JOURNAL OF CHROMATOGRAPHY A
·
2019
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IF 3.858
Dongsheng Xu,Qiqin Wang,Elena Sánchez-López,Zhengjin Jiang,María Luisa Marina
An O -[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine (MQD)-silica hybrid monolithic column was prepared by a facile “one-step” strategy within a 100 μm I.D. capillary. The influence of the methanol, ethylene glycol and water volume ratio, reaction temperature and time, cetyltrimethylammonium bromide and MQD monomers content and volume ratio of tetramethoxysilane and vinyltrimethoxysilane was investigated to obtain a satisfactory morphology of monolithic columns. The optimized MQD-silica hybrid monolithic column was evaluated in terms of permeability, stability, efficiency, reproducibility, and was characterized by scanning electron microscopy and nano-liquid chromatography. Among the 52 N-derivatized protein and non-protein amino acids , a total of 44 analytes could be baseline enantioseparated using the optimized conditions in either reversed phase mode (RPM) or polar organic phase mode (POM). The results showed that POM (ACN/MeOH/HAc/TEA (60/40/0.055/0.005, v/v/v/v)) offered better performance than RPM (10 mM ammonium acetate/ACN (30/70, v/v) (apparent pH=5.3)) in terms of enantioresolution and efficiency with shorter analysis times.
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高影响因子
Antioxidants
·
2025
·Vol. 14
·期 4
·490
·
IF 6.6
Chao Ma,Yu Nie,Donglei Zhang,Lulu Ran,Su Xu,Xun Ran,Junya Huang,Lingshuai Meng
Background: Blueberry anthocyanin such as Cyanidin-3-O-glucoside may help prevent Alzheimer’s disease. We aimed to investigate the preventive and therapeutic effects of Cyanidin-3-O-glucoside against Aβ1–42-induced apoptosis of SH-SY5Y cells as well as the underlying mechanisms. Methods: Cell viability and intracellular and mitochondrial reactive oxygen species were detected by MTT, a reactive oxygen species detection kit, and a MitoSOX red mitochondrial superoxide indicator. The mitochondrial membrane potential, intracellular calcium ion content, and adenotriphophate (ATP) were identified via a mitochondrial membrane potential detection kit, calcium ion detection kit, and ATP detection kit, and apoptosis was detected via flow cytometry. Transcription of apoptosis-related genes was detected using real-time fluorescence quantitative polymerase chain reaction, and expression of apoptosis-related proteins was identified using Western blot. Results: We found that Cyanidin-3-O-glucoside could downregulate the expression of cytochrome c, caspase 9, caspase 3, and other genes and proteins, which consequently reduced the rate of apoptosis. Additionally, it could upregulate Bcl-2 gene and protein expression, downregulate Bax gene and protein expression, regulate mitochondrial membrane permeability and calcium-release channels, reduce calcium influx into mitochondria, maintain intracellular calcium ion levels, reduce intracellular levels of reactive oxygen species and increase ATP levels, maintain the mitochondrial membrane potential at a normal level, maintain normal mitochondrial functioning, and prevent apoptosis. Discussion: Taken together, Cyanidin-3-O-glucoside showed dose-dependent preventive and therapeutic effects against Aβ1–42-induced apoptosis of SH-SY5Y cells. Conclusions: Cyanidin 3-O-glucoside showed a better preventive effect than therapeutic effect against Aβ1–42-induced apoptosis in SH-SY5Y cells.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yongjiang Li,Ailing Zhang,Yanhui Wang,Donglei Fan,Yichao Lin,Jie Liu,Tao Tang
Phosphorus containing flame-retardants with low oxidation states are widely used in Flexible polyurethane foam (FPUF) due to their excellent gas-phase flame retardancy. However, achieving good migration resistance in prepared flame retardant while balancing or even improving the mechanical properties (such as ductility, good rebound ability) and flame retardancy of FPUF remains a challenging issue. To solve the above problem, we have designed diphenylphosphine oxide silicon glycol (DPPSG) that combines a phosphorus-based flame retardant group with a Si-O-C bond structure. Chemically linking DPPSG into the molecular chain of flexible polyurethane foam and mechanical properties at the same time. On one hand, DPPSG has good compatibility with polyether polyols 330, reacting uniformly with isocyanates and participating in the foaming and gelation process of FPUF. This ensures its enduring flame retardancy. On the other hand, the tensile strength and elongation at break of the flame retardant foam (10DPPSG foam) prepared by adding 10% DPPSG of polyether polyol 330 increased by 71.4% and 77.6% respectively. Moreover, even after 100 cycles of compression rebound testing, 10DPPSG foam exhibited excellent elasticity with a permanent compression deformation rate of only 4.9%. This work provides a new approach to develop FPUF that achieves a balance between mechanical and flame-retardant properties.
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Bioresources and Bioprocessing
·
2025
·Vol. 12
·期 1
·1-16
·
IF 5.1
Deng Jie,Zheng Jia,Li Xing,Huang Dan,Ye Guangbin,Luo Huibo
Qu -aroma is a critical quality indicator for medium–high temperature Daqu (MT- Daqu ). Due to the differences in regional and environmental conditions, these differences are likely to cause variations in the Qu -aroma of MT- Daqu . Despite this, comprehensive research on the variations in Qu -aroma across different regions has been lacking. This study aims to address this gap to analyze the differences in Qu -aroma characteristics of MT- Daqu from seven distinct production areas. Sensory analysis identified seven broad aroma categories and 25 specific aromas characterizing the Qu -aroma of MT- Daqu samples. Chen aroma and roasted aroma were notably more prevalent in MT- Daqu samples from Sichuan compared to those from other regions ( P < 0.05 ). In total, 123 volatile compounds were detected in MT- Daqu , with 42 classified as aroma-active compounds. Among these, 21 aroma-active compounds were identified as markers distinguishing Sichuan MT- Daqu from those produced in non-Sichuan regions, showing significant differences in their concentrations ( P < 0.05 ). Additionally, six major aroma-active compounds were found to significantly contribute to the aroma differences between Sichuan and non-Sichuan MT- Daqu . This study delineates the distinct Qu -aroma characteristics of MT- Daqu from various SAB production areas. The insights gained from this research offer valuable guidance for optimizing flavor profiles in MT- Daqu production. Graphical
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APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Wei Jiang,Zhaomei Wu,Yingming Zhu,Wen Tian,Bin Liang
Four silver chalcogen compounds, Ag 2 O, Ag 2 S, Ag 2 Se and Ag 2 Te, can be utilized as visible-light-driven photocatalysts. In this research, the electronic structures of these compounds were analyzed by simulation and experiments to systematically reveal the relationship between photocatalytic performance and energetic structure. All four chalcogenides exhibited interesting photocatalytic activities under ultraviolet, visible and near-infrared light. However, their photocatalytic performances and stability significantly depended on the band gap width, and the valence band and conduct band position, which was determined by their composition. Increasing the X atomic number from O to Te resulted in the upward movement of the valence band top and the conduct band bottom, which resulted in narrower band gaps, a wider absorption spectrum, a weaker photo-oxidization capacity, a higher recombination probability of hole and electron pairs, lower quantum efficiency, and worse stability. Among them, Ag 2 O has the highest photocatalytic performance and stability due to its widest band gap and lowest position of VB and CB. The combined action of photogenerated holes and different radicals, depending on the different electronic structures, including anion ozone radical, hydroxide radical, and superoxide radical, was observed and understood. The results of experimental observations and simulations of the four silver chalcogen compounds suggested that a proper electronic structure is necessary to obtain a balance between photocatalytic performance and absorbable light region in the development of new photocatalysts.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2020
·
IF 4.939
Wei Cheng,Xue Zhao,Wenxiu Luo,Yi Wang,Guangyin Fan
Oxygen and nitrogen-rich functional groups which are generally present in carbon materials may significantly affect their catalytic properties . The development of O, N-rich functional carbon materials with a simplified and low-budget strategy is of great importance for practical application. Herein, we describe a facile and straightforward method to prepare high contents of nitrogen and oxygen-rich carbon derived from ethylenediamine tetra-acetic acid tetra-sodium salt (Na 4 EDTA) by one-step carbonization in muffle furnace without inert gas protection. Compared with the carbon (EC-N700) synthesized in an argon atmosphere , the carbon (EC-A700) synthesized in an air-rich condition was more conducive to the formation of edge defects and topological defects and possessed higher contents of N and O elements. Consequently, the O, N-rich carbon EC-A700 was used as an efficient support of palladium nanoparticles toward catalytic formic acid dehydrogenation and nitroarene reduction. The catalyst Pd/EC-A700 achieved outstanding activity for formic acid dehydrogenation with a turnover frequency (TOF) up to 7039 h −1 at 60 °C. At the same time, the obtained catalyst Pd/EC-A700 also demonstrated exceptional catalytic performance in the 4-nitrophenol (4-NP) reduction with corresponding rate constant k of 0.72 min −1 under mild reaction conditions, which proved that the prepared catalyst Pd/EC-A700 has potentially applied in catalytic hydrogenation. This low-cost and simple approach breaks the tradition in mind that pyrolysis should always operate under inert conditions and provides a straightforward route to construct O, N-rich carbon as appealing materials for a wide variety of applications.
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高影响因子
Materials Today Chemistry
·
2020
·
IF 0
H. Wang,Y. Xia,J. Liu,Z. Ma,Q. Shi,J. Yin
Reduction of inflammation and thrombosis caused by implanted devices is critical for clinical success. To this end, the strategy based on programmable release of anti-inflammatory and anti-thrombotic agents from the widely-used polycaprolactone (PCL)/gelatin nanofiber scaffold is developed. The release of 2-O- d -Glucopyranosyl- l -ascorbic Acid (AA-2G) and heparin are controlled by reactive oxygen species (ROS)-responsive poly(ethylene glycol)-based β-thioether ester copolymer (PEGDA-EDT) and mesoporous silica nanoparticles (MSN) in the nanofiber, respectively. The in vitro assay demonstrate that the scaffolds are hemocompatible with the resistance of platelet adhesion; the control release of AA-2G prevents initial inflammation and oxidation of the blood cells, and the subsequent release of heparin entitles nanofibers with long-term anti-thrombotic capability. In addition, rapid endothelialization is obtained on the surface of nanofiber scaffolds for the further enhancement of the hemocompatibility. In vivo implant evaluation convinces that the nanofiber scaffolds possess high biocompatibility with the substantial resistance for inflammation and thrombosis. Hence, our work paves a new way to develop the anti-inflammatory and anti-thrombotic tissue-engineering substrates through programmable delivery of two or multiple drugs.
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ACS Applied Energy Materials
·
2023
·
IF 6.4
Yu Lin,Fangfang Li,Xiaoqing Li,Hongwei Zhao,Gang Liu
To recycle wastes and develop renewable energy, much effort has been focused on converting biowastes into porous carbon for supercapacitors. Porous nanocage-like carbons have excellent capacitive properties, but generally their preparation methods are costly or complex. Herein, a “one-step” strategy of synchronous activation and support through the thermal decomposition of a multifunctional template (magnesium acetate, Mg(Ac)2) is designed to prepare N-, O-, and S-codoped mesoporous hollow biochar nanocages (BNC-700). The BNC-700 prepared displays an interconnected porous structure and a two-dimensional (2D) multilayer wall/three-dimensional (3D) hollow nanocage structure with abundant active heteroatoms and edge defects. Due to their specific structures, high surface areas (1369 m2 g–1), and large pore volumes (1.81 cm3 g–1), the assembled supercapacitor delivers a considerable energy density of 37.4 Wh kg–1 at 212 W kg–1 and cycling stability of 99.5% after 15,000 cycles. The unique structure and N, O, and S codoping characteristics ensure a potential application for BNC-700 in supercapacitors. In summary, a strategy is designed for the green, simple, and cost-effective preparation of high-performance biochar for advanced energy storage devices.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ziying Guo,Yuting Zhou,Ping Wang,Qiang Wang,Bo Xu,Man Zhou,Li Cui,Ying Zhang,Yuanyuan Yu
The high energy consumption and pollution associated with traditional cotton fabric treatment have become increasingly serious concerns; thus, in this study, a synergistic cotton fabric treatment based on Novozymes pectinate lyase (NPL) scouring/ultraviolet light-mediated catalytic (UV/H 2 O 2 ) bleaching was innovatively proposed. This study investigated the degradation mechanisms of impurities in cotton fabrics, concluding that the oxidative bleaching reaction of morin follows first-order kinetics; in the UV/H 2 O 2 /NPL system, pectin degradation occurs through the β-elimination of NPL and oxidation by free radicals. Under optimized conditions—254 nm UV irradiation, 8 g⋅L −1 NPL, 30 g⋅L −1 H 2 O 2 , pH 9, and one-side irradiation for 45 min. The fabric whiteness could reach 79.04 %，but the fiber damage was severe, manifested by a 40 % decrease in polymerization and strength. After adjusting the process parameters, adjust the UV wavelength to 302 nm and add 6 g⋅L −1 of the activator (NOBS), whiteness of the fabric was about 76.7 % and strength retention rate was 96.38 %. This method overcomes the shortcomings of traditional pretreatment processes for cotton fabrics, under low temperature and alkaline conditions, low-strength damaged fabrics can be obtained, providing a new strategy for developing environmentally friendly pre-treatment processes for cotton fabrics.
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ACS Catalysis
·
2025
·
IF 13.1
Siyu Ma,Shufei Wang,Shuguang Wang,Xinze Chen,Hongyuan He,Xiaoxin Zhang,Shuo Zhai,Qingyang Han,Pengfei Zhang,Kai Zhao,Ning Yan,Yue Tie,Ding Ding,Xingyu Chen,Yingru Zhao,Meidan Ye,Abdullah N. Alodhayb,Zhou Chen,Yanping Zheng,Jianhui Li,Yifei Sun
Perovskite oxides are promising anodic electrocatalysts for alkaline saline water electrolysis, yet their performance is often limited by sluggish oxygen evolution reaction kinetics and competing chloride corrosion. Building on Pr0.1Sr0.9Co0.5Fe0.5O3 (PSCF), a candidate previously identified via our transfer learning paradigm, we further leveraged data-driven compositional searching of the A-site configuration, which led to an optimized catalyst with a proper Ce/Sr/Pr ratio (Ce-PSCF). The asymmetric Ce–O–Co motifs invoked a negative charge-transfer regime and activated the evolution of nonbonding oxygen (ONB) states, which reconciled the activity-stability trade-off and promoted a dual-site intramolecular lattice oxygen mechanism, as evidenced by promoted 18O–18O evolution. The electrolyzer with Ce-PSCF lowered the overpotential of the PSCF-based one by 100 mV at 300 mA cm–2 and exhibited 15-fold greater durability. Electrochemical analysis revealed a higher reaction order, promoted *OH coverage, and faster surface reconstruction on the Ce-incorporated electrocatalyst, indicating *OH-controlled chemical-step kinetics. Theoretical insight inferred a variation of the rate-determining step from O–O coupling to secondary OH– refilling with a reduced energy barrier from 0.68 to 0.54 eV. Moreover, ab initio molecular dynamics simulations visualized a dynamically strengthened affinity for OH– and significant repulsion of Cl–, arising from its intrinsic Lewis acidic and basic microenvironment.
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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2024
·
IF 5.6
Xin Gan,Yuna Wu,Min Zhu,Bo Liu,Miaomiao Kong,Zixuan Xi,Ke Li,Haibao Wang,Tiande Su,Jiali Yao,Fatehi Khushafah,Baozhu Yi,Jiabing Wang,Wulan Li,Jianzhang Wu
The structure-activity relationship (SAR) between toxicity and the types of linking ketones of C7 bridged monocarbonyl curcumin analogs (MCAs) was not clear yet. In the pursuit of effective and less cytotoxic chemotherapeutics, we conducted a SAR analysis using various diketene skeletons of C7-bridged MCAs, synthesized cyclic C7-bridged MCAs containing the identified low-toxicity cyclopentanone scaffold and an o-methoxy phenyl group, and assessed their anti-gastric cancer activity and safety profile. Most compounds exhibited potent cytotoxic activities against gastric cancer cells. We developed a quantitative structure-activity relationship model (R2 > 0.82) by random Forest method, providing important information for optimizing structure. An optimized compound 2 exhibited in vitro and in vivo anti-gastric cancer activity partly through inhibiting the AKT and STAT3 pathways, and displayed a favorable in vivo safety profile. In summary, this paper provided a promising class of MCAs and a potential compound for the development of chemotherapeutic drugs.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Wen Chen,Xiaodong Zheng,Fujie Yan,Lizhou Xu,Xiang Ye
Microplastics derived from plastic waste have emerged as a pervasive environmental pollutant with potential transfer and accumulation through the food chain, thus posing risks to both ecosystems and human health. The gut microbiota, tightly intertwined with metabolic processes, exert substantial influences on host physiology by utilizing dietary compounds and generating bacterial metabolites such as tryptophan and bile acid. Our previous studies have demonstrated that exposure to microplastic polystyrene (PS) disrupts the gut microbiota and induces colonic inflammation. Meanwhile, intervention with cyanidin-3-O-glucoside (C3G), a natural anthocyanin derived from red bayberry, could mitigate colonic inflammation by reshaping the gut bacterial composition. Despite these findings, the specific influence of gut bacteria and their metabolites on alleviating colonic inflammation through C3G intervention remains incompletely elucidated. Therefore, employing a C57BL/6 mouse model, this study aims to investigate the mechanisms underlying how C3G modulates gut bacteria and their metabolites to alleviate colonic inflammation. Notably, our findings demonstrated the efficacy of C3G in reversing the elevated levels of pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α) and the upregulation of mRNA expression (Il-6, Il-1β, and Tnf-α) induced by PS exposure. Meanwhile, C3G effectively inhibited the reduction in levels (IL-22, IL-10, and IL-4) and the downregulation of mRNA expression (Il-22, Il-10, and Il-4) of anti-inflammatory cytokines induced by PS exposure. Moreover, PS-induced phosphorylation of the transcription factor NF-κB in the nucleus, as well as the increased level of protein expression of iNOS and COX-2 in the colon, were inhibited by C3G. Metabolisms of gut bacterial tryptophan and bile acids have been extensively implicated in the regulation of inflammatory processes. The 16S rRNA high-throughput sequencing disclosed that PS treatment significantly increased the abundance of pro-inflammatory bacteria (Desulfovibrio, norank_f_Oscillospiraceae, Helicobacter, and Lachnoclostridium) while decreasing the abundance of anti-inflammatory bacteria (Dubosiella, Akkermansia, and Alistipes). Intriguingly, C3G intervention reversed these pro-inflammatory changes in bacterial abundances and augmented the enrichment of bacterial genes involved in tryptophan and bile acid metabolism pathways. Furthermore, untargeted metabolomic analysis revealed the notable upregulation of metabolites associated with tryptophan metabolism (shikimate, l-tryptophan, indole-3-lactic acid, and N-acetylserotonin) and bile acid metabolism (3b-hydroxy-5-cholenoic acid, chenodeoxycholate, taurine, and lithocholic acid) following C3G administration. Collectively, these findings shed new light on the protective effects of dietary C3G against PS exposure and underscore the involvement of specific gut bacterial metabolites in the amelioration of colonic inflammation.
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高影响因子
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