SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Zhen Lin,Chuangui Cai,Wei Chen,Qian Deng,Jialin Yang,Kaiyuan Huang,Haohua Deng,Xinhua Lin,Wei Chen,Wensong Yao
Chemiluminescence (CL) intensity of luminol-H 2 O 2 system was dramatically enhanced by cetyltrimethylammonium bromide (CTAB) micelle-mediated 6-aza-2-thiothymine-protected gold nanoclusters (ATT-AuNCs). It is proved that spherical micelles of CTAB in aqueous solution improved the dispersity of ATT-AuNCs, thus enhancing their catalytic activity, which brought in the increased CL intensity of luminol-H 2 O 2 system. Carbazochrome sodium sulfonate (CSS) with a hemostatic containing tetrahydroindole structure broke the spherical micelles and notably quenched the CL intensity of luminol-H 2 O 2 -CTAB-ATT AuNCs system. Based on these results, a simple, fast, and sensitive CL method has been developed for the detection of CSS with a linear range of 0.25–25 μM and a detection limit of 0.11 μM. The method has also been successfully applied to the determination of CSS in serum with satisfied recoveries in the range of 89.6 % to 103.7 %. This study not only provides an effective approach for CSS detection but also paves the way for AuNCs-based CL applications.
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高影响因子
MATERIALS & DESIGN
·
2023
·
IF 8.4
Peifeng Wang,Yang Du,Xingyang Zhao,Yueyang Hu,Tianjun Zhou,Xiaolong Liang,Chihua Fang,Jie Tian
Hepatocellular carcinoma is a common and highly malignant disease. As a currently designated systemic chemotherapeutic agent for advanced Hepatocellular carcinoma, sorafenib has been confronted with dilemma of drug-resistance caused by tumor hypoxia, which hinders the therapeutic efficacy of the drug. Based on this, a multifunctional mesoporous polydopamine nanoprobe 2Me-SPIO-CY5.5@AAZ-MPDA with a mesoporous frame loaded 2-Methoxyestradiol, Superparamagnetic Iron Oxide Nanoparticles and the near-infrared dye cyanine 5.5, conjugated with hypoxia Hepatocellular carcinoma-specific targeting molecule of sulfonamides acetazolamide, is fabricated for hypoxic region targeting, sorafenib resistance reversion and photothermal therapy of Hepatocellular carcinoma. In addition, the magnetic resonance imaging/fluorescence/photoacoustic tri-modal imaging ability enables the tracing of the nanoprobes and monitoring the treatment procedure in vivo, providing a new methods of imaging-guided Hepatocellular carcinoma synergic treatment which improves the long-term therapeutic effects of sorafenib.
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2023
·
IF 2.6
Qinghai Long,Shuo Wang,Xin Yin,Shufeng Shen
Nonaqueous solvents containing secondary alkanolamines and 2-alkoxyethanols, have recently gained significant attention for energy-efficient CO 2 capture process. However, the information of physicochemical property, particularly involving 2-(hexyloxy)ethanol (EGHE), is very limited for mass transfer and process modeling development. In this work, densities and viscosities were measured for binary mixtures of EGHE with 2-(methylamino)ethanol, 2-(ethylamino)ethanol and 2-(butylamino)ethanol at temperatures of (293.15–353.15)K and atmospheric pressure in the entire concentration range. The excess/deviation properties were derived from the experimental data and fitted by the Redlich-Kister equation to estimate the binary interaction parameters. The variation of excess properties with solvent composition and temperature was also discussed in terms of intermolecular interactions. The calculated from the proposed correlations matched well with the experimental values, with AARDs within 0.01% and 1.60% for density and viscosity respectively.
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高影响因子
SENSORS
·
2023
·Vol. 23
·期 13
·5814
·
IF 3.9
Jing Liu,Xiaozong Dou,Hongyan Zhang
In this paper, a 2-mercaptobenzimidazole-copper nanoparticles (MBI-CuNPs) fluorescent probe with high performance based on 2-mercaptobenzimidazole functionalized copper nanoparticles was synthesized by a hydrothermal method and used for cysteine (Cys) detection in serum. The MBI-CuNPs probe exhibits strong fluorescence emission at 415 nm under the excitation at 200 nm, which is attributed to the metal-ligand charge transfer (MLCT) transition through the coordination of an MBI ligand and monovalent copper. Furthermore, the MBI-CuNPs probe has a high quenching fluorescence response to Cys, and shows a good linearity relationship with Cys in 0.05–65 µM, with a detection limit of 52 nM. Moreover, the MBI-CuNPs probe could eliminate the interference of biological mercaptan Hcy and GSH with a similar structure and reaction properties, due to the strong electron-donating ability of Cys, which can quench the fluorescence of the MBI-CuNPs probe. The MBI-CuNPs probe was applied to the analysis of Cys in real serum, and the absolute recovery rate was as high as 90.23–97.00%. Such a fluorescent probe with high sensitivity and selectivity has potential applications for the early prevention of various diseases caused by abnormal Cys levels.Keywords:fluorescent probe;monovalent copper;metal-ligand charge transfer transition;cysteine detection;serum
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Tianyu Zeng,Shuai Wu,Qizhi Liang,Hai Shi,Jue Gong,Ningjun Duan,Wei Li,Genxi Li,Yongmei Yin
The emergence of antibody-drug conjugates (ADCs) targeting trophoblast cell-surface antigen-2 (Trop-2) has reshaped the therapeutic landscape of advanced breast cancer. Accurate profiling of the Trop-2 status of tumor cells can facilitate the identification of patients who will benefit from Trop-2-targeting therapy; however limited analytical method has hindered this process. In this study, we have proposed a specific and sensitive biosensor for visual tracking of the Trop-2 status of breast cancer cells based on tetrahedral DNA nanostructure (TDN)-decorated Fe-based metal-organic framework nanoparticles (TDN-PCN-222 (Fe)). In the design, a dual-aptamer-assisted biomimetic capture strategy shows high capture efficiency while maintaining the viability and original phenotype of captured cells, ensuring the accurate profiling of the Trop-2 status. Meanwhile, by using the high intrinsic peroxidase activity and excellent targeting ability of Trop-2-specific aptamer-linked TDN-PCN-222 (Fe), specific detection of Trop-2-positive tumor cells can be achieved with a limit of detection (LOD) of 10 cells/mL, and the Trop-2 status of tumor cells can be visually tracked. Moreover, the proposed biosensor has been successfully used for tracking the Trop-2 status of tumor cells in breast cancer tissues, suggesting that our method has great promise for clinical applications.
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高影响因子
Inorganics
·
2023
·Vol. 11
·期 6
·236
·
IF 2.9
Jia-Lin Cui,Zhong-Liang Liu,Hui-Hui Li,Chun-Zhong Li
The synthesis of highly efficient heterogeneous catalysts with uniformly dispersed noble metal particles and a suitable size is crucial for various industrial applications. However, the high cost and rarity of noble metals limit their economic efficiency, making it essential to improve the catalytic performance with lower noble metal loading. Herein, a two-step method was developed for the synthesis of uniformly dispersed ~3 nm Pt nanoparticles (NPs), strongly anchored on Ni(OH)2nanosheets (NSs), which was proven by adequate structural characterizations. XPS analysis demonstrated that Ni(OH)2NSs with abundant oxygen vacancies provided sufficient anchor sites for Pt NPs and prevented their agglomeration. The catalytic performance of Ptn/Ni(OH)2(n (represents the addition amount of Pt precursors during the synthesis, μmol) = 5, 10, 15, and 20) NSs with controllable Pt loading were evaluated via the reduction of 4-nitrophenol to 4-aminophenol as a model reaction. The Pt10/Ni(OH)2NSs exhibited the best activity and stability, with a reaction rate constant of 0.02358 s−1and negligible deterioration in ten reaction cycles. This novel synthetic method shows potentials for the synthesis of highly efficient noble-metal-supported catalysts for heterogeneous catalysis.Keywords:Pt/Ni(OH)2nanosheets;oxygen vacancy;heterogeneous catalysis;reduction of 4-nitrophenol
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高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Li Zheng,Chao-Rui Zhang,Dan Zhao,Xuan Wanga,Ting-Ting Du
A β-Ni(OH) 2 flakes modified carbon paste electrode [Ni(OH) 2 /CPE] has fabricated for hydrazine sensing. The β-Ni(OH) 2 flakes derived from nickel hexacyanoferrate (NiHCF) through a facile in situ electrochemical method and characterized by Fourier transform infrared spectrometry, X-ray diffraction, and scanning electron microscopy. Meanwhile, the electrochemical performances of the modified electrode studied by electrochemical impedance spectroscopy, chronocoulometry, cyclic voltammetry, and linear sweep voltammetry. Owing to the large active surface area and enhanced electron transfer efficiency of β-Ni(OH) 2 flakes, the Ni(OH) 2 /CPE showed enhanced catalytic activity toward the oxidation of hydrazine compared with NiHCF/CPE and unmodified CPE. Under the optimized conditions, the amperometric current presented linear dependence on the concentration of hydrazine in the ranges of 0.1 ~ 600 μM with the detection limit of 0.04 μM. Furthermore, the sensor has applied for the determination of hydrazine in water samples.
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高影响因子
APPLIED CLAY SCIENCE
·
2023
·
IF 5.6
Xuemin Zhong,Peng Yuan,Samahe Sadjadi,Dong Liu,Yanfu Wei
The oxidation of 5-hydroxymethylfurfural (HMF) to 2, 5-diformylfuran (DFF) is an important reaction for the conversion of renewable biomass into feedstock chemicals. In this work, palygorskite (Pal)-supported ruthenium (Ru) catalysts were developed for the efficient selective oxidation of HMF to DFF. Using natural clay mineral palygorskite as the support enabled the immobilization and dispersion of Ru nanoparticles . A 100% HMF conversion, 98% DFF yield, and 98% DFF selectivity were obtained over Ru(III)/Pal catalyst after 4.5 h under the optimal reaction conditions at 110 °C and 10 bar of O 2 in toluene. Ru nanoparticles and palygorskite synergistically achieve the excellent catalytic performance of the catalyst. The Ru metal active sites facilitate the activation of the reactants or intermediates, accelerating the formation of DFF. Furthermore, due to their different particle sizes and Ru species, the Ru(III)/Pal catalyst exhibits higher catalytic activity than the Ru(0)/Pal catalyst for the oxidation of HMF to DFF. The palygorskite-enhanced dispersion effect on Ru nanoparticles augments the catalytic activity. Moreover, the palygorskite-supported Ru catalyst showed good stability and was reused for at least five times consecutive cycles without significant loss of its catalytic activity.
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JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Yutong Zhao,Bo Lv,Wei Song,Jinkai Hao,Junfang Zhang,Zhigang Shao
Conventional high-temperature proton exchange membranes use phosphoric acid (PA) as a proton conductor . However, PA loss, poor mechanical stability, and catalyst poisoning represent major limitations. Solid acids are an alternative to PA that does not require humidification and is less prone to leaching. In this study, we prepared two composite membranes by high-temperature impregnation to investigate the effects of the structure of polybenzimidazole (PBI) on the anchoring of solid acids: a laboratory-synthesized m -PBI/CsH 5 (PO 4 ) 2 and the commercial OPBI/CsH 5 (PO 4 ) 2 . Compared to PA-doped membranes, CsH 5 (PO 4 ) 2 -doped membranes showed excellent mechanical properties , particularly m -PBI/CsH 5 (PO 4 ) 2 . Scanning electron microscopy and energy dispersive spectroscopy images showed that CsH 5 (PO 4 ) 2 was uniformly dispersed on the surface and cross-section of both membranes, conducive to the formation of proton transport channels following the CsH 5 (PO 4 ) 2 melting in both samples. The characterization of the physical structures proved the interaction between the imidazole ring and solid acid. Furthermore, the proton conductivity without humidification was similar in m -PBI/CsH 5 (PO 4 ) 2 and OPBI/CsH 5 (PO 4 ) 2 , demonstrating the suitability of m -PBI for fuel cells production. To test this, we assembled a m -PBI/CsH 5 (PO 4 ) 2 cell that showed competitive performances, with a peak power density of 361.28 mW cm −2 at 160 °C in H 2 /O 2 atmosphere.
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高影响因子
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
·
2023
·Vol. 238
·期 3
·541-543
·
IF 0.3
Chuanguo Cui,Jinxiao Zhang,Zhiyin Xiao
C 61 H 50 Cl 2 Fe 2 I 12 N 12 , orthorhombic, Pbcn (no. 60), a = 13.0247(4) Å, b = 17.0204(5) Å, c = 34.1475(9) Å, β = 90, V = 7570.0(4) Å 3 , Z = 4, R gt
( F ) = 0.0694, wR ref
( F
2 ) = 0.1605, T = 293(2) K.
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高影响因子
Journal of Biophotonics
·
2023
·
IF 2.8
Shuxia Lai,Yi Liu,Shubin Fang,Qiong Wu,Min Fan,Duo Lin,Jizhen Lin,Shangyuan Feng
The fast spread and transmission of the coronavirus 2019 (COVID-19) has become one of serious global public health problems. Herein, a surface enhanced Raman spectroscopy-based lateral flow immunoassay (LFA) was developed for the detection of SARS-CoV-2 antigen. Using uniquely designed core–shell nanoparticle with embedded Raman probe molecules as the indicator to reveal the concentration of target protein, excellent quantitative performance with a limit of detection (LOD) of 0.03 ng/mL and detection range of 10–1000 ng/mL can be achieved within 15 min. Besides, the detection of spiked virus protein in human saliva was also performed with a portable Raman spectrometer, proposing the feasibility of the method in practical applications. This easy-to-use, rapid and accurate method would provide a point-of-care testing way as the ideal alternative for current detection requirement of virus-related biomarkers.
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高影响因子
CHEMISTRY & BIODIVERSITY
·
2023
·Vol. 20
·期 6
·e202201145
·
IF 2.9
Huiying Bai,Zhen Cao,Sha Meng,Rui Ge,Shurong Ban,Yuanlin Zhang,Li Tang,Qing-Shan Li
Myeloid differentiation protein 2 (MD2), a key TLR4 adaptor protein for sensing LPS, plays an important role in inflammatory process and has been identified as a promising target for the treatment of a variety of inflammatory diseases. In our study, a series of benzoxazolone derivatives were synthesized, characterized and tested for anti-inflammatory activity in vitro . The compounds 3c , 3d and 3g demonstrated the greatest anti-inflammatory activity against IL-6 with IC 50 values of 10.14±0.08, 5.43±0.51 and 5.09±0.88 μM, respectively. Furthermore, the bis-ANS displacement assay revealed that these compounds competitively inhibited the binding between the probe bis-ANS and the MD2 protein. The most active compound 3g , revealed a directly bind with MD2 protein via Arg90 binding and a dissociation constant value of 1.52×10 −6 mol L −1 as determined by the biological layer interference (BLI) assay. Our finding suggested that compounds 3g could be a promising lead compound as MD2 inhibitor for further anti-inflammatory agent development.
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