microenvironment (TME) in tumor initiation and progression is increasingly acknowledged. Conventional therapeutic approaches face limitations within the complex TME, including the restrictions imposed by hypoxia on photodynamic therapy (PDT) and the deficiency of endogenous H₂O₂ affecting chemodynamic therapy (CDT). In response to the TME's characteristics of high metabolism, hypoxia, and weak acidity, a multifunctional nanosystem MNPs/GOD@CS/IR820, which synergistically integrates CDT and PDT, has been developed. This system can actively accumulate at tumor sites under an external magnetic field and release active components in response to the weakly acidic TME. It mitigates the limitations imposed by hypoxia and endogenous H₂O₂ deficiency on PDT and CDT, respectively, thereby enabling synergistic treatment. Additionally, the system's multimodal imaging capabilities facilitate precise tumor localization and real-time, non-invasive in vivo assessment via fluorescence imaging and MRI. In vitro and in vivo evaluations demonstrate significant antitumor efficacy, effectively inhibiting tumor growth and improving survival rates. By comprehensively addressing the challenges posed by the complex TME and enhancing real-time monitoring capabilities, our nanosystem paves the way for personalized and precise cancer treatment. Statement of Significance This study introduces an innovative MNPs/GOD@CS/IR820 nanosystem that represents a significant advancement in cancer nanomedicine by addressing critical limitations of conventional photodynamic therapy (PDT), particularly in hypoxic tumor microenvironments. By synergistically integrating chemodynamic therapy (CDT) with PDT and incorporating MRI and fluorescence dual-modal imaging capabilities, this multifunctional platform offers enhanced therapeutic efficacy and real-time monitoring. The system's ability to generate oxygen in situ overcomes hypoxia-induced limitations, while its multimodal mechanism of action induces tumor cell apoptosis through multiple pathways. In vitro and in vivo studies demonstrate remarkable antitumor efficacy across diverse cancer types, significantly inhibiting tumor growth and improving survival rates. This comprehensive approach to cancer diagnosis and treatment not only advances precision medicine for targeted, multimodal cancer management but also provides a promising foundation for future clinical applications, potentially transforming cancer treatment strategies and improving patient outcomes.
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ANALYST
·
2024
·Vol. 149
·期 6
·1784-1790
·
IF 3.6
Huilan Chen,Yunyan Li,Ziyi Wang,Di Wang,Luping Feng,Shuai Li,Choufei Wu,Hua Wang
Mesoporous Fe3O4-loaded silver nanocomposites (Fe3O4@Ag) were simply fabricated as bi-functional nanozymes for the catalysis-based detection and removal of Hg2+ ions. It was found that the as-prepared magnetic Fe3O4@Ag could display peroxidase-like catalysis activity that could be rationally enhanced in the presence of Hg2+ ions. To our surprise, the shell of the Ag element may decrease the catalysis of the Fe3O4 to some degree. However, the Ag particles could serve as the probes for specifically recognizing Hg2+ ions and trigger increased catalysis through the formation of Ag–Hg alloys, with a decreased signal background. A high-throughput colorimetric analytical method was thereby developed based on the Fe3O4@Ag catalysis for probing Hg2+ ions in the muscles of fish by using 96-well plates, at linear Hg2+ concentrations ranging from 0.010 to 2.5 mg kg−1. Moreover, the developed colorimetric analytical method was applied to evaluate Hg2+ levels in muscle samples of different kinds of fish. Unexpectedly, an obvious difference of Hg2+ levels in muscles of four kinds of fish was discovered, with the order of snakehead (Ophicephalus argus) > largemouth bass (Micropterus salmoides) > crucian carp (Carassius auratus) > silver carp (Hypophthalmichthys molitrix), where the carnivorous fish showed higher Hg2+ levels than the omnivorous or plant-based ones. Moreover, the as-fabricated Fe3O4@Ag adsorbents with their large specific surface area and high environmental robustness could exhibit efficient Hg2+ adsorption with capacities of up to 397.60 mg g−1. A removal efficiency of 99.40% can also be expected for Hg2+ ions from wastewater, with the magnet-aided recycling of Fe3O4@Ag adsorbents. Such an Fe3O4@Ag-based colorimetric analysis and removal strategy for Hg2+ ions should find wide applications in the fields of aquatic food safety, environmental monitoring, and clinical diagnostics of Hg-poisoning diseases.
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Analytical Methods
·
2024
·
IF 2.7
Honglin Qin,Ruozhu Xu,Lizhen Qiao,Xupeng Zhai,Peixin Guo,Chen Li,Bingyan Han
The widespread use of endocrine disruptors (EDPs) has certain potential hazards to organisms and environments, and it is particularly important to develop effective pretreatment methods before detection of EDPs in complex samples. In this work, a novel magnetic nanocomposite decorated with layered double hydroxides (LDHs) and carbon dots (CDs) was designed and prepared for magnetic solid-phase extraction (MSPE) of EDPs (bisphenol S, bisphenol F, bisphenol A, bisphenol AF, diethylstilbestrol and 4-cumylphenol) combined with high-performance liquid chromatography-ultraviolet (HPLC-UV) detection. The prepared composites were characterized by field emission scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS), and the adsorption mechanism towards these EDPs might be mainly based on hydrogen bonds and π–π conjugation. Under the optimized conditions, the proposed method showed limits of detection within 0.05–0.50 μg L−1 and limits of quantitation within 0.2–2.0 μg L−1, and good linearity (R2 ≥ 0.9975) was presented in the range of 0.2–200 μg L−1. Finally, the Fe3O4@C@NiCo-LDH@CDs composite-based MSPE-HPLC-UV method was applied for enrichment and determination of EDPs in water, milk, and tea beverage samples with recoveries in the range of 81.2–119.8% and relative standard deviations below 9.7%.
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INORGANIC CHEMISTRY COMMUNICATIONS
·
2025
·
IF 5.4
Naeem Akram,Wenlan Ma,Shehla Riaz,Jia Guo,Ali Ahmad,Jide Wang
In this study, Ni-Fe-based Prussian Blue Analogues (Ni-Fe PBA) served as precursors, giving rise to a NiO/Fe 3 O 4 -based bimetallic catalyst that underwent comprehensive examination for both chemocatalytic water oxidation and photocatalytic degradation of organic dyes. The morphologies and chemical compositions of the precursor and resultant bimetallic catalysts were thoroughly characterized using XRD, SEM, XPS, mapping, and FTIR techniques. The results indicated that the catalytically active center is the NiO/Fe 3 O 4 -based bimetallic nanocomposite. The in-situ-synthesized bimetallic catalyst demonstrated remarkable catalytic oxidation activity when evaluated with Sodium Persulfate (PS) as an oxidant. Oxygen evolution results revealed an impressive catalytic water oxidation activity, with an O 2 production rate of approximately 1594.3 µmol·g −1 ·h −1 . Moreover, the NiO/Fe 3 O 4 catalyst was utilized as a heterogeneous photocatalyst to activate photosensitizer (PS) for the two azo dye’s deterioration caused by the exposure to visible light. Both organic dyes were photocatalytically degraded with great efficiency when Fe 3 O 4 and NiO were combined because they increased the catalyst’s capacity to absorb light. Electron Spin Resonance (ESR) and radical trapping studies revealed that sulfate (SO4· - ) and hydroxyl (OH·) radicals played pivotal roles. The degradation mechanism and pathway for Rhodamine B (RhB) were also elucidated. The exceptional recyclability and stability of the NiO/Fe 3 O 4 catalyst make it particularly promising for potential applications in water treatment, addressing challenges related to energy sustainability and environmental toxicity.
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CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Huiling Ding,Mengke Zhang,Yan Liu,Yize Yao,Zenghui Mai,Huaixin Zheng,Bo Song,Bingbing Fan,Hailong Wang,Hongxia Lu
With the rapid development of global economy and industrialization, the management and protection of water resources have become increasingly important. In this paper, a novel three-dimensional Chitosan/Fe 3 O 4 /TiO 2 @MXene photocatalyst with excellent degradation and bacterial inhibition properties was prepared by a simple one-step hydrothermal method using FeCl 3 ·6H 2 O, Chitosan (CS) and MXene (Ti 3 C 2 ) as main raw materials. TiO 2 was generated in-situ on the surface of Ti 3 C 2 nanosheets and modified by loading Fe 3 O 4 nanoparticles and CS films. The conformations and band gaps of the composites were modified, and then photocatalytic mechanisms, phase compositions, morphological structures, magnetic properties and photoelectrochemical properties of the photocatalysts were systematically analyzed. The degradation efficiency of the CS/Fe 3 O 4 /TiO 2 @Ti 3 C 2 composite photocatalyst can reach 95.9 % when the ration of CS to FeCl 3 ·6H 2 O is 1:3 and the hydrothermal temperature is 180 °C, which showing excellent photocatalytic performance. Meanwhile, the inhibition rate of Staphylococcus aureus ( S. aureus ) is close to 98.91 % under the light condition. This study further reveals that visible light is a cost-effective way to treat pollution in terms of degradation and bacteriostatic inhibition, and the composite photocatalysts can be efficiently recycled and reused under the action of a magnetic field.
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NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Jie Song,Yingnan Zhou,Lijun Chen,Zhiwen Yuan,Yuhua Niu,Xi Li,Liangxian Huang
This study employed β-cyclodextrin (β-CD) for the hydrophilic modification of iron tetraoxide (Fe3O4) magnetic materials. Subsequently, potassium humate (KHA) and carboxymethyl cellulose (CMC) were used as raw materials. A β-CD@Fe3O4/KHA/CMC/AM/MAH hydrogel with magnetic properties which can be easily recycled was synthesized for the slow release of glyphosate (GLY). FTIR, XRD, TG and VSM analyses demonstrated that the hydrogel possesses good thermal stability and magnetic properties with a saturation magnetization strength of 29.77 emu g−1. The equilibrium solubility of the hydrogel in pH = 7.4 and pH = 8.5 buffer was 24.58 g g−1 and 25.83 g g−1, respectively. The maximum release of GLY was recorded at 63.31% and 67.78%, with the drug release behavior under different loading gels following the Fickian diffusion mechanism. A pot planting experiment indicated that the water content of plants treated with the β-CD@Fe3O4/KHA/CMC/AM/MAH drug-loaded gel decreased by 51.69%. Additionally, soluble protein levels decreased to 2.69 mg g−1, chlorophyll content decreased to 0.486 mg g−1, SOD levels decreased to 43.81 U g−1, and MDA increased to 4.02 μmol g−1, effectively inhibiting the growth of grass and providing a theoretical basis for achieving slow drug release.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Wei Li,Qing Li,Liangliang Zhu,Su Chen
Global plastic production, particularly polyethylene terephthalate (PET), has surged in modern society, yet conventional disposal methods like incineration and landfills pose severe environmental risks. Photothermal catalysis emerges as a sustainable solution, combining photo with thermal catalysis processes to reduce energy consumption while enhancing catalytic efficiency. Herein, we demonstrate a promising approach employing black phosphorus nanosheets (BPNSs) featuring exceptional photothermal conversion and singlet oxygen ( 1 O 2 ) generation to photothermally accelerate PET depolymerization. Integrating with Fe 3 O 4 nanoparticles, the formed covalent P-O bonds shield reactive phosphorus atoms in BPNSs from oxidation to improve their stability, and Fe 3 O 4 enables magnetic recovery and synergy with PET's carbonyl groups. Under solar irradiation, the BPNSs-Fe 3 O 4 composite achieves 98.3 % PET conversion and 95.2 % bis(2-hydroxyethyl) terephthalate (BHET) yield at 185 °C in ethylene glycol, 2.8-fold and 6.5-fold higher than traditional thermal catalysis, respectively. Mechanistic studies reveal that localized photothermal heating and 1 O 2 -driven nucleophilic elimination of ester groups collaboratively enhance the reaction kinetics, reducing the activation energy by 53.7 %. Successful outdoor validation and BHET repolymerization confirm the practicability. This closed-loop photothermal strategy demonstrates excellent efficiency and product quality, offering a viable pathway toward sustainable plastic upcycling with dual environmental and economic potentials.
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POLYMER COMPOSITES
·
2025
·
IF 4.7
Jie Wang,Min Cai,Yue Zheng,Xinyu Yi,Xin Chen,Peng Zhou,Hongdi Zhou,Biao Zhang,Fugang Qi,Jing Ma,Xiaoping Ouyang
To meet the stealth needs of submarines at sea, researchers have developed wave-absorbing coatings. However, the marine environment tends to corrode the coatings and affect their performance. Therefore, it is necessary to develop materials with both wave-absorbing and anti-corrosion functions. In this study, we developed Fe 3 O 4 /LDHs composite with enhanced microwave absorption properties by uniformly anchoring Fe 3 O 4 particles onto the surface of hexagonal MgAl-layered double hydroxides (LDHs) through one-step hydrothermal and hot-solvent methods. The even dispersion of Fe 3 O 4 mitigates nanoparticle agglomeration and promotes synergistic effects between the magnetic and dielectric components, significantly boosting magnetic loss. The composite achieved a minimum reflection loss (RL min ) of −53.46 dB, nearly double that of pure Fe 3 O 4 (−27.31 dB), while maintaining the same effective absorption bandwidth (EAB). Moreover, the Fe 3 O 4 /LDHs demonstrate excellent dispersion ability in epoxy (EP). The resistance to corrosion of Fe 3 O 4 /LDHs@EP is significantly enhanced, shown by the low-frequency impedance modulus, which stays above 10 11 Ω cm 2 even after 19 days of immersion, which was four orders of magnitude higher than that of the pure Fe 3 O 4 @EP coatings (10 7 Ω cm 2 ). The Fe 3 O 4 /LDHs composite material exhibits dual capabilities of stealth and anti-corrosion, providing valuable insights for the development of marine stealth technologies. Graphical Dual function microwave absorption-corrosion protection of Fe 3 O 4 /LDHs composite coatings.
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Journal of Environmental Health Science and Engineering
·
2025
·Vol. 23
·期 2
·1-17
·
IF 2.8
Huang Jiaru,Li Jinhuan,Lu Chunmiao,Wang Xu,Xu Jingjing
A magnetic double-layer metal-organic framework composite (Fe 3 O 4 @ZIF-8@ZIF-67) was successfully synthesized through a facile layer-by-layer self-assembly method at room temperature and thoroughly characterized using various techniques. The composite Fe 3 O 4 @ZIF-8@ZIF-67 was explored as an adsorbent for the removal of two harmful organic pollutants, Congo red (CR) and tetracycline hydrochloride (TC). Some essential parameters, including initial concentration, adsorbent dose, contact time, pH, and temperature, were systematically optimized. Under optimal conditions, Fe 3 O 4 @ZIF-8@ZIF-67 demonstrated the maximum adsorption capacities of 276.77 mg/g for CR and and 356.12 mg/g for TC, respectively. The double-layer structure endowed Fe 3 O 4 @ZIF-8@ZIF-67 high adsorption efficiency for CR (99.44%) than the pristine Fe 3 O 4 @ZIF-8 (73.26%). Adsorption kinetics and isotherms studies revealed that the adsorption process followed pseudo-second-order kinetics and Langmuir model, indicating a monolayer chemisorption-dominated mechanism. Furthermore, the spent Fe 3 O 4 @ZIF-8@ZIF-67 was regenerated through a Fenton-like oxidative degradation reaction, maintaining a removal efficiency above 70% after three consecutive cycles. With its facile synthesis, cost-effectiveness, mild operating conditions, and high selectivity for anionic dyes, Fe 3 O 4 @ZIF-8@ZIF-67 emerges as a highly promising material for advanced wastewater treatment applications.
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