INORGANIC CHEMISTRY
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2025
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IF 4.7
Jin Chai,Chunpeng Liu,Hongtian Yang,Yide Han,Yufeng Liu,Ying Zhang,Xia Zhang
The bifunctions of fluorescence activity and peroxidase mimics were well-integrated by a hemin chloride-modified Zr-based metal–organic framework (Hemin@NH2-UiO-66), which can catalyze the oxidation of o-phenylenediamine (OPD) to generate 2,3-diaminophenazine (DAP), presenting typical peroxidase mimic properties. The influence of the introduction of hemin chloride upon the enhanced peroxidase mimic activity was clarified, and the nanozyme catalytic parameters were optimized. Interestingly, the oxidized product of DAP presents strong fluorescence emission at 564 nm; combining it with the intrinsic fluorescence emission of NH2-UiO-66 at 452 nm, a dual-emission system could be built up by the resulting Hemin@NH2-UiO-66 in the presence of definite OPD and H2O2. Moreover, the fluorescence quenching effect (564 nm) was observed by adding l-cysteine (l-Cys); based on that, a straight-line dependence of the fluorescence intensity ratio (I452/I564) upon the concentrations of l-Cys was established. The detection limit was 0.21 μmol, and the analytical selectivity for l-Cys was also demonstrated. The work highlights the idea of combining the intrinsic fluorescence property and nanozyme catalytic activity in a functional MOF, and its special usability is found in the ratiometric fluorescence sensing analyses.
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PubMed
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2022
·
IF 2.216
Yi Liu,Yifan Huang,Chao Hou,Tingxiao Li,Binjie Xin
Core-shell nanofibers for biomedical applications have been successfully prepared by emulsion electrospinning, utilizing the model drug Tetracycline hydrochloride (TCH) water solution as the “aqueous phase” and hydrophobic polymer solution as the “organic phase.” The morphology of nanofibers was assessed by scanning electron microscopy (SEM) and the core-shell structure was confirmed by inverted fluorescence microscopy and transmission electron microscopy (TEM). The improved hydrophilicity might be caused by the presence of the emulsifier Span 80 on the surface of the nanofibers. The mechanical properties study showed that core-shell nanofibers membranes were softer and more elastic than blended nanofibers. In vitro drug release study showed that the TCH could release continuously for 34 days. The release mechanism of the nanofibers followed Fickian diffusion at low drug efficiency, but drug diffusion was the best fit with the First-order kinetic model when increasing drug loading rates. Overall, emulsion core-shell nanofibers could be used as a promising drug reservoir for sustained and continuous drug release behaviors. Meanwhile, the study of drug release kinetics was used in conjunction with model drug properties to develop a wider range of nanofibers carriers and biomaterials.
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高影响因子
TALANTA
·
2011
·Vol. 85
·期 4
·1738-1743
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IF 3.722
Junling Duan,Xiaochen Jiang,Shouqing Ni,Min Yang,Jinhua Zhan
This paper described an investigation of a novel eco-friendly fluorescence sensor for Hg 2+ ions based on N-acetyl- l -cysteine (NAC)-capped ZnS quantum dots (QDs) in aqueous solution. By using safe and low-cost materials, ZnS QDs modified by NAC were easily synthesized in aqueous medium via a one-step method. The quantitative detection of Hg 2+ ions was developed based on fluorescence quenching of ZnS QDs with high sensitivity and selectivity . Under optimal conditions, its response was linearly proportional to the concentration of Hg 2+ ions in a range from 0 to 2.4 × 10 −6 mol L −1 with a detection limit of 5.0 × 10 −9 mol L −1 . Most of common physiologically relevant cations and anions did not interfere with the detection of Hg 2+ . The proposed method was applied to the trace determination of Hg 2+ ions in water samples. The possible quenching mechanism was also examined by fluorescence and UV–vis absorption spectra .
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高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Wan-Jie Si,Li Yang,Jiang Zhu,Yi-dong Li,Jian-Bing Zeng
Three biodegradable elastomers with different chemical structures , i.e., polyurethane (PU), poly( l -lactide)-b-polyurethane-b-poly( l -lactide) (LPUL) and poly( d -lactide)-b-polyurethane-b-poly( d -lactide) (DPUD) triblock copolymers were prepared to blend with commercial poly( l -lactide) (PLLA) to provide weak, medium and strong interfacial interactions through weak van der Walls, interfacial chain entanglement and interfacial stereocomplex (SC) crystallization, respectively. Morphology analysis indicated that the size of dispersed phase in the amorphous PLLA matrix decreased with increasing PLLA or PDLA content of the biodegradable elastomers and agglomeration of dispersed particles occurred obviously during matrix crystallization for PLLA/PU and PLLA/LPUL blends due to the relatively weak interfacial interactions, while agglomeration did not occur apparently for PLLA/DPUD blends due to the strong interfacial interaction arisen from the interfacial SC crystallites . With well-tuned and stabilized phase morphology, PLLA/DPUD exhibited the best toughening efficiency for both the amorphous and highly crystalline PLLA matrix. Moreover, the PLLA/DPUD showed the highest mechanical strength and crystallization rate, attributing to the presence of interfacial SC crystallites , which could reinforce the mechanical strength and work as efficient nucleating agents for crystallization of PLLA matrix. In addition, PLLA/DPUD blends showed superior heat resistance over PLLA/PU and PLLA/LPUL blends by processing on conventional machine. All the excellent performances were attributed to the special interfacial interaction originated from interfacial SC crystallites of PLLA/DPUD blends.
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高影响因子
PEST MANAGEMENT SCIENCE
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2017
·Vol. 74
·期 1
·210-218
·
IF 3.253
Delong Wang,Na Xie,Shandong Yi,Chuanyuan Liu,Hui Jiang,Zhiqing Ma,Juntao Feng,He Yan,Xing Zhang
BACKGROUND The cotton aphid ( Aphis gossypii Glover) is one of the most invasive pests of cotton. Many botanical phytochemicals have a long history as a source of insecticides, and as templates for new insecticides. This study was undertaken to isolate aphicidal compounds from the seeds of Erythrina crista-galli L. using the bioassay-guided isolation method. RESULTS Three novel and 11 known Erythrina alkaloids were isolated. Erysodine ( 9 ), erysovine ( 10 ), erysotrine ( 8 ) and erythraline ( 11 ) showed moderate to excellent aphicidal activity with LD 50 values of 7.48, 6.68, 5.13 and 4.67 ng aphid –1 , respectively. The Potter spray tower bioassay gave corresponding LC 50 values of 186.81, 165.35, 163.74 and 112.78 µg ml –1 . A unique substructure, which presents an sp 3 methylene at C-8, a non-oxygenated site at N-9 and a conjugated dienes group (Δ 1,2 and Δ 6,7 ), plays a crucial role in the aphicidal activity. Application of erythraline ( 11 ) led to different increases in the activities of superoxide dismutase, catalase and glutathione S -transferase. CONCLUSION The study demonstrated that the Erythrina alkaloids erysodine ( 9 ), erysovine ( 10 ), erysotrine ( 8 ) and erythraline ( 11 ) have potential use as botanical aphicides for commercial application, or as templates for the development of new insecticides. © 2017 Society of Chemical Industry
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
·
IF 5.9
Ziyi Zhao,Xiaoxiao Huang,Lining Huang,Hui Xing,Yuhui Yang,Guanhai Wang,Yunfeng Hu,Xiaoxu Zhu,Dong Ma
L -Arginine ( L -Arg), a precursor of nitric oxide (NO), is efficiently delivered to the deeper layers of the skin via a hyaluronic acid-based liposomal transdermal delivery system (HL@ L -Arg), which enhanced cutaneous delivery and local retention of L -Arg. Through nitric oxide synthase (NOS)-mediated conversion, HL@ L -Arg promoted endogenous NO production and provided a sustained NO-related therapeutic effect. • Transcriptomic analysis indicated that HL@ L -Arg treatment in androgenetic alopecia (AGA) was associated with pathways related to Wnt signaling, inflammatory responses, and steroid hormone biosynthesis. Functional studies further showed that HL@ L -Arg reduced SRD5A1/5α-reductase activity and DHT production, while promoting β-catenin/IGF-1-associated follicular growth responses. • HL@ L -Arg improved the follicular microenvironment by suppressing inflammatory factors (TNF-α and IL-6) and androgen receptor (AR) expression, while enhancing Ki67 and VEGF expression, endothelial responses, and local blood perfusion, thereby promoting hair regeneration. Androgenetic alopecia (AGA) is a common hair loss disorder caused by genetic susceptibility and androgen-driven follicular miniaturization. Current FDA-approved therapies, including finasteride and minoxidil, are limited by adverse effects. Here, we developed a hyaluronic acid-based liposomal transdermal delivery system loaded with L -arginine (HL@ L -Arg) to enhance cutaneous delivery and promote endogenous nitric oxide (NO) production through nitric oxide synthase. Transcriptomic analysis indicated significant changes in pathways related to inflammatory responses, Wnt signaling, and steroid hormone biosynthesis. Mechanistically, HL@ L -Arg inhibited 5α-reductase activity and reduced dihydrotestosterone (DHT) production while promoting endogenous NO generation. In an AGA mouse model, HL@ L -Arg reduced TNF-α, IL-6, and androgen receptor (AR) expression, increased VEGF and Ki67 levels, and markedly promoted hair regeneration. Collectively, transdermal L -Arg delivery represents a promising endogenous NO-based therapeutic strategy for AGA through DHT suppression, regulation of the follicular microenvironment, and anti-inflammatory activity.
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高影响因子
ENERGY & FUELS
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2017
·
IF 3.091
Zi-zhe Cai,Sheng-qing Wu,Guo Sun,Yi Niu,Dong Zheng,Shi-yi Peng,Wen-zhe Yang,Yong Wang,Depo Yang
With the cost of traditional lipid feedstocks constituting 70% of the total cost of biolubricant production, it is urgent to find a new lipid source for the biodiesel and biolubricant industry. With the elevated acid value (61.8 mg of KOH/g) of housefly larval lipids, converting the free fatty acid (FFA) into a biolubricant could serve as a value-added approach to the larval diesel industry, other than pretreatment by acid-catalyzed esterification for biodiesel production. This study developed a method of producing high-purity fatty acid n-octyl esters (FAOEs) from housefly (Musca domestica L.) larvae. The housefly larva free fatty acids (HLFFAs) from the larva lipids were obtained by wipe-film short-path distillation. FAOEs were produced by esterifying n-octanol with HLFFAs (catalyzed by benzenesulfonic acid under the following conditions: catalyst loading, 2 wt %; molar ratio of n-octanol to FFA, 3:1; temperature, 100 °C; time, 2 h). Excess n-octanol was effectively removed by high-vacuum (80 Pa) distillation at 90 °C. The unreacted FFAs were neutralized using demethylated crude glycerin, which is a byproduct of biodiesel production. A practical method of producing high-purity fatty acid n-octyl esters (99.19 wt %) derived from housefly larva lipids was thus developed, and the product could serve as a replacement for certain low-viscosity mineral lubricants such as liquid paraffin, polyalphaolefin 6, and SN 500.
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高影响因子
PLANT AND SOIL
·
2025
·
IF 4.1
Song Yang,Liu Yang,Li Haipu,Liu Qianwen,Lu Denglong,Yang Zhaoguang
Background and Aims Sulfur (S) decreases arsenic (As) accumulation in crops, yet its mechanism and applicability to other plants remain unclear. This study investigated the role of S in As behavior in lettuces ( Lactuca sativa L.) and evaluated S application in leafy plants, focusing on As complexation. Methods Plants were stressed with arsenate (AsV) and dimethylarsinic acid (DMA) under three different S supplementation (0, 1, and 3 mM) in hydroponic culture. As species, As-phytochelatins, ascorbate–glutathione (AsA-GSH) cycle enzymes and mineral elements in plants were analyzed. Results The effect of S was As-species-dependent. Specifically, under AsV stress, 3 mM S significantly decreased As content by 20.8% in leaves and As translocation factor (TF) by 17.4%, while root As (230–252 mg/kg, dry weight) and As-phytochelatins (1.02–1.27 mg/kg, fresh weight) remained unaffected, which is contrary to other reports. In terms of As species, leaf arsenite (AsIII) content and TF-AsIII were decreased, but AsV and root AsIII content were not significantly changed. Under DMA stress, 3 mM S significantly decreased As content by 17.7% in roots but did not alter leaf As content. The root DMA was significantly decreased, while monomethylarsonic acid (MMA) and leaf DMA content were unchanged. Additionally, exogenous S regulated root AsA-GSH cycle over leaves under both As stresses and increased leaf Fe and Zn accumulation. Conclusions Exogenous S inhibited AsV and DMA uptake, suppressed AsV-to-AsIII conversion and AsIII transfer to leaves, and facilitated DMA-to-MMA conversion, highlighting its potential applications in agriculture to restrict As in leaves on contaminated lands.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Yanxiao Quan,Guojun Weng,Jian Zhu,Jianjun Li,Junwu Zhao
Background Volatile organic compounds (VOCs) in human exhaled breath serve as molecular fingerprints that reflect metabolic dysregulation and can indicate the onset and progression of diseases such as lung cancer. Surface-enhanced Raman scattering (SERS), characterized by its high sensitivity, molecular specificity, and tolerance to humidity, offers a promising approach for breath analysis. However, the intrinsically weak Raman activity of exhaled biomarkers and poor gas adsorption on solid substrates still hinder its practical implementation. Therefore, it is essential to develop a SERS-based breath sensor that simultaneously enables signal amplification, gas enrichment, rapid operation, and cost-effectiveness. Results This study presents a novel ultrasensitive SERS sensing platform based on a core-shell ZIF-L@Au NTs composite, integrating high sensitivity, selectivity, and rapid detection capabilities. The anisotropic gold nanotriangles (Au NTs), serving as the plasmonic core, exhibit excellent structural stability and strong electromagnetic field enhancement. The outer ZIF-L metal-organic framework (MOF) shell facilitates the selective adsorption and pre-enrichment of target analytes, while its confinement effect synergistically amplifies the SERS signal, markedly improving detection sensitivity. As a result, the system enables reliable quantification of 4-ethylbenzaldehyde in the concentration range of 10 −4 -10 −8 M, achieving a detection limit down to the sub-ppm level with high stability and repeatability. Simulated detection of the potential lung cancer biomarker 4-ethylbenzaldehyde demonstrated the platform's strong enrichment capability and outstanding sensing performance. Significance This work establishes an ascorbic-acid-directed strategy to construct flower-like ZIF-L and, for the first time, integrates gold nanotriangles with a metal-organic framework into a core-shell ZIF-L@Au NTs SERS platform. The synergistic combination of MOF-based gas enrichment, sharp-tip plasmonic hot spots and 4-ATP/aldehyde chemistry enables sub-ppm level detection of exhaled 4-ethylbenzaldehyde, highlighting a promising route for non-invasive breath diagnostics.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
·
IF 6.7
Yehua Yang,Jiaqi Li,Xuejin Li,Qichang Huang,Weiwei Jiang,Wei Zhang,Yuqian Jiang,Yao Tang
Phyllanthus emblica L. is a fruit with high medicinal and edible value. Its main bioactive component, gallic acid (GA), is significantly increased by hot air drying, yet the underlying chemical mechanism remains unclear. This study investigated the temperature-dependent transformation of phenolics during drying (80–130 °C) using UHPLC-MS/MS and Global Natural Products Social Molecular Networking (GNPS). High-temperature drying (110 to 130 °C) increases the GA content by 13.4–26.9 fold. Integrated metabolomic analysis suggests this accumulation results primarily from two nonenzymatic pathways: the thermal hydrolysis of glucose galloyl derivatives (e.g., glucogallin, digalloylglucose, and trigalloylglucose), and the degradation of glucuronic acid galloyl derivatives (e.g., 2-O-galloylgalactaric acid and monogalloylgalactonolactone). While temperatures >110 °C maximize gallic acid yield, the Maillard reaction products (e.g., 5-HMF) were also promoted. These findings elucidate the chemical mechanism of GA accumulation via ester bond cleavage, providing a scientific basis for optimizing drying protocols to balance medicinal quality and safety.
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PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 4
·287
·
IF 2.8
Tang Ruxuan,Chen Yuan-Bin,Su Xiuyuan,Tang Ling
With the rapid development of 5G/6G mobile communication technology, microwave dielectric materials are facing increasingly strict performance requirements. As core fundamental materials for modern communication systems, performance optimization of microwave dielectric ceramics has become a research hotspot. Addressing the limitations of single-phase ceramic materials, dense microwave dielectric ceramics of (Nd 1- x La x ) 2 [Zr 0.89 (Bi 0.5 Ta 0.5 ) 0.11 ] 3 (MoO 4 ) 9 ( x = 0.01, 0.03, 0.05, 0.07) were prepared by the conventional solid-state reaction method. The experimental process involved 550 °C pre-sintering followed by gradient sintering at 600–725 °C (4 h holding time). X-ray diffraction (XRD) analysis confirmed that all samples exhibited trigonal crystal structure with \(R\overline{3} c\) space group. The lattice parameters were obtained by Rietveld refinement method. Scanning electron microscopy (SEM) characterization indicates that compactness has a significant impact on the dielectric constant ( ε r ) and the quality factor ( Q × f ). Raman spectroscopy analysis indicated strong associations of ε r and Q × f values with characteristic peak shifts and full width at half maximum ( FWHM ), respectively. When sintered at 675 °C, the NLZBTM ( x = 0.03) ceramics exhibited exceptional comprehensive performance: ε r = 11.24 ± 0.02, Q × f = 116,914 ± 5738 GHz, and τ f = − 37 ± 1.5 ppm/℃. The bond property analysis based on the P–V–L theory shows that the ionicity of the Nd/La–O bond makes the greatest contribution to εᵣ , while the covalency of the Mo–O bond significantly affects the Q × f value and τ f parameter. It is noteworthy that this material achieves low-temperature sintering at 675 °C while maintaining excellent microwave dielectric properties, demonstrating significant potential as a candidate material for low-temperature co-fired ceramics (LTCC).
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Journal of Water Process Engineering
·
2026
·
IF 6.7
Bang Li,Juncai Ren,Jiayi Xie,Junfeng Wu,Yingchun Wang,Xiaogang Gu,Xiaoxian Hu,Xiang Guo,Zuwen Liu,Yanbin Yun,Chunli Li,Xiying Hao,Shasha Chen,Shiqiang Yin
The discharge of oily wastewater and industrial wastewater poses serious threats to aquatic ecosystems and human health, highlighting the urgent need for advanced antifouling membranes capable of efficient oil-in-water emulsion separation. Unlike conventional surface coating or single-component modification strategies, herein, we report a facile strategy to transform hydrophobic PVDF membranes into superhydrophilic ones with hierarchically gradient pores. This approach distinctively exploits mussel-inspired L-3,4-dihydroxyphenylalanine (L-DOPA), rather than dopamine, in combination with polyethyleneimine (PEI) co-deposition and carbon nanotubes (CNTs) nanostructuring, forming a highly stable, multifunctional hydrophilic network that anchors CNTs while synergistically regulating pore size, pore distribution, and surface wettability. As a result, the average pore size decreased from 0.4075 μm to 0.2883 μm, enhancing selective permeability. The optimized L-DOPA/PEI/CNTs/PVDF membrane exhibited an ultrahigh pure water flux of 5367.9 L m −2 h −1 bar −1 and achieved over 99 % rejection of diverse surfactant-stabilized emulsions. Moreover, the membrane demonstrated excellent antifouling, consistently maintaining ≥98 % oil rejection over seven cycles, attributed to the formation of a compact hydration layer. By integrating bio-inspired adhesion chemistry with nanostructured pore-gradient engineering，this study provides a scalable and environmentally relevant route for fabricating high-performance separation membranes, offering strong potential for sustainable oily wastewater treatment and resource recovery applications.
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