Science China-Chemistry
·
2025
·
IF 9.7
Liang Haoyue,Zhong Xingguo,Huang Guxin,Liu Wenpan,Liu Yao,Wang Shuhao,Wang Deyu,Liu Hao,Wang Hao,Zhai Tianyou,Li Huiqiao
Li 3 VO 4 has been a promising insertion anode material for Li-ion batteries, which has high theoretical capacity (up to ∼600 mAh g −1 ) and safe Li insertion voltage (0.5–1 V vs. Li/Li + ). However, the low initial Coulombic efficiency (ICE) has always been the bottleneck limiting its commercialisation. Here, we propose a facile pre-lithiation method to controllably elevate the ICE by the post-treatment of the prepared Li 3 VO 4 composite electrode based on an immersion reaction. In this process, the whole electrode was immersed in the liquid Li source, via which the ICE of the Li 3 VO 4 electrode can be controllably elevated from 80% to over 100% within 5 min of pre-lithiation. Rather than the traditional powder treatment for pre-lithiation, this process we proposed minimizes the impact of pre-lithiation on the battery assembly process. Moreover, we further investigated the effect of this pre-lithiation process on the functional components in the electrode. For the first time the ICE of Li 3 VO 4 electrode was elevated to 100%. As a result, the initial reversible capacity of LiFePO 4 ∥Li 3 VO 4 full cell was improved from 44.0 to 146.3 mAh g −1 , demonstrating the feasibility and great potential of the process.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·Vol. 416
·期 19
·4397-4407
·
IF 3.8
Wang Yichun,Xia Yu
Plasmalogens are a special class of glycerophospholipids characterized by a vinyl ether bond (-C = C-O-) at the sn -1 position of the glycerol backbone. Altered plasmalogen profiles have been observed in neurodegenerative diseases and cancers. Profiling of plasmalogens requires specifying the vinyl ether bond and differentiating them from various types of isobars and isomers. Herein, by coupling C = C derivatization via offline Paternò–Büchi reaction with liquid chromatography-tandem mass spectrometry, we have developed a sensitive workflow for analysis of plasmalogens from biological samples. Using bovine heart lipid extract as a model system, we profiled more than 100 distinct structures of plasmenylethanolamines (PE-Ps) and plasmenylcholines (PC-Ps) at the C = C location level, far exceeding previous reports. Analysis of human glioma and normal brain tissue samples revealed elevated n-10 C = C isomers of PE-Ps in the glioma tissue samples. These findings suggest that the developed workflow holds potential in aiding the study of altered metabolism of plasmalogens in clinical samples. Graphical Abstract
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FIBERS AND POLYMERS
·
2024
·
IF 2.2
Gouda Mohamed,Khalaf Mai. M.,Taleb Manal F. Abou,Abdelaziz Mahmoud A.,El-Lateef Hany M. Abd
To tackle the intense concern about low-priced drinking water point-of-use techniques, cotton fabric (CF) microfilters (MF) loaded with silver nanoparticles (AgNPs) were utilized to degrade the carcinogenic Congo red (CR) dye as well as deactivate pathogenic bacteria. In the present study, AgNPs were precisely synthesized using Gum Arabic as reducing and stabilizing agent, leading to spherical nanoparticles with a small size (24 nm) with monodispersity (PdI = 0.468), as proved by TEM and DLS analysis. The bleached cotton fabric was immersed in AgNPs solution and then dried and cured at 130 °C to make functionalized cotton fabrics suitable for filtration and dye degradation. Morphology, microstructure, and chemical composition were assessed using SEM and EDX analysis, suggesting the incorporation and deposition of AgNPs as fine particles to the surface of the cotton fabric. The AgNPs@CF-MF were tested in laboratories to determine their capability to perform CR removal and neutralize bacteria. The research showed that the same dose of CR dye obtained higher photocatalytic breakage percentages under the light source and the photocatalyst. The findings of our study indicate that the photocatalytic degradation of CR dye exhibited the optimal efficiency when the concentration was maintained at 10 ppm. The degradation efficiency reached to 100% after an exposure time of 180 min under visible light. The results of our study showed that AgNPs@CF-MF exhibited enhanced bactericidal activity in comparison to untreated CF-MF. The clear zone widths highlighted the efficacy of AgNPs in suppressing bacterial proliferation. Clear zone diameters against , E. coli, Salmonella enterica , Staphylococcus aureus, and Enterococcus feacalis were 12 ± 0.59, 11 ± 0.68, 10 ± 0.43, and 8 ± 0.71 mm, respectively. This raises the prospects for using the AgNPs@CF-MF as an antimicrobial agent in the treatment of water, air filtration, and other situations where infection control is critical. AgNPs@CF-MF offers an innovative microfilter through the degradation of CR dye and water disinfection due to their photocatalytic activities and antibacterial properties, and ability to remove contaminants from polluted water during filtration.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·
IF 3.8
He Ziyun,Dai Haibing,Shen Jian,Huang Yanjie,Liu Jinsong,Yan Renqing,Zhang Feng,Yan Shengkai
17α-Hydroxyprogesterone (17α-OHP) quantification in dried blood spots (DBS) is essential for newborn screening for congenital adrenal hyperplasia (CAH), which is challenging due to its low physiological concentration. The high false-positive rates of immunoassays necessitate the development of more accurate methods. Liquid chromatography tandem mass spectrometry (LC-MS/MS) offers increased specificity and sensitivity, yet standardized procedures for 17α-OHP measurement are required for clinical application. A candidate reference measurement procedure (cRMP) using isotope dilution LC-MS/MS was developed for 17α-OHP quantification in DBS. By utilizing stable isotope-labeled D8-17α-OHP as an internal standard, the cRMP was optimized, covering sample preparation, calibration, and LC-MS/MS analysis. The method performance was validated across several parameters, including precision, accuracy, specificity, detection limits, and matrix effects. Clinical applicability was further assessed through the establishment of reference intervals for healthy newborns. The developed cRMP exhibited a linear range of 1.00 to 80.00 ng/mL for 17α-OHP, with detection and quantification limits of 0.14 ng/mL and 0.52 ng/mL, respectively. Inter- and intraday precision demonstrated coefficients of variation within 1.27 to 5.69%. The recovery rates and matrix effects were well within acceptable limits, ensuring method reliability. Clinical application showed distinct reference intervals for healthy newborns that were unaffected by sex but influenced by weight and gestational age. This method significantly enhances CAH diagnostic accuracy in newborns, providing a valuable tool for clinical laboratories and improving newborn screening program standardization and traceability.
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IRANIAN POLYMER JOURNAL
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2024
·
IF 2.4
Yang Yuhao,Pu Zejun,Meng Chihan,Zhong Jiachun,Pang Jiahong,Yang Kaijie,Yue Mengjie,Wu Fang
Semi-aromatic polyamides have excellent comprehensive properties and can effectively adjust thermodynamic properties through monomer composition and ratio to meet different application requirements. Therefore, in this study, two copolyamides (PA6T/66 and PA6T/610) were synthesized by one-pot method and their thermal and mechanical properties were subsequently analyzed and compared. Firstly, the chemical compositions and microstructures of the two copolyamides were characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance hydrogen spectroscopy ( 1 H NMR), wide-field X-ray diffraction (XRD) and polarized ophthalmic microscopy (POM), and the viscosities [η] of the specimens were tested. Secondly, the heat resistance of the two copolyamides was analyzed using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Subsequently, the mechanical strength of the two copolyamides was evaluated. The FTIR, NMR and XRD results show that the molecular structure and crystal morphology of the two copolyamides are highly similar, which may prove the success of the target products. The TG results show that the heat resistance of the two copolyamides is very good, with the extrapolated initial decomposition temperature above 430 °C, and PA6T/66 has better heat resistance. The DSC results show that PA6T/66 has a higher melting and glass transition temperature. The mechanical test results show that PA6T/66 has greater tensile and flexural strengths of 70 MPa and 110 MPa, respectively, while PA6T/610 has better impact toughness. The above comparative results can be extended to determine the differences in performance between long-chain and short-chain polyamides, which can provide a reference for future related research. Graphical abstract
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Friction
·
2024
·Vol. 12
·期 8
·1728-1740
·
IF 6.3
Cui Yuhong,Xue Shenghua,Wang Tiantian,Liu Shujuan,Ye Qian,Zhou Feng,Liu Weimin
Herein, we have prepared SiO 2 particles uploaded MXene nanosheets via in-situ hydrolysis of tetraetholothosilicate. Due to the large number of groups at the edges of MXene, SiO 2 grows at the edges first, forming MXene@SiO 2 composites with a unique core-rim structure. The tribological properties of MXene@SiO 2 as lubricating additive in 500 SN are evaluated by SRV-5. The results show that MXene@SiO 2 can reduce the friction coefficient of 500 SN from 0.572 to 0.108, the wear volume is reduced by 73.7%, and the load capacity is increased to 800 N. The superior lubricity of MXene@SiO 2 is attributed to the synergistic effect of MXene and SiO 2 . The rolling friction caused by SiO 2 not only improves the bearing capacity but also increases the interlayer distance of MXene, avoiding accumulation and making it more prone to interlayer slip. MXene@SiO 2 is adsorbed on the friction interface to form a physical adsorption film and isolate the friction pair. In addition, the high temperature and high load induce the tribochemical reaction and form a chemical protection film during in the friction process. Ultimately, the presence of these protective films results in MXene@SiO 2 having good lubricating properties.
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MOLECULAR DIVERSITY
·
2024
·
IF 3.9
Zhang Yuhao,Bai Ruofei,Du Tengyi,Wang Yiwei,Zhou Bohang,Zhou Congwei,Zhou Le
N ′-phenylpicolinohydrazide has been proven to be a promising lead compound for research and development of novel fungicides for agriculture in our previous study. As our continuing research, in this study, a series of N -substituted derivatives of N ′-phenylpicolinohydrazide were synthesized and explored for the inhibition activity on nine phytopathogenic fungi and action mechanism. The results found that eleven of the compounds had excellent antifungal activity with more than 80% inhibition rates at 50 µ g/mL on part or most of the fungi, especially A. solani and P. piricola . Compounds 5i , 5j and 5k showed EC 50 values of < 8.0 µg/mL against A. solani superior to positive control carbendazim (EC 50 = 36.0 µg/mL) while 5p and 5q exhibited the highest activity with EC 50 values of 2.72 and 2.80 µg/mL against P. piricola superior to positive control boscalid (EC 50 > 50.0 µg/mL). Furthermore, 5k also showed significant protective effect against A. solani infection on tomatoes in a concentration-dependent manner. Action mechanism research showed that 5k was able to increase the intracellular ROS level, change both MMP and permeability of cell membrane and damage mycelial morphology. Molecular docking studies showed that 5k could bind into ubiquinone-binding region of succinate dehydrogenase by hydrogen bonds, π-cation, π–π stacked, π-alkyl, and alkyl interactions. Additionally, the antibacterial activity was also investigated. Thus, N -substituted derivatives of N ′-phenylpicolinohydrazide were emerged as novel and highly promising antifungal molecular skeletons to develop new fungicides for crop protection. Graphic abstract
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Nature Sustainability
·
2024
·
IF 25.7
Wang Junxiong,Ji Haocheng,Li Junfeng,Liang Zheng,Chen Wen,Zhu Yanfei,Ji Guanjun,Shi Ruyu,Zhou Guangmin,Cheng Hui-Ming
Direct recycling is a promising route for the sustainable management of end-of-life spent cathodes. However, its practical implementation is greatly restricted as most existing methods require heating or high-pressure conditions during the lithiation step to overcome the thermodynamic obstacles and realize lithium replenishment. In this study, we explored a strategy to realize spontaneous lithiation via simple solid–liquid mixing at ambient conditions. The thermodynamic barrier of the lithiation reaction was reduced by self-adsorbed amyloxylithium, which can spontaneously adsorb on the surface of degraded cathode particles without an external driving force. This strategy can regenerate both laboratory-dismantled LiNi 0.6 Co 0.2 Mn 0.2 O 2 from 10 Ah pouch cells and industrial-dismantled LiNi 0.5 Co 0.2 Mn 0.3 O 2 black mass. The capacity retention rate of a 1 Ah pouch cell assembled using regenerated LiNi 0.5 Co 0.2 Mn 0.3 O 2 as cathode material was 80.5% after 500 cycles. The proposed strategy has big economic advantages over conventional pyro- and hydrometallurgical methods, as evidenced by the techno-economic analysis, accompanied by obvious environmental benefits, as evidenced by reduced CO 2 emissions. This work provides a viable approach for the direct recycling of spent cathode material, improving the circularity of the battery industry.
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Biomass Conversion and Biorefinery
·
2024
·
IF 3.5
Yang Shuanghao,Feng Ruirui,Sun Bo,Lu Meizi,Zhao Xingchu,Shen Qirong,Wan Qun
Corncob, as an agricultural waste rich in hemicellulose, plays a crucial role in the effective utilization for biomass conversion and biorefinery. Here, we report a thermophilic GH11 xylanase (Xyn11B) and a β-xylosidase (Xyl43B) in the compost metatranscriptome database, with optimal temperature of 75 ℃ and 70 ℃, respectively, utilized for the synergistic degradation of corncob. Xyn11B consists of a catalytic domain (CD) and a carbohydrate-binding module 60 (CBM60). After deleting CBM60, the T m of the remaining CD Xyn increased by 2.4 ℃ and the half-life at 80 ℃ increased threefold. After 10-h hydrolysis on the NaOH-treated corncob using Xyn11B and CD Xyn , the conversion yield reached 78 and 94 mg sugar/g raw corncob, respectively. Interestingly, in the absence of alkali pretreatment, the conversion yield can reach 107 mg sugar/g raw corncob using 0.1% (mg enzyme/mg corncob) Xyn11B, which is two times higher than that of CD Xyn . Our analysis shows that CBM60 can reduce the non-catalytic adsorption to lignin, which increases the capability of the full-length enzyme to hydrolyze hemicellulose without alkali pretreatment. Furthermore, synergistic hydrolysis with both 0.1% Xyn11B and 0.1% Xyl43B considerably elevates the conversion yield to 296 mg sugar/g raw corncob, which is 2.8-fold higher than that achieved using Xyn11B alone, and comparable to the enzymatic effect observed with the combination of CD Xyn and Xyl43B in alkali pretreatment. Our strategy demonstrates a good example of green hydrolysis of lignocellulosic biomass using enzymes without chemical pretreatment.
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EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
·
2024
·
IF 8.6
Lu Ganghua,Gao Dingwei,Jiang Wen,Yu Xiaqing,Tong Junyu,Liu Xiaoyan,Qiao Tingting,Wang Ru,Zhang Mengyu,Wang Shaoping,Yang Jianshe,Li Dan,Lv Zhongwei
Background Despite the potential radiotoxicity in differentiated thyroid cancer (DTC) patients with high-dose 131 I therapy, the alterations and regulatory mechanisms dependent on intestinal microecology remain poorly understood. We aimed to identify the characteristics of the gut microbiota and metabolites in DTC patients suffering from high-dose 131 I therapy and explore the radioprotective mechanisms underlying arachidonic acid (ARA) treatment. Methods A total of 102 patients with DTC were recruited, with fecal samples collected before and after 131 I therapy for microbiome and untargeted and targeted metabolomic analyses. Mice were exposed to total body irradiation with ARA replenishment and antibiotic pretreatment and were subjected to metagenomic, metabolomic, and proteomic analyses. Results 131 I therapy significantly changed the structure of gut microbiota and metabolite composition in patients with DTC. Lachnospiraceae were the most dominant bacteria after 131 I treatment, and metabolites with decreased levels and pathways related to ARA and linoleic acid were observed. In an irradiation mouse model, ARA supplementation not only improved quality of life and recovered hematopoietic and gastrointestinal systems but also ameliorated oxidative stress and inflammation and preserved enteric microecology composition. Additionally, antibiotic intervention eliminated the radioprotective effects of ARA. Proteomic analysis and ursolic acid pretreatment showed that ARA therapy greatly influenced intestinal lipid metabolism in mice subjected to irradiation by upregulating the expression of hydroxy-3-methylglutaryl-coenzyme A synthase 1. Conclusion These findings highlight that ARA, as a key metabolite, substantially contributes to radioprotection. Our study provides novel insights into the pivotal role that the microbiota-metabolite axis plays in radionuclide protection and offers effective biological targets for treating radiation-induced adverse effects.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-24
·
IF 10.6
Luo Qipei,Yang Yuxin,Ho Chingchun,Li Zongtai,Chiu Weicheng,Li Anqi,Dai Yulin,Li Weichang,Zhang Xinchun
Periodontitis is a prevalent chronic inflammatory disease, which leads to gradual degradation of alveolar bone. The challenges persist in achieving effective alveolar bone repair due to the unique bacterial microenvironment’s impact on immune responses. This study explores a novel approach utilizing Metal–Organic Frameworks (MOFs) (comprising magnesium and gallic acid) for promoting bone regeneration in periodontitis, which focuses on the physiological roles of magnesium ions in bone repair and gallic acid's antioxidant and immunomodulatory properties. However, the dynamic oral environment and irregular periodontal pockets pose challenges for sustained drug delivery. A smart responsive hydrogel system, integrating Carboxymethyl Chitosan (CMCS), Dextran (DEX) and 4-formylphenylboronic acid (4-FPBA) was designed to address this problem. The injectable self-healing hydrogel forms a dual-crosslinked network, incorporating the MOF and rendering its on-demand release sensitive to reactive oxygen species (ROS) levels and pH levels of periodontitis. We seek to analyze the hydrogel’s synergistic effects with MOFs in antibacterial functions, immunomodulation and promotion of bone regeneration in periodontitis. In vivo and in vitro experiment validated the system's efficacy in inhibiting inflammation-related genes and proteins expression to foster periodontal bone regeneration. This dynamic hydrogel system with MOFs, shows promise as a potential therapeutic avenue for addressing the challenges in bone regeneration in periodontitis.Graphical Abstract
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2024
·Vol. 42
·期 10
·1479-1487
·
IF 4.1
Chen Ke-Xiang,Cui Chen-Hui,Li Zhen,Xu Ting,Teng Hao-Qing,He Zhi-Yuan,Guo Yin-Zhou,Ming Xiao-Qing,Ge Zhi-Shen,Zhang Yan-Feng,Wang Tie-Jun
Sulfur-containing dynamic polymers had attracted significant attention due to their unique chemical structures with high reversibility. Utilizating sulfur, an inexpensive industrial waste product, to synthesize dynamic polysulfide polymers through reverse vulcanization has been a notable approach. However, this method required high temperatures and resulted in the release of unpleasant oders. In this study, we presented a robust method for the preparation of sulfur-rich polymers with dynamic polysulfide bonds from elemental sulfur and inexpensive epoxide monomers via a one-pot strategy at the mild room temperature. Different types of polysulfide molecules and polymers were synthesized by reacting various epoxide compounds with sulfur, along with the investigation of their structures and dynamic behaviors. It was noteworthy that the obatined polymers prepared from m -(2,3-epoxypropoxy)- N,N -bis(2,3-epoxypropyl)aniline and elemental sulfur exhibit multiple dynamic behaviors, including polysulfide metathesis and polysulfide-thiol exchange, enabling their rapid stress relaxation, self-healing, reprocessing and degradable properties of the cross-linked polymer. More importantly, the hydroxyl groups at the side chains from epoxide ring opening exhibited potential transesterification. This work provided a facile strategy for designing dynamic sulfur-rich polymers via a mild synthesis route.
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