JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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2019
·Vol. 19
·期 9
·5463-5468
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IF 1.093
Zhang Nan,Liu Xinyang,Hou Ruirui,Zhang Jiangnan,Li Jia,Huo Pengchao,Xu Yue,Zhang Zhenzhong
The purpose of current research is to develop ultrasound-triggered gas-generating Doxorubicin PLGA nanoparticle for cancer therapy. Method: pH-sensitive PLGA nanoparticles (PLGANPs) was fabricated to deliver doxorubicin (DOX) and sodium bicarbonate (NaHCO3) using the water-in-oil-in-water
(w/o/w) double emulsion method. Result: The nanoparticle with the size (650 nm) and high drug loading (15.8±2.3%) were successfully prepared and showed pH-responsive release characteristics. In vitro results indicate that DOX/NaHCO3@PLGANPs with ultrasound had higher
inhibition and cell uptake on MCF-7 cells than free DOX and other formulation. In vivo animal experiments showed that after treatment of DOX/NaHCO3@PLGANPs with ultrasound, the relative tumor volume (0.63) of S180-tumor-bearing mice was lower than that of without ultrasound
(0.81), DOX@PLGANPs (1.00) and Free DOX (1.12). Moreover, safety evaluation result indicated that DOX/NaHCO3@PLGANPs was safer than free DOX. In conclusion, the DOX/NaHCO3@PLGANPs was successfully developed and evaluated In vitro and In vivo. This drug delivery
system will be a promising strategy for cancer therapy and diagnosis.
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ACTA MATERIALIA
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2019
·
IF 7.293
Ruixuan Song,Yu Zhao,Weili Li,Yang Yu,Jie Sheng,Ze Li,Yulei Zhang,Hetian Xia,Wei-Dong Fei
Low temperature stability has limited the applications at elevated temperature for ABO 3 -type lead-free ceramics. And multi-grade resonances of piezoelectric ceramics are hardly obtained although the resonances are very important in some applications such as filter and resonator . High piezoelectric properties and large mechanical quality factors with multi-grade resonances can be obtained in (Li + -La 3+ ) co-doped BaTiO 3 ceramics, and excellent temperature stabilities are achieved in the ceramics. It has been shown that the thermal treatments both with and without electric field at 200 °C improve the piezoelectric properties and thermal stability further. Large piezoelectric constant (272 pC N 1 ) and huge mechanical quality factor (2010) was obtained after thermal-electrical treatment, which is caused by Li + -La 3+ ionic pair aligning along the external electric filed during thermal-electrical treatment. Moreover, the present study provides an effective method to design combination properties with high temperature stability for ABO 3 perovskite ferroelectric ceramics .
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
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IF 3.131
Chuanmin Zhang,Shubiao Zhang,Defu Zhi,Yinan Zhao,Shaohui Cui,Jingnan Cui
This work designed a new delivery system (L-PTX-PSur), which could efficiently co-deliver paclitaxel (PTX) and survivin siRNA (Sur) to overcome the dose-limiting toxicity by effectively accumulating PTX in tumor and obtain enhanced therapy by synergistic effect. In this co-delivery system, protamine was selected to condense siRNA into a compacted ‘core’, and a carbamate-linked cationic lipid was used to develop PTX-loaded liposome to entrap the core. L-PTX-PSur with protamine could facilitate Sur entry into NCI-H460 cells and exhibited high encapsulation efficiency of PTX. In vitro studies on the NCI-H460 lung cancer cells revealed that L-PTX-PSur offered significant advantages over the control groups, and it had the highest cellular uptake, the lowest cell viability and the strongest apoptosis. Western blot result showed that survivin protein expression could be noticeably suppressed by L-PTX-PSur in NCI-H460 cells. And the down-regulation of survivin protein could lower the apoptotic threshold of cancer cells and render PTX more effective with low doses. Collectively, L-PTX-PSur with a low dose of PTX could induce a synergistic inhibitory effect on cancer cells growth by the collaboration of PTX and Sur. This work provides a promising strategy for the treatment of lung cancer.
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Materials Science & Engineering C-Materials for Biological Applications
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2019
·
IF 4.959
Ling Zheng,Bingjie Zhou,Xiaofeng Qiu,Xin Xu,Gang Li,Wayne Y.W. Lee,Jia Jiang,Yulin Li
The multidrug resistance of tumor cells has been creating a high requirement on development of nanocarriers for administration of different drugs, among which their drug loading capacity and controllable release properties are the key factors to overcome tumor drug resistance. This study aims to use a kind of bioactive 2D nanoplatelets (25 nm in diameter and 0.92 nm in thickness) to load different anticancer drugs (doxorubicin and methotrexate) via a step-by-step assembly, where variation of each drug amount can be used for adjustment of the sizes of the resulting nanocomplexes. The dual-drug loaded nanosystems allow for a sequential release of the loaded drugs. Furthermore, drug release rate can be accelerated under both acidic pathological triggers of tumors and/or by heating treatment, resulting in a synergistic anticancer bioactivity. The drug-mediated formation of nanocarriers may enlighten a design of novel nanoplatform for co-delivery of therapeutic agents, beyond anticancer drugs, in a combinative way for drug delivery applications.
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Journal of Materials Chemistry C
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2019
·Vol. 7
·期 11
·3181-3189
·
IF 6.641
Xin Cheng,Lin Wang,Fengmei Gao,Weiyou Yang,Zhentao Du,Ding Chen,Shanliang Chen
The third-generation semiconductor silicon carbide (SiC) is identified as one of the vitally important candidate materials to serve as a functional unit that performs stably and reliably under harsh working conditions, with respect to its excellent piezoresistive effects and robust physical/chemical characteristics. In the current work, we put forward the fabrication of SiC nanowires with co-doped N and P elements, which were fabricated via the pyrolysis of a polymeric material. The as-grown nanowires have a typical diameter of ∼260 nm with a 10 surface. The measured transverse piezoresistance coefficient π[10] of the established SiC nanowires increased from 5.07 to −146.30 × 10−11 Pa−1 as the loading forces varied from 24.95 to 130.51 nN. Meanwhile, the corresponding gauge factor (GF) was calculated up to ca. −877.79, which is higher than the values for all SiC nanostructures ever reported. The mechanism concerning the giant negative piezoresistance behavior of SiC nanowire is proposed. The current exploration may pave a new avenue for the development of highly sensitive and robust pressure sensors that could survive under harsh working conditions.
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Results in Physics
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2019
·
IF 3.042
Yang Zhou,Xiaoyuan Liu,Ke Wang,Jing Li,Xinglai Zhang,Xin Jin,Xinyue Tang,Xiuhui Zhu,Ruishi Zhang,Xin Jiang,Baodan Liu
Series of “Hopcalite” catalysts for low-temperature CO oxidation are prepared through a facile ultra-sonic spray pyrolysis approach. It has been found that the spray pyrolysis temperature and Cu/Mn atomic ratio in initial precursors show significant impacts on the catalytic activity of Cu-Mn-O catalysts. The catalyst synthesized at 550 °C with Cu/Mn = 1/2 in precursor (Cu1Mn2-550) shows the highest catalytic activity towards CO oxidation (T 100 = 63 °C; E a = 17.04 KJ mol −1 ), owing to the formation of CuMn 2 O 4 phase with poor crystallinity. The synergistic effect of Cu and Mn species in spinel Cu-Mn-O phases attributes to the evaluated catalytic activity compared with those of pure oxides of copper or manganese towards CO oxidation. The results reveal that Cu1Mn2-550 not only provides more defects and vacancies to create more active sites, but also generates more highly active Cu (II) to promote CO oxidation. On the contrary, the decreasing amount of Cu (II) and the higher degree of crystallinity resulting from higher synthesis temperature lead to the deterioration of catalytic activity. Moreover, the phase transformation among the Cu x Mn 3-x O 4 spinels also shows significant effect on CO conversion rate. Finally, the formation mechanism of Cu-Mn-O catalysts and related CO oxidation process are discussed based on series of characterizations.
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Polymer Chemistry
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2019
·Vol. 10
·期 35
·4789-4800
·
IF 4.76
Zongke He,Hui Niu,Nan Zheng,Shuhui Liu,Yang Li
A series of elastomeric hydrogels with repeated processability were prepared in this work. These hydrogels were obtained by cross-linking of two common polymers, poly(ethylene-co-propylene) (ethylene-propylene rubber, EPR) and poly(ethylene glycol) (PEG), via dynamic covalent bonds, specifically, through firstly furyl functionalization of EPR at the side groups and maleimide modification of PEG at the chain ends, and followed by the Diels–Alder reaction between furan and maleimide to construct thermoreversible EPR–PEG networks. The composition and microstructure of the network were adjustable in a wide range by facilely tuning the PEG feeding ratios and molecular weights (as the cross-linking agent). In the network the crystalline PEG and the elastic EPR endowed the material with strength and toughness respectively in the dry state, giving a fracture strength of 4–6 MPa and elongation at break of up to 380%; meanwhile, due to the hydrophilicity of PEG, the network could absorb water and form hydrogels, in which the hydrophobic EPR elastomer enhanced the hydrogels effectively. By tailoring the amount and the chain structure of the PEG moiety, the water absorption of the copolymer could reach as high as 356% in 1 hour, and the hydrogel elongation at break could achieve ∼400%, which was comparable to that of pristine cross-linked EPR. The material displayed low cytotoxicity in MC3T3-L1 cells and was biocompatible.
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INTEGRATED FERROELECTRICS
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2019
·
IF 0.486
Chengyi Chu,Huangsheng Wu,Aihua Sun,Xiaobing Tang,Yugang Yan,Guoxiong Shao,Zhixiang Li,Jianjun Guo,Gaojie Xu
The multresponsive photonic hydrogels (MRPHs) based on Fe3O4@C NPs and Acrylamide-N-isopropylacrylamide (AM-NIPAM) was prepared by UV polymerization process with the help of magnetic field. This work is mainly about the long-term stability of MRPHs. The mechano-response performance of MRPHs after being remained in water for a year has been measured and discussed in details. The result shows that the MRPHs were still very sensible and exhibit brilliant structure color. The reflectance peak of MRPHs changed markedly (from 700 nm to 550 nm) as increasing compression from 0 to 1N and the structure color change can be made reversible for ∼100 times or even more if necessary. Besides, the structure color of MRPHs was broken after being natural air-dried for 3 months and it can recover when dried MRPHs were immerged in water for 10 hours. So the MRPHs have good stability and the structure color can persevere for long time without fading, which contributes to the piratical application of MRPHs used as sensors.
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RSC Advances
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2019
·Vol. 9
·期 40
·22875-22882
·
IF 3.049
Pengjian Wang,Tingbiao Yuan,Huifang Yuan,Xiaoyan Zheng,Hamza Ijaz,Junfeng Hui,Daidi Fan,Yuxin Zhao,Shi Hu
In this paper, we developed a simple two-step route to prepare a PdO/SnO2 heterostructure with the diameter of the SnO2 and PdO nanoparticles at about 15 nm and 3 nm, respectively. In the evaluation temperature window between 80 °C and 340 °C, PdO/SnO2 shows the best response to 100 ppm of CO at 100 °C with fast response time (14 s) and recovery time (8 s). Furthermore, the PdO/SnO2 nanoparticles exhibit a low detection limit and good selectivity to CO against interfering gases as well as rarely-seen low-temperature stability and reversibility. Such enhanced gas sensing performance could be attributed to both the ultrafine structure of PdO and the synergy between PdO and SnO2. The results clearly indicate the application of PdO/SnO2 as a pratical low-temperature sensing material for CO.
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ACS Applied Nano Materials
·
2019
·
IF 0
Chunlei Zhang,Ping Wu,Guojuan Liu,Zhigao Zhu,Gaofeng Zeng
Direct oxidation of methanol to high value oxygenated chemicals on V2O5/TiO2 based catalysts is a green alternative to the commercial methods. But the V–Ti based catalysts are challenged by the relatively low reactivity. Herein, we demonstrated a facile and practicable strategy to directly fabricate hollow structure VOx/TiO2 nanofibers (VTO-HNF) through the coelectrospinning and calcination method. The effects of V/Ti ratio on the structure, the surface chemistry and methanol oxidation performance were investigated in detail. VTO-HNFs with appropriate V/Ti ratio have hierarchical structure, large surface area, uniform nanoparticles, narrowed grain sizes, and high dispersions of vanadium. Moreover, both the oxidation properties and the acidities of the catalyst were enhanced due to the high content of surface V4+. The VTO-HNF catalysts featured excellent activities and reliable stability for the selective oxidation of methanol to methyl formate (MF) and dimethoxymethane (DMM). The MF yield reached 90% at 150 °C, which is comparable with the noble metal based catalysts. In situ NAP-XPS investigations suggested that the variable valence of vanadium was involved in the oxidation of methanol.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2019
·
IF 4.175
Xianfeng Meng,Shenhui Dong
C/Co composites are promising materials for electromagnetic (EM) wave absorption. In this work, C/Co nanofibres were synthesised via a facile electrospinning method followed by an in situ reduction process. The results indicate that the heterogeneous structure and Co content play a vital role in determining the EM wave absorption performance of the C/Co nanofibres. At 15 wt% Co content, the C/Co nanofibres exhibit optimal impedance matching and attenuation ability, and the minimum reflection loss for the sample with thickness 3.5 mm is −58.8 dB. The effective absorption bandwidth reaches 12.9 GHz in the range of 2–18 GHz, which partially and completely covers the C and X-Ku bands, respectively. The EM wave absorption mechanism based on the conductive, dielectric , and magnetic losses is discussed in detail. The results indicate that the C/Co nanofibres possess significant potential for microwave absorption applications.
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APPLIED CLAY SCIENCE
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2019
·
IF 3.89
Chun Hui Zhou,Li Cun Jun,Will P. Gates,Ting Ting Zhu,Yu Wei Hua
Organo-montmorillonite (OMt) has been widely used in paints, drilling fluids, clay/polymer nanocomposites , adsorbents and biosensors , however the full potential of OMt is yet to be discovered. The co-introduction of cationic and nonionic species into Mt has great potential to expand modification strategies and applications of Mt However, details regarding the intercalation mechanism of dual organic species remain unclear and the aspects of hydrophobicity and swellability of OMt are unknown. In this work, the co-introduction into OMt of octadecyltrimethylammonium (ODTMA + ) cations and a nonionic specie erucamide (EA), and ODTMA + with an oleamide (OA). was investigated. The resultant OMt samples were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy. Hydrophobicity and swellability of the OMt were examined. The results showed that neither EA nor OA could be effectively introduced into the interlayer spaces of Mt, although adsorption of EA and OA onto the external surface of Mt did occur. In the presence of ODTMA + , however, both EA and OA were successfully co-intercalated into the interlayer spaces of Mt, and the basal spacing (d 001 ) of ODTMA + , EA and OA co-intercalated OMt increased to as much as 4.2 nm. Such dual modification appeared to be effective at tailoring hydrophobicity. The swellability of ODTMA + , EA and OA co-intercalated OMt in xylene increased with the increase in the amount of EA and OA loaded. When Mt was modified using 1.0 CEC ODTMA + with 0.5–1.75 CEC EA, 0.2 g OMt in 10 mL xylene swelled to take 10 ml volume, equating to a swell index of 100%. Here, a two-stage intercalation is proposed: cationic exchange of ODTMA + to form a paraffin-type monolayer, followed by hydrophobic entropy-driven adsorption of nonionic EA and OA by intertwining organic chains into the interlayer spaces of the OMt The findings show the promise of co-intercalation to introduce many other cations and nonionic organic species into the interlayer spaces of Mt, and thus greatly expands the types of OMt for new applications.
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