ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Wu Huaxin,Huang Ting,Zhang Wei,Yao Huan,Li Xueyao,Su Ping,Yang Yi
In the biomedical and chemical fields, purity assessment of compounds is a critical step in ensuring product quality and safety. In this study, a method for purity quantification was proposed as two-signal suppression–internal standard correction–high-performance liquid chromatography–quantitative nuclear magnetic resonance (TSS-ISC-HPLC-qNMR). The two-signal suppression effectively suppresses the interference of solvent signals in the NMR spectra, and the internal standard correction eliminates the influence of many variables during sample preparation and analysis. The purity result (99.89%) of the quantification of certified reference material of acesulfame (AF) by this method matched with the certified value (99.88%), which verified the accuracy of the method. The purity result (with standard deviation) of 94.42% ± 0.10% for the quantification of the low-purity drug digitoxin by the method matched with the purity result of 94.42% ± 0.11% by qNMR with deconvolution (as a validated method), which proved that the method could be used for the quantification of low-purity compounds. The methodology achieved a substantial reduction in total analysis time, from 28 to 4 h (considering only the routine analysis time after optimization), in contrast to the ISC-HPLC-qNMR approach. Additionally, it effectively decreased bias to undetectable with a standard deviation of 0.10%, while the bias of the TSS-HPLC-qNMR method was 0.93%. The present method ensures the accuracy of the quantitative results while demonstrating a low economic burden and significant time efficiency, which shows great potential for application in the accurate quantitative analysis of low-purity organic compounds. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2025
·
IF 2.3
Zhou Siqi,Guo Yangfeng,Zhang Tingting,Ding Kangjia,Wang Dongfang,Li Zihui,Li Qian
The fabrication of PTFE micron filaments with superior mechanical properties remains both a key research focus and a considerable challenge in the field of engineering technology. In this study, the PTFE micron filaments were successfully prepared via wet spinning and molding process by optimizing the concentration of the carrier polyethylene oxide (PEO) aqueous solution, molecular weight of the coagulation bath poly-(ethylene glycol) PEG, mass ratio of PTFE to PEO, and sintering temperature. Due to its higher hygroscopicity and surface tension compared to the spinning solution, PEG provided favorable conditions for the solidification of the PTFE/PEO primary filaments. Elemental analysis results confirmed the complete removal of PEO and PEG from the PTFE fibers after sintering. When the mass fraction of PEO is 4%, the mass ratio of PTFE to PEO is 4:1, PEG molecular weight is 200 Da, and the sintering temperature is 370 ℃, the resulting PTFE fibers display a smooth and compact Surface, with a diameter of 27.50 ± 0.66 μm. Furthermore, tensile testing reveals that the PTFE filaments achieved a tensile strength of 133.02 ± 5.39 MPa and an elongation at break of 567.77 ± 93.67%. These findings demonstrate a feasible and efficient approach for the fabrication of high-performance PTFE micron filaments.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2025
·
IF 2
Liu Shuai,Liu Fang,Guan Liandi,Zhang Jianwei
BF is a promising reinforcing material for resin matrix composites. Still, it fails to fully utilize its excellent mechanical and functional properties due to the weak interfacial bonding between BF and the resin matrix. In this work, the fibers were treated by acid and alkali synergistically with nano-infiltrant (containing nano-SiO 2 ) to improve the inertness of the fiber surface and enhance the interfacial bonding. Then, BFFC was prepared by hand-coating bisphenol F epoxy resin on the surface of BFF. The microstructure, mechanical properties, durability, thermal stability, and sound absorption properties of the composites were investigated. The results showed that the acid and alkali synergistic nano-infiltrant-modified BF surfaces showed excellent interfacial bonding with increased roughness and reactive groups, which effectively revised the bonding strength between BF and the resin matrix. In particular, the tensile strength, durability, and thermal stability of the composites with alkali synergistic nano-infiltrant were revised by 59.8%, 45.9%, and 48.1%, respectively, compared with the untreated samples, and the structure of the composites was also optimized to enhance the sound-absorbing performance, reaching an average sound absorption coefficient of 0.49. In future, it can promote the development of BF composites toward multi-functionalization.
✓ 已验证
产品关联
DOI
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2025
·
IF 3.5
Han Lijuan,Chai Keyi,Du Xinyu,Wang Xiangtong,Zhang Ping,Wang Xiaotian
Tetracycline poses a serious threat to the ecosystems even if the concentration is very low due to its structural stability. In this work, a series of magnetic separable Fe 3 O 4 /ZnO/g-C 3 N 4 composite with excellent degrading tetracycline performance were prepared. And, repeated calcination method was used to strengthen the bonding effect of single component improving the formation of heterojunction. Electrochemical analysis confirmed that the ZnO/g-C 3 N 4 and Fe 3 O 4 /ZnO/g-C 3 N 4 heterojunctions were generated, effectively accelerating the electron separation and transfer in photocatalytic process. The characterization results also showed that ZnO and Fe 3 O 4 nanoparticles are evenly distributed on the surface of g-C 3 N 4 . With the increase of the loading mass concentration of ZnO/g-C 3 N 4 , the degradation rate of tetracycline on Fe 3 O 4 /ZnO/g-C 3 N 4 composite increased and then decreased. The degradation rate of tetracycline on optimal Fe 3 O 4 /ZnO/g-C 3 N 4 composite reached to 94.50% while the TC mineralization rate reached to 61.61% under visible light irradiation for 120 min, exhibiting excellent photocatalytic performance. Due to the effect of Fe 3 O 4 , Fe 3 O 4 /ZnO/g-C 3 N 4 materials exhibited good magnetic property, which is beneficial to separation and recovery of photocatalysts. The reusability experiment showed that the degradation rate of tetracycline was 80.66% after five cycles, displaying good reusability.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Food Measurement and Characterization
·
2025
·
IF 3.3
Lv Junli,Ren Zhilong,Niu Jianjiao,Lian Guohua
Pepsin is a crucial digestive enzyme in the human body. However, its hyperactivity can readily contribute to the development of gastrointestinal disorders. Research has indicated that certain phenolic acids can bind to pepsin, thereby attenuating its activity, which may be affected by the molecular weight and conformation of phenolic acids. Nonetheless, there are few reports in the literature regarding comparative studies on the inhibition of pepsin by various phenolic acids. Hence, three phenolic acids—ferulic acid, chlorogenic acid, and gallic acid—were selected for investigation in this study. A combination of spectroscopic experiments, molecular docking simulations, and antioxidant tests were employed to elucidate the interactions and mechanisms between these phenolic acids and pepsin. The findings demonstrated that the interaction between the three phenolic acids and pepsin occurred via a static quenching mechanism. Notably, chlorogenic acid exhibited the most pronounced impact on the fluorescence of pepsin. At temperatures of 298 K and 310 K, the fluorescence intensity of pepsin was reduced by 75.23% and 76.17% at a concentration of 0.6 × 10 −3 mol/L, respectively. Furthermore, thermodynamic parameter analysis indicated that the interaction between the polyphenols and pepsin was a spontaneous process, primarily driven by van der Waals forces and hydrogen bonding interactions. Molecular docking results corroborated the thermodynamic analysis, highlighting hydrogen bonding as the predominant force. Through an analysis of binding free energy, it was determined that the binding affinity of phenolic acids to pepsin follows the order: chlorogenic acid > gallic acid > ferulic acid. Furthermore, upon interaction with pepsin, the DPPH radical scavenging activity of these phenolic acids was diminished. The findings of this study may enhance the understanding of the health implications of phenolic acids in future research.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2025
·
IF 1.6
Tao Qinqin,Wang Yusheng,Chen Chuanhong,Dai Ying
This study investigates the role of hydrogen bonding in Hydrogen-Bonded Complex Extractants (HBCEs) for uranium extraction from wastewater. Through integrated experimental and theoretical approaches including electrostatic potential (ESP) analysis, molecular binding energy calculations, Atoms in Molecules (AIM) theory, and spectroscopic characterization, we reveal how structural variations (carbon chain length, unsaturation degree, spatial configuration, and functional groups) modulate hydrogen bond characteristics. Results show that extending carbon chains enhances hydrogen bond strength (TBPO-18: -24.28 kcal/mol binding energy), while increasing unsaturation initially weakens then strengthens interactions. Linear structures exhibit superior hydrogen bonding versus cyclic configurations (TBPO-OH vs TBPO-HOH: 18.60 vs 14.47 kcal/mol). Extraction performance correlates with hydrogen bond stability, where TBPO-12 achieves maximum capacity (40.55 mg/L) due to optimal acid resistance. Mechanistic studies via 31 P NMR titration confirm a two-step process: initial \({\text{UO}}_{2}^{2 + }\) complexation with TBPO’s P = O group, followed by hydrogen bond formation with HBDs. This work provides fundamental insights for rational design of high-efficiency HBCEs, highlighting hydrogen bond engineering as a key strategy for nuclear wastewater treatment.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER BULLETIN
·
2025
·
IF 4
Chen Sixian,Fu Jun,Lin Qianbing,Wu Yibo,Shi Qisong
Flexible sensors, due to their unique advantages, are anticipated to find applications in electronic skin, human monitoring, human–computer interaction, and other fields. Among these, flexible strain sensors have garnered significant attention owing to their broad detection range, high sensitivity, and robust anti-interference capability. This paper presents a method for constructing a uniform conductive network within a thermoplastic polyurethane (TPU) matrix by incorporating ionic liquids (ILs) and carbon black nanoparticles (CB). The resulting flexible strain sensor exhibits sensitivities of 1.16 and 2.15 at 0–60% and 60–200% strain levels, respectively. This sensor can accurately monitor various tensile signals and demonstrates response recovery times of 130 ms and 98 ms in tensile mode, and 191 ms and 195 ms in bending mode. Its output signal remains stable after over 200 cycles of 50% strain, indicating excellent durability and stability. Finally, by encapsulating and sewing it onto clothing, it can generate SOS distress signals in two ways, making it a potential tool for emergency calls. This flexible strain sensor showcases superior performance and immense potential in the realm of wearable electronics. Graphic abstract
✓ 已验证
产品关联
DOI
高影响因子
NATURE MATERIALS
·
2025
·Vol. 24
·期 11
·1716-1725
·
IF 38.5
Zhang Zhi,Zhang Yuwei,Lu Kangjun,Zhang Jun-Jie,Zhang Nannan,Feng Rui,Ye Haoran,Zhou Xiaoli,Li Linglong,Wan Dongyang,Lu Junpeng,Ni Zhenhua,Wang Jinlan,Chen Qian,Lu Jiong,Li Zejun
Rolling two-dimensional materials into one-dimensional nanoscrolls introduces curvature, chirality and symmetry breaking, enabling emergent properties. Conventional methods relying on external driving forces, however, exhibit poor control, low yield and limited reproducibility. Here we report spontaneous scrolling in polar van der Waals materials via an electrochemical intercalation/exfoliation process, enabling scalable nanoscroll production. This self-rolling is driven intrinsically by out-of-plane electric polarization ( P ⊥ ), where the magnitude of P ⊥ is modulated by the intercalant size. Validated across eight polar materials, this approach achieves virtually 100% yield and reproducibility with defined scrolling direction, surpassing external driving force limitations. The nanoscrolls exhibit layer-independent inversion symmetry breaking and coherently enhanced second-harmonic generation, exceeding two-dimensional flakes by ~100-fold and rivalling leading two-dimensional nonlinear materials. Electrochemical initiation further facilitates metal-ion co-intercalation, yielding ten hybrid nanoscroll architectures. These findings establish a scalable route to create one-dimensional nanostructures and hybrid heterostructures, paving the way for designer quantum solids and van der Waals superlattices in quantum nanodevices.
✓ 已验证
DOI
PubMed
高影响因子
Nano-Micro Letters
·
2025
·Vol. 17
·期 1
·1-14
·
IF 36.3
Yin Guang,Wu Jing,Qi Chengzhang,Zhou Xinfeng,Yu Zhong-Zhen,Zhang Hao-Bin
A versatile surfactant-free emulsion construction strategy is proposed to customize functional hydrogels.
The synergistic emulsification mechanism between amphiphilic polymers and MXene is comprehensively elucidated.
Programmable functional structures confer hydrogels with excellent EMI shielding and water evaporation performance.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano-Micro Letters
·
2025
·Vol. 17
·期 1
·1-28
·
IF 36.3
Shi Tao,Gao Xing,Liu Huan,Wang Xiaodong
A “five-in-one” multifunctional phase-change composite is developed for magnetothermal, electrothermal, solar-thermal, and thermoelectric energy conversion and electromagnetic shielding applications.
The developed composite is based on an innovative combination of carbonized polyimide/Kevlar/graphene oxide@ZIF-67 complex aerogel as a supporting material and paraffin wax as a phase-change material.
The developed composite exhibits excellent solar-thermal, thermoelectric, electrothermal, and magnetothermal energy conversion performance along with high electromagnetic interference shielding effectiveness.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AMB Express
·
2022
·Vol. 12
·期 1
·1-15
·
IF 4.126
Liu Shasha,She Pengfei,Li Zehao,Li Yimin,Yang Yifan,Li Linhui,Zhou Linying,Wu Yong
According to a 2019 report from the Centers of Disease Control and Prevention (CDC), methicillin-resistant Staphylococcus aureus (MRSA) was listed as one of the “serious threats” that had become a global public challenge in hospitals and community. Biofilm-associated infections and refractory persisters of S. aureus also impede the effectiveness of conventional antibiotics that have greatly increased difficulty in clinical therapy. There is an urgent need to develop new antimicrobials with antibiofilm and anti-persister capacities, and drug repurposing is the most effective and most economical solution to the problem. The present study profiles the antimicrobial activity of ceritinib, a tyrosine kinase inhibitor, against S. aureus in vitro and in vivo. We investigated the antimicrobial efficacy of ceritinib against planktonic and persistent S. aureus by a time-killing kinetics assay. Then, antibiofilm effect of ceritinib was assessed by crystal violet staining and laser confocal microscope observation. Ceritinib showed biofilm inhibition and mature biofilm eradication, and possesses robust bactericidal activity against S. aureus persisters. We also evaluated antimicrobial efficacy in vivo using a subcutaneous abscess infection model. Ceritinib ameliorated infection in a subcutaneous abscess mouse model and only showed negligible systemic toxicity in vivo. Mechanism exploration was conducted by transmission electron microscopy, fluorescently labeled giant unilamellar vesicle assays, and a series of fluorescent dyes. In conclusion, we find ceritinib represents potential bactericidal activity against MRSA by disrupting cell membrane integrity and inducing reactive oxygen species production, suggesting ceritinib has the potential to treat MRSA-related infections.
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-14
·
IF 16.6
Yang Ye,Yang Yaozhang,Liu Dingyuan,Wang Yuanyuan,Lu Minqiao,Zhang Qi,Huang Jiqing,Li Yongchuan,Ma Teng,Yan Fei,Zheng Hairong
Acoustic tweezers can control target movement through the momentum interaction between an acoustic wave and an object. This technology has advantages over optical tweezers for in-vivo cell manipulation due to its high tissue penetrability and strong acoustic radiation force. However, normal cells are difficult to acoustically manipulate because of their small size and the similarity between their acoustic impedance and that of the medium. In this study, we use the heterologous expression of gene clusters to generate genetically engineered bacteria that can produce numerous sub-micron gas vesicles in the bacterial cytoplasm. We show that the presence of the gas vesicles significantly enhances the acoustic sensitivity of the engineering bacteria, which can be manipulated by ultrasound. We find that by employing phased-array-based acoustic tweezers, the engineering bacteria can be trapped into clusters and manipulated in vitro and in vivo via electronically steered acoustic beams, enabling the counter flow or on-demand flow of these bacteria in the vasculature of live mice. Furthermore, we demonstrate that the aggregation efficiency of engineering bacteria in a tumour is improved by utilizing this technology. This study provides a platform for the in-vivo manipulation of live cells, which will promote the progress of cell-based biomedical applications.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）