Nature Communications
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2024
·Vol. 15
·期 1
·1-14
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IF 14.7
Yuan Guanghui,Jin Zihao,Cao Yingchang,Schulz Hans-Martin,Gluyas Jon,Liu Keyu,He Xingliang,Wang Yanzhong
Organic-inorganic interactions regulate the dynamics of hydrocarbons, water, minerals, CO 2 , and H 2 in thermal rocks, yet their initiation remains debated. To address this, we conducted isotope-tagged and in-situ visual thermal experiments. Isotope-tagged studies revealed extensive H/O transfers in hydrous n -C 20 H 42 -H 2 O-feldspar systems. Visual experiments observed water microdroplets forming at 150–165 °C in oil phases near the water-oil interface without surfactants, persisting until complete miscibility above 350 °C. Electron paramagnetic resonance (EPR) detected hydroxyl free radicals concurrent with microdroplet formation. Here we propose a two-fold mechanism: water-derived and n- C 20 H 42 -derived free radicals drive interactions with organic species, while water-derived and mineral-derived ions trigger mineral interactions. These processes, facilitated by microdroplets and bulk water, blur boundaries between organic and inorganic species, enabling extensive interactions and mass transfer. Our findings redefine microscopic interplays between organic and inorganic components, offering insights into diagenetic and hydrous-metamorphic processes, and mass transfer cycles in deep basins and subduction zones.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
He Meng,Li Rui,Cheng Chuanqi,Liu Cuibo,Zhang Bin
The high Faradaic efficiency (FE) of the electrocatalytic deuteration of organics with D 2 O at a large current density is significant for deuterated electrosynthesis. However, the FE and current density are the two ends of a seesaw because of the severe D 2 evolution side reaction at nearly industrial current densities. Herein, we report a combined scenario of a nanotip-enhanced electric field and surfactant-modified interface microenvironment to enable the electrocatalytic deuteration of arylacetonitrile in D 2 O with an 80% FE at −100 mA cm −2 . The increased concentration with low activation energy of arylacetonitrile due to the large electric field along the tips and the accelerated arylacetonitrile transfer and suppressed D 2 evolution by the surfactant-created deuterophobic microenvironment contribute to breaking the trade-off between a high FE and large current density. Furthermore, the application of our strategy in other deuteration reactions with improved Faradaic efficiencies at −100 mA cm −2 rationalizes the design concept.
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JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-16
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IF 10.6
Xia Tian,Zhu Yuting,Li Kaiqiang,Hao Ke,Chai Yingqian,Jiang Hongyi,Lou Chao,Yu Jiachen,Yang Wei,Wang Jilong,Deng Junjie,Wang Zhen
Background Rheumatoid arthritis (RA) is a prevalent inflammatory autoimmune disease characterised by persistent inflammation and joint damage with elevated levels of reactive oxygen species (ROS). Current treatment modalities for RA have significant limitations, including poor bioavailability, severe side effects, and inadequate targeting of inflamed joints. Herein, we synthesised cerium/manganese oxide nanoparticles (NPs) as efficient drug carriers with antioxidant and catalytic-like functions that can eliminate ROS to facilitate the polarization of macrophages phenotype from M1 to M2 and alleviate inflammation. Methotrexate (MTX), a first-line RA medication, was loaded into the NPs, which were further modified with bovine serum albumin (BSA) and integrated into dissolving hyaluronic acid-based microneedles (MNs) for transdermal delivery. Result This innovative approach significantly enhanced drug delivery efficiency, reduced RA inflammation, and successfully modulated macrophage polarization toward an anti-inflammatory phenotype. Conclusion This research not only presents a promising drug delivery strategy for RA but also contributes broadly to the field of immune disease treatment by offering an advanced approach for macrophage phenotypic reprogramming.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Shi Chenyang,Wang Jianan,Lei Xia,Zhou Qisen,Wang Weitao,Yang Zhichun,Liu Sanwan,Zhang Jiaqi,Zhu He,Chen Rui,Pan Yongyan,Tan Zhengtian,Liu Wenguang,Zhao Zhengjing,Cai Zihe,Qin Xiaojun,Zhao Zhiguo,Li Jingbai,Liu Zonghao,Chen Wei
The employment of self-assembled molecular hybrid could improve buried interface in perovskite solar cells (PSCs). However, the interplay among hybrid self-assembled monolayers (SAMs) during the deposition process has not been well-studied. Herein, we study the interaction between co-adsorbents and commonly used SAM material, [4-(3,6-dimethyl-9 H -carbazol-9-yl)butyl]phosphonic acid (Me-4PACz) for wide-bandgap (WBG) PSCs. It is found that the co-adsorbent, 6-aminohexane-1-sulfonic acid (SA) tends to fill the uncovered sites without interference with Me-4PACz, ensuring the formation of a dense hole selective layer. Moreover, the use of SA/Me-4PACz mixed SAMs could effectively reduce the interfacial non-radiative recombination loss, optimize the energy alignment at the buried interface and regulate the crystallization of WBG perovskite. As a result, the 1.77 eV WBG PSCs deliver a power conversion efficiency (PCE) of 20.67% (20.21% certified) and an impressive open-circuit voltage ( V OC ) of 1.332 V (1.313 V certified). By combining with a 1.26 eV narrow-bandgap (NBG) PSC, we further fabricate 2-terminal all-perovskite tandem solar cells (TSCs) with a PCE of 28.94% (28.78% certified) for 0.087 cm 2 and 23.92% for mini-module with an aperture area of 11.3 cm 2 .
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Applied Biological Chemistry
·
2024
·Vol. 67
·期 1
·1-14
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IF 2.3
Wang Hong,Liao Xiang,Lin Chunyao,Bai Weidong,Xiao Gengsheng,Huang Xingyuan,Liu Gongliang
The aims of the present stud were to optimize fermentation parameters of seedless wampee wine using response surface methodology (RSM) and evaluate the changes in flavor metabolites during fermentation. Seedless wampee wine of optimal sensory quality was produced using an inoculum concentration of 0.6%, initial sugar levels of 200 g/L, a fermentation temperature of 22 °C, and a fermentation period of 9 days. Then the flavor compound profiles (amino acids, organic acids and volatile aroma compounds) of seedless wampee wine during the fermentation under optimal conditions were analyzed using high performance liquid chromatography (HPLC) and gas chromatography–mass spectrometr (GC-MS). The main fermented phase of fermentation resulted in fluctuations in both total amino acids and organic acids, with stabilization occurring later on. A total of 54 volatile components, including esters, alcohols, terpenes, and acids, were putatively identified. Terpenes were the primary drivers of the flavor characteristics of seedless wampee. The rise of esters and decline of terpenes have the potential to significantly alter the flavor of wine during fermentation. These results would contribute to the further development of seedless wampee wine.
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Advanced Fiber Materials
·
2024
·
IF 17.2
Wang Peng,Li Xiaodan,Sun Guifen,Wang Guoqing,Han Qing,Meng Chuizhou,Wei Zhonghe,Li Yang
Wearable sensors have been rapidly developed for application in various human monitoring systems. However, the wearing comfort and thermal properties of these devices have been largely ignored, and these characteristics urgently need to be studied. Herein, we develop a wearable and breathable nanofiber-based sensor with excellent thermal management functionality based on passive heat preservation and active Joule heating effects. The multifunctional device consists of a micropatterned carbon nanotube (CNT)/thermoplastic polyurethane (TPU) nanofiber electrode, a microporous ionic aerogel electrolyte and a microstructured Ag/TPU nanofiber electrode. Due to the presence of a supercapacitive sensing mechanism and the application of microstructuration, the sensor shows excellent sensing performance, with a sensitivity of 24.62 kPa −1 . Moreover, due to the overall porous structure and hydrophobicity of TPU, the sensor shows good breathability (62 mm/s) and water repellency, with a water contact angle of 151.2°. In addition, effective passive heat preservation is achieved by combining CNTs with high solar absorption rates (85%) as the top layer facing the outside, aerogel with a low thermal conductivity (0.063 W m −1 k −1 ) as the middle layer for thermal insulation, and Ag with a high infrared reflectance rate as the bottom layer facing the skin. During warming, this material yields a higher temperature than cotton. Furthermore, the active Joule heating effect is realized by applying current through the bottom resistive electrode, which can quickly increase the temperature to supply controlled warming on demand. The proposed wearable and breathable sensor with tunable thermal properties is promising for monitoring and heat therapy applications in cold environments. Graphical Abstract We reported a wearable and breathable nanofiber-based sensor with excellent thermal management functionality based on passive heat preservation and active Joule heating effects.
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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2024
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IF 3.1
Wang Guanghui,Cheng Jianxiang,Yao Meizhen,Li Jing,Chen Ting,Zhang Jia,Du Wensheng,Chen Youguo
Ovarian cancer stands as the foremost cause of mortality among gynaecological diseases globally, characterized by high morbidity and mortality. Pinocembrin, a flavonoid from natural plant sources, exhibits diverse pharmacological properties. Despite its known pharmacological activities, its specific role in ovarian cancer treatment remains scarcely reported, and its precise molecular mechanism remains elusive. This study integrates network pharmacology and molecular docking techniques to explore pinocembrin’s potential mechanism in ovarian cancer treatment. The targets of pinocembrin were compiled from the several online databases. Ovarian cancer targets were identified using the GeneCards database, with common target genes determined by data aggregation. Protein–protein interactions were analysed using the STRING platform. Subsequent Gene Ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed. Molecular docking assessed the binding affinity between potential targets and active compounds. Finally, target validity was verified through in vitro experiments. We identified 163 potential pinocembrin targets for ovarian cancer treatment. GO and KEGG analyses revealed pinocembrin’s involvement in protein kinase activity, protein phosphorylation, protein kinase complexes and cancer pathways in ovarian cancer treatment. Molecular docking demonstrated strong binding affinity between pinocembrin and most potential target active sites. In vitro experiments suggested pinocembrin’s potential to induce apoptosis in ovarian cancer cells through the AKT1-mTOR signalling pathway. This study comprehensively elucidates pinocembrin’s potential targets and mechanisms against ovarian cancer, aiming to provide promising candidates for developing novel and effective alternative and/or complementary nutritional supplements for the clinical treatment of ovarian cancer.
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IONICS
·
2024
·
IF 2.4
Yuan Huaming,Zhang Yunqiang,Lu Yiming,Li Xin,Liu Ming,Cui Jiaxi,Li Mei,Jing Laiying
Lithium-sulfur batteries (LSBs) have a high theoretical specific capacity (1675 mAh/g) and are expected to replace lithium-ion batteries as a new generation of high-density energy storage devices. However, the existence of problems such as the “shuttle effect” causes an irreversible loss of LSB capacity. In view of this, carbon nanorods embedded with cobalt nanoparticles (Co-CNRs-CTAB) were successfully prepared through the high-temperature pyrolysis of prism-shaped polypyrrole loaded with zeolitic imidazolate framework-67 under the assistance of cetyltrimethylammonium bromide (CTAB), applied as commercial polypropylene (PP) separator modifiers to promote the rapid capture and redox conversion of soluble polysulfides for upgrading LSBs. The results show that the LSBs assembled with modified Co-CNRs-CTAB/PP separator have amazing electrochemical performance, involving a high initial mass specific capacity of 1091.8 mAh/g (1 C) and excellent cycling stability (594.7 mAh/g after 300 cycles at 3 C). Even at − 10 °C, the capacity attenuation of the LSBs per cycle is only 0.05% after 150 cycles. Therefore, this work provides an operationally simple and low-cost solution for improving the cycle life of LSBs.
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Discover Oncology
·
2025
·Vol. 16
·期 1
·1-16
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IF 2.9
Wang Biao,Zhang Nianjie,Dai Lin,Zhang Yuanwei,Yin Shuo,Yang Xuefeng
Nonylphenol (NP) is a common environmental contaminant and endocrine disruptor. Our previous research demonstrated that NP could promote the proliferation and epithelial-mesenchymal transition (EMT) of colorectal cancer (CRC) cells; however, the specific mechanism remains unclear. miRNA sequencing revealed that NP upregulated the expression levels of microRNA(miR)-151a-3p in CRC. Analysis of The Cancer Genome Atlas (TCGA) data revealed increased expression levels of miR-151a-3p in CRC tissues. The present experiments showed that NP could activate the WNT/β-catenin signaling pathway, and promoted the migration and invasion of CRC cells by increasing the expression levels of miR-151a-3p. Through bioinformatics analysis and dual-luciferase reporter assays, Fyn-related kinase (FRK) was identified as a target gene of miR-151a-3p. Knockdown of FRK promoted NP-induced EMT in CRC cells and activated the WNT/β-catenin signaling pathway, while overexpression had the opposite effect. In summary, the present study demonstrated that NP could inhibit FRK expression via miR-151a-3p, activate the WNT/β-catenin signaling pathway, and promote EMT in CRC cells.
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Advanced Fiber Materials
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2024
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IF 17.2
Hu Xili,Zhang Bo,You Chaoyu,Tian Mingwei,Xing Dongming,Zhang Xueji,Qu Lijun
Alternating current electroluminescent (ACEL) fibers with wearable characteristics, such as flexibility, light weight, stitchability and comfort, are emerging in textile displays for daily applications. To construct efficient ACEL fibers, a judiciously designed and low-cost electrode is also extremely important but seems to receive less attention. Inspired by fiber dyeing, we propose a method that employs non-noble metals to design fiber electrodes by constructing microconductive channels inside commercial fibers. This method relies on the window period formed by the glass transition temperature of the PAN fibers, which is sufficiently flexible to extend to mass production at a low cost (approximately US$ 1.86/kg). The resulting ACEL fibers interwoven with a transparent fiber electrode formed a textile display with an acceptable luminescence performance of 46 cd · m −2 (160 V). Notably, a visual feedback e-textile (VFET) was constructed by integrating fiber sensors, which demonstrates the concept of wearable real-time visual monitoring and interaction. Compared with their individual counterparts, VFET has been conveniently and efficiently for visual monitoring, communication, and interaction, i.e., the visualization of physiological parameters (heartbeat, respiration, etc.) and nonverbal communications (literal or cryptographic) for special groups and specific scenes. Graphical Abstract
Non-noble metal electroluminescent (EL) fibers and accessible, sensitive, and flexible visual feedback e-textiles (VFET) capable of being integrated into smart clothing and wearable devices are proposed in this work
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Journal of Analysis and Testing
·
2025
·
IF 7
Liang Yunyan,Zhou Xiaomeng,Liu Wenfeng,Shang Li
Rapid and effective differentiation of cancerous cells is essential for early diagnosis and treatment of tumors. Here, a multichannel sensor array is developed based on four surface-engineered gold-silver nanoclusters (AuAgNCs) to discriminate multiple cancerous and normal cells. Different binding affinities between various cells and AuAgNCs lead to changes in the intrinsic fluorescence of AuAgNCs as well as their peroxide-like activity. Based on the distinct response of dual fluorescence signals of four AuAgNCs, a multichannel sensor array is established, which is capable of accurately identifying both normal and cancerous cells, even cells of different subtypes and homologous cells from various individuals with high sensitivity. Moreover, this fluorescent clusterzyme-based sensor array enables quantitative detection of cancerous cells (e.g., HeLa cells) with good performance, which holds great potential as a promising platform for further cancer diagnosis.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-9
·
IF 14.7
Qi Cheng,Ma Xudong,Zeng Qi,Huang Zhangwei,Zhang Shanshan,Deng Xiaokang,Kong Tiantian,Liu Zhou
Hierarchical compartmentalization, a hallmark of both primitive and modern cells, enables the concentration and isolation of biomolecules, and facilitates spatial organization of biochemical reactions. Coacervate-based compartments can sequester and recruit a large variety of molecules, making it an attractive protocell model. In this work, we report the spontaneous formation of core-shell cell-sized coacervate-based compartments driven by spontaneous evaporation of a sessile droplet on a thin-oil-coated substrate. Our analysis reveals that such far-from-equilibrium architectures arise from multiple, coupled segregative and associative liquid-liquid phase separation, and are stabilized by stagnation points within the evaporating droplet. The formation of stagnation points results from convective capillary flows induced by the maximum evaporation rate at the liquid-liquid-air contact line. This work provides valuable insights into the spontaneous formation and maintenance of hierarchical compartments under non-equilibrium conditions, offering a glimpse into the real-life scenario.
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