IONICS
·
2024
·
IF 2.4
Yan Lichen,Chen Wei,Song Zehui,Xiao Li
A novel NiO/MnO 2 pompon-like hybrid structure was synthesized through a facile one-step hydrothermal in situ growth approach in this paper. NiO nanosheets grow on MnO 2 pompon-like microsphere to form typical hybrid structures which significantly increase the abundant active sites of electrode materials. The resulting NiO/MnO 2 electrode material exhibits an impressive specific capacity of 2706.1 F/g at a current density of 1 A/g. Remarkably, NiO/MnO 2 pompon-like hybrid structure shows excellent cycling performance and its capacity retention is maintained at 84.8% and the charge–discharge efficiency at 96% after 15,000 cycles. Even after undergoing 40,000 cycles, the electrode material maintains an outstanding charge–discharge efficiency of 95.2% with capacity retention of 69%, which revealing promising application as long-term electrode materials for supercapacitors.
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POLYMER BULLETIN
·
2024
·
IF 3.1
Yu Zuolong,Chen Yao,Chen Yongfei,Wei Yunxiao,Fu Changchun,Liu Dan,Niranjan Keshavan,Han Chao
Six types of γ-polyglutamic acid (γ-PGA)/cold water-soluble starch (St) composite film models were constructed using molecular dynamics simulation, and their properties were investigated and compared with the corresponding experimental values. The compatibility between the composite film components was analyzed using the radial distribution function and mean square displacement (MSD). The hydrogen-bond number and bond energy were used to track the film-formation process. The mechanical property data of the films were extracted, and MSD was used to analyze the permeability of the film to carbon dioxide, oxygen, water vapor, and carbon-16 saturated fatty acids. Finally, the simulated values of mechanical properties and permeability were compared with the experimental values. The results demonstrated that γ-PGA is well compatible with St. The intramolecular and intermolecular hydrogen bonds of γ-PGA and St did not change considerably during the film-formation process. The simulated values of the mechanical properties exhibited a similar trend as the experimental values; however, in terms of permeability, a difference was observed between the initial values of the simulated design and actual material parameters, as well as the complexity of the experiment.
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Nature Chemistry
·
2024
·
IF 19.2
Ma Baochen,Zhang Haikuo,Li Ruhong,Zhang Shuoqing,Chen Long,Zhou Tao,Wang Jinze,Zhang Ruixin,Ding Shouhong,Xiao Xuezhang,Deng Tao,Chen Lixin,Fan Xiulin
Ideal rechargeable lithium battery electrolytes should promote the Faradaic reaction near the electrode surface while mitigating undesired side reactions. Yet, conventional electrolytes usually show sluggish kinetics and severe degradation due to their high desolvation energy and poor compatibility. Here we propose an electrolyte design strategy that overcomes the limitations associated with Li salt dissociation in non-coordinating solvents to enable fast, stable Li chemistries. The non-coordinating solvents are activated through favourable hydrogen bond interactions, specifically F δ− –H δ+ or H δ+ –O δ− , when blended with fluorinated benzenes or halide alkane compounds. These intermolecular interactions enable a dynamic Li + –solvent coordination process, thereby promoting the fast Li + reaction kinetics and suppressing electrode side reactions. Utilizing this molecular-docking electrolyte design strategy, we have developed 25 electrolytes that demonstrate high Li plating/stripping Coulombic efficiencies and promising capacity retentions in both full cells and pouch cells. This work supports the use of the molecular-docking solvation mechanism for designing electrolytes with fast Li + kinetics for high-voltage Li batteries.
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PubMed
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·1-17
·
IF 3.9
Xing Yamin,Li Guangyuan,Li Ganggang,Xu Jixuan,Zhang Ting,Li Mengxue,Gao Chunxiao,Fu Miaoran,Zheng Pengyuan,Chu Xiufeng
Metallothioneins (MTs) are a class of cysteine-rich proteins that actively participate in the cellular defense against free radicals. However, owing to the high heterogeneity among different MTs, comprehensive investigations are needed to determine the biological activities and distribution patterns of each MT in different tissues. In the present study, ectopic expression of MT1H significantly inhibited the proliferation of gastric cancer cells. Mechanistically, MT1H was transported into the nucleus and regulated the expression of key genes involved in nutrient transportation and homeostasis, such as SLC6A19, TTC39B, and ADM2, and thereby activating the p53 and autophagy pathways. Additionally, survival analysis of data from the TCGA and other databases revealed that gastric cancer patients with high expression of MT1H had longer survival. Furthermore, MT1H was undetectable in most gastric cell lines, but its expression was increased upon treatment with dexamethasone (Dexa) and the metal ion zinc. Therefore, MT1H emerges as a valuable tumor suppressor, a biomarker for the prognosis, and a promising therapeutic target in gastric cancer patients.
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高影响因子
Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 5
·1-14
·
IF 23.2
Gao Han,Qin Long,Tao Shifei,Xiong Ziming,Wu Fan,Lei Ming
Optimizing high dielectric constant materials is a promising strategy for manufacturing efficient electromagnetic wave absorbing materials, which aims to fully exploit the performance advantages of micro-nano materials and overcome the adverse effects at low scales. This requires reasonable and meticulous component optimization. The low-cost and environmentally friendly fillers possess significant advantages. In this work, two specifications of carbon nanotubes (CNTs) are selected as the research objects. A simple solvothermal method is used to compound rare earth oxides (REO). Finally, CNTs/REO composites are prepared. The effects of different particle sizes on the electromagnetic wave absorption properties of the system are studied in detail from the microscopic morphology. Improve the interface effect and impedance matching in the system. When the filling amount is 30 wt.%, the minimum reflection loss (RL min ) can reach − 69.94 dB, and the effective absorption bandwidth (EAB) is widened from 3.00 to 5.20 GHz. The huge performance span is attributed to the optimization of REO nanoparticles in the regulation of CNTs from morphology structure to electromagnetic parameters. The interfacial polarization, dielectric polarization, and dipole relaxation are improved significantly. The excellent electromagnetic wave absorption performance makes CNTs/REO have great application prospects in electronic devices. In addition, radar cross section (RCS) simulation provides theoretical support for the practical application of CNTs/REO composites. Graphical Abstract
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 6
·1-14
·
IF 5.3
Guo Qi,Wang Du,Ma Fei,Fang Mengxue,Zhang Liangxiao,Li Peiwu,Yu Li
Phytosterols (PSs), a class of naturally occurring bioactive lipid compounds, have been found to possess a significant cholesterol-lowering effect. In developing countries, the consumption of rapeseed oil is the primary pathway of PS intake for the general population. However, developing low-cost, real-time, and high-throughput screening techniques for PSs remains a challenge. Here, a Cu-based nanocomposite CuOx@C was synthesized via a simple method of the calcination of HKUST-1 and systematically characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The CuOx@C demonstrated excellent peroxidase-like (POD-like) activity, functioning as a peroxidase mimic to facilitate the catalysis of 3,3′,5,5′-tetramethylbenzidine (TMB) into its oxidized form (oxTMB), thereby initiating a discernible color response. On the basis of this discovery, a CuOx@C-based colorimetric method for detecting total sterols in rapeseed was successfully constructed via cascade reactions. After optimizing the conditions, the high-throughput screening of total sterols in rapeseed could be completed in only 21 min, which significantly facilitated the sensing of PSs. A linear range of 0.6–6 mg/g was achieved for the detection of total sterols in rapeseed samples, thereby satisfying the requirements for detection. In addition, due to the high stability of CuOx@C and the specificity of cholesterol oxidase, the developed method had excellent stability and selectivity toward PSs, indicating that this work has huge prospects for commercial application. This innovative work overcomes the limitation of the instrumental method and provides a portable and reliable tool for total sterols detection. It can also facilitate the development of oilseeds with a high content of PSs. Graphical abstract
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Science China-Chemistry
·
2025
·
IF 9.7
Zhang Wenwen,Xuan Huixia,Xu Xiaofei,Lou Jiaming,Guan Qingbao,You Zhengwei
For room temperature self-healing triboelectric nanogenerators (TENGs), the inherent contradiction between mechanical strength and self-healing properties was an urgent problem to be solved. Based on the phenol-carbamate bond, this paper proposed a strategy to design a new molecular structure and coordinate the triple dynamic bonds, which provided a feasible strategy to solve this contradiction. With polytetramethylene ether glycol ( M n = 1,000) as the soft segment in the main chain of polyurethane (PU), meanwhile methylene diphenyl diisocyanate and 4,4′-dihydroxybiphenyl (BP) as the hard segment and chain extension agent, respectively, the combination of tetrad benzene ring endowed the resultant 4BP-PU with π-π interaction. The effective reversible dissociation and association with hydrogen bond not only bestowed 4BP-PU with high mechanical strength (16.14 MPa), but also promoted high self-healing efficiency (94.8%) at room temperature. 4BP-PU was selected as the elastic substrate between polydimethylsiloxane and copper sheet to prepare a self-healing TENG to collect energy from natural motion. Consequently, the rational molecular structure design provided new ideas for developing self-healing materials and fabricating energy harvest electronics.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-16
·
IF 14.7
Ye Qian-Ni,Zhu Long,Liang Jie,Zhao Dong-Kun,Tian Tai-Yu,Fan Ya-Nan,Ye Si-Yi,Liu Hua,Huang Xiao-Yi,Cao Zhi-Ting,Shen Song,Wang Jun
The functions of natural killer (NK) and T cells in innate and adaptive immunity, as well as their functions in tumor eradication, are complementary and intertwined. Here we show that utilization of multi-specific antibodies or nano-antibodies capable of simultaneously targeting both NK and T cells could be a valuable approach in cancer immunotherapy. Here, we introduce a tri-specific Nano-Antibody (Tri-NAb), generated by immobilizing three types of monoclonal antibodies (mAbs), using an optimized albumin/polyester composite nanoparticle conjugated with anti-Fc antibody. This Tri-NAb, targeting PDL1, 4-1BB, and NKG2A (or TIGIT) simultaneously, effectively binds to NK and CD8 + T cells, triggering their activation and proliferation, while facilitating their interaction with tumor cells, thereby inducing efficient tumor killing. Importantly, the antitumor efficacy of Tri-NAb is validated in multiple models, including patient-derived tumor organoids and humanized mice, highlighting the translational potential of NK and T cell co-targeting.
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PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2025
·Vol. 27
·期 2
·1-9
·
IF 2.6
Li Guo-Wei,Yan Hang-Yu,Zhang Feng-Yuan,Liu Run-Min,Luoshan Meng-Dai,Zhou Li,Wang Qu-Quan
Highly uniform gold nanorods (GNRs) with tunable surface plasmon resonances (SPRs) across the visible and near-infrared (NIR) spectral regions exhibit attractive photothermal conversion properties along with their chemical stability, good dispersibility, and biocompatibility. In this study, we investigate the optimization of photothermal conversion utilizing GNRs as an agent under the laser excitation at 808 nm, within the NIR-I window. The aspect ratio of GNRs is tuned by the AgNO 3 amount in the reaction solution, and the characteristic longitudinal SPR is of 810 nm at the aspect ratio of 4.43, matching well with the laser wavelength. When the extinction intensity (located around 808 nm) of 810-nm GNR solution is adjusted to 1.0, the photothermal conversion efficiency is achieved to an optimal value of 36.1%, which is approximately 1.7 times that of the sample with the extinction intensity of 0.3. These findings offer insights for the design of effective photothermal conversion agents.
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TRANSITION METAL CHEMISTRY
·
2018
·Vol. 43
·期 3
·259-271
·
IF 1.261
Liu Ya-Xian,Mo Hui-Wen,Lv Zhen-Yu,Shen Fang,Zhang Chun-Lian,Qi Yong-Yu,Mao Zong-Wan,Le Xue-Yi
A copper complex [Cu(HPBM)( l -Phe)(H 2 O)]·ClO 4 (1) (HPBM = 5-methyl-2-(2′-pyridyl)benzimidazole, l -Phe = l -phenylalanine anion) was synthesized and characterized by elemental analysis, IR, ESI–MS, HR–ESI–MS, ESR spectroscopy, and by X-ray single-crystal analysis. The binding constant of the complex with calf thymus DNA (CT-DNA) was determined as 7.38 (± 0.57) × 10 4 M −1 . Further studies indicated that the complex interacts with CT-DNA through minor groove binding. The in vitro cytotoxic activities of both the free proligand and the complex against Eca-109, HeLa and A549 cancer cells and normal LO2 cells were evaluated by the MTT method. The IC 50 values range from 5.7 ± 0.1 to 8.3 ± 0.6 µM. Free HPBM displays no cytotoxic activity against the selected cancer cells, with IC 50 values more than 100 µM. Double staining analysis showed that the complex can induce apoptosis in Eca-109 cells. Comet assays demonstrated that the complex can damage DNA and cause apoptosis. The complex also induces an increase in intracellular reactive oxygen species and a reduction in mitochondrial membrane potential. The complex can also increase the intracellular Ca 2+ level and induce release of cytochrome c . The cell cycle arrest was investigated by flow cytometry. The results demonstrate that the complex induces apoptosis in Eca-109 cells through DNA-binding and ROS-mediated mitochondrial dysfunctional pathways.
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ANNALS OF MICROBIOLOGY
·
2017
·Vol. 68
·期 1
·27-34
·
IF 1.122
Xiao Yaqing,Li Peijun,Xu Mei,Wang Wu,Chen Conggui
The objective of this study was to evaluate the ability of five strains of meat-borne bacteria to decrease N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) and to elucidate the mechanism in Mann-Rogosa-Sharp (MRS) broth. Lactobacillus pentosus R3 was found to be the most effective in decreasing the concentration of the two N-nitrosamines (NAs) in MRS broth, with a rate of 22.05% for NDMA and 23.31% for NDEA. The concentration of the two NAs could not be reduced by either extracellular metabolites or intracellular extracts of Lb. pentosus R3 (P > 0.05), and proteinaceous substances in the cell debris were found to be responsible for the decrease. These were surface-layer proteins (SLPs) located on the cell wall. Therefore, the decrease in NDMA and NDEA by Lb. pentosus R3 is associated with its SLPs. Lb. pentosus R3 may be developed as a starter culture in the production of fermented foods with lower NAs.
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Journal of Coatings Technology and Research
·
2017
·Vol. 15
·期 3
·611-621
·
IF 1.557
Wang Bin,Lei Binghang,Tang Yuhao,Xiang Dong,Li Hui,Ma Qi,Zhao Chunxia,Li Yuntao
The removal of oil and organic pollutants from water is highly desired due to increasing industrial oil-contaminated wastewater, as well as frequent oil spill accidents. In this paper, superhydrophobic and superoleophilic fabrics were facilely fabricated for oil/water separation application via in situ growth of polysiloxane nanowires on cotton fabrics. The polysiloxane nanowires were immobilized on the cotton fabrics through a self-assembly process of alkylsilane on the microfibers of fabrics. The combination of the hierarchical structure and the low-surface-energy polysiloxane nanowires greatly contributed to the superhydrophobicity of the fabrics. Furthermore, the superhydrophobicity remained even after they were exposed to different chemicals for 72 h and strong ultraviolet irradiation and repeated abrasion, indicating excellent stability. More importantly, the as-prepared cotton fabrics were successfully used for separating various oil/water mixtures by a solely gravity-driven process with high separation efficiency and desirable durability. The cotton fabrics are commercially available, low-cost, and environmentally friendly materials, and thus such superhydrophobic and superoleophilic cotton fabrics could be very attractive for oil/water separation and oil spill cleanup when high flexibility, strength, and chemical resistance are taken into account.
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