RSC Advances
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2016
·Vol. 6
·期 115
·113940-113950
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IF 3.289
Xi Wen,Chun-Tao Shao,Wei Chen,Yong Lei,Qin-Fei Ke,Ya-Ping Guo
Pb(II) ions are highly harmful to the environment and human health because of their bioaccumulation, non-degradability and toxicity. Herein, we fabricated mesoporous carbonated hydroxyapatite (HAP)/chitosan (CS) porous materials (MHCMs) by using calcium carbonate/CS porous materials (CCPMs) as precursors. After soaking in phosphate buffer solution (PBS), the CaCO3 particles in the CCPMs were converted to carbonated HAP plates with a preferred c-plane orientation via a dissolution–precipitation reaction. The MHCMs possessed interconnected macropores with pore sizes of 50–150 μm and mesopores with pore sizes of 3.97 nm, which caused them to have a great BET surface area of 111.3 m2 g−1 and a pore volume of 0.199 cm3 g−1. The sorption performance of the MHCMs for Pb(II) ions was evaluated by the flow of 400 mg L−1 lead solutions through the adsorbents, and HAP/CS porous materials (HCPMs) served as control samples. After adsorbing Pb(II) ions, the HAP particles in both the MHCMs and HCPMs were transferred into lead hydroxyapatite (PbHAP) rods. At the adsorption equilibrium, the adsorption amounts of the MHCMs and HCPMs arrived at 559.6 and 264.4 mg g−1, respectively. The MHCMs had better adsorption properties than the HCPMs because of their large surface area, hierarchically porous structures, low Ca/P ratio, good degradability and plate-like carbonated HAP with a preferred c-plane orientation. The adsorption of Pb(II) ions on MHCMs exhibited higher compliance with the pseudo-second-order kinetic model than the pseudo-first-order kinetic model, suggesting that the adsorption process was mainly controlled by chemical adsorption for Pb(II) ions. Therefore, the MHCMs have great potential for the removal of Pb(II) ions from aqueous solutions even under flow conditions.
研究领域:
环境科学
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材料科学
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水处理
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吸附技术
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无机化学
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2015
·Vol. 22
·期 13
·9668-9675
·
IF 2.828
Yin Zheng,Cao Jingjing,Li Zhen,Qiu Dong
Dithiocarbamate chitosan (DTC-CTS) was used as a new amendment for remediation of cadmium (Cd)-contaminated soils to reduce the Cd bioavailability. Arabidopsis thaliana was chosen as a model plant to evaluate its efficiency. It was found that DTC-CTS could effectively improve the growth of A. thaliana . The amount of Cd up-taken by A. thaliana could be decreased by as much as 50 % compared with that grown in untreated Cd-contaminated soil samples. The chlorophyll content and the aerial biomass of Arabidopsis also increased substantially and eventually returned to a level comparable to plants grown in non-contaminated soils, with the addition of DTC-CTS. These findings suggested that DTC-CTS amendment could be effective in immobilizing Cd and mitigating its accumulation in plants grown in Cd-contaminated soils, with potential application as an in situ remediation of Cd-polluted soils.
研究领域:
环境科学
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土壤学
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植物生理学
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修复技术
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FOOD RESEARCH INTERNATIONAL
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2026
·
IF 8
Shanglin Li,Shuaiyan Liu,Yiding Yu,Xinyi Huang,Meng Yang,Longjiang Tian,Ting Zhang,Jingbo Liu,Yajuan Li,Zhiyang Du
Developing oral nanoparticles (NPs) that combine anti-inflammatory effects with gut microbiome modulation enables an effective strategy for integrated ulcerative colitis (UC) therapy. Yet, the complex and dynamically evolving nature of the gastrointestinal milieu presents formidable challenges to the consistency and specificity of NP interventions. To address this challenge, this study designed and developed gastrointestinal microenvironment-adaptive NP via self-assembly, utilizing curcumin (Cur) for anti-inflammatory effects and anthocyanin (Cy) for microbiome regulation to achieve dual functional therapeutic outcomes. Employing the esterification strategy, hydroxypropyl-β-cyclodextrin (HPCD) was modified using citric acid (CA) and sulfonic acid (SA) to synthesize CACD (CA-modified HPCD) and SACD (SA-modified HPCD), respectively, which self-assembled in the presence of quaternary ammonium chitosan (HTCC), Cur, and Cy to yield NPs. NPs demonstrated high Cur encapsulation efficiency (EE) and encapsulation capacity (EC) across pH 2.0–7.0, highlighting their high gastrointestinal adaptability. In vivo experiments showed clear amelioration of colitis symptoms, including downregulation of pro-inflammatory cytokines and attenuation of tissue damage. HTCC-Cy-CACD-Cur NPs enriched Eubacterium siraeum_group and Prevotellaceae , HTCC-Cy-SACD-Cur NPs favored Peptococcus expansion , potentially contributing to improved immune regulation and attenuation of UC. These bifunctional NPs offer innovative UC therapy and precision nutrition interventions.
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PubMed
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.5
Xiaoqiang Chen,Yipei Liu,Enze Zhu,Yue Wu,Kun Chen,Zhusheng Feng,Mingyu Liu,Na Peng
This study introduces a multifunctional sponge (CS/EGO-EK) designed for rapid hemostasis and treatment of infected wounds. By integrating graphene oxide-grafted engineered kaolin nanotubes (EGO-EK) into a chitosan matrix, the composite demonstrated enhanced pore interconnectivity, mechanical strength, and fluid absorption. The EGO-EK component preserved biocompatibility while promoting platelet activation. In vitro , CS/EGO-EK exhibited approximately 2.1 times higher blood adsorption compared to pure chitosan, with significantly improved platelet adhesion. Antibacterial assays revealed over 99% inhibition of E. coli and S. aureus , which was further amplified by near-infrared (NIR) irradiation via photothermal synergy. In vivo , CS/EGO-EK reduced blood loss by 50–70% and shortened hemostasis time to approximately 40–60% of the control in rat models of tail, liver, and femoral artery injuries. In full-thickness infected wounds, CS/EGO-EK + NIR achieved over 97% wound closure and more than 95% bacterial reduction by day 14, along with enhanced epithelial regeneration and collagen deposition. These results underscore CS/EGO-EK as a promising platform that integrates structural optimization, kaolin-induced coagulation, and NIR-enhanced antibacterial effects for effective emergency bleeding control and infected wound healing.
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BioNanoScience
·
2026
·Vol. 16
·期 2
·120
·
IF 3.2
He Yifei,Wang Zhe
Pathogenic bacteria such as Staphylococcus aureus ( S. aureus ) represent a serious global health concern by forming biofilms that enhance bacterial resistance and persistence in host and environmental niches. Natural compounds such as α-mangostin (α-m) exhibit promising antibacterial potential but low solubility, instability and limited bioavailability restrict their biomedical application. This study prepared α-mangostin-loaded casein–chitosan nanoparticles (α-m NPs) via ionic crosslinking–emulsification under neutral pH conditions and characterized them using dynamic light scattering, scanning electron microscopy, and Fourier-transform infrared spectroscopy, which confirmed efficient encapsulation and structural stability. The results showed that α-m NPs achieved sustained drug release over 72 h and exhibited significantly enhanced bacteriostatic and bactericidal effects. Biofilm assays further revealed that α-m NPs more effectively suppressed extracellular polysaccharide secretion and biofilm formation in MRSA T144 and ATCC 29213 strains. These findings as a whole validate α-m NPs as an efficient antibacterial and anti-biofilm nanosystem and establish a polysaccharide–protein nanoplatform with considerable potential for applications in nanomedicine and anti-infective therapy. Graphical abstract
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.5
Lei Nie,Xiaoyue Ding,Yiran Lin,Letian Yan,Yanting Han,Yuanna Sun,Yanfang Sun,Guohua Jiang
Decellularized extracellular matrix (dECM) has been widely used in tissue engineering and regenerative medicine due to its excellent biocompatibility and biological activities. In this work, the dECM was obtained by treating porcine Achilles tendon tissue via a combination of chemical, physical, and biological approaches. The obtained dECM was interpenetrated with genipin crosslinked quaternary ammonium chitosan (QCS) network to fabricate the composite genipin/QCS/dECM (QGD) hydrogels. The prepared QGD hydrogels exhibited an interconnected microstructure and a suitable water-absorption capacity. Furthermore, the QGD hydrogels exhibited strong adhesion to the surfaces of different matrices and various organs, including lung, liver, trachea, heart, and spleen. The remodelling of dECM gave the QGD hydrogels adjustable self-healing ability and mechanical properties. In addition, the QGD bio-adhesives exhibit effective antibacterial activity against the typical Gram-positive S. aureus and Gram-negative E. coli . 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) radical scavenging and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging tests confirmed the antioxidant abilities of QGD hydrogels, and the cellular reactive oxygen species (ROS) scavenging potential was also investigated using RAW264.7 cells. Furthermore, the QGD hydrogels possessed excellent hemocompatibility, cytocompatibility, and cell pro-migration abilities. The results confirmed that the proposed QGD hydrogels could serve as potential bioadhesives for biomedical applications.
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Journal of Materials Chemistry B
·
2026
·
IF 5.7
Peifang Xu,Yiming Sun,Jun Huang,Yishu Zhang,Tong Zhou,Jiawei Wang,Pengjie Chen,Mingyu Xu,Yifan Zhou,Shan Yu,Juan Ye
Effective intervention during the early phases of alkali burns is crucial for preventing progressive ocular damage and persistent inflammation, necessitating multifunctional solutions beyond single-component therapies. In this study, we developed a thermosensitive hydrogel based on L-arginine-modified hydroxybutyl chitosan (HBC_Arg). The hydrogel remains liquid at room temperature for easy application and undergoes thermosensitive gelation upon reaching the ocular surface temperature, ensuring prolonged retention and enhanced drug efficacy. The L-arginine modification enables the hydrogel to release nitric oxide (NO), which plays a critical role in modulating immune responses and controlling excessive inflammation. Additionally, EPL@MnO2 nanosheets were encapsulated within the hydrogel for extended-release and enhanced scavenging of reactive oxygen species (ROS), reducing oxidative stress and mitigating alkali burn-induced damage. In a rat ocular alkali burn model, the composite HBC_Arg/MnO2 hydrogel significantly suppressed inflammation, promoted re-epithelialization, enhanced stromal healing, and prevented corneal vascularization and opacity. This multifunctional hydrogel offers a promising advanced therapeutic strategy for treating acute ocular alkali burns, providing potential improvements in visual outcomes and overall quality of life.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2026
·
IF 8.3
Zi-Qiang Luo,Da-Kang Xiong,Ya Hu,Tao Peng,Tao Zou
Chitosan derived hierarchical porous materials (CDHPM) were successfully prepared using chitosan as a ‘green’ carbon source and potassium permanganate as a pore-making agent through a simple pyrolytic synthesis. CDHPM were used as carriers for Pt-based catalysts and tested for their electrocatalytic performance oxygen reduction reaction (ORR) in alkaline electrolyte. The prepared CDHPM can effectively optimize the electrocatalytic performance of Pt-based catalysts due to their large specific surface area, abundant oxygen-containing functional groups, and defect sites. Compared with the commercial catalyst Pt/C (20 % Pt content), Pt/CDHPM (5.75 % Pt content) has higher catalytic activity, durability, and methanol resistance. In conclusion, this study provides an effective strategy for the synthesis of ORR catalysts with high-performance and high-stability, which paves a new way for the development of advanced fuel cell catalysts.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Rui He,KangLi Yang,XuYu Long,Qian Su,ZhiQing Yuan,ShiMing Fu,ZeXin Dai,ShouTong Meng,CanCheng Li
Surface fouling and bacterial contamination present significant challenges to daily life and industrial production, motivating the development of multifunctional surfaces with antifouling and antimicrobial properties. In this context, the development of multifunctional surfaces based on environmentally friendly green materials, which possess both superhydrophobic anti-fouling and highly efficient antibacterial properties, has become one of the approaches to address the aforementioned issues. In this study, superhydrophobic antimicrobial multifunctional coatings were successfully prepared by using environmentally friendly materials chitosan (CS) and curcumin (Cur) as antimicrobial agents, shellac and rosin instead of the traditional fluoride as low surface energy substances and adhesives, and nano‑calcium carbonate (Nano-CaCO 3 ) as hydrophobic particles. The multifunctional coating exhibits a contact angle exceeding 150° for both water and other liquids, demonstrating exceptional liquid-repellent properties and superior antifouling performance. Under an 80 g load, the coating withstands 45 cycles of sandpaper abrasion testing and 50 cycles of adhesive tape peeling testing. Furthermore, the composite coating samples show a 28% increase in tear strength and a 24% enhancement in puncture resistance compared to the pristine counterpart. The coating exhibits significant antibacterial activity against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), achieving antibacterial efficiency rates of 99.1% and 99.3%, respectively. In strawberry preservation tests, the shelf life of the samples was extended to the sixth day. Composed of non-toxic and sustainable chemicals, the coating integrates superhydrophobicity, antifouling properties, and antimicrobial functionalities, thereby demonstrating broad applicability across diverse sectors, including paper protection, packaging, biomedical applications, and the food industry.
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DIAMOND AND RELATED MATERIALS
·
2026
·
IF 5.1
Luyu Ji,Meilin Zhang,Hanzhong Cui,En Zhang,Jin Zhang
The properties of biomass porous carbon materials are important for supercapacitor energy storage devices. This study presents a novel B and N co-doped hierarchical porous carbon (BPC) synthesized from chitosan via a facile K 2 CO 3 activation strategy. The chitosan precursor was pretreated to enhance its suitability for carbonization, resulting in a highly conductive carbon skeleton with a developed hierarchical porous structure and a specific surface area of 507 m 2 /g. The effects of B and N element doping on the surface morphology and electrochemical properties of BPC were investigated. The electrochemical properties of the materials were characterized using cyclic voltammetry, galvanostatic charge-discharge tests, and impedance spectroscopy. The optimized sample (CBP-1) demonstrated exceptional electrochemical performance: achieving a specific capacitance of 527 F g −1 at 4.5 A g −1 and exhibiting outstanding cycling stability with 84% capacitance retention after 10,000 charge/discharge cycles at 10 A g −1 . Electrochemical impedance spectroscopy confirmed superior interfacial properties with a low equivalent series resistance (R s ) of 1.19 Ω. Chitosan distinguishes itself from other biomass materials by its rich -NH 2 groups, which allow for effective nitrogen self-doping. This intrinsic advantage translates into enhanced conductivity and wettability for BPC, contributing to its improved electrochemical performance. B and N co-doping creates structural defects that facilitate electrolyte penetration and shorten ion diffusion paths while providing pseudo capacitance. Chitosan-based B and N co-doped hierarchical porous carbon is a promising capacitor-modified electrode material with potential applications in energy storage.
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CHEMICAL ENGINEERING JOURNAL
·
2012
·
IF 3.461
Kungang Chai,Hongbing Ji
Removal of benzoic acid from industrial wastewater is important for the water treatment, and adsorption is an efficient treatment process. Chitosan and β-cyclodextrin (β-CD) are well investigated as feedstock for preparing polysaccharide-based toxic compounds removing adsorbents. In this study, chitosan grafted β-CD (CGC) was synthesized using glutaraldehyde as cross-linker in acidic aqueous solution. The successful grafting of β-CD onto chitosan was confirmed by FTIR and XRD. Compared with β-CD-epichlorohydrin copolymer (CDP) and cross-linked chitosan resin (CCR), CGC showed an excellent ability to adsorb benzoic acid. The CGC adsorption kinetics toward benzoic acid at 298.15 K, and isotherms at varying temperatures were studied systematically. Kinetics of the adsorption process agreed well with the pseudo-second-order kinetic model, and the experimental data of equilibrium isotherms fitted well with Langmuir model ( R 2 > 0.99). Furthermore, thermodynamic parameters revealed the spontaneity and exothermic nature of the adsorption process. The adsorption–desorption of benzoic acid by CGC and other two commercial adsorbents were evaluated and compared in five cycles, demonstrating high regeneration efficiency of CGC. The reversibility of benzoic acid adsorption by CGC was further proved by column recycle test. Finally, the adsorption mechanism was proposed according to the inclusion behavior of β-CD toward benzoic acid as well as the electrostatic interaction between chitosan units and benzoic acid.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Jing Zhang,Yiming Chen,Wenya Meng,Huifang Liu,Jing Li,Long Yu,Ping Dong
The biomedical potential of chitosan (CS) in wound healing is constrained by poor solubility and processability. Herein, we report a green and efficient route to synthesize water-soluble sulfated chitosan (SCS) with controlled sulfation patterns, using a sulfamic acid-urea deep eutectic solvent (DES). Comprehensive characterization (FTIR, 13 C and HSQC NMR, HPSEC-MALLS-RI, and elemental analysis) verified tunable sulfation and molecular weights, with zeta potential further delineating the corresponding surface properties. Biological evaluations demonstrated that SCS possesses excellent biocompatibility, promotes cell migration, enhances TGF-β1/VEGF secretion, and facilitates angiogenesis, collagen deposition, and extracellular matrix remodeling. Structure-activity analysis revealed sulfation patterns determined bioactivity, with 6-O-sulfated SCS demonstrating superior wound closure rates (96.2% in 6-O-SCS vs. 88.6% in control group on 12 day post-treatment). This study provides a sustainable approach to SCS production and highlights its therapeutic potential in wound management.
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